Bone DensityTEEN-BMDNCT07164248
Evaluation of Bone Mineral Density Indications and Outcomes in Female Adolescents: Implications for Early Detection of Osteopenia/Osteoporosis and Gynecologic Practice
An observational study of Bone Density and Osteopenia, run by Bagcilar Training and Research Hospital at 1 site in Turkey (Türkiye).
Trial summary
This retrospective study evaluates bone mineral density (BMD) measurements obtained by dual-energy X-ray absorptiometry (DEXA) in adolescent girls aged 12 to 21 years at a tertiary care center. The study focuses on patients referred from the adolescent gynecology clinic as well as from other medical specialties. Read more about this study
- Who is it for?
- Ages 12 to 21 years, women only
- Conditions the study is for
- Bone Density, Osteopenia, Amenorrhea
- How many people
- 74 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Jun 2025to 1 Aug 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 12 to 21 years
- Women only
- No healthy volunteers
- Child, Adult
Study population: Female adolescents aged 12-21 years who underwent bone mineral density (BMD) measurement by dual-energy X-ray absorptiometry (DEXA) at a tertiary care hospital. The study includes patients referred from the adolescent gynecology clinic as well as those referred from other medical specialties (e.g., pediatrics, endocrinology).
Who may be able to join
- Female adolescents aged 12-21 years
- Underwent bone mineral density (BMD) measurement with DEXA at the study center between 2020 and 2025
- Available clinical and biochemical records, including referral indication
Who cannot join
- Incomplete or missing BMD scan data
- Insufficient clinical information in medical records
- Patients with underlying conditions unrelated to bone health that preclude accurate evaluation (e.g., major skeletal deformities interfering with DEXA interpretation)
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Bagcilar Training and Research Hospital
Istanbul, 34200
About this study
Official title: Retrospective Evaluation of Bone Mineral Density Measurements, Clinical Indications, and Risk Factors for Osteopenia/Osteoporosis in Female Adolescents Attending at a Tertiary Care Center
This retrospective study evaluates bone mineral density (BMD) measurements obtained by dual-energy X-ray absorptiometry (DEXA) in adolescent girls aged 12 to 21 years at a tertiary care center. The study focuses on patients referred from the adolescent gynecology clinic as well as from other medical specialties.
Key objectives are:
Read more
Comparing the BMD indications and results requested from the gynecology department with the indications and BMD results requested from other departments. Thus, the BMD scores of patients with hypogonadism can be compared with other groups at risk for bone health.
To assess BMD Z-scores across specific gynecologic diagnoses, including premature ovarian insufficiency, functional hypothalamic amenorrhea (FHA), and hypogonadotropic hypogonadism.
To analyze the relationship between gynecologic clinical features-such as age at menarche and duration of amenorrhea-and BMD Z-scores.
By combining clinical, hormonal, and densitometric data, this study aims to identify risk factors for low bone density in adolescents, support earlier recognition of osteopenia/osteoporosis, and provide guidance for appropriate interventions in adolescent gynecology practice.
Read the detailed description
Adolescence is a critical period for bone mass acquisition, and disturbances during this stage may predispose to osteopenia or osteoporosis in later life. Various clinical conditions encountered in gynecology, endocrinology, and other specialties may require evaluation of bone mineral density (BMD). However, data on referral indications and bone health outcomes in adolescents remain scarce.
This retrospective study focuses on female adolescents aged 12-21 years who underwent dual-energy X-ray absorptiometry (DEXA) scans at a tertiary care center. The cohort includes patients referred from the adolescent gynecology clinic as well as those referred from other medical departments.
The study objectives are:
To compare referral indications for BMD testing between gynecology and other specialties.
To evaluate differences in BMD Z-scores across specific gynecologic diagnoses, including premature ovarian insufficiency (POI), functional hypothalamic amenorrhea (FHA), and hypogonadotropic hypogonadism.
To examine the relationship between clinical features (such as age at menarche and duration of amenorrhea) and BMD outcomes within the gynecology group.
The analysis will provide insight into how referral patterns, gynecologic and endocrine conditions, and clinical characteristics influence bone health in adolescent girls. By highlighting risk factors for low BMD, the study aims to support earlier recognition and management of bone health problems in this population.
