AnxietyNCT07144540
The Effectiveness of NeuroBot in Alleviating Anxiety of Patients Undergoing Neurovascular Surgeries
A study testing NeuroBot in people with Anxiety and Patient Compliance, run by Chinese University of Hong Kong at 2 sites in Hong Kong.
Trial summary
The goal of this randomized controlled trial is to investigate the effectiveness of NeuroBot in alleviating anxiety of patients undergoing neurovascular procedures. The main questions it aims to answer are: Is NeuroBot effective in alleviating anxiety? Is NeuroBot effective in enhancing patients' procedure and… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Anxiety, Patient Compliance, Knowledge
- What is being tested?
- NeuroBot
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 146 participants
- Where
- 2 sitesHong Kong
- Study dates
- 1 Oct 2025to 30 May 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- aged above 18 years;
- scheduled for elective neuroendovascular surgery;
- able to understand Chinese and read Chinese;
- mobile device with internet capability.
Who cannot join
- identified cognitive impairment or have difficulty in understanding study procedures, following instructions, or providing informed consent;
- prior exposure to health chatbot to acquire health-related information in previous 3 months;
- have neurovascular surgeries before
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
Hong Kong2 sites
The Chinese University of Hong Kong
Hong Kong
Cho Lee Wong, PhD Nursing, 852 +39438166, jojowong@cuhk.edu.hk
The Chinese University of Hong Kong
Hong Kong
About this study
The goal of this randomized controlled trial is to investigate the effectiveness of NeuroBot in alleviating anxiety of patients undergoing neurovascular procedures. The main questions it aims to answer are:
Is NeuroBot effective in alleviating anxiety? Is NeuroBot effective in enhancing patients' procedure and disease-related knowledge? Is NeuroBot effective in enhancing patients' compliance to treatment? If there is a comparison group: Researchers will compare with standard perioperative education (control group) to see if there is any difference in results.
Participants will be invited to chat with the artificial intelligence based chatbot "NeuroBot" for 6 weeks, from the date of preoperative clinic visit till 4 weeks after the surgery. The participants are allowed to access the NeuroBot at anytime anywhere, to ask surgery- related questions at their discretion.
Read the detailed description
The NeuroBot is co-developed by the neurosurgeons, nuerosurgical specialty nurses in Queen Elisabeth Hospital and AI experts from the Hong Kong Polytechnic University and the Chinese University of Hong Kong. The NeuroBot is developed based on the large language model that used machine learning algorithm and generative pretrained transformer model. Vast dataset of neurovascular surgery related information from validated sources, including DynaMed, UpToDate and textbooks were included and used for training of NeuroBot. The precision of the responses generated by NeuroBot was verified by a group of neurosurgical domain experts (neurosurgeons and experienced neurosurgical nurses).
- Conditions
- Anxiety, Patient Compliance, Knowledge
- Being tested
- NeuroBot, Standard Care (in control arm)
- Keywords
- Chatbot, NeuroBot, Perioperative education, Neurovascular surgery
- Medical subject headings
- Anxiety Disorders, Patient Compliance
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
NeuroBotOther
NeuroBot is an artificial intelligence online accessible chatbot that used machine learning and generative pretrained transformer model for supporting patients undergoing neurovascular surgery during perioperative period
Standard Care (in control arm)Other
Standard care include face-to-face consultation in preoperative nurse clinic and provision of leaflet
| Study group | Role | What they receive |
|---|---|---|
| Standard care arm | Active comparator | The participants will receive standard perioperative care as usual care Receives: Other: Standard Care (in control arm) |
| NeuroBot arm | Experimental | Patients will receive additional support from NeuroBot during perioperative period Receives: Other: NeuroBot; Other: Standard Care (in control arm) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Anxiety
Level of preoperative and postoperative anxiety, measured using State Trait Anxiety Inventory - State scale (6-item Chinese version). There are total of 6-item in the questionnaire, each item uses a 1 to 4 point rating scale. 1: not at all; 2: somewhat; 3: moderate; 4: very much so. The higher the score indicates the greater levels of anxiety
Measured: From preoperative (at nurse clinic) to postoperative from 1 week to 4 weeks after surgery
Secondary outcomes (4)
Knowledge
The level of procedure and disease related knowledge. A 10-item multiple choice questionnaire was developed and validated by neurosurgical experts. It will be used to assess participants' level of knowledge. Each participant will score 1 mark if they correctly answer each question. The higher the score, the higher the level of knowledge.
Measured: From preoperative nurse clinic visit to 1 week postoperative
Compliance
Compliance to prescribed treatment including follow-up visit, arranged investigation. The incidence of non-compliance will be traced through reviewing medical records. Each missed follow-up visit and investigation within 1 month after surgery will be counted. Each incidence of missed follow-up visits and investigations will be descriptively reported in both groups
Measured: 4 weeks after surgery
Readmission
Readmission related to the surgery. The incidence of readmission related to the postoperative complications will be traced in medical record. Number of Participants with readmission will be descriptively reported.
Measured: 4 weeks after surgery
Postoperative complications
surgery-related postoperative complications. The incidence of surgery-related postoperative complications will be traced in medical record. Number of Participants with surgery-related postoperative complications will be descriptively reported in both groups
Measured: 4 weeks after surgery
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Aug 2025
- Study start1 Oct 2025 (estimated)
- Primary completion30 May 2027 (estimated)
- Study completion30 May 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AnxietyStudies of the same condition, open and under way.
