Ischemic PreconditioningNCT07146399
The Impact of Ischemic Preconditioning on Exercise Performance and Physiological Function
A study testing Ischemic Preconditioning in people with Ischemic Preconditioning and Autonomic Nervous System (ANS) Functioning and Mood State, run by Ziyue Ou at 1 site in China.
Trial summary
Ischemic Preconditioning has been confirmed to prevent long-term ischemic damage to tissues, among which the improvement of autonomic nerve system function may be one of its mechanisms of action. Read more about this study
- Who is it for?
- Ages 18 to 22 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Ischemic Preconditioning, Autonomic Nervous System (ANS) Functioning and Mood State
- What is being tested?
- Ischemic Preconditioning
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 15 participants
- Where
- 1 siteChina
- Study dates
- 31 Dec 2023to 7 Feb 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 22 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Taekwondo athletes with a national ranking of level two or higher, including those placed in the top three at the Provincial Professional Taekwondo Championship (combat) and the top eight at the National Professional Taekwondo Championship (combat);
- adult males aged 18 years or older;
- regular participation in specialized Taekwondo training for the past three months.
- All the subjects were from the same team.
Who cannot join
- consumption of alcohol or caffeine within 24 hours prior to the experiment;
- engagement in strenuous physical activity within 24 hours before the experiment;
- presence of acute or chronic diseases, including cardiovascular diseases, anxiety disorders, and metabolic diseases;
- use of creatine supplements
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Ischemic Preconditioning Enhances Autonomic Nervous System Modulation During Frequency Speed of Kick Test in Taekwondo Athletes: A Randomized Crossover Study
Ischemic Preconditioning has been confirmed to prevent long-term ischemic damage to tissues, among which the improvement of autonomic nerve system function may be one of its mechanisms of action. In recent years, IPC has gradually been applied to enhance athletic performance and accelerate postexercise recovery; however, there has been limited research on the effects of IPC on ANS function and competitive condition before and after exercise. This study investigated the effects of IPC on ANS function before and after sport-specific testing in taekwondo athletes. The objectives of our study are (1) to investigate the impact of IPC on two indicators of autonomic nervous function-HRV and HRR-and (2) to reveal the coordinating effect of IPC on the sympathetic and parasympathetic nervous systems during the warm-up phase and after specific testing in taekwondo athletes. The investigators hypothesize that IPC enhances sympathetic drive during the warm-up phase and rapidly activates the parasympathetic nervous system postexercise, which is accompanied by improvements in the athletes' competitive condition.
- Being tested
- Ischemic Preconditioning, Sham (No Treatment)
- Keywords
- Ischemic preconditioning, Autonomic nervous system, Heart rate variability, Heart rate recovery
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Ischemic PreconditioningProcedure or surgery
Compression cuff width: 10CM; Compression duration: 5min/5min (ischemia/reperfusion) *4. 220 mmHg
Sham (No Treatment)Procedure or surgery
Compression cuff width: 10CM; Compression duration: 5min/5min (compression/relaxation) *4. 20 mmHg
| Study group | Role | What they receive |
|---|---|---|
| IPC Trial | Experimental | 220 mmHg Receives: Procedure: Ischemic Preconditioning |
| SHAM Trial | Placebo comparator | 20 mmHg Receives: Procedure: Sham (No Treatment) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Taekwondo-specific sports performance test.
The specialized athletic ability in Taekwondo is measured by the number of kicks performed during the test.
Measured: Five minutes after the intervention, a standard warm-up lasting 10 minutes is conducted. Following the warm-up, a rest period of 5 minutes is observed. Subsequently, three sets of specialized sports performance tests are administered, with each set lasti
Heart rate variability
Used to measure the autonomic nervous function of taekwondo athletes.
Measured: The measurement time points were as follows: heart rate variability was assessed in the resting state upon participants' arrival at the testing site, after a warm-up, and following the sport-specific performance test.
Heart rate recovery
Used to measure the autonomic nervous function of taekwondo athletes.
Measured: The measurement time points were established as follows: heart rate recovery was assessed for 1 minute during the intervals of each test group. Additionally, heart rate recovery was recorded at both 1 minute and 5 minutes following the completion of thre
Blood lactate
Used to measure the intensity and metabolic adaptations during the testing process of taekwondo athletes.
Measured: Blood lactate measurements were taken at several key time points during the study: upon participants' arrival at the test site while they were in a quiet state; at the 3rd minute following the conclusion of the intervention; prior to the commencement of
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Aug 2025
- Study start31 Dec 2023
- Primary completion7 Feb 2024
- Study completion7 Feb 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (5)Papers the sponsor has linked to this study.
