Ischemic StrokeNCT07156955
Proprioceptive Error Correction for Post-Stroke Upper Limb Rehabilitation
A study testing Electrical stimulation cue, Visual stimulation cue and No cue in people with Ischemic Stroke and Proprioception, run by Sungkyunkwan University at 1 site in South Korea.
Trial summary
The investigators aim to develop sensory transformation and augmentation technologies that minimize the impact of proprioceptive errors, thereby significantly enhancing motor learning and rehabilitation of the upper limbs. This study is designed to test proprioceptive error compensation techniques in stroke patients. Read more about this study
- Who is it for?
- Ages 19 years and older
- Conditions the study is for
- Ischemic Stroke, Proprioception
- What is being tested?
- Electrical stimulation cue, Visual stimulation cue and No cue
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 3 participants
- Where
- 1 siteSouth Korea
- Study dates
- 1 Sep 2026to 30 Mar 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 19 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Diagnosed with ischemic or hemorrhagic stroke
- Stroke confirmed by CT or MRI
- Stroke patients with proprioceptive sensory deficits
- Chronic stroke patients with onset at least 3 months prior
- Able to voluntarily flex and extend the elbow joint
- Age 19 years or older
- Provide written informed consent (participant or legal representative)
Who cannot join
- Severe pain during elbow joint movement
- Elbow joint contracture, spasticity, ataxia, musculoskeletal disorders, fractures, - non-healing ulcers, or open wounds
- Progressive or unstable stroke
- Presence of unilateral neglect
- Coexisting severe neurological disorders
- Major psychiatric disorders such as major depressive disorder, schizophrenia, bipolar disorder, or dementia Presence of a pacemaker
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
South Korea1 site, 1 recruiting
- Recruiting
Shinchon Severance Rehabilitation Hospital
Seoul, 03722
HyunHee Lim, +82-10-3342-1879, hhlim01@yuhs.ac
About this study
Official title: Proprioceptive Error Correction Technique Development to Promote Post-stroke Upper Limbs Motor Rehabilitation
The investigators aim to develop sensory transformation and augmentation technologies that minimize the impact of proprioceptive errors, thereby significantly enhancing motor learning and rehabilitation of the upper limbs. This study is designed to test proprioceptive error compensation techniques in stroke patients.
The human nervous system often receives mismatched information from vision and proprioception during upper limb control, resulting in conflicting sensory inputs that limit the effectiveness of motor learning. In other words, real-time sensory feedback - a critical component of motor learning in the nervous system - is not reliably delivered. Therefore, this study seeks to resolve sensory conflicts by providing additional sensory information through electrical stimulation, with the goal of dramatically improving the effectiveness of motor learning.
- Conditions
- Ischemic Stroke, Proprioception
- Being tested
- Electrical stimulation cue, Visual stimulation cue, No cue
- Medical subject headings
- Ischemic Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Electrical stimulation cueBehavioural
A single 30-minute session is provided. Electrodes are attached to the cubital fossa, and stimulation is delivered at a frequency that increases up to 70 Hz as the elbow joint approaches the target angle. Target angles are set between 0 degrees and 120 degrees, based on each participant's available range of motion determined during the initial assessment. Participants adjust their elbow joint angle to match the provided target angle using feedback from the electrical stimulation. When the elbow joint angle matches the target angle, the maximum frequency is applied to the cubital fossa. Participants match their elbow joint angle to the target angle based on the given frequency.
Visual stimulation cueBehavioural
A single 30-minute session is provided. The difference between the current elbow joint angle and the pre-set target angle is displayed on a screen using two colored needles (a red needle for the target angle and a black needle for the current elbow joint angle). The target angle is set within each participant's available range of motion based on the initial assessment. Participants continue the intervention by adjusting their elbow angle using the visual feedback. When the elbow joint angle matches the target angle, the two needles overlap. Based on this visual cue, participants adjust their elbow joint angle to match the target angle.
