Sedentary Middle Age and Older Aged AdultsRemoteEx+NCT07171255
Improving Exercise Adherence With App Technology for At-Risk Adults Living in Rural Kansas and Nebraska
A study testing RemoteEx+ Programming in people with Sedentary Middle Age and Older Aged Adults, run by Creighton University at 2 sites in United States.
Trial summary
Alzheimer's disease and related dementias are a public health crisis impacting individuals across the world. In the United States, adults living in rural areas face an elevated risk for cognitive impairment mainly due to disparities in care, higher sedentary behavior, and reduced education. Read more about this study
- Who is it for?
- Ages 40 to 85 yearsHealthy volunteers can take part
- Conditions the study is for
- Sedentary Middle Age and Older Aged Adults
- What is being tested?
- RemoteEx+ Programming
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 54 participants
- Where
- 2 sitesUnited States
- Study dates
- 22 Aug 2025to 30 Jun 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 85 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Age 40-85 years
- Characterized as underactive by the Telephone Assessment of Physical Activity (TAPA)50
- Self-reported proficiency in English
- Own a smartphone and willing to download an application
- Primary care provider clearance to participate for those who do not pass the PAR-Q+51
- Live in a rural area (Rural-Urban Commuting Area [RUCA] Codes) 52
Who cannot join
- Contraindications to high-intensity exercise
- Cognitive impairment (<19 on the Telephone Montreal Cognitive Assessment [MoCA])
- Neurodegenerative or acute neurological diagnoses (e.g., Parkinson's disease, stroke, traumatic brain injury)
- Orthopedic surgery or injuries in the last 6 months
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
Erin Blocker, PhD contact
United States2 sites, 2 recruiting
- Recruiting
Emporia State University
Emporia, Kansas, 66801
- Recruiting
Creighton University
Omaha, Nebraska, 68178
4022805691
About this study
Alzheimer's disease and related dementias are a public health crisis impacting individuals across the world. In the United States, adults living in rural areas face an elevated risk for cognitive impairment mainly due to disparities in care, higher sedentary behavior, and reduced education. This project proposes to assess the impact of a remotely delivered exercise program (i.e., RemoteEx+) through a smartphone application. The app is programmed by our team and provides video demonstrations of exercises, workout regimes, motivational messaging, and weekly ADRD risk reduction education. The project aims to assess with a pre/post design the following aims:
- Aim 1. Assess the RemoteEx+ intervention exercise adherence, efficacy, enjoyment, and quality of life. We hypothesize that rural adults will report high exercise adherence (80% of session adherence), efficacy (>50% on Self Efficacy for Exercise), and enjoyment (>5.0 on Intrinsic Motivation Inventory - Interest / Enjoyment Subscale) and that these variables will be positively correlated with quality of life scores (36-Item Short Form Health Survey [SF-36])
- Aim 2. Determine the impact of a technology-driven exercise program on blood pressure and functional mobility associated with dementia risk. We hypothesize that the exercise program will result in improvements in blood pressure and functional mobility (2-minute step test and 30-second chair rise test) and that participants with high exercise adherence will see the greatest improvements in biomarkers associated with reduced dementia risk.
- Aim 3. Reduce health disparities among rural-dwelling Nebraska and Kansas residents. We hypothesize that RemoteEx+ will reduce barriers to exercise (Barriers to Being Active Quiz and improve knowledge surrounding dementia and modifiable risk factors (Dementia Knowledge Assessment Tool - Version 2 [DKAT2]) that will result in fewer lifestyle-related health disparities for the communities involved in this study.
The results from this project will inform whether RemoteEx+ has an impact on the stated outcomes above for adults living in rural areas.
- Being tested
- RemoteEx+ Programming
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
RemoteEx+ ProgrammingBehavioural
The exercise program will include video instruction for all exercises, motivational cues, and ADRD risk education throughout the 16-week exercise program to encourage exercise adherence. RemoteEx+ is optimized to enhance exercise knowledge surrounding dementia risk factors to facilitate ADRD risk reduction and overall health improvement. The purpose of this study is to investigate the efficacy of RemoteEx+ on health outcomes associated with dementia risk in underactive rural adults.
| Study group | Role | What they receive |
|---|---|---|
| RemoteEx+ Program | Experimental | Not described Receives: Behavioral: RemoteEx+ Programming |
What is being measured
The primary outcome is the main question the study is designed to answer.
