Nutritional SupplementationThermal effectNCT07150533
Green Tea Extract and Ginger
A study testing Green Tea Extract, Ginger and Combined Supplement (Green Tea + Ginger) in people with Nutritional Supplementation and Exercise Physiology, run by Erzurum Technical University at 1 site in Turkey (Türkiye).
Trial summary
This study investigates the effects of green tea extract and ginger supplementation, both individually and in combination, on endurance performance, metabolism, thermal comfort, and muscle soreness in recreationally active young men. Read more about this study
- Who is it for?
- Ages 18 to 35 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Nutritional Supplementation, Exercise Physiology
- What is being tested?
- Green Tea Extract, Ginger and Combined Supplement (Green Tea + Ginger)
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 16 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Mar 2025to 30 Jul 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Male participants aged 18-35 years
- Recreationally active (≥3 aerobic exercise sessions per week, ≥30 minutes per session, for at least 6 months)
- VO₂max between 40-50 mL/kg/min (recreationally active fitness level)
- Body mass index within the normal to slightly overweight range (approximately 18.5-27.5 kg/m²)
- Willingness to comply with study requirements, including supplementation and exercise testing protocols
- Provided written informed consent
Who cannot join
- History of cardiovascular, respiratory, metabolic, or neurological disorders
- Allergy or intolerance to green tea, ginger, or maltodextrin
- Current use of ergogenic supplements, medications affecting metabolism, or stimulants (e.g., beta-blockers, caffeine pills)
- Smoking or excessive alcohol consumption (>14 units per week)
- Inconsistent exercise habits (<3 sessions/week in the past 6 months)
- Participation in another clinical trial within the past 3 months
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Erzurum Technical University Sport Sciences Faculty
Erzurum, Erzurum, 25240
About this study
Official title: Synergistic Effects of Green Tea Extract and Ginger Supplementation on Endurance Performance and Thermal Perception in Normal and Cold Environments: A Randomized Crossover Trial
This study investigates the effects of green tea extract and ginger supplementation, both individually and in combination, on endurance performance, metabolism, thermal comfort, and muscle soreness in recreationally active young men. Participants will complete cycling tests under both normal room temperature (21-24°C) and cold (5-7°C) conditions. The study uses a randomized, double-blind, placebo-controlled, crossover design to compare the outcomes of placebo, green tea, ginger, and combined supplementation. The findings may help to identify nutritional strategies that improve exercise performance and comfort in different environmental conditions.
Read the detailed description
This randomized, double-blind, placebo-controlled, crossover trial is designed to evaluate the effects of green tea extract and ginger supplementation, both individually and in combination, on endurance performance, metabolic responses, thermal sensation, and muscle soreness in recreationally active men.
Sixteen healthy participants will complete eight experimental conditions: placebo, green tea extract (500 mg), ginger (1 g), and a combination of both, tested under normal (21-24°C) and cold (5-7°C) environments. Each condition will be separated by a washout period to avoid carryover effects.
Endurance capacity will be measured using a time-to-exhaustion cycling test at 70% of maximal oxygen uptake (VO₂max). Metabolic responses will be assessed by gas analysis to determine respiratory exchange ratio (RER). Perceptual measures will include the Borg Rating of Perceived Exertion (RPE) and a thermal sensation scale, while muscle soreness will be evaluated 24 hours post-exercise using a visual analog scale (VAS).
The study aims to determine whether the combined intake of green tea and ginger provides synergistic benefits over individual supplementation, particularly in cold environments where thermoregulation and endurance capacity are challenged. Findings may contribute to practical nutritional strategies that enhance exercise performance, comfort, and recovery under environmental stress conditions.
- Conditions
- Nutritional Supplementation, Exercise Physiology
- Being tested
- Placebo Arm, Green Tea Extract, Ginger, Combined Supplement (Green Tea + Ginger)
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Placebo ArmDietary supplement
Participants receive a placebo consisting of maltodextrin in capsule form, matched in appearance and taste to the active supplements.
Green Tea ExtractDietary supplement
Participants receive 500 mg of standardized green tea extract in capsule form.
