Inactivity, PhysicalNCT07146867
Effects of One HIIT Session on Adiponectin Isoforms
A study testing High intensity interval training (exercise) in people with Inactivity, Physical, run by Universidad San Sebastián at 1 site in Chile.
Trial summary
The goal of this observational quasi-experimental study is to evaluate whether a single session of high-intensity interval training (HIIT) can acutely modulate metabolic markers, particularly adiponectin isoforms, in insufficiently active young adults (men and women, 18-29 years, free of cardiometabolic disease). Read more about this study
- Who is it for?
- Ages 18 to 29 yearsHealthy volunteers can take part
- Conditions the study is for
- Inactivity, Physical
- What is being tested?
- High intensity interval training (exercise)
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 21 participants
- Where
- 1 siteChile
- Study dates
- 1 Mar 2023to 15 Jan 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 29 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Age between 18 and 29 years
- Engage in less than 150 minutes of moderate-intensity or 75 minutes of vigorous-intensity physical activity per week)
- Having no positive responses on the PAR-Q \& YOU questionnaire
Who cannot join
- Diagnosis of cardiometabolic disease
- Use of anti-inflammatory treatment during the week prior to participation
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Metabolic Responses to a Single Session of High-intensity Interval Training in Insufficiently Active Young Adults. Effects on Adiponectin Isoforms
The goal of this observational quasi-experimental study is to evaluate whether a single session of high-intensity interval training (HIIT) can acutely modulate metabolic markers, particularly adiponectin isoforms, in insufficiently active young adults (men and women, 18-29 years, free of cardiometabolic disease).
The main questions it aims to answer are:
Read more
Does a single HIIT session increase circulating medium- and high-molecular-weight adiponectin?
Does HIIT acutely alter lipid and glucose metabolism markers such as non-HDL cholesterol, insulin, and lactate?
Participants completed the following tasks:
Underwent baseline assessments (anthropometry, body composition, and resting cardiovascular parameters).
Performed one HIIT session consisting of six 3-minute intervals at 80% heart rate reserve, each followed by 3 minutes of active recovery.
Provided blood samples before and immediately after exercise to analyze adiponectin isoforms (LMW, MMW, HMW) via Western blot and to measure glucose, insulin, lipid profile, liver enzymes, and lactate.
Summary of findings:
A single HIIT session significantly increased medium-molecular-weight adiponectin (~19%), decreased the HMW/MMW ratio, and elevated lactate and non-HDL cholesterol. No significant changes were observed in LMW or HMW adiponectin. These results suggest that MMW adiponectin is an early, sensitive marker of acute exercise response in sedentary young adults, though further research is needed to confirm long-term implications
- Conditions
- Inactivity, Physical
- Being tested
- High intensity interval training (exercise)
- Keywords
- adiponectin, high intensity interval training
- Medical subject headings
- Sedentary Behavior
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
High intensity interval training (exercise)Behavioural
One 30 minute session of high intensity interval training
| Study group | Role | What they receive |
|---|---|---|
| High intensity interval training | Experimental | One session of high intensity interval training Receives: Behavioral: High intensity interval training (exercise) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Adiponectin isoforms
Measured: Before and immediately after the exercise session
Adiponectin isoforms
Measured: Before and immediately after the exercise session (30 minutes)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Aug 2025
- Study start1 Mar 2023
- Primary completion1 Dec 2024
- Study completion15 Jan 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Inactivity, PhysicalStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 21 participants (actual)
Sponsor and investigators
- Lead sponsor
- Universidad San Sebastián
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Sergio Martinez-Huenchullan, Universidad San Sebastián
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07146867
- Sponsor's protocol ID
- AcuteHIIT
- Status last verified
- Apr 2026
- First submitted
- 21 Aug 2025
- Last updated
- 5 May 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes
Publications
Alvarado-Carrasco D, Gonzalez-Maraboli A, Reyes-Montalva M, Videla-Aguilar J, Bentes A, Penailillo L, Sandoval V, Martinez-Huenchullan S. Acute effects of high-intensity interval training on adiponectin isoforms in inactive young adults: a quasi-experimental study. BMC Sports Sci Med Rehabil. 2025 Dec 30;17(1):387. doi: 10.1186/s13102-025-01433-7.
