Migraine Seizures EncephalopathyNCT07184008
Echo and ECG Findings in Neuropediatrics
An observational study of Migraine Seizures Encephalopathy and Arrythmia Congenital Heart Disease Cardiomyopathy, run by Assiut University.
Trial summary
Evaluate the echo-electrocardiographic findings in patients with neurological affection to identify potential cardiac involvement, and explore correlation between cardiac and neurological abnormalities.Objectives are To assess echocardiographic findings in patients with neurological affection , to analyze ECG patterns… Read more about this study
- Who is it for?
- Ages 1 month to 18 years
- Conditions the study is for
- Migraine Seizures Encephalopathy, Arrythmia Congenital Heart Disease Cardiomyopathy
- How many people
- 70 participants
- Where
- No sites listed yet
- Study dates
- 1 Oct 2025to Oct 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 1 month to 18 years
- All sexes
- Child, Adult
Study population: The study population will include pediatric patients presenting with neurological manifestations (such as seizures, motor deficits, stroke, or altered consciousness) who are admitted to the Pediatric Neurology and Cardiology Departments, or presenting to the Emergency Room (ER) at Assiut University Hospital. These patients will be further evaluated for underlying cardiac diseases using echocardiography (ECHO) and electrocardiography (ECG). Both male and female patients will be included.
Who may be able to join
- pediatric patients (1 month - 18 years) diagnosed with a neurological disorder (e.g., stroke, epilepsy, demyelinating disorders, neuromuscular diseases and migraine) confirmed by clinical data (history \& examination) and/or neuroimaging ( CT \& MRI ).
- Both sexes (Male \& Female) were included in the study.
- Patients willing to participate and provide informed consent
Who cannot join
- patients younger than 1 month old.
- critically unstable patients in whom echocardiography could not be performed safely or was technically in adequate for interpretation.
- patients refuse to participate in the research.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Echocardiographic and Electrocardiographic Findings in Pediatric Patients With Neurological Findings.
Evaluate the echo-electrocardiographic findings in patients with neurological affection to identify potential cardiac involvement, and explore correlation between cardiac and neurological abnormalities.Objectives are To assess echocardiographic findings in patients with neurological affection , to analyze ECG patterns in the same patient group and to explore clinical significance of detected cardiac findings in the management of neurological patients.
Read the detailed description
Neurological disorders in pediatric patients represent a significant cause of morbidity and mortality worldwide. These disorders may have multifactorial etiologies , including congenital , infectious , metabolic , inflammatory , and vascular causes , with clinical presentations ranging from seizures to motor deficits and altered consciousness.
The interplay between neurological conditions and cardiovascular involvement has gained increasing attention in recent years. Cardiac manifestations may occur secondary to neurological diseases due to autonomic dysregulation , systemic inflammation , or direct neuro cardiac interaction , potentially affecting patient outcomes.
Several studies have demonstrated that pediatric patients with neurological diseases, such as epilepsy, cerebral palsy, and acute encephalitis, may exhibit significant echocardiographic and electrocardiographic changes. These changes may be transient or persistent, and recognizing them early is crucial for comprehensive patient management.
Moreover, neurological complications may also arise as a consequence of primary cardiac disease. Conditions such as congenital heart disease, infective endocarditis, or shunt lesions can predispose to embolic stroke, brain abscess, or hypoxic-ischemic injury, representing critical intersections between heart and brain.
Electrocardiographic abnormalities are frequently observed in children with congenital and acquired heart disease, and some of these changes are associated with neurological complications. For instance, prolonged QT interval or QT dispersion has been linked to an increased risk of arrhythmia-related cerebral hypoperfusion and syncope, which in turn can precipitate transient ischemic attacks or seizures.
Atrial fibrillation, although less common in children, may also occur in certain congenital heart conditions and cardiomyopathies. It is a well-recognized source of cardioembolic stroke, as thrombi formed in the atria can dislodge and travel to the cerebral circulation. Early detection of such arrhythmias by ECG is essential to prevent neurological sequelae.
Understanding the cardiac profile of patients with neurological affection may therefore help in early detection, appropriate intervention, and reduction of long-term complications.
What is being measured
The primary outcome is the main question the study is designed to answer.
Detection of cardiac abnormalities in pediatric patients with neurological disorders
Proportion of patients showing abnormalities in either electrocardiography (arrhythmias, conduction defects, prolonged QTc) or echocardiography (structural heart disease, ventricular dysfunction, pulmonary hypertension, vegetations).
