Muscle Planes, Muscle Volumes, Fat Infiltration in Cervical MRINCT07148167
Comparison of Cervical Extensor Muscle Thickness, Fat Infiltration, and Cervical Alignment in Patients With Ankylosing Spondylitis With a Healthy Population: a Retrospective Controlled Study
An observational study of Muscle Planes, Muscle Volumes, Fat Infiltration in Cervical MRI, run by Kayseri City Hospital at 1 site in Turkey (Türkiye).
Trial summary
In the literature, we found only one study evaluating the thickness of the cervical paraspinal muscles (multifidus, semispinalis cervicis, semispinalis capitis, splenius capitis, and trapezius) in patients with AS. Read more about this study
- Who is it for?
- Ages 18 to 50 yearsHealthy volunteers can take part
- Conditions the study is for
- Muscle Planes, Muscle Volumes, Fat Infiltration in Cervical MRI
- What is being tested?
- Magnetic resonance imaging
- How many people
- 158 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Jan 2025to 30 Nov 2025
- How long will I take part?
- 1 Month
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- All sexes
- Healthy volunteers accepted
- Adult
Study population: For the study group: * Patients diagnosed with ankylosing spondylitis, aged 18-50. * Patients who underwent a cervical MRI between January 2020 and September 2023. Control Group Patients aged 18-50 who underwent cervical MRI between January 2020 and September 2023 due to nonspecific neck pain, who did not have an AS diagnosis and whose cervical MRI was reported as normal.
Who may be able to join
- For the study group:
- Patients diagnosed with ankylosing spondylitis, aged 18-50.
- Patients who underwent a cervical MRI between January 2020 and September 2023. Control Group Patients aged 18-50 who underwent cervical MRI between January 2020 and September 2023 due to nonspecific neck pain, who did not have an AS diagnosis and whose cervical MRI was reported as normal.
Who cannot join
- Patients over 50 years of age
- History of spine surgery;
- Presence of pain, numbness, and weakness in the upper extremities
- History of cervical injury or neck injury
- Presence of tuberculosis, tumor, fracture, infection, instability, cervical myelopathy, cervical disc herniation (protrusion, extrusion) (will be considered cervical bulging)
- Presence of cervical radiculopathy
- Those with a detectable pathological spinal condition related to neck pain, including spinal deformity; inflammatory or rheumatic diseases other than AS, malignancies, or neurological diseases
- A cognitive or psychological disorder
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Cervical MRI Findings in Patients With Ankylosing Spondylitis
In the literature, we found only one study evaluating the thickness of the cervical paraspinal muscles (multifidus, semispinalis cervicis, semispinalis capitis, splenius capitis, and trapezius) in patients with AS. This study examined the morphology of all neck extensor muscles (multifidus, semispinalis capitis, semispinalis cervicis, splenius capitis, and trapezius muscles) using ultrasound and their relationship to activities of daily living and compared them with a control group. As is well known, the user's experience is crucial in ultrasound. Furthermore, ultrasound cannot accurately assess the deep paravertebral muscles. Therefore, inspired by this study, we decided to use Magnetic Resonance Imaging (MRI) to evaluate the cervical muscle planes in AS patients in more detailed and objective ways. In this study, in addition to cervical muscle volumes in AS patients, we also aimed to evaluate cervical fat infiltration and cervical alignment, which have not been previously evaluated in AS patients.
- Being tested
- Magnetic resonance imaging
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Magnetic resonance imagingOther
use Magnetic Resonance Imaging (MRI) to evaluate the cervical muscle planes in AS patients in more detailed and objective ways. In this study, in addition to cervical muscle volumes in AS patients, we also aimed to evaluate cervical fat infiltration and cervical alignment, which have not been previously evaluated in AS patients.
| Study group | Role | What they receive |
|---|---|---|
| Ankylosing Spondylitis group | For the study group:
* Patients diagnosed with ankylosing spondylitis, aged 18-50.
