Primary AldosteronismNCT07182175
Comparative Study of Perioperative Cardiac Injury in Patients With Functional Adrenal Tumors
An observational study of Primary Aldosteronism and Adrenal Tumor, run by Peking University First Hospital at 1 site in China.
Trial summary
The main goal of this study is to follow patients with functional adrenal tumors during the time before and after their surgery. The main questions it aims to answer are: What heart and blood pressure changes do patients with different types of adrenal tumors have before surgery? What factors affect how the heart and… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Primary Aldosteronism, Adrenal Tumor, Cushing s Syndrome
- How many people
- 150 participants
- Where
- 1 siteChina
- Study dates
- 19 Sep 2024to 29 May 2026
- How long will I take part?
- 48 Weeks
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: The study population consists of patients with functional adrenal tumors who are hospitalized and/or seen in the outpatient clinic of the Department of Urology at Peking University First Hospital.
Who may be able to join
- Patients diagnosed in the Department of Urology, Peking University First Hospital with pheochromocytoma and paraganglioma (PPGL), primary aldosteronism (PA), or Cushing syndrome (CS);
- Written informed consent obtained.
Who cannot join
- Patients with PPGL, PA, or CS who receive medication or conservative treatment and are not eligible for surgical resection;
- Patients with communication disorders or severe physical impairments such as aphasia, or visual/hearing disabilities;
- Patients with severe mental illness who cannot cooperate with the study;
- Pregnant women or patients otherwise deemed unsuitable for participation by the investigators.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Dynamic Monitoring and Comparative Study of Perioperative Cardiac Injury in Patients With Functional Adrenal Tumors
The main goal of this study is to follow patients with functional adrenal tumors during the time before and after their surgery.
The main questions it aims to answer are:
Read more
- What heart and blood pressure changes do patients with different types of adrenal tumors have before surgery?
- What factors affect how the heart and blood pressure recover after surgery?
- Do the heart and blood pressure conditions before surgery influence recovery and the risk of heart or brain problems after surgery?
Patients will have heart ultrasound checks and health monitoring before and after surgery. The results will help doctors choose the right medicines before surgery, better understand possible risks during the operation, and make safer treatment plans for patients with functional adrenal tumors.
- Conditions
- Primary Aldosteronism, Adrenal Tumor, Cushing s Syndrome, Pheochromocytoma/Paraganglioma (PPGL)
- Medical subject headings
- Hyperaldosteronism, Adrenal Gland Neoplasms, Pheochromocytoma, Paraganglioma
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| primary aldosteronism | Not described | |
| Cushing s Syndrome | Not described | |
| Pheochromocytoma/Paraganglioma (PPGL) | Not described |
What is being measured
The primary outcome is the main question the study is designed to answer.
Recovery of cardiac function after adrenal surgery
global longitudinal stress
Measured: from enrollment to 4,24,48 weeks after surgery
Secondary outcomes (1)
Recovery of blood pressure after adrenal surgery
Decrease in 24h average blood pressure
Measured: from enrollment to 4,24,48 weeks after surgery
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Sep 2025
- Study start19 Sep 2024
- Primary completion17 Nov 2024
- Study completion29 May 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Primary AldosteronismStudies of the same condition, open and under way.
- More trials run by Peking University First HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 150 participants (estimated)
- Target duration
- 48 Weeks
Sponsor and investigators
- Lead sponsor
- Peking University First Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07182175
- Sponsor's protocol ID
- 2024yan411-002
- Status last verified
- Sep 2025
- First submitted
- 11 Sep 2025
- Last updated
- 19 Sep 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Data cannot be shared, because data from this study may contain potentially or sensitive patient information.
Study at a glance
From the registry record, last updated by the sponsor on 19 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Dynamic Monitoring and Comparative Study of Perioperative Cardiac Injury in Patients With Functional Adrenal Tumors
- ClinicalTrials.gov ID
- NCT07182175
- Acronym / sponsor ID
- 2024yan411-002
- Conditions
- Primary Aldosteronism, Adrenal Tumor, Cushing s Syndrome, Pheochromocytoma/Paraganglioma (PPGL)
- Study type
- Observational
- Recruitment status
- Enrolling by invitation
- Enrolment
- 150 participants (estimated)
- Lead sponsor
- Peking University First HospitalUniversity, hospital or other
- Study start
- 19 Sep 2024 (actual)
- Primary completion
- 17 Nov 2024 (actual)
- Study completion
- 29 May 2026 (estimated)
- First posted
- 19 Sep 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The main goal of this study is to follow patients with functional adrenal tumors during the time before and after their surgery.
The main questions it aims to answer are:
- What heart and blood pressure changes do patients with different types of adrenal tumors have before surgery?
- What factors affect how the heart and blood pressure recover after surgery?
- Do the heart and blood pressure conditions before surgery influence recovery and the risk of heart or brain problems after surgery?
Patients will have heart ultrasound checks and health monitoring before and after surgery. The results will help doctors choose the right medicines before surgery, better understand possible risks during the operation, and make safer treatment plans for patients with functional adrenal tumors.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Target follow-up
- 48 Weeks
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| primary aldosteronism | – | – |
| Cushing s Syndrome | – | – |
| Pheochromocytoma/Paraganglioma (PPGL) | – | – |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- The study population consists of patients with functional adrenal tumors who are hospitalized and/or seen in the outpatient clinic of the Department of Urology at Peking University First Hospital.
Key inclusion criteria (2 listed)
- Patients diagnosed in the Department of Urology, Peking University First Hospital with pheochromocytoma and paraganglioma (PPGL), primary aldosteronism (PA), or Cushing syndrome (CS);
- Written informed consent obtained.
Key exclusion criteria (4 listed)
- Patients with PPGL, PA, or CS who receive medication or conservative treatment and are not eligible for surgical resection;
- Patients with communication disorders or severe physical impairments such as aphasia, or visual/hearing disabilities;
- Patients with severe mental illness who cannot cooperate with the study;
- Pregnant women or patients otherwise deemed unsuitable for participation by the investigators.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Recovery of cardiac function after adrenal surgery
Time frame: from enrollment to 4,24,48 weeks after surgery
global longitudinal stress
1 secondary outcome
Recovery of blood pressure after adrenal surgery
Time frame: from enrollment to 4,24,48 weeks after surgery
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Sep 2025.
- Individual participant dataSharing planned: No. Data cannot be shared, because data from this study may contain potentially or sensitive patient information.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Primary Aldosteronism and Adrenal Tumor, run by Peking University First Hospital at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 19 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Recovery of cardiac function after adrenal surgery (time frame: from enrollment to 4,24,48 weeks after surgery). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Sep 2025; AzTrials last refreshed its copy on 7 Nov 2026.