Systolic Blood Pressure
Measured: Baseline and Week 16
Secondary outcomes (7)
Cardiovascular Endurance
2-Minute Step Test
Measured: Baseline and Week 16
Lower Extremity Strength
30-second chair rise test
Measured: Baseline and Week 16
Exercise Adherence
% of sessions completed over the 16-week program
Measured: Baseline and Week 16
Exercise Efficacy
Self Efficacy for Exercise (SEE) Scale (points)
Measured: Baseline and Week 16
Quality of Life Improvement
36-Item Short Form Health Survey
Measured: Baseline and Week 16
Barriers to Being Active
Barriers to Being Active Quiz
Measured: Baseline and Week 16
Knowledge of dementia
Dementia Knowledge Assessment Tool
Measured: Baseline and Week 16
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Sep 2025
- Study start22 Aug 2025
- Primary completion30 Jun 2026 (estimated)
- Study completion30 Jun 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Sedentary Middle Age and Older Aged AdultsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 54 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Creighton University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07171255
- Sponsor's protocol ID
- 2005493
- Acronym
- RemoteEx+
- Status last verified
- Apr 2025
- First submitted
- 26 Aug 2025
- Last updated
- 12 Sep 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 12 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Improving Exercise Adherence With App Technology for At-Risk Adults Living in Rural Kansas and Nebraska
- ClinicalTrials.gov ID
- NCT07171255
- Acronym / sponsor ID
- RemoteEx+ / 2005493
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 54 participants (estimated)
- Lead sponsor
- Creighton UniversityUniversity, hospital or other
- Study start
- 22 Aug 2025 (actual)
- Primary completion
- 30 Jun 2026 (estimated)
- Study completion
- 30 Jun 2026 (estimated)
- First posted
- 12 Sep 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Alzheimer's disease and related dementias are a public health crisis impacting individuals across the world. In the United States, adults living in rural areas face an elevated risk for cognitive impairment mainly due to disparities in care, higher sedentary behavior, and reduced education. This project proposes to assess the impact of a remotely delivered exercise program (i.e., RemoteEx+) through a smartphone application. The app is programmed by our team and provides video demonstrations of exercises, workout regimes, motivational messaging, and weekly ADRD risk reduction education. The project aims to assess with a pre/post design the following aims:
- Aim 1. Assess the RemoteEx+ intervention exercise adherence, efficacy, enjoyment, and quality of life. We hypothesize that rural adults will report high exercise adherence (80% of session adherence), efficacy (>50% on Self Efficacy for Exercise), and enjoyment (>5.0 on Intrinsic Motivation Inventory - Interest / Enjoyment Subscale) and that these variables will be positively correlated with quality of life scores (36-Item Short Form Health Survey [SF-36])
- Aim 2. Determine the impact of a technology-driven exercise program on blood pressure and functional mobility associated with dementia risk. We hypothesize that the exercise program will result in improvements in blood pressure and functional mobility (2-minute step test and 30-second chair rise test) and that participants with high exercise adherence will see the greatest improvements in biomarkers associated with reduced dementia risk.
- Aim 3. Reduce health disparities among rural-dwelling Nebraska and Kansas residents. We hypothesize that RemoteEx+ will reduce barriers to exercise (Barriers to Being Active Quiz and improve knowledge surrounding dementia and modifiable risk factors (Dementia Knowledge Assessment Tool - Version 2 [DKAT2]) that will result in fewer lifestyle-related health disparities for the communities involved in this study.
The results from this project will inform whether RemoteEx+ has an impact on the stated outcomes above for adults living in rural areas.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| RemoteEx+ Program | Experimental | Behavioral: RemoteEx+ Programming |
Who may qualify
- Ages
- 40 to 85 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Age 40-85 years
- Characterized as underactive by the Telephone Assessment of Physical Activity (TAPA)50
- Self-reported proficiency in English
- Own a smartphone and willing to download an application
- Primary care provider clearance to participate for those who do not pass the PAR-Q+51
Key exclusion criteria (4 listed)
- Contraindications to high-intensity exercise
- Cognitive impairment (<19 on the Telephone Montreal Cognitive Assessment [MoCA])
- Neurodegenerative or acute neurological diagnoses (e.g., Parkinson's disease, stroke, traumatic brain injury)
- Orthopedic surgery or injuries in the last 6 months
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| RemoteEx+ ProgrammingThe exercise program will include video instruction for all exercises, motivational cues, and ADRD risk education throughout the 16-week exercise program to encourage exercise adherence. RemoteEx+ is optimized to enhance exercise knowledge surrounding dementia risk factors to facilitate ADRD risk reduction and overall health improvement. The purpose of this study is to investigate the efficacy of RemoteEx+ on health outcomes associated with dementia risk in underactive rural adults. | Behavioural | RemoteEx+ Program |
Primary outcome
Systolic Blood Pressure
Time frame: Baseline and Week 16
7 secondary outcomes
Cardiovascular Endurance
Time frame: Baseline and Week 16
Lower Extremity Strength
Time frame: Baseline and Week 16
Exercise Adherence
Time frame: Baseline and Week 16
Exercise Efficacy
Time frame: Baseline and Week 16
Quality of Life Improvement
Time frame: Baseline and Week 16
Barriers to Being Active
Time frame: Baseline and Week 16
Knowledge of dementia
Time frame: Baseline and Week 16
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Sep 2025.
- Individual participant dataSharing planned: Undecided
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Erin Blocker, PhD contact
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing RemoteEx+ Programming in people with Sedentary Middle Age and Older Aged Adults, run by Creighton University at 2 sites in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 12 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Rashelle Hoffman, PT, DPT, PhD (402-546-8997, rashellehoffman@creighton.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Systolic Blood Pressure (time frame: Baseline and Week 16). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Sep 2025.