GingerDietary supplement
Participants receive 1 g of ginger supplement in capsule form.
Combined Supplement (Green Tea + Ginger)Dietary supplement
Participants receive a combination of 500 mg green tea extract and 1 g ginger, both administered in capsule form.
| Study group | Role | What they receive |
|---|---|---|
| Placebo Arm | Placebo comparator | Participants receive a placebo consisting of maltodextrin in capsule form, matched in appearance and taste to the active supplements. Receives: Dietary Supplement: Placebo Arm |
| Green Tea Extract Arm | Experimental | Participants receive 500 mg of standardized green tea extract in capsule form. Receives: Dietary Supplement: Green Tea Extract |
| Ginger Arm | Experimental | Participants receive 1 g of ginger supplement in capsule form. Receives: Dietary Supplement: Ginger |
| Combined Supplement Arm | Experimental | Participants receive a combination of 500 mg green tea extract and 1 g ginger, both administered in capsule form. Receives: Dietary Supplement: Combined Supplement (Green Tea + Ginger) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Time to Exhaustion (TTE)
Endurance performance assessed as the total time in seconds participants are able to maintain cycling at 70% of VO₂max on a cycle ergometer, until volitional exhaustion defined as the inability to sustain a cadence of 60 rpm for 10 consecutive seconds
Measured: Immediately during each exercise test session (after supplement ingestion, under normal and cold environmental conditions)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Sep 2025
- Study start1 Mar 2025
- Primary completion1 Jul 2025
- Study completion30 Jul 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Nutritional SupplementationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 16 participants (actual)
Sponsor and investigators
- Lead sponsor
- Erzurum Technical University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Süleyman Ulupınar, Erzurum Technical University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07150533
- Sponsor's protocol ID
- ETU-Green Tea and Ginger
- Acronym
- Thermal effect
- Status last verified
- Aug 2025
- First submitted
- 25 Aug 2025
- Last updated
- 2 Sep 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Demirli A, Ulupinar S, Terzi M, Ozbay S, Ozkara AB, Gencoglu C, Ouergui I, Ardigo LP. Synergistic Effects of Green Tea Extract and Ginger Supplementation on Endurance Performance and Thermal Perception in Normothermic and Cold Environments: A Randomized, Placebo-Controlled, Double-Blind Crossover Trial. Nutrients. 2025 Sep 13;17(18):2949. doi: 10.3390/nu17182949.
PubMed 41010475
Study at a glance
From the registry record, last updated by the sponsor on 2 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Synergistic Effects of Green Tea Extract and Ginger Supplementation on Endurance Performance and Thermal Perception in Normal and Cold Environments: A Randomized Crossover Trial
- ClinicalTrials.gov ID
- NCT07150533
- Acronym / sponsor ID
- Thermal effect / ETU-Green Tea and Ginger
- Conditions
- Nutritional Supplementation, Exercise Physiology
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 16 participants (actual)
- Lead sponsor
- Erzurum Technical UniversityUniversity, hospital or other
- Study start
- 1 Mar 2025 (actual)
- Primary completion
- 1 Jul 2025 (actual)
- Study completion
- 30 Jul 2025 (actual)
- First posted
- 2 Sep 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study investigates the effects of green tea extract and ginger supplementation, both individually and in combination, on endurance performance, metabolism, thermal comfort, and muscle soreness in recreationally active young men. Participants will complete cycling tests under both normal room temperature (21-24°C) and cold (5-7°C) conditions. The study uses a randomized, double-blind, placebo-controlled, crossover design to compare the outcomes of placebo, green tea, ginger, and combined supplementation. The findings may help to identify nutritional strategies that improve exercise performance and comfort in different environmental conditions.
Detailed description
This randomized, double-blind, placebo-controlled, crossover trial is designed to evaluate the effects of green tea extract and ginger supplementation, both individually and in combination, on endurance performance, metabolic responses, thermal sensation, and muscle soreness in recreationally active men.
Sixteen healthy participants will complete eight experimental conditions: placebo, green tea extract (500 mg), ginger (1 g), and a combination of both, tested under normal (21-24°C) and cold (5-7°C) environments. Each condition will be separated by a washout period to avoid carryover effects.
