Nerve Excitation SensitivityPERNEACNCT07160413
Peripheral Nerve Activation Sensitivity
A study testing Electric and electromagnetic stimulation in people with Nerve Excitation Sensitivity, run by Thomas Niederhauser at 1 site in Switzerland.
Trial summary
Volunteers will undergo various peripheral nerve stimulations (electric, electromagnetic, and temporal interference) to evaluate each method's sensitivity. The main objective is to examine the relationship between nerve activation and coil placement relative to the nerve, as well as how different coil types influence… Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Nerve Excitation Sensitivity
- What is being tested?
- Electric and electromagnetic stimulation
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- 1 siteSwitzerland
- Study dates
- 1 Sep 2025to 31 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Person aged > 18 years
- Signed informed consent
- Healthy
- Willingness and ability to adhere to study procedures
Who cannot join
- Known hypersensitivity to electric or electromagnetic stimulation
- Any implanted metal or electronic device in the upper body (except dental work such as fillings or braces), e.g., active medical devices, metal implants
- Neurological or neuromuscular disorders or conditions
- History of seizures or epilepsy
- Current treatment with drugs that lower seizure threshold (e.g., certain analgesics, methylxanthines, antipsychotics, antidepressants, antiepileptics, anesthetics)
- Pregnancy or breastfeeding
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- Surgical intervention of the arm within the last 4 weeks
- Allergy to adhesives or ultrasound gel components (e.g., polyethylene glycols)
- Skin lesions, infections, or strictures in the arm region
- Tattoos on the stimulated (right) arm and hand, or in any area likely to be captured in video recordings
- Inability to follow study procedures (e.g., due to language barrier, psychological disorders, dementia)
- Participant deprived of liberty by administrative or judicial decision or under legal guardianship
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Switzerland1 site, 1 recruiting
- Recruiting
Institute for Human Centered Engineering HuCE
Biel, Biel, 2502
Thomas Niederhauser, Prof. Dr., +41 32 321 67 63, thomas.niederhauser@bfh.ch
About this study
Official title: Peripheral Nerve Activation Sensitivity to Electromagnetic and Electrical Stimulation in the Upper Arm
Volunteers will undergo various peripheral nerve stimulations (electric, electromagnetic, and temporal interference) to evaluate each method's sensitivity. The main objective is to examine the relationship between nerve activation and coil placement relative to the nerve, as well as how different coil types influence maximal nerve activation.
- Conditions
- Nerve Excitation Sensitivity
- Being tested
- Electric and electromagnetic stimulation
- Keywords
- Peripheral nerve stimulation, Magnetic and electric stimulation, Sensitivity of nerves to magnetic fields
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Electric and electromagnetic stimulationDevice
Application of electromagnetic and electric stimulation using coils of different designs and electrodes to assess peripheral nerve sensitivity. The stimulation is momentary, non-therapeutic, and performed for basic science research purposes
| Study group | Role | What they receive |
|---|---|---|
| Stimulated | Experimental | Not described Receives: Device: Electric and electromagnetic stimulation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Maximum nerve activation response to electromagnetic stimulation with different coils
Maximum of the measured signals (muscle contraction from electromyography (EMG) and finger movement from accelerometer) obtained across all stimulation positions at a given stimulation intensity for each coil type. This reflects the relative sensitivity of peripheral nerves to electromagnetic stimulation with different coil designs.
Measured: Day 1
Secondary outcomes (3)
Spatial range of nerve activation with electromagnetic coils
Distance around the stimulation position yielding the maximum response (E1), within which the measured signals (muscle contraction and finger movement) remain at least 50% of the maximum, across all coil positions at a given stimulation intensity.
Measured: Day 1
Spatial range of nerve activation with neuromuscular electrical stimulation electrodes (NMES)
Distance around the stimulation position yielding the maximum response, within which the measured signals (muscle contraction and finger movement) remain at least 50% of the maximum, across all NMES electrode positions at a given stimulation intensity.
