Hemophilia A Without InhibitorNCT07200609
The Effects of Virtual Reality-Based Gamified Rehabilitation in Children With Hemophilia
A study testing Virtual Reality Intervention and Home-Based Exercise Intervention in people with Hemophilia A Without Inhibitor, run by Hacettepe University.
Trial summary
Hemophilia is an inherited bleeding disorder caused by deficiencies or low levels of clotting factors VIII (hemophilia A) and IX (hemophilia B). It is a chronic disease that negatively affects physical function, mobility, and quality of life by causing damage to joint and muscle structures due to bleeding disorders. Read more about this study
- Who is it for?
- Ages 6 to 18 years, men only
- Conditions the study is for
- Hemophilia A Without Inhibitor
- What is being tested?
- Virtual Reality Intervention and Home-Based Exercise Intervention
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- No sites listed yet
- Study dates
- Nov 2025to Sep 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 6 to 18 years
- Men only
- No healthy volunteers
- Child, Adult
Who may be able to join
- Hemophilia A diagnosed by a pediatric hematologist
- Boys aged 6-18
- Have moderate to severe hemophilia
- Do not exercise regularly
- Be able to move independently or with minimal support (ambulatory)
- Have the capacity to understand research instructions
Show all 9Show fewer
- Prevent active bleeding
- Voluntary participation in expenses and parental record keeping
- Continued prophylactic treatment
Who cannot join
- Children with active bleeding
- Those who have had lower extremity surgery
- Those with mental retardation
- Children with neurological, orthopedic, or psychological illnesses that may affect functional performance
About this study
Official title: The Effects of a Virtual Reality-Based Gamified Rehabilitation Program on Body Structure and Function, Activity, and Participation in Children With Hemophilia: A Randomized Controlled Trial
Hemophilia is an inherited bleeding disorder caused by deficiencies or low levels of clotting factors VIII (hemophilia A) and IX (hemophilia B). It is a chronic disease that negatively affects physical function, mobility, and quality of life by causing damage to joint and muscle structures due to bleeding disorders. Traditional rehabilitation methods can sometimes be boring for children and lead to a loss of motivation. Therefore, there is a need for innovative methods that will increase treatment compliance and improve children's physical activity levels.
Virtual reality (VR) technology provides a realistic and interactive environment that enables children to actively participate in the rehabilitation process. Combined with gamification elements, VR offers a fun learning and practice environment that supports the development of motor skills, reduces fear of movement, and can increase motivation for repetitive exercises.
Read more
This randomized controlled trial will evaluate the effects of virtual reality-based gamified rehabilitation on joint health, pain, posture, gait function, proprioception, and quality of life. Additionally, the contribution of this intervention to changes in activity and participation levels will be demonstrated using the International Classification of Functioning, Disability, and Health (ICF) model.
This study has the potential to guide future clinical practice by offering a more enjoyable and effective rehabilitation alternative for children with hemophilia. The widespread adoption of virtual reality-supported programs will be an important step in reducing physical disabilities associated with hemophilia.
- Conditions
- Hemophilia A Without Inhibitor
- Being tested
- Virtual Reality Intervention, Home-Based Exercise Intervention
- Keywords
- virtual reality, home-based exercise, joint health, body structure and function, activity, participation
- Medical subject headings
- Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Virtual Reality InterventionOther
The virtual reality training group will have sessions lasting 40 minutes, 3 days a week for 8 weeks.
- A 30-minute VR-based training session using Kinect Xbox (5 min warm-up, 30 min VR, 5 min cool-down)
- The device has an infrared camera sensor (Kinect sensor) that detects the participant's movement in real time
- Even if the user's movement is not performed correctly in the game settings, the user receives visual and auditory sensory feedback about movement errors.
- All games are provided to engage participants' interest in the topics and require the use of the person's lower extremities.
- Each game will be played for 10 minutes during the 30-minute training session. (A total of 3 games will be played)
- Participants in VR programs typically perform active hip flexion, hip abduction, hip external and internal rotation, knee flexion and extension, ankle dorsiflexion, and plantar flexion while standing.
