Centric Relation RegistrationNCT07184346
Accuracy of Centric Relation Recording: Conventional to Optical
A study testing Intra Oral Scanner and Mod Jaw in people with Centric Relation Registration, run by Mohammed Bin Rashid University of Medicine and Health Sciences.
Trial summary
The current study aims to evaluate the accuracy of different techniques used to record the centric relation. The sample size was determined based on a previous study by Revilla-León et al. (2023), which indicated that 18 participants per group would provide sufficient power for statistical analysis. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Centric Relation Registration
- What is being tested?
- Intra Oral Scanner and Mod Jaw
- Type of treatment
- Pill or oral medicine, Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- No sites listed yet
- Study dates
- 30 Sep 2025to 1 Jun 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Adults above the age of eighteen years
- Presenting with good oral health
- Fully or partially dentate
Who cannot join
- Fully edentulous
- Partially dentate with lack of posterior stops
- Temporomandibular Joint Disorders (TMD)
- Limited mouth opening
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Comparison of Conventional, Digital, and Optical Jaw Tracking Techniques for Recording Centric Relation: An Evaluation of Accuracy
The current study aims to evaluate the accuracy of different techniques used to record the centric relation.
The sample size was determined based on a previous study by Revilla-León et al. (2023), which indicated that 18 participants per group would provide sufficient power for statistical analysis. Eligible participants will be adults above 18 years of age with good oral health who are fully or partially dentate. Exclusion criteria include complete edentulism, absence of posterior stops, temporomandibular joint disorders, and limited mouth opening.
Read more
Centric relation (CR) will be recorded for all participants using three methods. In Group 1 (Conventional), a 2 mm Lucia jig fabricated from pattern resin (Dura-lay) will be positioned intraorally with the participant reclined at 45°. Polyvinyl siloxane (PVS) bite registration material will be injected bilaterally from the canines to first molars and allowed to set. Alginate impressions, facebow records, and subsequent mounting on a semi-adjustable articulator will be performed, and the casts will be digitized with a laboratory scanner. In Group 2 (Intraoral Scanner), the iTero Element scanner (Align Technology, San Jose, CA) will be used to capture maxillary and mandibular arches. The same Lucia jig will be placed intraorally, and the bite will be digitally captured using the PVS record. In Group 3 (Optical Jaw Tracking), the Modjaw system will be used with previously acquired iTero scans. The Lucia jig will again standardize mandibular position during CR registration. All recordings will be performed by a single experienced prosthodontist to ensure consistency.
For accuracy assessment, STL files from all recordings will be imported into Geomagic Control X (3D Systems). Six digital markers will be placed on maxillary and mandibular reference scans at standardized anatomical landmarks (buccal surfaces of first molars, canines, and central incisors). Thirty-six baseline inter-landmark distances will be calculated. Each experimental scan will then be aligned to the reference scan using a best-fit alignment protocol, with marker coordinates transferred from the reference scan to maintain consistency and avoid manual errors. Inter-landmark distances will be recalculated for each experimental scan. Accuracy will be assessed in terms of trueness (mean absolute deviation between reference and experimental measurements) and precision (consistency of distances within each group).
Data will be statistically analyzed using analysis of variance (ANOVA), with significance set at p < 0.05.
- Conditions
- Centric Relation Registration
- Being tested
- Control, Intra Oral Scanner, Mod Jaw
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ControlOther
Control Group
Intra Oral ScannerDevice
Experimental group 1
Mod JawDevice
4 D Jaw Tracker
| Study group | Role | What they receive |
|---|---|---|
| Accuracy of Centric Relation Record (Control) | Experimental | Centric relation will be recorded using a conventional method with a 2 mm Kois deprogrammer and polyvinyl siloxane (PVS) bite registration. Alginate impressions and facebow records will be taken, mounted on a semi-adjustable articulator, and digitized with a laboratory scanner. Receives: Other: Control |
| Accuracy of Centric Relation record IOS | Experimental | Centric relation will be recorded using an intraoral scanner. Maxillary and mandibular arches will be scanned, and the Kois deprogrammer with PVS registration will be used to digitally capture mandibular position Receives: Device: Intra Oral Scanner |
| Accuracy of Centric Relation record ModJaw | Experimental | Centric relation will be recorded using the ModJaw optical jaw tracking system (4D jaw tracker). Previously acquired scans will be imported into ModJaw, and the kois deprogrammer will standardize mandibular position during registration Receives: Device: Mod Jaw |
What is being measured
The primary outcome is the main question the study is designed to answer.