- Conditions
- Bone Density, Osteopenia, Amenorrhea, Primary Amenorrhea
- Keywords
- Osteoporosis, Amenorrhea, DEXA, Adolescent, Bone Health, Osteopenia
- Medical subject headings
- Bone Diseases, Metabolic, Amenorrhea, Osteoporosis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Cohort 1 - Adolescent gynecology referrals | Patients referred for DEXA scans due to gynecologic indications such as hypogonadism, amenorrhea, premature ovarian insufficiency [POI], functional hypothalamic amenorrhea [FHA], or hypogonadotropic hypogonadism | |
| Cohort 2 - Referrals from other specialties | Patients referred for DEXA scans by other departments, such as pediatrics, endocrinology, or additional medical specialties |
What is being measured
The primary outcome is the main question the study is designed to answer.
Bone Mineral Density (BMD) Z-scores in Adolescent Girls
Comparison of BMD Z-scores between adolescents (12-21 years) referred from the adolescent gynecology clinic and those referred from other specialties.
Measured: At the time of DEXA scan (retrospective chart review, 2020-2025
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Sep 2025
- Study start1 Jun 2025
- Primary completion15 Jun 2025
- Study completion1 Aug 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Bone DensityStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Retrospective
- Enrolment
- 74 participants (actual)
Sponsor and investigators
- Lead sponsor
- Bagcilar Training and Research Hospital
- Sponsor type
- Other government
- Responsible party
- Principal investigator, Nursen Kurtoglu Aksoy, Bagcilar Training and Research Hospital
- Investigators
- Nursen Kurtoglu, Principal investigator, Bagcilar Training and Research Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07164248
- Sponsor's protocol ID
- 2025/05/05/048
- Acronym
- TEEN-BMD
- Status last verified
- Sep 2025
- First submitted
- 2 Sep 2025
- Last updated
- 15 Sep 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: No individual participant data (IPD) will be shared. The study is retrospective and based on medical records, and patient confidentiality restrictions prevent data sharing.
Study at a glance
From the registry record, last updated by the sponsor on 15 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Retrospective Evaluation of Bone Mineral Density Measurements, Clinical Indications, and Risk Factors for Osteopenia/Osteoporosis in Female Adolescents Attending at a Tertiary Care Center
- ClinicalTrials.gov ID
- NCT07164248
- Acronym / sponsor ID
- TEEN-BMD / 2025/05/05/048
- Conditions
- Bone Density, Osteopenia, Amenorrhea, Primary Amenorrhea
- Keywords
- Osteoporosis, Amenorrhea, DEXA, Adolescent, Bone Health, Osteopenia
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 74 participants (actual)
- Lead sponsor
- Bagcilar Training and Research HospitalOther government
- Study start
- 1 Jun 2025 (actual)
- Primary completion
- 15 Jun 2025 (actual)
- Study completion
- 1 Aug 2025 (actual)
- First posted
- 10 Sep 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This retrospective study evaluates bone mineral density (BMD) measurements obtained by dual-energy X-ray absorptiometry (DEXA) in adolescent girls aged 12 to 21 years at a tertiary care center. The study focuses on patients referred from the adolescent gynecology clinic as well as from other medical specialties.
Key objectives are:
Comparing the BMD indications and results requested from the gynecology department with the indications and BMD results requested from other departments. Thus, the BMD scores of patients with hypogonadism can be compared with other groups at risk for bone health.
To assess BMD Z-scores across specific gynecologic diagnoses, including premature ovarian insufficiency, functional hypothalamic amenorrhea (FHA), and hypogonadotropic hypogonadism.
To analyze the relationship between gynecologic clinical features-such as age at menarche and duration of amenorrhea-and BMD Z-scores.
By combining clinical, hormonal, and densitometric data, this study aims to identify risk factors for low bone density in adolescents, support earlier recognition of osteopenia/osteoporosis, and provide guidance for appropriate interventions in adolescent gynecology practice.