No cueBehavioural
A single 30-minute session is provided. The target angle is determined within each participant's available range of motion based on the initial assessment. Throughout the session, participants receive verbal feedback from the assessor and adjust their elbow joint angle accordingly to match the target angle.
| Study group | Role | What they receive |
|---|---|---|
| Electrical stimulation cue first | Experimental | Patients undergo three types of interventions, following one of two processes. Each process has its own protocol in the following order Electrical stimulation cue, Visual cue, and No cue or Electrical stimulation cue, No cue, and Visual cue. Receives: Behavioral: Electrical stimulation cue; Behavioral: Visual stimulation cue; Behavioral: No cue |
| Visual stimulation cue first | Experimental | Patients undergo three types of interventions, following one of two processes. Each process has its own protocol in the following order: Visual cue, Electrical stimulation cue, and No cue, or Visual cue, No cue, and Electrical stimulation cue. Receives: Behavioral: Electrical stimulation cue; Behavioral: Visual stimulation cue; Behavioral: No cue |
| No cue first | Experimental | Patients undergo three types of interventions, following one of two processes. Each process has its own protocol in the following order: No cue, Electrical stimulation cue, and Visual cue, or No cue, Visual cue, and Electrical stimulation cue. Receives: Behavioral: Electrical stimulation cue; Behavioral: Visual stimulation cue; Behavioral: No cue |
| Only electrical stimulation cue | Experimental | Patients undergo one types of interventions which is the Electrical stimulation cue. Receives: Behavioral: Electrical stimulation cue |
| Only visual stimulation cue | Experimental | Patients undergo one types of interventions which is the Visual stimulation cue. Receives: Behavioral: No cue |
| Only no cue | Experimental | Patients undergo one types of interventions which is the No cue. Receives: Behavioral: Visual stimulation cue |
What is being measured
The primary outcome is the main question the study is designed to answer.
Improvement in upper limb motor function
Upper limb motor function will be evaluated using standardized clinical scales such as the Fugl-Meyer Assessment and proprioceptive accuracy tests.
0 indicates severe movement limitation, while a score of 66 reflects normal motor function of upper limb.
Participants will undergo evaluations and treatment during six visits over approximately three weeks.
Measured: 6 visits over 3 weeks
Secondary outcomes (1)
Proprioceptive accuracy
Assessment of improvements in upper limb motor function and proprioceptive accuracy after applying sensory error correction techniques in stroke patients. Motor performance will be evaluated using standardized clinical scales and joint position sense tests. The expected outcome measures are a reduction of the error angle relative to the target angle to within ±5 degrees.
Measured: Baseline before intervention and immediately after the 30-minute training session
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Sep 2025
- Study start1 Sep 2026 (estimated)
- Primary completion31 Dec 2026 (estimated)
- Study completion30 Mar 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Ischemic StrokeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 3 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Sungkyunkwan University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Hangue Park, Sungkyunkwan University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07156955
- Sponsor's protocol ID
- 2025-06-075-001
- Status last verified
- Jun 2026
- First submitted
- 11 Aug 2025
- Last updated
- 12 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 12 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Proprioceptive Error Correction Technique Development to Promote Post-stroke Upper Limbs Motor Rehabilitation
- ClinicalTrials.gov ID
- NCT07156955
- Acronym / sponsor ID
- 2025-06-075-001
- Conditions
- Ischemic Stroke, Proprioception
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 3 participants (estimated)
- Lead sponsor
- Sungkyunkwan UniversityUniversity, hospital or other
- Study start
- 1 Sep 2026 (estimated)
- Primary completion
- 31 Dec 2026 (estimated)
- Study completion
- 30 Mar 2027 (estimated)
- First posted
- 5 Sep 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The investigators aim to develop sensory transformation and augmentation technologies that minimize the impact of proprioceptive errors, thereby significantly enhancing motor learning and rehabilitation of the upper limbs. This study is designed to test proprioceptive error compensation techniques in stroke patients.
