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Pulmonary NodulesNCT07153263

Local Anaesthetic Spread and Sensory Block Range of the Retro-superior Costotransverse Ligament Space Block

A study testing Ultrasound-guided retro-SCTLB and Ultrasound-guided TPVB in people with Pulmonary Nodules and Nerve Block, run by Nanjing First Hospital, Nanjing Medical University at 2 sites in China.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
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Trial summary

The aim of this clinical trial is to investigate the effects of local anesthetic diffusion range and sensory block range during retro-SCTLB(retro superior costotransverse ligament space block) and TPVB(thoracic paravertebral block) in patients undergoing CT-guided lung nodule localization. Read more about this study

Who is it for?
Ages 18 to 80 years
Conditions the study is for
Pulmonary Nodules, Nerve Block
What is being tested?
Ultrasound-guided retro-SCTLB and Ultrasound-guided TPVB
Type of treatment
Surgery or procedure
Could I receive a placebo?
No, everyone receives an active treatment
How many people
50 participants
Where
2 sitesChina
Study dates
12 Sep 2025to 30 Sep 2026
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 80 years
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Patients scheduled for CT-guided lung nodule localization under local anesthesia will be selected
  • aged 18-80 years
  • BMI 18-30 kg/m²
  • ASA classification I-III

Who cannot join

  • Allergy to the study drug or local anesthetic;
  • History of opioid abuse;
  • Pre-existing skin infection at the puncture site of ITPN or TPVB;
  • Peripheral infectious neuropathy;
  • Dysfunction of blood coagulation

Trial locations and contacts

2 sites in 1 country. Contact the study team or a site near you to ask about taking part.

China2 sites, 2 recruiting
  • Tao Shan

    Nanjing, Jiangsu, 210006

    Tao Shan, +8618852095135, shantao2021@163.com

    Recruiting
  • Nanjing First Hospital

    Nanjing

    Tao Shan, MD, +8618852095135, 858727933@qq.com

    Recruiting

Other trials in China

About this study

Official title: Comparison of Local Anaesthetic Spread Between the Retro-superior Costotransverse Ligament Space Block and Thoracic Paravertebral Block: A Three-dimensional CT Reconstruction Imaging Study

The aim of this clinical trial is to investigate the effects of local anesthetic diffusion range and sensory block range during retro-SCTLB(retro superior costotransverse ligament space block) and TPVB(thoracic paravertebral block) in patients undergoing CT-guided lung nodule localization. The main issue of the study is to determine the differences in the diffusion range and sensory block range of local anesthetics between the retro-SCTLB and TPVB nerve block methods.

Read the detailed description

Fifty patients were selected to undergo CT guided puncture localization of lung nodules under local anesthesia, and the patients were divided into groups using a computer-generated random number in a ratio of 1:1. To ensure objectivity, a nurse who was not involved in the study prepared a sealed opaque envelope containing grouping information. Patients were randomly divided into two groups: the retro-SCTLB group (group R, 25 patients), and the TPVB group (group T, 25 patients). All patients underwent ultrasound guided retro-SCTLB or TPVB before CT-guided nodule localization. Ultrasound-guided retro-SCTLB method: Using an ultrasound low-frequency convex array probe (1-6 MHZ, Sonosite, USA), the probe was placed parallel to the spine 2-3cm outside the spinous process of the fifth thoracic vertebra, on the surface of the transverse process tip. First, the probe was placed above the rib and costo-transverse process joint and observed from the inside out to clearly show the spinous process, lamina, transverse process and rib. Then, the probe was gently moved towards the caudal side. Until the sound shadows of the ribs and transverse processes disappear and inferior articular processes appear on the medial side, and when high-echo superior ligaments of the costal transverse processes appear behind the paravertebral space and anterolateral of the inferior articular processes, then gently rotate the outer edge of the probe towards the caudal side and a low-echo area can be seen behind the superior ligaments of the costal transverse processes, which is the target area. Then, using a long oblique plane puncture needle, with the in-plane technique, insert the needle from the outer side of the probe. When the needle tip reaches the target area, use the water separation technique to inject 1ml of normal saline to confirm the needle tip position, then inject 20ml of local anesthetic solution (0.375% ropivacaine 10ml+ iohexol 10ml) within 1 minute; Ultrasound-guided TPVB: Using an ultrasound low-frequency convex array probe (1-6 MHZ, Sonosite, USA), the probe is placed perpendicularly to the spine at the fifth thoracic vertebra on the midline of the trunk. First, the spinous process is identified, and then the ultrasound probe is gradually moved towards the surgical side. Structures such as the transverse process, pleura, and intercostal intima are visible. At this point, the ultrasound probe is moved parallel to the caudal side. The area between the parietal pleura, intercostal endometrium and transverse process is the target area for injection. Then, using a short inclined plane puncture needle, using the in-plane technique, the needle is inserted from the outside of the probe. When the needle tip reaches the target position, 1ml of normal saline is injected using the water separation technique to confirm the needle tip position. Then 20ml of local anesthetic solution (0.375% ropivacaine 10ml+ iohexol 10ml) is injected, and the injection is completed in 1 minute. 15 minutes after the block was completed, CT scans were performed and punctures were located, followed by three-dimensional reconstruction. Observe and record the local anesthetic solution: 1. The range of diffusion to the cranial and caudal side; 2 The range of diffusion to the intercostal space 3; The range of diffusion to the paravertebral space; 4. The range of diffusion to the epidural space; 5. The range of diffusion to the intervertebral foramen; 6. The range of diffusion to the anterolateral vertebrae (sympathetic ganglion).