- Game content: Kinect Sports, Kinect Adventures and Kinect Sports Rivals.
Home-Based Exercise InterventionOther
- Home-based exercise training group will also be given online exercises 3 days a week for 8 weeks.
- Active/passive stretching exercises within pain limits
- Patients will perform exercises at home under a supervised exercise program
- They will perform exercises matching the virtual reality group in terms of exercise sequence, intensity, duration, and mode, incorporating open and closed kinetic chain movements
- A 20-second stretch followed by a 20-second relaxation performed five times per session for each muscle
- Light resistance exercises targeting muscle groups in the lower extremities, with a 5-second contraction followed by a 5-second relaxation, performed five times per session
- Bodyweight exercises
- Balance exercises
- Posture exercises
| Study group | Role | What they receive |
|---|---|---|
| Virtual reality group | Experimental | Inclusion criteria:
Diagnosed with Hemophilia A by a pediatric hematologist Aged 6-18 years With moderate to severe hemophilia Not regularly exercising No active bleeding complaints Children who are willing to participate in the study and continue prophylactic treatment
Exclusion criteria:
Children with active bleeding complaints Children who have undergone lower extremity surgery Children with neurological, orthopedic, or psychological conditions that affect functional performance Receives: Other: Virtual Reality Intervention |
| Home-Based Exercise Group | Active comparator | Inclusion criteria:
Diagnosed with Hemophilia A by a pediatric hematologist Aged 6-18 years With moderate to severe hemophilia Not regularly exercising No active bleeding complaints Children who are willing to participate in the study and continue prophylactic treatment
Exclusion criteria:
Children with active bleeding complaints Children who have undergone lower extremity surgery Children with neurological, orthopedic, or psychological conditions that affect functional performance Receives: Other: Home-Based Exercise Intervention |
What is being measured
The primary outcome is the main question the study is designed to answer.
Hemophilia Joint Health Score (HJHS)
HJHS is a commonly used clinical assessment scale developed to evaluate joint health in patients with hemophilia. It aims to detect hemophilia-related joint damage early, particularly in children and adolescents. Purpose of development: To detect hemophilic arthropathy (joint damage) through physical examination without the need for radiological methods. Scope: The elbow, knee, and ankle joints, which are the most commonly affected joints in hemophilia patients, are evaluated.
Target group: Although initially developed for children aged 4-18, it is now also used in adults. The following joint characteristics are scored in the HJHS:
Joint swelling (acute/chronic) Muscle atrophy Joint pain Loss of joint range of motion (ROM) Crepitus (sound or friction sensation during joint movement) Gait (walking) assessment Scoring: These parameters are evaluated for each joint using a specific scoring system.
A total score of 0 = normal joint health, a higher score = more joint damage.
Measured: From enrollment to the end of treatment at 8 weeks
Physical Activity Questionnaire for Children (PAQ-C)
Target group: Children and adolescents. Objective: To determine the level of physical activity performed through play, sports, and exercise in daily life.
Method: The child is asked to indicate how many times they performed the activities on the list (e.g., jumping rope, running, cycling, walking, skating, games) in the last 7 days.
Answer options:
Never done it = 0 points 1-2 times = 1 point 3-4 times = 2 points 5-6 times = 3 points 7 times and above = 4 points Points awarded for all activities (e.g., jumping rope, running, cycling, walking, skating, tag, etc.) are added together. This total gives the child's total physical activity score for the last 7 days.
Measured: From enrollment to the end of treatment at 8 weeks
CHO-KLAT (Canadian Hemophilia Outcomes-Kids' Life Assessment Tool)
Purpose of development: To measure the daily life experiences, social participation, and quality of life of children with hemophilia.
Age group:
Child version (8-18 years) → Completed by the child. Parent version (for ages 0-7 and 8-18) → Based on parental observation. Includes questions that relate conditions specific to hemophilia (e.g., bleeding, treatment burden, physical limitations) to quality of life.