Measured: Day 1
Amplitude ratios of temporal interference stimulation (TIS) electrodes associated with nerve activation
Electrode amplitude ratios during Temporal Interference Stimulation (TIS) for which measured signals remain at least 50% of the maximum signals observed at the optimal position.
Measured: Day 1
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Sep 2025
- Study start1 Sep 2025 (estimated)
- Primary completion31 Dec 2025 (estimated)
- Study completion31 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Nerve Excitation SensitivityStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 50 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Thomas Niederhauser
- Sponsor type
- University, hospital or other
- Collaborators
- Bern University of Applied Sciences, Swiss Paraplegic Research, Nottwil
- Responsible party
- Sponsor-investigator, Thomas Niederhauser, Bern University of Applied Sciences
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07160413
- Sponsor's protocol ID
- 2025-00776
- Other IDs
- 108.018 IP-LS, 2025
- Acronym
- PERNEAC
- Status last verified
- Sep 2025
- First submitted
- 29 Aug 2025
- Last updated
- 12 Sep 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 12 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Peripheral Nerve Activation Sensitivity to Electromagnetic and Electrical Stimulation in the Upper Arm
- ClinicalTrials.gov ID
- NCT07160413
- Acronym / sponsor ID
- PERNEAC / 2025-00776
- Conditions
- Nerve Excitation Sensitivity
- Keywords
- Peripheral nerve stimulation, Magnetic and electric stimulation, Sensitivity of nerves to magnetic fields
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 50 participants (estimated)
- Lead sponsor
- Thomas NiederhauserUniversity, hospital or other
- Collaborators
- Bern University of Applied Sciences, Swiss Paraplegic Research, Nottwil
- Study start
- 1 Sep 2025 (estimated)
- Primary completion
- 31 Dec 2025 (estimated)
- Study completion
- 31 Dec 2026 (estimated)
- First posted
- 8 Sep 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Volunteers will undergo various peripheral nerve stimulations (electric, electromagnetic, and temporal interference) to evaluate each method's sensitivity. The main objective is to examine the relationship between nerve activation and coil placement relative to the nerve, as well as how different coil types influence maximal nerve activation.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Stimulated | Experimental | Device: Electric and electromagnetic stimulation |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Person aged > 18 years
- Signed informed consent
- Healthy
- Willingness and ability to adhere to study procedures
Key exclusion criteria (12 listed)
- Known hypersensitivity to electric or electromagnetic stimulation
- Any implanted metal or electronic device in the upper body (except dental work such as fillings or braces), e.g., active medical devices, metal implants
- Neurological or neuromuscular disorders or conditions
- History of seizures or epilepsy
- Current treatment with drugs that lower seizure threshold (e.g., certain analgesics, methylxanthines, antipsychotics, antidepressants, antiepileptics, anesthetics)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Electric and electromagnetic stimulationApplication of electromagnetic and electric stimulation using coils of different designs and electrodes to assess peripheral nerve sensitivity. The stimulation is momentary, non-therapeutic, and performed for basic science research purposes | Device | Stimulated |
Primary outcome
Maximum nerve activation response to electromagnetic stimulation with different coils
Time frame: Day 1
Maximum of the measured signals (muscle contraction from electromyography (EMG) and finger movement from accelerometer) obtained across all stimulation positions at a given stimulation intensity for each coil type. This reflects the relative sensitivity of peripheral nerves to electromagnetic stimulation with different coil designs.
3 secondary outcomes
Spatial range of nerve activation with electromagnetic coils
Time frame: Day 1
Spatial range of nerve activation with neuromuscular electrical stimulation electrodes (NMES)
Time frame: Day 1
Amplitude ratios of temporal interference stimulation (TIS) electrodes associated with nerve activation
Time frame: Day 1
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Sep 2025.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Electric and electromagnetic stimulation in people with Nerve Excitation Sensitivity, run by Thomas Niederhauser at 1 site in Switzerland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 12 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 12 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Switzerland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Thomas Niederhauser, PhD (+41 32 321 67 63, thomas.niederhauser@bfh.ch), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Maximum nerve activation response to electromagnetic stimulation with different coils (time frame: Day 1). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Sep 2025.