Hip Pain ChronicMRI USGNCT07198646
Correlation of Ultrasound and MRI Measurements of Quadratus Femoris Thickness and Ischiofemoral Distance in Clinically and Radiologically Diagnosed Ischiofemoral Impingement
An observational study of Hip Pain Chronic and Impingement Syndrome, run by Kutay Can ÇAMLICA at 1 site in Turkey (Türkiye).
Trial summary
The goal of this observational study is to evaluate the correlation between ultrasound measurements of quadratus femoris muscle thickness and ischiofemoral distance, as well as clinical parameters, with MRI measurements in patients diagnosed with ischiofemoral impingement (IFI) through MRI imaging and clinical… Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Hip Pain Chronic, Impingement Syndrome
- How many people
- 30 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 10 Oct 2024to 10 Apr 2025
- How long will I take part?
- 8 Months
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: 1. Patients older than 18 years and younger than 65 years. 2. Patients diagnosed by MRI 3. Those with a body mass index below 25 kg/m2 4. those with hip pain or positive physical examination tests
Who may be able to join
- Patients older than 18 years and younger than 65 years.
- Patients diagnosed by MRI
- Those with a body mass index below 25 kg/m2
- those with hip pain or positive physical examination tests
Who cannot join
- Sciatic nerve damage detected on EMG
- Patients with operative ischiofemoral decompression
- Corticosteroid or any injection to the hip in the last 3 months
- History of peripheral nerve damage
- Femoroacetabular impingement
- Pregnancy
Show all 12Show fewer
- Malignancy
- Inflammatory pathologies: rheumatic, septic
- Coxarthrosis-Kelgren-Lawrence grade 3-4
- Those who have undergone hip arthroplasty/surgery
- Causes of lumbar radiculopathy, spondylolisthesis
- Patients with increased femoral anteversion - patients with increased hip internal rotation (Toe-in)
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Seyrantepe Hamidiye Etfal Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
Istanbul, sarıyer
About this study
Official title: Evaluation of the Correlation of Ultrasound Measurements of Quadratus Femoris Muscle Thickness and Ischiofemoral Distance With MR Measurements in Patients Diagnosed With Ischiofemoral Impingement by MR Imaging and Clinical Examination.
The goal of this observational study is to evaluate the correlation between ultrasound measurements of quadratus femoris muscle thickness and ischiofemoral distance, as well as clinical parameters, with MRI measurements in patients diagnosed with ischiofemoral impingement (IFI) through MRI imaging and clinical examination. The main questions it aims to answer are: Is there a correlation between ultrasound and MRI measurements of quadratus femoris muscle thickness and ischiofemoral distance in patients with clinically and radiologically confirmed IFI? How do clinical parameters relate to ultrasound and MRI findings in these patients? What is the intra- and inter-rater reliability of ultrasound measurements for these parameters? Participants will undergo ultrasound measurement of quadratus femoris muscle thickness and ischiofemoral distance, assessment of clinical parameters related to ischiofemoral impingement, and measurements performed twice by two independent raters to assess intra- and inter-rater reliability. Researchers will compare ultrasound and MRI measurements as well as clinical parameters to determine if ultrasound can serve as a reliable and cost-effective alternative for diagnosing ischiofemoral impingement.
Read the detailed description
Ischiofemoral impingement (IFI) was first described in 1977 by Karl A. Johnson, and his study is widely regarded as the first clinical definition of the syndrome. IFI is defined as an extra-articular hip impingement syndrome resulting from the narrowing of the space between the ischium and the lesser trochanter, leading to compression of the quadratus femoris muscle and surrounding soft tissues, thereby causing clinical symptoms.
IFI findings are associated with edema and irritation of the quadratus femoris muscle, as well as secondary atrophic fatty degeneration in chronic cases. The primary symptom is posterior and lateral hip pain, often exacerbated by physical activity. Due to the close anatomical relationship between the quadratus femoris muscle and the sciatic nerve, irritation of the nerve may lead to pain radiating anteriorly, to the posterior thigh, and distally to the knee.