CHO-KLAT assesses the child's life from a physical, social, and emotional perspective.
The question topics are generally:
School and social activities (participation, friendships, involvement in games) Physical activities (sports, games, ability to exercise) Daily living activities (mobility, care, freedom of movement) Emotional state (anxiety, feelings about illness) Experiences related to treatment (injections, access to healthcare) Each item is scored between 0 and 4 (0 = strongly disagree, 4 = strongly agree).
All scores are then added up and converted to a 0-100 range.
Measured: From enrollment to the end of treatment at 8 weeks
Secondary outcomes (12)
Stability Index
The Hur SmartBalance device is a digital system used primarily in clinical settings to assess balance, postural control, and weight transfer.
Purpose: To objectively measure balance, detect balance disorders, and monitor the rehabilitation process.
It includes a pressure-sensitive platform/force plate. The patient's weight distribution, sway, and stability level are recorded as numerical values.
Both assessment and exercise can be performed thanks to the visual feedback screen.
Parameters to be Evaluated:
Stability Index Indicates how stable the person is in static/dynamic balance.
Measured: From enrollment to the end of treatment at 8 weeks
Posture
The DIERS device is an advanced technology system used in clinics and research for gait analysis, posture assessment, and spinal measurements. General Features of the DIERS System Uses an optical 3D/4D scanning method → does not expose the body to radiation. It is non-invasive; there is no need to attach sensors to the child or adult. Provides detailed data on posture, spinal alignment, pressure distribution, and gait in a short time (within seconds).
Posture and Spinal Analysis
With the DIERS formetric (4D spine \& posture) system:
Spinal alignment (curvatures in the sagittal and frontal planes: scoliosis, kyphosis, lordosis) Shoulder and pelvic asymmetries Head and torso position Body imbalance (lateral shift, rotations) Postural balance Postural changes over time are monitored and evaluated.
Measured: From enrollment to the end of treatment at 8 weeks
Multidimensional Hemophilia Pain
The Multidimensional Hemophilia Pain Scale (MHPQ / MHPS) is a measurement tool developed to assess the characteristics of pain in hemophilia patients in a multidimensional manner and is used in clinical practice and research. Although the MHPQ/MHPS shows minor variations across different studies, it generally covers the following areas:
Pain intensity (severity) - typically assessed using a visual analog scale (VAS) or a 0-10 rating scale.
Pain frequency - assessment of daily, weekly, or monthly bleeding/pain episodes.
Pain duration - acute (minutes-hours) or chronic (weeks-months). Pain location - which joints or muscle groups are affected. Pain type - sharp, aching, throbbing, burning, etc. Functional effects of pain - impact on daily activities, sleep, school/work attendance, mobility.
Emotional/psychosocial dimension - anxiety, depression, limited social participation.
Measured: From enrollment to the end of treatment at 8 weeks
Proprioception
The JTECH Digital Inclinometer: This is a highly accurate digital goniometer/inclinometer that measures the angular movement of joints.
It provides more reliable and repeatable measurements than traditional goniometers.
The following method is used to assess proprioception (the ability to sense the position of a joint in space) in the hio and knee joints:
Target Position Sense (JPS):
The device is placed on the joint. The participant's joint is passively or actively moved to a specific angle (e.g., 30° of flexion for the knee).
This angle is recorded as the reference angle.
Target Repetition:
The participant attempts to move the joint to the same position with their eyes closed.
The JTECH device measures the difference between the actual angle and the target angle in degrees.
Results:
The smaller the margin of error, the better the proprioception. Measurements can be made separately for the hip and knee.
Measured: From enrollment to the end of treatment at 8 weeks
Functional Independence Score in Hemophilia (FISH)
FISH is a specialized scale developed to assess functional independence in activities of daily living in patients with hemophilia. It measures the functional reflection of joint health and movement capacity in children and adults with hemophilia.