Detailed description
Adolescence is a critical period for bone mass acquisition, and disturbances during this stage may predispose to osteopenia or osteoporosis in later life. Various clinical conditions encountered in gynecology, endocrinology, and other specialties may require evaluation of bone mineral density (BMD). However, data on referral indications and bone health outcomes in adolescents remain scarce.
This retrospective study focuses on female adolescents aged 12-21 years who underwent dual-energy X-ray absorptiometry (DEXA) scans at a tertiary care center. The cohort includes patients referred from the adolescent gynecology clinic as well as those referred from other medical departments.
The study objectives are:
To compare referral indications for BMD testing between gynecology and other specialties.
To evaluate differences in BMD Z-scores across specific gynecologic diagnoses, including premature ovarian insufficiency (POI), functional hypothalamic amenorrhea (FHA), and hypogonadotropic hypogonadism.
To examine the relationship between clinical features (such as age at menarche and duration of amenorrhea) and BMD outcomes within the gynecology group.
The analysis will provide insight into how referral patterns, gynecologic and endocrine conditions, and clinical characteristics influence bone health in adolescent girls. By highlighting risk factors for low BMD, the study aims to support earlier recognition and management of bone health problems in this population.
Study design
- Observational model
- Case only
- Time perspective
- Retrospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Cohort 1 - Adolescent gynecology referrals | – | –Patients referred for DEXA scans due to gynecologic indications such as hypogonadism, amenorrhea, premature ovarian insufficiency [POI], functional hypothalamic amenorrhea [FHA], or hypogonadotropic hypogonadism |
| Cohort 2 - Referrals from other specialties | – | –Patients referred for DEXA scans by other departments, such as pediatrics, endocrinology, or additional medical specialties |
Who may qualify
- Ages
- 12 to 21 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult
- Study population
- Female adolescents aged 12-21 years who underwent bone mineral density (BMD) measurement by dual-energy X-ray absorptiometry (DEXA) at a tertiary care hospital. The study includes patients referred from the adolescent gynecology clinic as well as those referred from other medical specialties (e.g., pediatrics, endocrinology).
Key inclusion criteria (3 listed)
- Female adolescents aged 12-21 years
- Underwent bone mineral density (BMD) measurement with DEXA at the study center between 2020 and 2025
- Available clinical and biochemical records, including referral indication
Key exclusion criteria (3 listed)
- Incomplete or missing BMD scan data
- Insufficient clinical information in medical records
- Patients with underlying conditions unrelated to bone health that preclude accurate evaluation (e.g., major skeletal deformities interfering with DEXA interpretation)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Bone Mineral Density (BMD) Z-scores in Adolescent Girls
Time frame: At the time of DEXA scan (retrospective chart review, 2020-2025
Comparison of BMD Z-scores between adolescents (12-21 years) referred from the adolescent gynecology clinic and those referred from other specialties.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Sep 2025.
- Individual participant dataSharing planned: No. No individual participant data (IPD) will be shared. The study is retrospective and based on medical records, and patient confidentiality restrictions prevent data sharing.
Related trials for Bone Density
Recruiting
Metabolic Health, Bones and Nuts During Weight Loss in Adults
Weight Loss, Bone Density
Active, not recruiting
AI-Supported Mobile High-Impact and Strengthening Exercise Program in Postmenopausal Women With Low Bone Density
Osteopenia
Enrolling by invitationObservational study
GRACE II (General Retrospective Analysis of Commercial Experience With AGN1 LOEP)
Osteoporosis
Recruiting
Optimized Osteosynthesis: Bone Mineral Density Recovery in Mandibular Body Fractures Using Patient-Specific Versus Conventional Plates
Mandibular Fractures
Recruiting
Digital Eye®-Assisted Bone Density Classification and Primary Dental Implant Stability.
Bone Mineral Density, Primary Implant Stability
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Nursen Kurtoglu principal investigator
Bagcilar Training and Research Hospital
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Bone Density and Osteopenia, run by Bagcilar Training and Research Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 15 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Bone Mineral Density (BMD) Z-scores in Adolescent Girls (time frame: At the time of DEXA scan (retrospective chart review, 2020-2025). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Sep 2025.