Ischemic PreconditioningNCT07170774
Research on the Enhancement of Aerobic Metabolic Energy Supply Capacity by Ischemic Preconditioning.
A study testing Ischemic Preconditioning in people with Ischemic Preconditioning and Aerobic Capacity, run by Ziyue Ou at 1 site in China.
Trial summary
The purpose of this clinical trial is to investigate whether IPC can improve aerobic capacity during exercise. The primary question it aims to answer is: Does IPC enhance the aerobic capacity of athletes? The researchers will compare IPC (220 mmHg pressure) with a placebo (20 mmHg pressure) to see if different… Read more about this study
- Who is it for?
- Ages 18 to 22 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Ischemic Preconditioning, Aerobic Capacity
- What is being tested?
- Ischemic Preconditioning
- Type of treatment
- Medical device
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 16 participants
- Where
- 1 siteChina
- Study dates
- 1 Apr 2024to 1 Jun 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 22 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- adult male athletes aged 18 years or older;
- taekwondo athletes classified as national second-class or above (having placed in the top three provincial professional taekwondo championships or the top eight national professional taekwondo championships);
- consistent and unified training over the past three months;
- no prior ischemic preconditioning;
- competitive taekwondo athletes.
Who cannot join
- supplementation with creatine;
- acute or chronic illnesses, including anxiety, depression, cardiovascular diseases, and metabolic disorders;
- engaging in vigorous physical activity within 48 hours prior to the experiment;
- consuming alcohol or caffeine within 24 hours before the experiment.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Ischemic Preconditioning Enhances Aerobic Metabolic Energy Supply Capacity During Frequency Speed of Kick Test in Taekwondo Athletes: A Randomized Crossover Study
The purpose of this clinical trial is to investigate whether IPC can improve aerobic capacity during exercise. The primary question it aims to answer is: Does IPC enhance the aerobic capacity of athletes? The researchers will compare IPC (220 mmHg pressure) with a placebo (20 mmHg pressure) to see if different interventions can enhance aerobic capacity and exercise performance.
Participants will:
- Undergo a randomized crossover controlled trial, visiting twice, with a one-week interval between each test.
- Conduct two assessments at the testing site each time, namely a pre-intervention assessment and a post-intervention assessment.
- Record their heart rate, blood pressure, weight, oxygen uptake, Taekwondo-specific performance, and other indicators.
- Conditions
- Ischemic Preconditioning, Aerobic Capacity
- Being tested
- Ischemic Preconditioning, Sham
- Keywords
- Ischemic preconditioning, Energy metabolism, Sports performance, Oxygen uptake
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Ischemic PreconditioningDevice
Compression cuff width: 10CM; Compression duration: 5min/5min (ischemia/reperfusion) *4. 220 mmHg
ShamDevice
Compression cuff width: 10CM; Compression duration: 5min/5min (compression/relaxation) *4. 20 mmHg
| Study group | Role | What they receive |
|---|---|---|
| IPC Trial | Experimental | 220 mmHg Receives: Device: Ischemic Preconditioning |
| SHAM Trial | Placebo comparator | 20 mmHg Receives: Device: Sham |
What is being measured
The primary outcome is the main question the study is designed to answer.
Oxygen uptake
To record the oxygen uptake of the subjects and compare the changes in oxygen uptake after the intervention.
Measured: Participants had their oxygen uptake measured continuously during both visits, extending until six minutes after the completion of the exercise test.
Taekwondo-specific sports performance test
The specialized athletic ability in Taekwondo is measured by the number of kicks performed during the test.
Measured: The subjects rested quietly for five minutes before baseline measurements were taken. After this, the collection of metabolic gases commenced. Throughout the experiment, metabolic gases were continuously collected until six minutes after the tests.
Blood lactate
Used to measure the intensity and metabolic adaptations during the testing process of taekwondo athletes
Measured: Blood lactate levels were measured at baseline, immediately after the intervention at 3 minutes, and at 3 and 10 minutes post-testing.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Sep 2025
- Study start1 Apr 2024
- Primary completion1 Jun 2024
- Study completion1 Jun 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Ischemic PreconditioningStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind
- Who is masked
- Investigator, Outcomes assessor
- Enrolment
- 16 participants (actual)
Sponsor and investigators
- Lead sponsor
- Ziyue Ou
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Ziyue Ou, Guangzhou Sport University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07170774
- Sponsor's protocol ID
- 2023WCXTD011
- Status last verified
- Sep 2025
- First submitted
- 7 Sep 2025
- Last updated
- 12 Sep 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: The data presented in this study are currently unpublished. The corresponding author will provide the relevant research data upon reasonable request after the associated paper has been officially accepted.
Publications
Cheng CF, Kuo YH, Hsu WC, Chen C, Pan CH. Local and Remote Ischemic Preconditioning Improves Sprint Interval Exercise Performance in Team Sport Athletes. Int J Environ Res Public Health. 2021 Oct 12;18(20):10653. doi: 10.3390/ijerph182010653.
PubMed 34682399Chen Y, Yang J, Muradov O, Li X, Lee JKW, Qiu J. Effect of ischemic preconditioning on maximum accumulated oxygen deficit in 400-meter runners. Eur J Sport Sci. 2023 May;23(5):789-796. doi: 10.1080/17461391.2022.2064769. Epub 2022 Apr 25.
PubMed 35400298Caru M, Levesque A, Lalonde F, Curnier D. An overview of ischemic preconditioning in exercise performance: A systematic review. J Sport Health Sci. 2019 Jul;8(4):355-369. doi: 10.1016/j.jshs.2019.01.008. Epub 2019 Jan 23.