Measured: Within the first week of hospital admission
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Sep 2025
- Study start1 Oct 2025 (estimated)
- Primary completionOct 2026 (estimated)
- Study completionOct 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Migraine Seizures EncephalopathyStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Cross-sectional
- Enrolment
- 70 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Andrew Youssef Qestandy Youssef, Assiut University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07184008
- Sponsor's protocol ID
- Ecg & Echo in neuropediatrics
- Status last verified
- Sep 2025
- First submitted
- 14 Sep 2025
- Last updated
- 19 Sep 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 19 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Echocardiographic and Electrocardiographic Findings in Pediatric Patients With Neurological Findings.
- ClinicalTrials.gov ID
- NCT07184008
- Acronym / sponsor ID
- Ecg & Echo in neuropediatrics
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 70 participants (estimated)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- 1 Oct 2025 (estimated)
- Primary completion
- Oct 2026 (estimated)
- Study completion
- Oct 2026 (estimated)
- First posted
- 19 Sep 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Evaluate the echo-electrocardiographic findings in patients with neurological affection to identify potential cardiac involvement, and explore correlation between cardiac and neurological abnormalities.Objectives are To assess echocardiographic findings in patients with neurological affection , to analyze ECG patterns in the same patient group and to explore clinical significance of detected cardiac findings in the management of neurological patients.
Detailed description
Neurological disorders in pediatric patients represent a significant cause of morbidity and mortality worldwide. These disorders may have multifactorial etiologies , including congenital , infectious , metabolic , inflammatory , and vascular causes , with clinical presentations ranging from seizures to motor deficits and altered consciousness.
The interplay between neurological conditions and cardiovascular involvement has gained increasing attention in recent years. Cardiac manifestations may occur secondary to neurological diseases due to autonomic dysregulation , systemic inflammation , or direct neuro cardiac interaction , potentially affecting patient outcomes.
Several studies have demonstrated that pediatric patients with neurological diseases, such as epilepsy, cerebral palsy, and acute encephalitis, may exhibit significant echocardiographic and electrocardiographic changes. These changes may be transient or persistent, and recognizing them early is crucial for comprehensive patient management.
Moreover, neurological complications may also arise as a consequence of primary cardiac disease. Conditions such as congenital heart disease, infective endocarditis, or shunt lesions can predispose to embolic stroke, brain abscess, or hypoxic-ischemic injury, representing critical intersections between heart and brain.
Electrocardiographic abnormalities are frequently observed in children with congenital and acquired heart disease, and some of these changes are associated with neurological complications. For instance, prolonged QT interval or QT dispersion has been linked to an increased risk of arrhythmia-related cerebral hypoperfusion and syncope, which in turn can precipitate transient ischemic attacks or seizures.
Atrial fibrillation, although less common in children, may also occur in certain congenital heart conditions and cardiomyopathies. It is a well-recognized source of cardioembolic stroke, as thrombi formed in the atria can dislodge and travel to the cerebral circulation. Early detection of such arrhythmias by ECG is essential to prevent neurological sequelae.
Understanding the cardiac profile of patients with neurological affection may therefore help in early detection, appropriate intervention, and reduction of long-term complications.
Study design
- Observational model
- Other
- Time perspective
- Cross-sectional
Who may qualify
- Ages
- 1 month to 18 years
- Sex
- All
- Age groups
- Child, Adult
- Study population
- The study population will include pediatric patients presenting with neurological manifestations (such as seizures, motor deficits, stroke, or altered consciousness) who are admitted to the Pediatric Neurology and Cardiology Departments, or presenting to the Emergency Room (ER) at Assiut University Hospital. These patients will be further evaluated for underlying cardiac diseases using echocardiography (ECHO) and electrocardiography (ECG). Both male and female patients will be included.
Key inclusion criteria (3 listed)
- pediatric patients (1 month - 18 years) diagnosed with a neurological disorder (e.g., stroke, epilepsy, demyelinating disorders, neuromuscular diseases and migraine) confirmed by clinical data (history \& examination) and/or neuroimaging ( CT \& MRI ).
- Both sexes (Male \& Female) were included in the study.
- Patients willing to participate and provide informed consent
Key exclusion criteria (3 listed)
- patients younger than 1 month old.
- critically unstable patients in whom echocardiography could not be performed safely or was technically in adequate for interpretation.
- patients refuse to participate in the research.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Detection of cardiac abnormalities in pediatric patients with neurological disorders
Time frame: Within the first week of hospital admission
Proportion of patients showing abnormalities in either electrocardiography (arrhythmias, conduction defects, prolonged QTc) or echocardiography (structural heart disease, ventricular dysfunction, pulmonary hypertension, vegetations).
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Sep 2025.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
An observational study of Migraine Seizures Encephalopathy and Arrythmia Congenital Heart Disease Cardiomyopathy, run by Assiut University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 19 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Andrew Youssef Qestandy (+201152156076, andro98youssef70@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Detection of cardiac abnormalities in pediatric patients with neurological disorders (time frame: Within the first week of hospital admission). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Sep 2025.