Periodontitis, AdultNCT07184268
Clinical Efficacy of NST With Adjunctive Local Delivery of Ozonated Olive Versus Curcumin Gel in Stage II Grade B Periodontitis.
A study testing full mouth non-surgical scaling in people with Periodontitis, Adult, run by Cairo University at 1 site in Egypt.
Trial summary
The aim of this clinical trial is to evaluate the effectiveness of local delivery ozonated olive gel versus curcumin gel as adjunct to scaling and root planing in the treatment of stage II grade B periodontitis in on both males and females in the age group between 18 and 50 years. Read more about this study
- Who is it for?
- Ages 18 to 50 yearsHealthy volunteers can take part
- Conditions the study is for
- Periodontitis, Adult
- What is being tested?
- full mouth non-surgical scaling
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 60 participants
- Where
- 1 siteEgypt
- Study dates
- 2 Nov 2025to 15 Mar 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Patients diagnosed with stage II periodontitis defined by having interdental CAL 3-4 mm and presence of pocket depth (PD) ≤ 5 mm, and grade B periodontitis characterized by a moderate rate of disease progression.
- Patients agree to a 3-month follow-up period and provide an informed consent.
Who cannot join
- Presence of prosthetic crowns, overhanging restorations and orthodontic treatment.
- Teeth with both endo-perio lesions.
- Antibiotics therapy that has an impact on the clinical signs and symptoms of periodontitis in the previous 3 months.
- Anti-inflammatory drugs in the previous 1 month.
- 6. History of systemic disease, allergy, cardiovascular diseases, diabetes mellitus, hypertension, bleeding disorders, hyperparathyroidism, and compromised medical conditions, pregnant and lactating females.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Clinical Efficacy of Non-surgical Therapy With Adjunctive Local Delivery of Ozonated Olive Oil Gel Versus Curcumin Gel in Stage II Grade B Periodontitis Randomized Controlled Clinical Trial.
The aim of this clinical trial is to evaluate the effectiveness of local delivery ozonated olive gel versus curcumin gel as adjunct to scaling and root planing in the treatment of stage II grade B periodontitis in on both males and females in the age group between 18 and 50 years. outcome measures are Clinical attachment level (CAL), plaque index (PI), gingival index (GI).
Read the detailed description
Periodontitis is an advanced periodontal disease with a distinctive clinical signs and symptoms as rapid attachment loss and bone destruction
The primary treatment approach for periodontitis is mechanical plaque removal through debridement, particularly scaling and root planing (SRP) using hand or ultrasonic instruments.
curcumin gel is an adjunct to non-surgical periodontal therapy is a highly potent local antioxidant and anti-inflammatory agent. While ozone has a potent antimicrobial and anti-inflammatory effects it also can be incorporated into a lipid carrier such as olive oil. Ozone's stability and ease of application are markedly enhanced. Ozonized olive oil can be formulated into a gel with ideal rheological properties for injection into periodontal pockets.
- Conditions
- Periodontitis, Adult
- Being tested
- full mouth non-surgical scaling
- Keywords
- Nonsurgical therapy, local delivery gel, curcumin gel, ozonated olive oil, molar incisor pattern periodontitis, Chronic periodontitis, stage II grade B
- Medical subject headings
- Chronic Periodontitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
full mouth non-surgical scalingProcedure or surgery
All patients will receive a full mouth scaling using ultrasonic scalers and hand instrumentation
| Study group | Role | What they receive |
|---|---|---|
| curcumin gel | Active comparator | full-mouth SRP + subgingival application of curcumin gel Receives: Procedure: full mouth non-surgical scaling |
| ozonated olive gel. | Active comparator | full-mouth SRP + subgingival application of ozonated olive oil gel Receives: Procedure: full mouth non-surgical scaling |
| placebo gel | Placebo comparator | full-mouth SRP followed by subgingival application of placebo gel Receives: Procedure: full mouth non-surgical scaling |
What is being measured
The primary outcome is the main question the study is designed to answer.
Clinical attachment level
measured from the cementoenamel junction (CEJ) to the bottom of pocket.
Measured: 3 months
Secondary outcomes (2)
Gingival Index
Index scores will be recorded showing gingival bleeding and inflammation
Measured: 3 months
Plaque index
be used to evaluate plaque accumulation
Measured: 3 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Sep 2025
- Study start2 Nov 2025
- Primary completion15 Mar 2026
- Study completion15 Mar 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Periodontitis, AdultStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- The test group "Group 3" will receive full Scaling and root planing (SRP) followed by subgingival application of ozonated olive gel. The test group "Group 2" will receive full-mouth SRP followed by subgingival application of curcumin gel The control group "Group 1" will receive full-mouth SRP followed by subgingival application of placebo gel
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Collaborators
- MTI University
- Responsible party
- Principal investigator, Parryhan Mohamed Abdelsamie, Cairo University
- Investigators
- Parryhan M Abdelsamie, Principal investigator, MTI University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07184268
- Sponsor's protocol ID
- 892025
- Status last verified
- Jul 2026
- First submitted
- 8 Sep 2025
- Last updated
- 6 Jul 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 6 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Clinical Efficacy of Non-surgical Therapy With Adjunctive Local Delivery of Ozonated Olive Oil Gel Versus Curcumin Gel in Stage II Grade B Periodontitis Randomized Controlled Clinical Trial.