Endurance capacity will be measured using a time-to-exhaustion cycling test at 70% of maximal oxygen uptake (VO₂max). Metabolic responses will be assessed by gas analysis to determine respiratory exchange ratio (RER). Perceptual measures will include the Borg Rating of Perceived Exertion (RPE) and a thermal sensation scale, while muscle soreness will be evaluated 24 hours post-exercise using a visual analog scale (VAS).
The study aims to determine whether the combined intake of green tea and ginger provides synergistic benefits over individual supplementation, particularly in cold environments where thermoregulation and endurance capacity are challenged. Findings may contribute to practical nutritional strategies that enhance exercise performance, comfort, and recovery under environmental stress conditions.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Placebo Arm | Placebo comparator | Dietary Supplement: Placebo ArmParticipants receive a placebo consisting of maltodextrin in capsule form, matched in appearance and taste to the active supplements. |
| Green Tea Extract Arm | Experimental | Dietary Supplement: Green Tea ExtractParticipants receive 500 mg of standardized green tea extract in capsule form. |
| Ginger Arm | Experimental | Dietary Supplement: GingerParticipants receive 1 g of ginger supplement in capsule form. |
| Combined Supplement Arm | Experimental | Dietary Supplement: Combined Supplement (Green Tea + Ginger)Participants receive a combination of 500 mg green tea extract and 1 g ginger, both administered in capsule form. |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Male participants aged 18-35 years
- Recreationally active (≥3 aerobic exercise sessions per week, ≥30 minutes per session, for at least 6 months)
- VO₂max between 40-50 mL/kg/min (recreationally active fitness level)
- Body mass index within the normal to slightly overweight range (approximately 18.5-27.5 kg/m²)
- Willingness to comply with study requirements, including supplementation and exercise testing protocols
Key exclusion criteria (6 listed)
- History of cardiovascular, respiratory, metabolic, or neurological disorders
- Allergy or intolerance to green tea, ginger, or maltodextrin
- Current use of ergogenic supplements, medications affecting metabolism, or stimulants (e.g., beta-blockers, caffeine pills)
- Smoking or excessive alcohol consumption (>14 units per week)
- Inconsistent exercise habits (<3 sessions/week in the past 6 months)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Placebo ArmParticipants receive a placebo consisting of maltodextrin in capsule form, matched in appearance and taste to the active supplements. | Dietary supplement | Placebo Arm |
| Green Tea ExtractParticipants receive 500 mg of standardized green tea extract in capsule form. | Dietary supplement | Green Tea Extract Arm |
| GingerParticipants receive 1 g of ginger supplement in capsule form. | Dietary supplement | Ginger Arm |
| Combined Supplement (Green Tea + Ginger)Participants receive a combination of 500 mg green tea extract and 1 g ginger, both administered in capsule form. | Dietary supplement | Combined Supplement Arm |
Primary outcome
Time to Exhaustion (TTE)
Time frame: Immediately during each exercise test session (after supplement ingestion, under normal and cold environmental conditions)
Endurance performance assessed as the total time in seconds participants are able to maintain cycling at 70% of VO₂max on a cycle ergometer, until volitional exhaustion defined as the inability to sustain a cadence of 60 rpm for 10 consecutive seconds
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Sep 2025.
- Derived from this study: PubMed 41010475Demirli A, Ulupinar S, Terzi M, Ozbay S, Ozkara AB, Gencoglu C, Ouergui I, Ardigo LP. Synergistic Effects of Green Tea Extract and Ginger Supplementation on Endurance Performance and Thermal Perception in Normothermic and Cold Environments: A Randomized, Placebo-Controlled, Double-Blind Crossover Trial. Nutrients. 2025 Sep 13;17(18):2949. doi: 10.3390/nu17182949.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Green Tea Extract, Ginger and Combined Supplement (Green Tea + Ginger) in people with Nutritional Supplementation and Exercise Physiology, run by Erzurum Technical University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 2 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Time to Exhaustion (TTE) (time frame: Immediately during each exercise test session (after supplement ingestion, under normal and cold environmental conditions)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07150533, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Sep 2025.