Maturation of the Midpalatal Suture and Maxillary Third Molar Mineralization in Healthy IndividualsNCT07181707
Correlation Between the Midpalatal Suture Maturity and the Maxillary Third Molar Mineralization: a CBCT Study
An observational study of Maturation of the Midpalatal Suture and Maxillary Third Molar Mineralization in Healthy Individuals, run by Central Hospital, Nancy, France at 1 site in France.
Trial summary
Assessing the maturation of the mid-palatal suture is an essential criterion for orthodontic decision-making. However, from a CBCT according to Angelieri's classification , it remains difficult for the practitioner's untrained eye. Read more about this study
- Who is it for?
- Ages 9 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Maturation of the Midpalatal Suture and Maxillary Third Molar Mineralization in Healthy Individuals
- How many people
- 200 participants
- Where
- 1 siteFrance
- Study dates
- 1 Jan 2026to 26 Mar 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 9 to 40 years
- All sexes
- Healthy volunteers accepted
- Child, Adult
Study population: Odontology department's patients
Who may be able to join
- No previous orthodontic or orthopedic treatment
- At least the maxillary third left molar
- No skeletal disability
Who cannot join
- Previous maxillofacial trauma
- Dentofacial deformities
- Endocrinological pathologies with implications for maxillofacial growth • - Syndromes
- History of maxillofacial or orthognathic surgery
- History of orthodontic treatment
- Incomplete data or incomplete CBCT
- Maxillary third left molar fracture/cavity/other deterioratedation
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Correlation Between the Midpalatal Suture Maturity and the Maxillary Third Molar Mineralization: a Cone Beam Computed Tomography Study
Assessing the maturation of the mid-palatal suture is an essential criterion for orthodontic decision-making. However, from a CBCT according to Angelieri's classification , it remains difficult for the practitioner's untrained eye.
As profile teleradiographs are almost routinely performed in orthodontic check-ups, numerous studies have looked for a correlation between the stage of maturation of the palatal suture and that of the cervical vertebrae. Some have also looked for a link with mineralization of mandibular third or second molars according to Demirjian's classification.
Read more
These techniques would provide a reliable and reproducible method without the use of CBCT.
In our study, the investigators will be looking for a correlation with mineralization of the maxillary third molar according to Nolla's classification. The latter has become common in practice and easy to apply on an orthopantomogram.
This would simplify decision-making without the need for a CBCT, but by using the orthopantomogram which is already routinely performed during the assessment.
Read the detailed description
The study is a non-interventional (observational) research involving the human person, research on existing data (retrospective study).
This study analyzes the maturation stage of the Midpalatal suture and the mineralization of the third left molar.
This is a comparative retrospective study of radiographs in three dimensions before any orthodontic treatment to study a potential correlation.
There is no control group but there are subgroups depending of the age of the patients.
- Conditions
- Maturation of the Midpalatal Suture and Maxillary Third Molar Mineralization in Healthy Individuals
- Keywords
- Molar, third, Cone Beam Computed Tomography, cranial suture, tooth calcification
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Patient aged under 14 years | Patients aged under 14 years. | |
| Patients aged between 14 and 18 years. | Patients aged between 14 and 18 years. | |
| Patients aged between 19 and 25 years. | Patients aged between 19 and 25 years. | |
| Patients aged over 25 years. | Patients aged over 25 years. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Maturation stages of the midpalatal suture
Stages according to Angelieri et al.
Measured: One day
Third molar calcification
Calcification's stages of the third left molar maxillary (from 0 to 10) according to Nolla.
Measured: One day
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Sep 2025
- Study start1 Jan 2026
- Primary completion26 Mar 2026
- Study completion26 Mar 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Maturation of the Midpalatal Suture and Maxillary Third Molar Mineralization in Healthy IndividualsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Retrospective
- Enrolment
- 200 participants (actual)
Sponsor and investigators
- Lead sponsor
- Central Hospital, Nancy, France
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, VANDE VANNET Bart, Central Hospital, Nancy, France
- Investigators
- Bart VANDE VANNET, PhD, Study director, Central Hospital, Nancy, France
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07181707
- Sponsor's protocol ID
- 2025PI009
- Status last verified
- Apr 2026
- First submitted
- 12 Sep 2025
- Last updated
- 30 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 30 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Correlation Between the Midpalatal Suture Maturity and the Maxillary Third Molar Mineralization: a Cone Beam Computed Tomography Study
- ClinicalTrials.gov ID
- NCT07181707
- Acronym / sponsor ID
- 2025PI009
- Conditions
- Maturation of the Midpalatal Suture and Maxillary Third Molar Mineralization in Healthy Individuals
- Keywords
- Molar, third, Cone Beam Computed Tomography, cranial suture, tooth calcification
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 200 participants (actual)
- Lead sponsor
- Central Hospital, Nancy, FranceUniversity, hospital or other
- Study start
- 1 Jan 2026 (actual)
- Primary completion
- 26 Mar 2026 (actual)
- Study completion
- 26 Mar 2026 (actual)
- First posted
- 18 Sep 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Assessing the maturation of the mid-palatal suture is an essential criterion for orthodontic decision-making. However, from a CBCT according to Angelieri's classification , it remains difficult for the practitioner's untrained eye.
As profile teleradiographs are almost routinely performed in orthodontic check-ups, numerous studies have looked for a correlation between the stage of maturation of the palatal suture and that of the cervical vertebrae. Some have also looked for a link with mineralization of mandibular third or second molars according to Demirjian's classification.
These techniques would provide a reliable and reproducible method without the use of CBCT.
In our study, the investigators will be looking for a correlation with mineralization of the maxillary third molar according to Nolla's classification. The latter has become common in practice and easy to apply on an orthopantomogram.
This would simplify decision-making without the need for a CBCT, but by using the orthopantomogram which is already routinely performed during the assessment.
Detailed description
The study is a non-interventional (observational) research involving the human person, research on existing data (retrospective study).
This study analyzes the maturation stage of the Midpalatal suture and the mineralization of the third left molar.
This is a comparative retrospective study of radiographs in three dimensions before any orthodontic treatment to study a potential correlation.
There is no control group but there are subgroups depending of the age of the patients.
Study design
- Observational model
- Other
- Time perspective
- Retrospective
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Patient aged under 14 years | – | –Patients aged under 14 years. |
| Patients aged between 14 and 18 years. | – | –Patients aged between 14 and 18 years. |
| Patients aged between 19 and 25 years. | – | –Patients aged between 19 and 25 years. |
| Patients aged over 25 years. | – | –Patients aged over 25 years. |
Who may qualify
- Ages
- 9 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult
- Study population
- Odontology department's patients
Key inclusion criteria (3 listed)
- No previous orthodontic or orthopedic treatment
- At least the maxillary third left molar
- No skeletal disability
Key exclusion criteria (7 listed)
- Previous maxillofacial trauma
- Dentofacial deformities
- Endocrinological pathologies with implications for maxillofacial growth • - Syndromes
- History of maxillofacial or orthognathic surgery
- History of orthodontic treatment
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Maturation stages of the midpalatal suture
Time frame: One day
Stages according to Angelieri et al.
Third molar calcification
Time frame: One day
Calcification's stages of the third left molar maxillary (from 0 to 10) according to Nolla.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Apr 2026.
- Individual participant dataSharing planned: Undecided
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Bart VANDE VANNET, PhD study director
Central Hospital, Nancy, France
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Maturation of the Midpalatal Suture and Maxillary Third Molar Mineralization in Healthy Individuals, run by Central Hospital, Nancy, France at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 30 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Maturation stages of the midpalatal suture (time frame: One day). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Apr 2026.