PubMed 31333890Albuquerque MR, Flor CAG, Ribeiro AIS, Mesquita PHC, Franchini E, Laurentino GC. Effects of Ischemic Preconditioning on Sport-Specific Performance in Highly Trained Taekwondo Athletes. Sports (Basel). 2024 Jun 26;12(7):179. doi: 10.3390/sports12070179.
PubMed 39058070
Study at a glance
From the registry record, last updated by the sponsor on 12 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Ischemic Preconditioning Enhances Aerobic Metabolic Energy Supply Capacity During Frequency Speed of Kick Test in Taekwondo Athletes: A Randomized Crossover Study
- ClinicalTrials.gov ID
- NCT07170774
- Acronym / sponsor ID
- 2023WCXTD011
- Conditions
- Ischemic Preconditioning, Aerobic Capacity
- Keywords
- Ischemic preconditioning, Energy metabolism, Sports performance, Oxygen uptake
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 16 participants (actual)
- Lead sponsor
- Ziyue OuUniversity, hospital or other
- Study start
- 1 Apr 2024 (actual)
- Primary completion
- 1 Jun 2024 (actual)
- Study completion
- 1 Jun 2024 (actual)
- First posted
- 12 Sep 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this clinical trial is to investigate whether IPC can improve aerobic capacity during exercise. The primary question it aims to answer is: Does IPC enhance the aerobic capacity of athletes? The researchers will compare IPC (220 mmHg pressure) with a placebo (20 mmHg pressure) to see if different interventions can enhance aerobic capacity and exercise performance.
Participants will:
- Undergo a randomized crossover controlled trial, visiting twice, with a one-week interval between each test.
- Conduct two assessments at the testing site each time, namely a pre-intervention assessment and a post-intervention assessment.
- Record their heart rate, blood pressure, weight, oxygen uptake, Taekwondo-specific performance, and other indicators.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind (investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| IPC Trial | Experimental | Device: Ischemic Preconditioning220 mmHg |
| SHAM Trial | Placebo comparator | Device: Sham20 mmHg |
Who may qualify
- Ages
- 18 to 22 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- adult male athletes aged 18 years or older;
- taekwondo athletes classified as national second-class or above (having placed in the top three provincial professional taekwondo championships or the top eight national professional taekwondo championships);
- consistent and unified training over the past three months;
- no prior ischemic preconditioning;
- competitive taekwondo athletes.
Key exclusion criteria (4 listed)
- supplementation with creatine;
- acute or chronic illnesses, including anxiety, depression, cardiovascular diseases, and metabolic disorders;
- engaging in vigorous physical activity within 48 hours prior to the experiment;
- consuming alcohol or caffeine within 24 hours before the experiment.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Ischemic PreconditioningCompression cuff width: 10CM; Compression duration: 5min/5min (ischemia/reperfusion) *4. 220 mmHg | Device | IPC Trial |
| ShamCompression cuff width: 10CM; Compression duration: 5min/5min (compression/relaxation) *4. 20 mmHg | Device | SHAM Trial |
Primary outcome
Oxygen uptake
Time frame: Participants had their oxygen uptake measured continuously during both visits, extending until six minutes after the completion of the exercise test.
To record the oxygen uptake of the subjects and compare the changes in oxygen uptake after the intervention.
Taekwondo-specific sports performance test
Time frame: The subjects rested quietly for five minutes before baseline measurements were taken. After this, the collection of metabolic gases commenced. Throughout the experiment, metabolic gases were continuously collected until six minutes after the tests.
The specialized athletic ability in Taekwondo is measured by the number of kicks performed during the test.
Blood lactate
Time frame: Blood lactate levels were measured at baseline, immediately after the intervention at 3 minutes, and at 3 and 10 minutes post-testing.
Used to measure the intensity and metabolic adaptations during the testing process of taekwondo athletes
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Sep 2025.
- Background: PubMed 34682399Cheng CF, Kuo YH, Hsu WC, Chen C, Pan CH. Local and Remote Ischemic Preconditioning Improves Sprint Interval Exercise Performance in Team Sport Athletes. Int J Environ Res Public Health. 2021 Oct 12;18(20):10653. doi: 10.3390/ijerph182010653.
- Background: PubMed 35400298Chen Y, Yang J, Muradov O, Li X, Lee JKW, Qiu J. Effect of ischemic preconditioning on maximum accumulated oxygen deficit in 400-meter runners. Eur J Sport Sci. 2023 May;23(5):789-796. doi: 10.1080/17461391.2022.2064769. Epub 2022 Apr 25.
- Background: PubMed 31333890Caru M, Levesque A, Lalonde F, Curnier D. An overview of ischemic preconditioning in exercise performance: A systematic review. J Sport Health Sci. 2019 Jul;8(4):355-369. doi: 10.1016/j.jshs.2019.01.008. Epub 2019 Jan 23.
- Background: PubMed 39058070Albuquerque MR, Flor CAG, Ribeiro AIS, Mesquita PHC, Franchini E, Laurentino GC. Effects of Ischemic Preconditioning on Sport-Specific Performance in Highly Trained Taekwondo Athletes. Sports (Basel). 2024 Jun 26;12(7):179. doi: 10.3390/sports12070179.
- Individual participant dataSharing planned: No. The data presented in this study are currently unpublished. The corresponding author will provide the relevant research data upon reasonable request after the associated paper has been officially accepted.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Ischemic Preconditioning in people with Ischemic Preconditioning and Aerobic Capacity, run by Ziyue Ou at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 12 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Oxygen uptake (time frame: Participants had their oxygen uptake measured continuously during both visits, extending until six minutes after the completion of the exercise test.). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07170774, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Sep 2025.