The etiology of IFI is multifactorial, involving congenital anatomical variations, post-traumatic sequelae, postoperative changes following hip surgery, and primary hip joint pathologies. Additional factors, such as femoral anteversion, acetabular retroversion, and abductor or adductor insufficiencies, may also contribute to its pathogenesis. The exact prevalence of IFI remains unknown, but it has been reported to be more common in females than in males, with a female-to-male ratio of approximately 3:1. This higher incidence in females is attributed to gender differences in pelvic morphology and a narrower ischiofemoral space. While IFI typically affects middle-aged and older adults, it has been observed across a wide age range (30-70 years). Although IFI generally presents unilaterally, bilateral involvement has been reported in 25-40% of cases, with no consensus in the literature regarding side predominance. The diagnosis of IFI requires a combination of detailed patient history, physical examination, and imaging techniques. Clinical tests such as the long-stride walking test and the ischiofemoral impingement test play a significant role in diagnosis, while MRI is considered the gold-standard imaging modality for confirmation.
The present study aims to investigate the correlation between ultrasound measurements and MRI findings in patients diagnosed with IFI through MRI and clinical examination. Specifically, ultrasound measurements of quadratus femoris muscle thickness and ischiofemoral distance will be evaluated for their consistency with MRI findings. Additionally, clinical parameters related to IFI will be assessed to explore their association with imaging results. The primary objective of this study is to determine the feasibility of using ultrasound, a more cost-effective imaging method, as an alternative diagnostic tool for IFI. The hypothesis is that by establishing a reliable correlation between ultrasound and MRI findings, it may be possible to implement a lower-cost and more accessible diagnostic approach for this condition.
- Conditions
- Hip Pain Chronic, Impingement Syndrome
- Keywords
- Ischiofemoral impingement, quadratus femoris compression, hip pain diagnosis, ultrasound-MRI correlation, cost-effective imaging in hip pathology.
What is being measured
The primary outcome is the main question the study is designed to answer.
Correlation of ultrasonographic ischiofemoral space (IFS) and quadratus femoris muscle thickness with clinical and MRI parameters
The primary outcome is to determine the relationship between ultrasonographically measured ischiofemoral space (IFS) and quadratus femoris muscle thickness with magnetic resonance imaging (MRI) findings (IFS and quadratus femoris space) and clinical parameters including pain intensity (Visual Analog Scale, VAS) and hip function (Harris Hip Score).
Measured: Baseline (at enrollment)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Sep 2025
- Study start10 Oct 2024
- Primary completion10 Mar 2025
- Study completion10 Apr 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Hip Pain ChronicStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Enrolment
- 30 participants (actual)
- Target duration
- 8 Months
Sponsor and investigators
- Lead sponsor
- Kutay Can ÇAMLICA
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Kutay Can ÇAMLICA, Sisli Hamidiye Etfal Training and Research Hospital
- Investigators
- Jülide Öncü Alptekin, Professor, Study director, Sisli Hamidiye Etfal Training and Research Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07198646
- Sponsor's protocol ID
- 4500
- Acronym
- MRI USG
- Status last verified
- Aug 2024
- First submitted
- 21 Sep 2025
- Last updated
- 30 Sep 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 30 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of the Correlation of Ultrasound Measurements of Quadratus Femoris Muscle Thickness and Ischiofemoral Distance With MR Measurements in Patients Diagnosed With Ischiofemoral Impingement by MR Imaging and Clinical Examination.
- ClinicalTrials.gov ID
- NCT07198646
- Acronym / sponsor ID
- MRI USG / 4500
- Conditions
- Hip Pain Chronic, Impingement Syndrome
- Keywords
- Ischiofemoral impingement, quadratus femoris compression, hip pain diagnosis, ultrasound-MRI correlation, cost-effective imaging in hip pathology.
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- Kutay Can ÇAMLICAUniversity, hospital or other
- Study start
- 10 Oct 2024 (actual)
- Primary completion
- 10 Mar 2025 (actual)
- Study completion
- 10 Apr 2025 (actual)
- First posted
- 30 Sep 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this observational study is to evaluate the correlation between ultrasound measurements of quadratus femoris muscle thickness and ischiofemoral distance, as well as clinical parameters, with MRI measurements in patients diagnosed with ischiofemoral impingement (IFI) through MRI imaging and clinical examination. The main questions it aims to answer are: Is there a correlation between ultrasound and MRI measurements of quadratus femoris muscle thickness and ischiofemoral distance in patients with clinically and radiologically confirmed IFI? How do clinical parameters relate to ultrasound and MRI findings in these patients? What is the intra- and inter-rater reliability of ultrasound measurements for these parameters? Participants will undergo ultrasound measurement of quadratus femoris muscle thickness and ischiofemoral distance, assessment of clinical parameters related to ischiofemoral impingement, and measurements performed twice by two independent raters to assess intra- and inter-rater reliability. Researchers will compare ultrasound and MRI measurements as well as clinical parameters to determine if ultrasound can serve as a reliable and cost-effective alternative for diagnosing ischiofemoral impingement.