Being tested
Ultrasound-guided retro-SCTLB, Ultrasound-guided TPVB
Keywords
nerve block, TPVB, ITPB, rSCTL
Medical subject headings
Multiple Pulmonary Nodules

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Ultrasound-guided retro-SCTLBProcedure or surgery

    Patients undergoing CT-guided lung nodule localization were selected for the study. Before the surgery, the retro-SCTLB was performed under ultrasound guidance.

  • Ultrasound-guided TPVBProcedure or surgery

    Patients undergoing CT-guided lung nodule localization were selected for the study. Before the surgery, the TPVB was performed under ultrasound guidance.

Study groups in NCT07153263
Study groupRoleWhat they receive
retro-SCTLB groupExperimentalA total of 20 ml of the local anesthetic solution (0.375% ropivacaine 10ml+ iohexol 10ml) is injected in the retro-superior costotransverse ligament space in the retro-SCTLB group within 60 seconds.
Receives: Procedure: Ultrasound-guided retro-SCTLB
TPVB groupExperimentalA total of 20 ml of the local anesthetic solution (0.375% ropivacaine 10ml+ iohexol 10ml) is injected in the paravertebral space in the TPVB group within 60 seconds.
Receives: Procedure: Ultrasound-guided TPVB

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Spread of local anesthetic into the paravertebral space

    Observation of incidence and thoracic level of local anesthetic spread into the paravertebral space with CT by a researcher who was blinded to group allocation

    Measured: 15 minutes after completion of the nerve block

Secondary outcomes (6)
  1. The range of the local anesthetic spreads to the intercostal space

    Observation of incidence and thoracic level of local anesthetic spread into the intercostal space with CT by a researcher who was blinded to group allocation

    Measured: 15 minutes after completion of the nerve block

  2. Observation of local anesthetic spread cephalocaudally in the erector spinae plane

    Observation of incidence and thoracic level of local anesthetic spread into the erector spinae plane cephalocaudally with CT by a researcher who was blinded to group allocation.

    Measured: 15 minutes after completion of the nerve block

  3. The range of the local anesthetic spread to the epidural space

    Observation of incidence and thoracic level of local anesthetic spread into the epidural space with CT by a researcher who was blinded to group allocation

    Measured: 15 minutes after completion of the nerve block

  4. The range of the local anesthetic spread to the anterolateral vertebrae (sympathetic ganglion).

    Observation of incidence and thoracic level of local anesthetic spread into the anterolateral vertebrae (sympathetic ganglion) with CT by a researcher who was blinded to group allocation

    Measured: 15 minutes after completion of the nerve block

  5. Assessment of skin sensory block with ice

    The sensation of skin to cold was assessed with ice. The area includes the anterior chest wall (midclavicular line), lateral chest wall (posterior axillary line), and posterior chest wall. The sensation was graded as 0 (no sensation), 1 (decreased sensation), or 2 (normal). A sensory block of the dermatome was considered to be achieved if the grade was either 0 or 1.

    Measured: 15 minutes after completion of the nerve block

  6. The range of the local anesthetic spread to the intervertebral foramen

    Observation of incidence and thoracic level of local anesthetic spread into the intervertebral foramen with CT by a researcher who was blinded to group allocation

    Measured: 15 minutes after completion of the nerve block

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted3 Sep 2025
  2. Study start12 Sep 2025
  3. Primary completion15 Sep 2026 (estimated)
  4. Study completion30 Sep 2026 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Prevention
Allocation
Randomised
Intervention model
Parallel groups
Masking
Triple blind
Who is masked
Participant, Investigator, Outcomes assessor
Enrolment
50 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07153263
Sponsor's protocol ID
KY 20250819-10
Status last verified
Aug 2026
First submitted
21 Aug 2025
Last updated
28 Aug 2026
Results posted
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Questions about this trial

What is this clinical trial studying?

A study testing Ultrasound-guided retro-SCTLB and Ultrasound-guided TPVB in people with Pulmonary Nodules and Nerve Block, run by Nanjing First Hospital, Nanjing Medical University at 2 sites in China.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 28 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 2 sites in China. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Tao Shan (+8618852095135, shantao2021@163.com), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Spread of local anesthetic into the paravertebral space (time frame: 15 minutes after completion of the nerve block). It is what the study was designed to measure, not a finding.

Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Aug 2026.

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