Bleeding on ProbingFLJS_TRENCT07143344
This Study Utilized Fermented Lingonberry Juice in a Spray Form, Allowing it to be Applied to the Mouth Four Times a Day.
A study testing Fermented lingonberry juice sprey in people with Bleeding on Probing and Pocket Depth, run by Lahanna oy at 1 site in Finland.
Trial summary
A human intervention study was performed to examine the antimicrobial effects of fermented lingonberry spray (FLJ spray) treatment, used for a period of 30 days. Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Bleeding on Probing, Pocket Depth, Plaque Control
- What is being tested?
- Fermented lingonberry juice sprey
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 11 participants
- Where
- 1 siteFinland
- Study dates
- 1 Mar 2025to 30 Jul 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- Healthy patients or patients with systemic diseases with good cognitive abilities
- with or without xerostomia.
Who cannot join
- use of other mouthwash products, including chlorhexidine
- current use of antibiotics.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Effect of Fermented Lingonberry Spray on Oral Health - The Pilot Study
A human intervention study was performed to examine the antimicrobial effects of fermented lingonberry spray (FLJ spray) treatment, used for a period of 30 days.
Read the detailed description
Traditional clinical oral examinations, periodontal status and sample gatherings were performed at start point, two and four weeks. Bleeding on probing (BOP), visible plaque index (VPI), probing pocket depths (PPD) were examined and active-matrix metalloproteinase - 8 (aMMP-8) mouthrinse assays (Cutt-off 20 ng/ml) were carried out. Additionally, stimulated and resting saliva, pH and buffering capacity were tested as saliva test. A questionnaire assessing dry mouth symptoms was also recorded from the patients.
- Conditions
- Bleeding on Probing, Pocket Depth, Plaque Control, Saliva Microbiome
- Being tested
- Fermented lingonberry juice sprey
- Keywords
- fermented lingonberry juice, saliva test, mouthrinse, aMMP-8 test
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Fermented lingonberry juice spreyOther
Also called FLJ, fermented lingonberry juice
Patented fermented lingonberry juice sprey
| Study group | Role | What they receive |
|---|---|---|
| Adult patients were randomly selected from a private dental clinic in Tampere, Finland for the study | Experimental | Participants used approximately ten sprays four times a day (approx. 5,5 ml/ day) of FLJ-spray (Lingora® Oral Spray, Berries United Ltd, Helsinki, Finland) for a month. Receives: Other: Fermented lingonberry juice sprey |
What is being measured
The primary outcome is the main question the study is designed to answer.
The effects of fermented lingonberry spray in the mouth.
Changes of bleeding on probing (BOP), from six measurement point, visible plaque index (VPI), score 1-3, probing pocket depths (PPD) and active-matrix metalloproteinase - 8 (aMMP-8) mouthrinse assays (Cutt-off 20 ng/ml), numerical value were carried out to one month.
Measured: Up to one month
the time points on the levels of each salivary parameter were determined with the repeated measures ANOVA analysis.
Measured: 6 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Aug 2025
- Study start1 Mar 2025
- Primary completion30 Jun 2025
- Study completion30 Jul 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Bleeding on ProbingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 11 participants (actual)
Sponsor and investigators
- Lead sponsor
- Lahanna oy
- Sponsor type
- University, hospital or other
- Collaborators
- University of Helsinki
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07143344
- Sponsor's protocol ID
- LING_TRE
- Other IDs
- TYH2022225, TYH 2024332, TYH 2025382, Y2519SU010
- Acronym
- FLJS_TRE
- Status last verified
- Aug 2025
- First submitted
- 12 Aug 2025
- Last updated
- 27 Aug 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: All IPD collected throughout the trial.
Study at a glance
From the registry record, last updated by the sponsor on 27 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Fermented Lingonberry Spray on Oral Health - The Pilot Study
- ClinicalTrials.gov ID
- NCT07143344
- Acronym / sponsor ID
- FLJS_TRE / LING_TRE
- Conditions
- Bleeding on Probing, Pocket Depth, Plaque Control, Saliva Microbiome
- Keywords
- fermented lingonberry juice, saliva test, mouthrinse, aMMP-8 test
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 11 participants (actual)
- Lead sponsor
- Lahanna oyUniversity, hospital or other
- Collaborators
- University of Helsinki
- Study start
- 1 Mar 2025 (actual)
- Primary completion
- 30 Jun 2025 (actual)
- Study completion
- 30 Jul 2025 (actual)
- First posted
- 27 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
A human intervention study was performed to examine the antimicrobial effects of fermented lingonberry spray (FLJ spray) treatment, used for a period of 30 days.
Detailed description
Traditional clinical oral examinations, periodontal status and sample gatherings were performed at start point, two and four weeks. Bleeding on probing (BOP), visible plaque index (VPI), probing pocket depths (PPD) were examined and active-matrix metalloproteinase - 8 (aMMP-8) mouthrinse assays (Cutt-off 20 ng/ml) were carried out. Additionally, stimulated and resting saliva, pH and buffering capacity were tested as saliva test. A questionnaire assessing dry mouth symptoms was also recorded from the patients.
Study design
- Primary purpose
- Supportive care
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Adult patients were randomly selected from a private dental clinic in Tampere, Finland for the study | Experimental | Other: Fermented lingonberry juice spreyParticipants used approximately ten sprays four times a day (approx. 5,5 ml/ day) of FLJ-spray (Lingora® Oral Spray, Berries United Ltd, Helsinki, Finland) for a month. |
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (2 listed)
- Healthy patients or patients with systemic diseases with good cognitive abilities
- with or without xerostomia.
Key exclusion criteria (2 listed)
- use of other mouthwash products, including chlorhexidine
- current use of antibiotics.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Fermented lingonberry juice spreyAlso: FLJ, fermented lingonberry juicePatented fermented lingonberry juice sprey | Other | Adult patients were randomly selected from a private dental clinic in Tampere, Finland for the study |
Primary outcome
The effects of fermented lingonberry spray in the mouth.
Time frame: Up to one month
Changes of bleeding on probing (BOP), from six measurement point, visible plaque index (VPI), score 1-3, probing pocket depths (PPD) and active-matrix metalloproteinase - 8 (aMMP-8) mouthrinse assays (Cutt-off 20 ng/ml), numerical value were carried out to one month.
the time points on the levels of each salivary parameter were determined with the repeated measures ANOVA analysis.
Time frame: 6 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Aug 2025.
- Individual participant dataSharing planned: Yes. All IPD collected throughout the trial.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Fermented lingonberry juice sprey in people with Bleeding on Probing and Pocket Depth, run by Lahanna oy at 1 site in Finland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 27 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Finland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The effects of fermented lingonberry spray in the mouth. (time frame: Up to one month). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Aug 2025.