PubMed 41469733
Study at a glance
From the registry record, last updated by the sponsor on 5 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Metabolic Responses to a Single Session of High-intensity Interval Training in Insufficiently Active Young Adults. Effects on Adiponectin Isoforms
- ClinicalTrials.gov ID
- NCT07146867
- Acronym / sponsor ID
- AcuteHIIT
- Conditions
- Inactivity, Physical
- Keywords
- adiponectin, high intensity interval training
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 21 participants (actual)
- Lead sponsor
- Universidad San SebastiánUniversity, hospital or other
- Study start
- 1 Mar 2023 (actual)
- Primary completion
- 1 Dec 2024 (actual)
- Study completion
- 15 Jan 2025 (actual)
- First posted
- 28 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this observational quasi-experimental study is to evaluate whether a single session of high-intensity interval training (HIIT) can acutely modulate metabolic markers, particularly adiponectin isoforms, in insufficiently active young adults (men and women, 18-29 years, free of cardiometabolic disease).
The main questions it aims to answer are:
Does a single HIIT session increase circulating medium- and high-molecular-weight adiponectin?
Does HIIT acutely alter lipid and glucose metabolism markers such as non-HDL cholesterol, insulin, and lactate?
Participants completed the following tasks:
Underwent baseline assessments (anthropometry, body composition, and resting cardiovascular parameters).
Performed one HIIT session consisting of six 3-minute intervals at 80% heart rate reserve, each followed by 3 minutes of active recovery.
Provided blood samples before and immediately after exercise to analyze adiponectin isoforms (LMW, MMW, HMW) via Western blot and to measure glucose, insulin, lipid profile, liver enzymes, and lactate.
Summary of findings:
A single HIIT session significantly increased medium-molecular-weight adiponectin (~19%), decreased the HMW/MMW ratio, and elevated lactate and non-HDL cholesterol. No significant changes were observed in LMW or HMW adiponectin. These results suggest that MMW adiponectin is an early, sensitive marker of acute exercise response in sedentary young adults, though further research is needed to confirm long-term implications
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| High intensity interval training | Experimental | Behavioral: High intensity interval training (exercise)One session of high intensity interval training |
Who may qualify
- Ages
- 18 to 29 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Age between 18 and 29 years
- Engage in less than 150 minutes of moderate-intensity or 75 minutes of vigorous-intensity physical activity per week)
- Having no positive responses on the PAR-Q \& YOU questionnaire
Key exclusion criteria (2 listed)
- Diagnosis of cardiometabolic disease
- Use of anti-inflammatory treatment during the week prior to participation
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| High intensity interval training (exercise)One 30 minute session of high intensity interval training | Behavioural | High intensity interval training |
Primary outcome
Adiponectin isoforms
Time frame: Before and immediately after the exercise session
Adiponectin isoforms
Time frame: Before and immediately after the exercise session (30 minutes)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 May 2026.
- Derived from this study: PubMed 41469733Alvarado-Carrasco D, Gonzalez-Maraboli A, Reyes-Montalva M, Videla-Aguilar J, Bentes A, Penailillo L, Sandoval V, Martinez-Huenchullan S. Acute effects of high-intensity interval training on adiponectin isoforms in inactive young adults: a quasi-experimental study. BMC Sports Sci Med Rehabil. 2025 Dec 30;17(1):387. doi: 10.1186/s13102-025-01433-7.
- Individual participant dataSharing planned: Yes
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing High intensity interval training (exercise) in people with Inactivity, Physical, run by Universidad San Sebastián at 1 site in Chile.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 5 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Chile. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Adiponectin isoforms (time frame: Before and immediately after the exercise session). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07146867, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 May 2026.