- More trials run by Chinese University of Hong KongThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- The control arm will receive standard preoperative education in the preoperative nurse clinic, apart from face-to-face consultation, leaflet will be provided for illustrating the surgical procedure and the disease. For the intervention arm, on top of the standard care as above, they will be additionally provided an artificial intelligence chatbot "NeuroBot" for perioperative support.
- Masking
- Triple blind
- Who is masked
- Care provider, Investigator, Outcomes assessor
- Enrolment
- 146 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Chinese University of Hong Kong
- Sponsor type
- University, hospital or other
- Collaborators
- The Hong Kong Polytechnic University, Hospital Authority, Hong Kong
- Responsible party
- Principal investigator, HO Chung Man, Chinese University of Hong Kong
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07144540
- Sponsor's protocol ID
- NeuroBot202527
- Status last verified
- Aug 2025
- First submitted
- 15 Aug 2025
- Last updated
- 27 Aug 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 27 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effectiveness of NeuroBot in Alleviating Anxiety of Patients Undergoing Neurovascular Surgeries
- ClinicalTrials.gov ID
- NCT07144540
- Acronym / sponsor ID
- NeuroBot202527
- Conditions
- Anxiety, Patient Compliance, Knowledge
- Keywords
- Chatbot, NeuroBot, Perioperative education, Neurovascular surgery
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 146 participants (estimated)
- Lead sponsor
- Chinese University of Hong KongUniversity, hospital or other
- Collaborators
- The Hong Kong Polytechnic University, Hospital Authority, Hong Kong
- Study start
- 1 Oct 2025 (estimated)
- Primary completion
- 30 May 2027 (estimated)
- Study completion
- 30 May 2027 (estimated)
- First posted
- 27 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this randomized controlled trial is to investigate the effectiveness of NeuroBot in alleviating anxiety of patients undergoing neurovascular procedures. The main questions it aims to answer are:
Is NeuroBot effective in alleviating anxiety? Is NeuroBot effective in enhancing patients' procedure and disease-related knowledge? Is NeuroBot effective in enhancing patients' compliance to treatment? If there is a comparison group: Researchers will compare with standard perioperative education (control group) to see if there is any difference in results.
Participants will be invited to chat with the artificial intelligence based chatbot "NeuroBot" for 6 weeks, from the date of preoperative clinic visit till 4 weeks after the surgery. The participants are allowed to access the NeuroBot at anytime anywhere, to ask surgery- related questions at their discretion.
Detailed description
The NeuroBot is co-developed by the neurosurgeons, nuerosurgical specialty nurses in Queen Elisabeth Hospital and AI experts from the Hong Kong Polytechnic University and the Chinese University of Hong Kong. The NeuroBot is developed based on the large language model that used machine learning algorithm and generative pretrained transformer model. Vast dataset of neurovascular surgery related information from validated sources, including DynaMed, UpToDate and textbooks were included and used for training of NeuroBot. The precision of the responses generated by NeuroBot was verified by a group of neurosurgical domain experts (neurosurgeons and experienced neurosurgical nurses).
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (care provider, investigator, outcomes assessor)
- Number of arms
- 2
- Model description
- The control arm will receive standard preoperative education in the preoperative nurse clinic, apart from face-to-face consultation, leaflet will be provided for illustrating the surgical procedure and the disease. For the intervention arm, on top of the standard care as above, they will be additionally provided an artificial intelligence chatbot "NeuroBot" for perioperative support.
| Arm | Type | Receives |
|---|---|---|
| Standard care arm | Active comparator | Other: Standard Care (in control arm)The participants will receive standard perioperative care as usual care |
| NeuroBot arm | Experimental | Other: NeuroBot, Other: Standard Care (in control arm)Patients will receive additional support from NeuroBot during perioperative period |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- aged above 18 years;
- scheduled for elective neuroendovascular surgery;
- able to understand Chinese and read Chinese;
- mobile device with internet capability.
Key exclusion criteria (3 listed)
- identified cognitive impairment or have difficulty in understanding study procedures, following instructions, or providing informed consent;
- prior exposure to health chatbot to acquire health-related information in previous 3 months;
- have neurovascular surgeries before
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| NeuroBotNeuroBot is an artificial intelligence online accessible chatbot that used machine learning and generative pretrained transformer model for supporting patients undergoing neurovascular surgery during perioperative period | Other | NeuroBot arm |
| Standard Care (in control arm)Standard care include face-to-face consultation in preoperative nurse clinic and provision of leaflet | Other | NeuroBot arm, Standard care arm |
Primary outcome
Anxiety
Time frame: From preoperative (at nurse clinic) to postoperative from 1 week to 4 weeks after surgery
Level of preoperative and postoperative anxiety, measured using State Trait Anxiety Inventory - State scale (6-item Chinese version). There are total of 6-item in the questionnaire, each item uses a 1 to 4 point rating scale. 1: not at all; 2: somewhat; 3: moderate; 4: very much so. The higher the score indicates the greater levels of anxiety
4 secondary outcomes
Knowledge
Time frame: From preoperative nurse clinic visit to 1 week postoperative
Compliance
Time frame: 4 weeks after surgery
Readmission
Time frame: 4 weeks after surgery
Postoperative complications
Time frame: 4 weeks after surgery
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Aug 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing NeuroBot in people with Anxiety and Patient Compliance, run by Chinese University of Hong Kong at 2 sites in Hong Kong.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 27 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Hong Kong. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Chung Man Ho, Master of Nursing (852 +35068887, 1007615401@link.cuhk.edu.hk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Anxiety (time frame: From preoperative (at nurse clinic) to postoperative from 1 week to 4 weeks after surgery). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Aug 2025.