Detailed description
Ischiofemoral impingement (IFI) was first described in 1977 by Karl A. Johnson, and his study is widely regarded as the first clinical definition of the syndrome. IFI is defined as an extra-articular hip impingement syndrome resulting from the narrowing of the space between the ischium and the lesser trochanter, leading to compression of the quadratus femoris muscle and surrounding soft tissues, thereby causing clinical symptoms.
IFI findings are associated with edema and irritation of the quadratus femoris muscle, as well as secondary atrophic fatty degeneration in chronic cases. The primary symptom is posterior and lateral hip pain, often exacerbated by physical activity. Due to the close anatomical relationship between the quadratus femoris muscle and the sciatic nerve, irritation of the nerve may lead to pain radiating anteriorly, to the posterior thigh, and distally to the knee.
The etiology of IFI is multifactorial, involving congenital anatomical variations, post-traumatic sequelae, postoperative changes following hip surgery, and primary hip joint pathologies. Additional factors, such as femoral anteversion, acetabular retroversion, and abductor or adductor insufficiencies, may also contribute to its pathogenesis. The exact prevalence of IFI remains unknown, but it has been reported to be more common in females than in males, with a female-to-male ratio of approximately 3:1. This higher incidence in females is attributed to gender differences in pelvic morphology and a narrower ischiofemoral space. While IFI typically affects middle-aged and older adults, it has been observed across a wide age range (30-70 years). Although IFI generally presents unilaterally, bilateral involvement has been reported in 25-40% of cases, with no consensus in the literature regarding side predominance. The diagnosis of IFI requires a combination of detailed patient history, physical examination, and imaging techniques. Clinical tests such as the long-stride walking test and the ischiofemoral impingement test play a significant role in diagnosis, while MRI is considered the gold-standard imaging modality for confirmation.
The present study aims to investigate the correlation between ultrasound measurements and MRI findings in patients diagnosed with IFI through MRI and clinical examination. Specifically, ultrasound measurements of quadratus femoris muscle thickness and ischiofemoral distance will be evaluated for their consistency with MRI findings. Additionally, clinical parameters related to IFI will be assessed to explore their association with imaging results. The primary objective of this study is to determine the feasibility of using ultrasound, a more cost-effective imaging method, as an alternative diagnostic tool for IFI. The hypothesis is that by establishing a reliable correlation between ultrasound and MRI findings, it may be possible to implement a lower-cost and more accessible diagnostic approach for this condition.
Study design
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Target follow-up
- 8 Months
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- 1. Patients older than 18 years and younger than 65 years. 2. Patients diagnosed by MRI 3. Those with a body mass index below 25 kg/m2 4. those with hip pain or positive physical examination tests
Key inclusion criteria (4 listed)
- Patients older than 18 years and younger than 65 years.
- Patients diagnosed by MRI
- Those with a body mass index below 25 kg/m2
- those with hip pain or positive physical examination tests
Key exclusion criteria (12 listed)
- Sciatic nerve damage detected on EMG
- Patients with operative ischiofemoral decompression
- Corticosteroid or any injection to the hip in the last 3 months
- History of peripheral nerve damage
- Femoroacetabular impingement
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Correlation of ultrasonographic ischiofemoral space (IFS) and quadratus femoris muscle thickness with clinical and MRI parameters
Time frame: Baseline (at enrollment)
The primary outcome is to determine the relationship between ultrasonographically measured ischiofemoral space (IFS) and quadratus femoris muscle thickness with magnetic resonance imaging (MRI) findings (IFS and quadratus femoris space) and clinical parameters including pain intensity (Visual Analog Scale, VAS) and hip function (Harris Hip Score).
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Sep 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Jülide Öncü Alptekin, Professor study director
Sisli Hamidiye Etfal Training and Research Hospital
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Hip Pain Chronic and Impingement Syndrome, run by Kutay Can ÇAMLICA at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 12 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 30 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Correlation of ultrasonographic ischiofemoral space (IFS) and quadratus femoris muscle thickness with clinical and MRI parameters (time frame: Baseline (at enrollment)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Sep 2025.