Eosinophilic Esophagitis (EoE)sEMGNCT07156357
Surface EMG Testing on Swallowing in EoE Patients
An observational study of Eosinophilic Esophagitis (EoE), run by Mayo Clinic at 1 site in United States.
Trial summary
Evaluating swallowing food with surface electromyography (EMG) machine in patients with Eosinophilic Esophagitis Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Eosinophilic Esophagitis (EoE)
- What is being tested?
- Surface Electromyography and Fiberoptic Endoscopic Evaluation of Swallowing
- How many people
- 30 participants
- Where
- 1 siteUnited States
- Study dates
- 4 Aug 2025to Jun 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Patients with EoE will be recruited from the esophageal clinic. Controls will be recruited by monitoring for patients that present for video swallow with speech language pathology and have a normal video swallow.
Who may be able to join
- Controls
- Normal video swallow or score of 0 for dysphagia on ESSAI questionnaire
- absence of dysphagia
- age >18 EoE participants
- Documentation of EoE diagnosis by histologic criteria,
- >15 eos/hpf on most recent esophageal biopsy
- age >18
Who cannot join
- Abnormal baseline video swallow
- lack of MSK coordination to eat test meal
- underlying neuromuscular disorder.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: sEMG Assessment of Swallowing and Bolus Preparation
Evaluating swallowing food with surface electromyography (EMG) machine in patients with Eosinophilic Esophagitis
Read the detailed description
Evaluating surface electromyography (sEMG) assessment of swallowing and bolus preparation in patients with Eosinophilic Esophagitis (EoE).
- Conditions
- Eosinophilic Esophagitis (EoE)
- Being tested
- Surface Electromyography, Fiberoptic Endoscopic Evaluation of Swallowing
- Medical subject headings
- Eosinophilic Esophagitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Surface ElectromyographyDiagnostic test
Tests performed to evaluate swallowing function
Fiberoptic Endoscopic Evaluation of SwallowingDiagnostic test
Assessment of swallowing function
| Study group | Role | What they receive |
|---|---|---|
| Controls | Subjects who can swallow normally Receives: Diagnostic Test: Surface Electromyography; Diagnostic Test: Fiberoptic Endoscopic Evaluation of Swallowing | |
| Eosinophilic Esophagitis | Subjects with Eosinophilic Esophagitis Receives: Diagnostic Test: Surface Electromyography; Diagnostic Test: Fiberoptic Endoscopic Evaluation of Swallowing |
What is being measured
The primary outcome is the main question the study is designed to answer.
Preparatory phase time
Comparison of preparatory phase between cohorts
Measured: Through study completion an average of 2 days
Secondary outcomes (1)
Time difference in swallow initiation
Time difference in swallow initiation between fiberoptic endoscopic evaluation of swallowing (FEES) vs sEMG
Measured: Through study completion an average of 2 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Sep 2025
- Study start4 Aug 2025
- Primary completionOct 2026 (estimated)
- Study completionJun 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Eosinophilic Esophagitis (EoE)Studies of the same condition, open and under way.
- More trials run by Mayo ClinicThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Prospective
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Mayo Clinic
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Karthik Ravi, M.D., Mayo Clinic
- Investigators
- Karthik Ravi, MD, Principal investigator, Mayo Clinic
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07156357
- Sponsor's protocol ID
- 24-009832
- Acronym
- sEMG
- Status last verified
- Jul 2026
- First submitted
- 15 Aug 2025
- Last updated
- 17 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 17 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- sEMG Assessment of Swallowing and Bolus Preparation
- ClinicalTrials.gov ID
- NCT07156357
- Acronym / sponsor ID
- sEMG / 24-009832
- Conditions
- Eosinophilic Esophagitis (EoE)
- Study type
- Observational
- Recruitment status
- Active, not recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Mayo ClinicUniversity, hospital or other
- Study start
- 4 Aug 2025 (actual)
- Primary completion
- Oct 2026 (estimated)
- Study completion
- Jun 2027 (estimated)
- First posted
- 5 Sep 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Evaluating swallowing food with surface electromyography (EMG) machine in patients with Eosinophilic Esophagitis
Detailed description
Evaluating surface electromyography (sEMG) assessment of swallowing and bolus preparation in patients with Eosinophilic Esophagitis (EoE).
Study design
- Observational model
- Case-control
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Controls | – | Diagnostic Test: Surface Electromyography, Diagnostic Test: Fiberoptic Endoscopic Evaluation of SwallowingSubjects who can swallow normally |
| Eosinophilic Esophagitis | – | Diagnostic Test: Surface Electromyography, Diagnostic Test: Fiberoptic Endoscopic Evaluation of SwallowingSubjects with Eosinophilic Esophagitis |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Patients with EoE will be recruited from the esophageal clinic. Controls will be recruited by monitoring for patients that present for video swallow with speech language pathology and have a normal video swallow.
Key inclusion criteria (7 listed)
- Controls
Key exclusion criteria (3 listed)
- Abnormal baseline video swallow
- lack of MSK coordination to eat test meal
- underlying neuromuscular disorder.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Surface ElectromyographyTests performed to evaluate swallowing function | Diagnostic test | Controls, Eosinophilic Esophagitis |
| Fiberoptic Endoscopic Evaluation of SwallowingAssessment of swallowing function | Diagnostic test | Controls, Eosinophilic Esophagitis |
Primary outcome
Preparatory phase time
Time frame: Through study completion an average of 2 days
Comparison of preparatory phase between cohorts
1 secondary outcome
Time difference in swallow initiation
Time frame: Through study completion an average of 2 days
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Jul 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Karthik Ravi, MD principal investigator
Mayo Clinic
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Eosinophilic Esophagitis (EoE), run by Mayo Clinic at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 17 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Preparatory phase time (time frame: Through study completion an average of 2 days). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Jul 2026.