- Other trials for Ischemic PreconditioningStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind
- Who is masked
- Investigator, Outcomes assessor
- Enrolment
- 15 participants (actual)
Sponsor and investigators
- Lead sponsor
- Ziyue Ou
- Sponsor type
- University, hospital or other
- Collaborators
- Guangzhou Sport University
- Responsible party
- Sponsor-investigator, Ziyue Ou, Guangzhou Sport University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07146399
- Sponsor's protocol ID
- 2023LCLL-81
- Status last verified
- Aug 2025
- First submitted
- 14 Aug 2025
- Last updated
- 28 Aug 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: The data presented in this study are currently unpublished. The corresponding author will provide the relevant research data upon reasonable request after the associated paper has been officially accepted.
Publications
Tsutsui H, Tanaka R, Yamagata M, Yukimura T, Ohkita M, Matsumura Y. Protective effect of ischemic preconditioning on ischemia/reperfusion-induced acute kidney injury through sympathetic nervous system in rats. Eur J Pharmacol. 2013 Oct 15;718(1-3):206-12. doi: 10.1016/j.ejphar.2013.08.032. Epub 2013 Sep 12.
PubMed 24036256Lopes TR, Sabino-Carvalho JL, Ferreira THN, Succi JE, Silva AC, Silva BM. Effect of Ischemic Preconditioning on the Recovery of Cardiac Autonomic Control From Repeated Sprint Exercise. Front Physiol. 2018 Oct 26;9:1465. doi: 10.3389/fphys.2018.01465. eCollection 2018.
PubMed 30416451Noronha Osorio D, Viana-Soares R, Marto JP, Mendonca MD, Silva HP, Quaresma C, Viana-Baptista M, Gamboa H, Vieira HLA. Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment. BMC Cardiovasc Disord. 2019 Sep 9;19(1):211. doi: 10.1186/s12872-019-1181-5.
PubMed 31500561Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 1986 Nov;74(5):1124-36. doi: 10.1161/01.cir.74.5.1124.
PubMed 3769170Ou Z, Yang L, Zhu H, Weng X, Xu G. Ischemic preconditioning enhances autonomic nervous system modulation during frequency speed of kick test in taekwondo athletes: a randomized crossover study. BMC Sports Sci Med Rehabil. 2026 Feb 12;18(1):136. doi: 10.1186/s13102-026-01602-2.
PubMed 41680854
Study at a glance
From the registry record, last updated by the sponsor on 28 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Ischemic Preconditioning Enhances Autonomic Nervous System Modulation During Frequency Speed of Kick Test in Taekwondo Athletes: A Randomized Crossover Study
- ClinicalTrials.gov ID
- NCT07146399
- Acronym / sponsor ID
- 2023LCLL-81
- Keywords
- Ischemic preconditioning, Autonomic nervous system, Heart rate variability, Heart rate recovery
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 15 participants (actual)
- Lead sponsor
- Ziyue OuUniversity, hospital or other
- Collaborators
- Guangzhou Sport University
- Study start
- 31 Dec 2023 (actual)
- Primary completion
- 7 Feb 2024 (actual)
- Study completion
- 7 Feb 2024 (actual)
- First posted
- 28 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Ischemic Preconditioning has been confirmed to prevent long-term ischemic damage to tissues, among which the improvement of autonomic nerve system function may be one of its mechanisms of action. In recent years, IPC has gradually been applied to enhance athletic performance and accelerate postexercise recovery; however, there has been limited research on the effects of IPC on ANS function and competitive condition before and after exercise. This study investigated the effects of IPC on ANS function before and after sport-specific testing in taekwondo athletes. The objectives of our study are (1) to investigate the impact of IPC on two indicators of autonomic nervous function-HRV and HRR-and (2) to reveal the coordinating effect of IPC on the sympathetic and parasympathetic nervous systems during the warm-up phase and after specific testing in taekwondo athletes. The investigators hypothesize that IPC enhances sympathetic drive during the warm-up phase and rapidly activates the parasympathetic nervous system postexercise, which is accompanied by improvements in the athletes' competitive condition.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind (investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| IPC Trial | Experimental | Procedure: Ischemic Preconditioning220 mmHg |
| SHAM Trial | Placebo comparator | Procedure: Sham (No Treatment)20 mmHg |
Who may qualify
- Ages
- 18 to 22 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Taekwondo athletes with a national ranking of level two or higher, including those placed in the top three at the Provincial Professional Taekwondo Championship (combat) and the top eight at the National Professional Taekwondo Championship (combat);
- adult males aged 18 years or older;
- regular participation in specialized Taekwondo training for the past three months.
- All the subjects were from the same team.
Key exclusion criteria (4 listed)
- consumption of alcohol or caffeine within 24 hours prior to the experiment;
- engagement in strenuous physical activity within 24 hours before the experiment;
- presence of acute or chronic diseases, including cardiovascular diseases, anxiety disorders, and metabolic diseases;
- use of creatine supplements
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Ischemic PreconditioningCompression cuff width: 10CM; Compression duration: 5min/5min (ischemia/reperfusion) *4. 220 mmHg | Procedure or surgery | IPC Trial |
| Sham (No Treatment)Compression cuff width: 10CM; Compression duration: 5min/5min (compression/relaxation) *4. 20 mmHg | Procedure or surgery | SHAM Trial |
Primary outcome
Taekwondo-specific sports performance test.