Accuracy of Centric Relation Recording (Trueness and Precision in millimeters)
Accuracy will be assessed by evaluating trueness and precision of centric relation (CR) records obtained with three techniques: conventional, intraoral scanner, and ModJaw optical jaw tracker. Trueness will be calculated as the mean absolute deviation (mm) between inter-landmark distances on reference STL scans and experimental scans using Geomagic Control X software. Precision will be measured as the standard deviation of repeated inter-landmark distances within each group. Data will be reported as mean ± SD values
Measured: Baseline (Day 5, immediately after centric relation recording).
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Sep 2025
- Study start30 Sep 2025 (estimated)
- Primary completion1 Mar 2026 (estimated)
- Study completion1 Jun 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Centric Relation RegistrationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 20 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Mohammed Bin Rashid University of Medicine and Health Sciences
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Haitham Elbishari, Mohammed Bin Rashid University of Medicine and Health Sciences
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07184346
- Sponsor's protocol ID
- MBRU-HBMCDM-RG2024-05
- Status last verified
- Sep 2025
- First submitted
- 3 May 2025
- Last updated
- 19 Sep 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Ries JM, Grunler C, Wichmann M, Matta RE. Three-dimensional analysis of the accuracy of conventional and completely digital interocclusal registration methods. J Prosthet Dent. 2022 Nov;128(5):994-1000. doi: 10.1016/j.prosdent.2021.03.005. Epub 2021 Apr 19.
PubMed 33888327Revilla-Leon M, Subramanian SG, Ozcan M, Krishnamurthy VR. Clinical Study of the Influence of Ambient Light Scanning Conditions on the Accuracy (Trueness and Precision) of an Intraoral Scanner. J Prosthodont. 2020 Feb;29(2):107-113. doi: 10.1111/jopr.13135. Epub 2019 Dec 30.
PubMed 31860144Renne W, Ludlow M, Fryml J, Schurch Z, Mennito A, Kessler R, Lauer A. Evaluation of the accuracy of 7 digital scanners: An in vitro analysis based on 3-dimensional comparisons. J Prosthet Dent. 2017 Jul;118(1):36-42. doi: 10.1016/j.prosdent.2016.09.024. Epub 2016 Dec 23.
PubMed 28024822
Study at a glance
From the registry record, last updated by the sponsor on 19 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Conventional, Digital, and Optical Jaw Tracking Techniques for Recording Centric Relation: An Evaluation of Accuracy
- ClinicalTrials.gov ID
- NCT07184346
- Acronym / sponsor ID
- MBRU-HBMCDM-RG2024-05
- Conditions
- Centric Relation Registration
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 20 participants (estimated)
- Lead sponsor
- Mohammed Bin Rashid University of Medicine and Health SciencesUniversity, hospital or other
- Study start
- 30 Sep 2025 (estimated)
- Primary completion
- 1 Mar 2026 (estimated)
- Study completion
- 1 Jun 2026 (estimated)
- First posted
- 19 Sep 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The current study aims to evaluate the accuracy of different techniques used to record the centric relation.
The sample size was determined based on a previous study by Revilla-León et al. (2023), which indicated that 18 participants per group would provide sufficient power for statistical analysis. Eligible participants will be adults above 18 years of age with good oral health who are fully or partially dentate. Exclusion criteria include complete edentulism, absence of posterior stops, temporomandibular joint disorders, and limited mouth opening.
Centric relation (CR) will be recorded for all participants using three methods. In Group 1 (Conventional), a 2 mm Lucia jig fabricated from pattern resin (Dura-lay) will be positioned intraorally with the participant reclined at 45°. Polyvinyl siloxane (PVS) bite registration material will be injected bilaterally from the canines to first molars and allowed to set. Alginate impressions, facebow records, and subsequent mounting on a semi-adjustable articulator will be performed, and the casts will be digitized with a laboratory scanner. In Group 2 (Intraoral Scanner), the iTero Element scanner (Align Technology, San Jose, CA) will be used to capture maxillary and mandibular arches. The same Lucia jig will be placed intraorally, and the bite will be digitally captured using the PVS record. In Group 3 (Optical Jaw Tracking), the Modjaw system will be used with previously acquired iTero scans. The Lucia jig will again standardize mandibular position during CR registration. All recordings will be performed by a single experienced prosthodontist to ensure consistency.