- ClinicalTrials.gov ID
- NCT07184268
- Acronym / sponsor ID
- 892025
- Conditions
- Periodontitis, Adult
- Keywords
- Nonsurgical therapy, local delivery gel, curcumin gel, ozonated olive oil, molar incisor pattern periodontitis, Chronic periodontitis, stage II grade B
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 60 participants (actual)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Collaborators
- MTI University
- Study start
- 2 Nov 2025 (actual)
- Primary completion
- 15 Mar 2026 (actual)
- Study completion
- 15 Mar 2026 (actual)
- First posted
- 19 Sep 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this clinical trial is to evaluate the effectiveness of local delivery ozonated olive gel versus curcumin gel as adjunct to scaling and root planing in the treatment of stage II grade B periodontitis in on both males and females in the age group between 18 and 50 years. outcome measures are Clinical attachment level (CAL), plaque index (PI), gingival index (GI).
Detailed description
Periodontitis is an advanced periodontal disease with a distinctive clinical signs and symptoms as rapid attachment loss and bone destruction
The primary treatment approach for periodontitis is mechanical plaque removal through debridement, particularly scaling and root planing (SRP) using hand or ultrasonic instruments.
curcumin gel is an adjunct to non-surgical periodontal therapy is a highly potent local antioxidant and anti-inflammatory agent. While ozone has a potent antimicrobial and anti-inflammatory effects it also can be incorporated into a lipid carrier such as olive oil. Ozone's stability and ease of application are markedly enhanced. Ozonized olive oil can be formulated into a gel with ideal rheological properties for injection into periodontal pockets.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 3
- Model description
- The test group "Group 3" will receive full Scaling and root planing (SRP) followed by subgingival application of ozonated olive gel. The test group "Group 2" will receive full-mouth SRP followed by subgingival application of curcumin gel The control group "Group 1" will receive full-mouth SRP followed by subgingival application of placebo gel
| Arm | Type | Receives |
|---|---|---|
| curcumin gel | Active comparator | Procedure: full mouth non-surgical scalingfull-mouth SRP + subgingival application of curcumin gel |
| ozonated olive gel. | Active comparator | Procedure: full mouth non-surgical scalingfull-mouth SRP + subgingival application of ozonated olive oil gel |
| placebo gel | Placebo comparator | Procedure: full mouth non-surgical scalingfull-mouth SRP followed by subgingival application of placebo gel |
Who may qualify
- Ages
- 18 to 50 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- Patients diagnosed with stage II periodontitis defined by having interdental CAL 3-4 mm and presence of pocket depth (PD) ≤ 5 mm, and grade B periodontitis characterized by a moderate rate of disease progression.
- Patients agree to a 3-month follow-up period and provide an informed consent.
Key exclusion criteria (5 listed)
- Presence of prosthetic crowns, overhanging restorations and orthodontic treatment.
- Teeth with both endo-perio lesions.
- Antibiotics therapy that has an impact on the clinical signs and symptoms of periodontitis in the previous 3 months.
- Anti-inflammatory drugs in the previous 1 month.
- 6. History of systemic disease, allergy, cardiovascular diseases, diabetes mellitus, hypertension, bleeding disorders, hyperparathyroidism, and compromised medical conditions, pregnant and lactating females.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| full mouth non-surgical scalingAll patients will receive a full mouth scaling using ultrasonic scalers and hand instrumentation | Procedure or surgery | curcumin gel, ozonated olive gel., placebo gel |
Primary outcome
Clinical attachment level
Time frame: 3 months
measured from the cementoenamel junction (CEJ) to the bottom of pocket.
2 secondary outcomes
Gingival Index
Time frame: 3 months
Plaque index
Time frame: 3 months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Jul 2026.
- Individual participant dataSharing planned: No
Related trials for Periodontitis, Adult
RecruitingObservational study
Prevalence and Associated Factors of High BMI and Periodontitis in Thai Adults Aged Under 60 Years
Diabete Mellitus, Dyslipidaemia
RecruitingObservational study
Evaluation of Masticatory Performance in Patients With Periodontitis
Periodontitis, Adult, Periodontitis
Not yet recruitingObservational study
Evaluation of Changes in Oral Health-related Quality of Life During the Treatment of Periodontitis.
Periodontitis, Adult, Periodontitis
Not yet recruiting
Sonic Irrigation Activation for Postoperative Pain After Root Canal Treatment
Asymptomatic Apical Periodontitis
Active, not recruiting
Utilization of a Videoscope in Periodontal Regeneration
Chronic Periodontitis
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Parryhan M Abdelsamie principal investigator
MTI University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing full mouth non-surgical scaling in people with Periodontitis, Adult, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Clinical attachment level (time frame: 3 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Jul 2026.