Time frame: Five minutes after the intervention, a standard warm-up lasting 10 minutes is conducted. Following the warm-up, a rest period of 5 minutes is observed. Subsequently, three sets of specialized sports performance tests are administered, with each set lasti
The specialized athletic ability in Taekwondo is measured by the number of kicks performed during the test.
Heart rate variability
Time frame: The measurement time points were as follows: heart rate variability was assessed in the resting state upon participants' arrival at the testing site, after a warm-up, and following the sport-specific performance test.
Used to measure the autonomic nervous function of taekwondo athletes.
Heart rate recovery
Time frame: The measurement time points were established as follows: heart rate recovery was assessed for 1 minute during the intervals of each test group. Additionally, heart rate recovery was recorded at both 1 minute and 5 minutes following the completion of thre
Used to measure the autonomic nervous function of taekwondo athletes.
Blood lactate
Time frame: Blood lactate measurements were taken at several key time points during the study: upon participants' arrival at the test site while they were in a quiet state; at the 3rd minute following the conclusion of the intervention; prior to the commencement of
Used to measure the intensity and metabolic adaptations during the testing process of taekwondo athletes.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Aug 2025.
- Background: PubMed 24036256Tsutsui H, Tanaka R, Yamagata M, Yukimura T, Ohkita M, Matsumura Y. Protective effect of ischemic preconditioning on ischemia/reperfusion-induced acute kidney injury through sympathetic nervous system in rats. Eur J Pharmacol. 2013 Oct 15;718(1-3):206-12. doi: 10.1016/j.ejphar.2013.08.032. Epub 2013 Sep 12.
- Background: PubMed 30416451Lopes TR, Sabino-Carvalho JL, Ferreira THN, Succi JE, Silva AC, Silva BM. Effect of Ischemic Preconditioning on the Recovery of Cardiac Autonomic Control From Repeated Sprint Exercise. Front Physiol. 2018 Oct 26;9:1465. doi: 10.3389/fphys.2018.01465. eCollection 2018.
- Background: PubMed 31500561Noronha Osorio D, Viana-Soares R, Marto JP, Mendonca MD, Silva HP, Quaresma C, Viana-Baptista M, Gamboa H, Vieira HLA. Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment. BMC Cardiovasc Disord. 2019 Sep 9;19(1):211. doi: 10.1186/s12872-019-1181-5.
- Background: PubMed 3769170Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 1986 Nov;74(5):1124-36. doi: 10.1161/01.cir.74.5.1124.
- Derived from this study: PubMed 41680854Ou Z, Yang L, Zhu H, Weng X, Xu G. Ischemic preconditioning enhances autonomic nervous system modulation during frequency speed of kick test in taekwondo athletes: a randomized crossover study. BMC Sports Sci Med Rehabil. 2026 Feb 12;18(1):136. doi: 10.1186/s13102-026-01602-2.
- Individual participant dataSharing planned: No. The data presented in this study are currently unpublished. The corresponding author will provide the relevant research data upon reasonable request after the associated paper has been officially accepted.
Related trials for Ischemic Preconditioning
Recruiting
Efficacy and Safety of Ischemic Preconditioning Therapy Versus Optimal Medical Therapy in Reducing the Recurrence of Ischemic Events in Symptomatic Moyamoya Disease
Moya Moya Disease, Moyamoya Syndrome
Recruiting
Effects of Remote Ischemic Preconditioning at Different Time Phases in Patients Undergoing Heart Valve Surgery
Heart Valve Surgery, Acute Kidney Injury
Recruiting
Effectiveness of Remote Ischemic Preconditioning for Prevention of Contrast Induced Acute Kidney Injury in Patients Undergoing Coronary Angiograms.
Contrast-induced Acute Kidney Injury (CI-AKI) Following Coronary Angiogram (CI-AKI), Contrast-induced Nephropathy Following Coronary Angiogram (CIN)
Recruiting
Remote Ischemic Preconditioning for Aute Type A Aortic Dissection Surgery
Aortic Dissection Type A
Not yet recruiting
Prevention of Ischemia in Aneurysmal Subarachnoid Hemorrhage Through Remote Ischemic Preconditioning
Aneurysmal Subarachnoid Hemorrhage
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Ischemic Preconditioning in people with Ischemic Preconditioning and Autonomic Nervous System (ANS) Functioning and Mood State, run by Ziyue Ou at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 28 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Taekwondo-specific sports performance test. (time frame: Five minutes after the intervention, a standard warm-up lasting 10 minutes is conducted. Following the warm-up, a rest period of 5 minutes is observed. Subsequently, three sets of specialized sports performance tests are administered, with each set lasti). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07146399, which also lists 5 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Aug 2025.