For accuracy assessment, STL files from all recordings will be imported into Geomagic Control X (3D Systems). Six digital markers will be placed on maxillary and mandibular reference scans at standardized anatomical landmarks (buccal surfaces of first molars, canines, and central incisors). Thirty-six baseline inter-landmark distances will be calculated. Each experimental scan will then be aligned to the reference scan using a best-fit alignment protocol, with marker coordinates transferred from the reference scan to maintain consistency and avoid manual errors. Inter-landmark distances will be recalculated for each experimental scan. Accuracy will be assessed in terms of trueness (mean absolute deviation between reference and experimental measurements) and precision (consistency of distances within each group).
Data will be statistically analyzed using analysis of variance (ANOVA), with significance set at p < 0.05.
Study design
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Accuracy of Centric Relation Record (Control) | Experimental | Other: ControlCentric relation will be recorded using a conventional method with a 2 mm Kois deprogrammer and polyvinyl siloxane (PVS) bite registration. Alginate impressions and facebow records will be taken, mounted on a semi-adjustable articulator, and digitized with a laboratory scanner. |
| Accuracy of Centric Relation record IOS | Experimental | Device: Intra Oral ScannerCentric relation will be recorded using an intraoral scanner. Maxillary and mandibular arches will be scanned, and the Kois deprogrammer with PVS registration will be used to digitally capture mandibular position |
| Accuracy of Centric Relation record ModJaw | Experimental | Device: Mod JawCentric relation will be recorded using the ModJaw optical jaw tracking system (4D jaw tracker). Previously acquired scans will be imported into ModJaw, and the kois deprogrammer will standardize mandibular position during registration |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Adults above the age of eighteen years
- Presenting with good oral health
- Fully or partially dentate
Key exclusion criteria (4 listed)
- Fully edentulous
- Partially dentate with lack of posterior stops
- Temporomandibular Joint Disorders (TMD)
- Limited mouth opening
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| ControlControl Group | Other | Accuracy of Centric Relation Record (Control) |
| Intra Oral ScannerExperimental group 1 | Device | Accuracy of Centric Relation record IOS |
| Mod Jaw4 D Jaw Tracker | Device | Accuracy of Centric Relation record ModJaw |
Primary outcome
Accuracy of Centric Relation Recording (Trueness and Precision in millimeters)
Time frame: Baseline (Day 5, immediately after centric relation recording).
Accuracy will be assessed by evaluating trueness and precision of centric relation (CR) records obtained with three techniques: conventional, intraoral scanner, and ModJaw optical jaw tracker. Trueness will be calculated as the mean absolute deviation (mm) between inter-landmark distances on reference STL scans and experimental scans using Geomagic Control X software. Precision will be measured as the standard deviation of repeated inter-landmark distances within each group. Data will be reported as mean ± SD values
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Sep 2025.
- Results publication: PubMed 33888327Ries JM, Grunler C, Wichmann M, Matta RE. Three-dimensional analysis of the accuracy of conventional and completely digital interocclusal registration methods. J Prosthet Dent. 2022 Nov;128(5):994-1000. doi: 10.1016/j.prosdent.2021.03.005. Epub 2021 Apr 19.
- Results publication: PubMed 31860144Revilla-Leon M, Subramanian SG, Ozcan M, Krishnamurthy VR. Clinical Study of the Influence of Ambient Light Scanning Conditions on the Accuracy (Trueness and Precision) of an Intraoral Scanner. J Prosthodont. 2020 Feb;29(2):107-113. doi: 10.1111/jopr.13135. Epub 2019 Dec 30.
- Results publication: PubMed 28024822Renne W, Ludlow M, Fryml J, Schurch Z, Mennito A, Kessler R, Lauer A. Evaluation of the accuracy of 7 digital scanners: An in vitro analysis based on 3-dimensional comparisons. J Prosthet Dent. 2017 Jul;118(1):36-42. doi: 10.1016/j.prosdent.2016.09.024. Epub 2016 Dec 23.
- Related InfoLink provided by the sponsor.
- Individual participant dataSharing planned: No
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing Intra Oral Scanner and Mod Jaw in people with Centric Relation Registration, run by Mohammed Bin Rashid University of Medicine and Health Sciences.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 19 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Haitham Elbishari, BDS PhD (+971529131315, haitham.elbishari@dubaihealth.ae), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Accuracy of Centric Relation Recording (Trueness and Precision in millimeters) (time frame: Baseline (Day 5, immediately after centric relation recording).). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07184346, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Sep 2025.