The human nervous system often receives mismatched information from vision and proprioception during upper limb control, resulting in conflicting sensory inputs that limit the effectiveness of motor learning. In other words, real-time sensory feedback - a critical component of motor learning in the nervous system - is not reliably delivered. Therefore, this study seeks to resolve sensory conflicts by providing additional sensory information through electrical stimulation, with the goal of dramatically improving the effectiveness of motor learning.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 6
| Arm | Type | Receives |
|---|---|---|
| Electrical stimulation cue first | Experimental | Behavioral: Electrical stimulation cue, Behavioral: Visual stimulation cue, Behavioral: No cuePatients undergo three types of interventions, following one of two processes. Each process has its own protocol in the following order Electrical stimulation cue, Visual cue, and No cue or Electrical stimulation cue, No cue, and Visual cue. |
| Visual stimulation cue first | Experimental | Behavioral: Electrical stimulation cue, Behavioral: Visual stimulation cue, Behavioral: No cuePatients undergo three types of interventions, following one of two processes. Each process has its own protocol in the following order: Visual cue, Electrical stimulation cue, and No cue, or Visual cue, No cue, and Electrical stimulation cue. |
| No cue first | Experimental | Behavioral: Electrical stimulation cue, Behavioral: Visual stimulation cue, Behavioral: No cuePatients undergo three types of interventions, following one of two processes. Each process has its own protocol in the following order: No cue, Electrical stimulation cue, and Visual cue, or No cue, Visual cue, and Electrical stimulation cue. |
| Only electrical stimulation cue | Experimental | Behavioral: Electrical stimulation cuePatients undergo one types of interventions which is the Electrical stimulation cue. |
| Only visual stimulation cue | Experimental | Behavioral: No cuePatients undergo one types of interventions which is the Visual stimulation cue. |
| Only no cue | Experimental | Behavioral: Visual stimulation cuePatients undergo one types of interventions which is the No cue. |
Who may qualify
- Ages
- 19 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (7 listed)
- Diagnosed with ischemic or hemorrhagic stroke
- Stroke confirmed by CT or MRI
- Stroke patients with proprioceptive sensory deficits
- Chronic stroke patients with onset at least 3 months prior
- Able to voluntarily flex and extend the elbow joint
Key exclusion criteria (6 listed)
- Severe pain during elbow joint movement
- Elbow joint contracture, spasticity, ataxia, musculoskeletal disorders, fractures, - non-healing ulcers, or open wounds
- Progressive or unstable stroke
- Presence of unilateral neglect
- Coexisting severe neurological disorders
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Electrical stimulation cueA single 30-minute session is provided. Electrodes are attached to the cubital fossa, and stimulation is delivered at a frequency that increases up to 70 Hz as the elbow joint approaches the target angle. Target angles are set between 0 degrees and 120 degrees, based on each participant's available range of motion determined during the initial assessment. Participants adjust their elbow joint angle to match the provided target angle using feedback from the electrical stimulation. When the elbow joint angle matches the target angle, the maximum frequency is applied to the cubital fossa. Participants match their elbow joint angle to the target angle based on the given frequency. | Behavioural | Electrical stimulation cue first, No cue first, Only electrical stimulation cue, Visual stimulation cue first |
| Visual stimulation cueA single 30-minute session is provided. The difference between the current elbow joint angle and the pre-set target angle is displayed on a screen using two colored needles (a red needle for the target angle and a black needle for the current elbow joint angle). The target angle is set within each participant's available range of motion based on the initial assessment. Participants continue the intervention by adjusting their elbow angle using the visual feedback. When the elbow joint angle matches the target angle, the two needles overlap. Based on this visual cue, participants adjust their elbow joint angle to match the target angle. | Behavioural | Electrical stimulation cue first, No cue first, Only no cue, Visual stimulation cue first |
| No cueA single 30-minute session is provided. The target angle is determined within each participant's available range of motion based on the initial assessment. Throughout the session, participants receive verbal feedback from the assessor and adjust their elbow joint angle accordingly to match the target angle. | Behavioural | Electrical stimulation cue first, No cue first, Only visual stimulation cue, Visual stimulation cue first |
Primary outcome
Improvement in upper limb motor function
Time frame: 6 visits over 3 weeks
Upper limb motor function will be evaluated using standardized clinical scales such as the Fugl-Meyer Assessment and proprioceptive accuracy tests. 0 indicates severe movement limitation, while a score of 66 reflects normal motor function of upper limb. Participants will undergo evaluations and treatment during six visits over approximately three weeks.
1 secondary outcome
Proprioceptive accuracy
Time frame: Baseline before intervention and immediately after the 30-minute training session
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Jun 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Electrical stimulation cue, Visual stimulation cue and No cue in people with Ischemic Stroke and Proprioception, run by Sungkyunkwan University at 1 site in South Korea.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 12 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in South Korea. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact June Seung Lee, Graduate student (+82-10 - 2087 - 0016, iijjuness@g.skku.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Improvement in upper limb motor function (time frame: 6 visits over 3 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Jun 2026.