* Patients who underwent a cervical MRI between January 2020 and September 2023. Receives: Other: Magnetic resonance imaging | |
| Control Group | Patients aged 18-50 who underwent cervical MRI between January 2020 and September 2023 due to nonspecific neck pain, who did not have an AS diagnosis and whose cervical MRI was reported as normal. Receives: Other: Magnetic resonance imaging |
What is being measured
The primary outcome is the main question the study is designed to answer.
servical MRI fındings in AS patients,
the cervical muscle planes, cervical muscle volumes in AS patients cervical fat infiltration
Measured: Patients who underwent cervical MRI between January 2020 and September 2023
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Aug 2025
- Study start1 Jan 2025
- Primary completion30 Nov 2025
- Study completion30 Nov 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Muscle Planes, Muscle Volumes, Fat Infiltration in Cervical MRIStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Other
- Enrolment
- 158 participants (actual)
- Target duration
- 1 Month
Sponsor and investigators
- Lead sponsor
- Kayseri City Hospital
- Sponsor type
- Other government
- Responsible party
- Principal investigator, Ayse Guc, Kayseri City Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07148167
- Sponsor's protocol ID
- Kayseri City EAH
- Status last verified
- Feb 2026
- First submitted
- 14 Jul 2025
- Last updated
- 20 Feb 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 20 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Cervical MRI Findings in Patients With Ankylosing Spondylitis
- ClinicalTrials.gov ID
- NCT07148167
- Acronym / sponsor ID
- Kayseri City EAH
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 158 participants (actual)
- Lead sponsor
- Kayseri City HospitalOther government
- Study start
- 1 Jan 2025 (actual)
- Primary completion
- 30 Nov 2025 (actual)
- Study completion
- 30 Nov 2025 (actual)
- First posted
- 29 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
In the literature, we found only one study evaluating the thickness of the cervical paraspinal muscles (multifidus, semispinalis cervicis, semispinalis capitis, splenius capitis, and trapezius) in patients with AS. This study examined the morphology of all neck extensor muscles (multifidus, semispinalis capitis, semispinalis cervicis, splenius capitis, and trapezius muscles) using ultrasound and their relationship to activities of daily living and compared them with a control group. As is well known, the user's experience is crucial in ultrasound. Furthermore, ultrasound cannot accurately assess the deep paravertebral muscles. Therefore, inspired by this study, we decided to use Magnetic Resonance Imaging (MRI) to evaluate the cervical muscle planes in AS patients in more detailed and objective ways. In this study, in addition to cervical muscle volumes in AS patients, we also aimed to evaluate cervical fat infiltration and cervical alignment, which have not been previously evaluated in AS patients.
Study design
- Observational model
- Case-control
- Time perspective
- Other
- Target follow-up
- 1 Month
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Ankylosing Spondylitis group | – | Other: Magnetic resonance imagingFor the study group: * Patients diagnosed with ankylosing spondylitis, aged 18-50. * Patients who underwent a cervical MRI between January 2020 and September 2023. |
| Control Group | – | Other: Magnetic resonance imagingPatients aged 18-50 who underwent cervical MRI between January 2020 and September 2023 due to nonspecific neck pain, who did not have an AS diagnosis and whose cervical MRI was reported as normal. |
Who may qualify
- Ages
- 18 to 50 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
- Study population
- For the study group: * Patients diagnosed with ankylosing spondylitis, aged 18-50. * Patients who underwent a cervical MRI between January 2020 and September 2023. Control Group Patients aged 18-50 who underwent cervical MRI between January 2020 and September 2023 due to nonspecific neck pain, who did not have an AS diagnosis and whose cervical MRI was reported as normal.
Key inclusion criteria (3 listed)
- For the study group:
- Patients diagnosed with ankylosing spondylitis, aged 18-50.
- Patients who underwent a cervical MRI between January 2020 and September 2023. Control Group Patients aged 18-50 who underwent cervical MRI between January 2020 and September 2023 due to nonspecific neck pain, who did not have an AS diagnosis and whose cervical MRI was reported as normal.
Key exclusion criteria (8 listed)
- Patients over 50 years of age
- History of spine surgery;
- Presence of pain, numbness, and weakness in the upper extremities
- History of cervical injury or neck injury
- Presence of tuberculosis, tumor, fracture, infection, instability, cervical myelopathy, cervical disc herniation (protrusion, extrusion) (will be considered cervical bulging)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Magnetic resonance imaginguse Magnetic Resonance Imaging (MRI) to evaluate the cervical muscle planes in AS patients in more detailed and objective ways. In this study, in addition to cervical muscle volumes in AS patients, we also aimed to evaluate cervical fat infiltration and cervical alignment, which have not been previously evaluated in AS patients. | Other | Ankylosing Spondylitis group, Control Group |
Primary outcome
servical MRI fındings in AS patients,
Time frame: Patients who underwent cervical MRI between January 2020 and September 2023
the cervical muscle planes, cervical muscle volumes in AS patients cervical fat infiltration
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Feb 2026.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Muscle Planes, Muscle Volumes, Fat Infiltration in Cervical MRI, run by Kayseri City Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 20 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
servical MRI fındings in AS patients, (time frame: Patients who underwent cervical MRI between January 2020 and September 2023). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Feb 2026.