FISH examines a total of 8 activities under 4 main categories:
- Lower extremity movements (Leg function) Sitting down and standing up Climbing stairs Walking (on level ground)
- Upper extremity movements (Arm function) Eating food (table setting) Wearing clothes
- Balance/postural function Standing Bending or reaching forward
- Fine motor skills (Fine motor function) Grasping and carrying objects Scoring
Each activity is scored from 1 to 4:
- = Completely dependent
- = Partially dependent
- = Slightly dependent
- = Completely independent The total score is obtained by summing the activity-based scores. Higher score: Better functional independence. Lower score: More joint damage or loss of function.
Measured: From enrollment to the end of treatment at 8 weeks
Postural Sway
The Hur SmartBalance device is a digital system used primarily in clinical settings to assess balance, postural control, and weight transfer.
Purpose: To objectively measure balance, detect balance disorders, and monitor the rehabilitation process.
It includes a pressure-sensitive platform/force plate. The patient's weight distribution, sway, and stability level are recorded as numerical values.
Both assessment and exercise can be performed thanks to the visual feedback screen.
Parameters to be Evaluated:
Postural Sway Staying centered while standing, sway distance and speeds.
Measured: From enrollment to the end of treatment at 8 weeks
Weight Distribution
The Hur SmartBalance device is a digital system used primarily in clinical settings to assess balance, postural control, and weight transfer.
Purpose: To objectively measure balance, detect balance disorders, and monitor the rehabilitation process.
It includes a pressure-sensitive platform/force plate. The patient's weight distribution, sway, and stability level are recorded as numerical values.
Both assessment and exercise can be performed thanks to the visual feedback screen.
Parameters to be Evaluated:
Weight Distribution Percentage of weight transfer to the right/left, front/back.
Measured: From enrollment to the end of treatment at 8 weeks
Dynamic Balance Test
The Hur SmartBalance device is a digital system used primarily in clinical settings to assess balance, postural control, and weight transfer.
Purpose: To objectively measure balance, detect balance disorders, and monitor the rehabilitation process.
It includes a pressure-sensitive platform/force plate. The patient's weight distribution, sway, and stability level are recorded as numerical values.
Both assessment and exercise can be performed thanks to the visual feedback screen.
Parameters to be Evaluated:
Dynamic Balance Tests Measured by tasks such as shifting weight in specific directions and following virtual targets.
Measured: From enrollment to the end of treatment at 8 weeks
Step Length and Step Width
The DIERS device is an advanced technology system used in clinics and research for gait analysis, posture assessment, and spinal measurements. General Features of the DIERS System Uses an optical 3D/4D scanning method → does not expose the body to radiation. It is non-invasive; there is no need to attach sensors to the child or adult. It provides detailed data on posture, spinal alignment, pressure, and gait in a short time (within seconds).
Gait Analysis
With DIERS' pedogait or gaitlab systems:
Step length, step width
Measured: From enrollment to the end of treatment at 8 weeks
Cadence (Steps per Minute)
The DIERS device is an advanced technology system used in clinics and research for gait analysis, posture assessment, and spinal measurements. General Features of the DIERS System Uses an optical 3D/4D scanning method → does not expose the body to radiation. It is non-invasive; there is no need to attach sensors to the child or adult. It provides detailed data on posture, spinal alignment, pressure, and gait in a short time (within seconds).
Gait Analysis
With DIERS' pedogait or gaitlab systems:
Cadence (number of steps/min) Number of steps per minute measured with the DIERS gait analysis system. Measurement Unit: steps/minute
Measured: From enrollment to the end of treatment at 8 weeks
Right/left load distribution
The DIERS device is an advanced technology system used in clinics and research for gait analysis, posture assessment, and spinal measurements. General Features of the DIERS System Uses an optical 3D/4D scanning method → does not expose the body to radiation. It is non-invasive; there is no need to attach sensors to the child or adult. It provides detailed data on posture, spinal alignment, pressure, and gait in a short time (within seconds).
Gait Analysis
With DIERS' pedogait or gaitlab systems:
Right/left load distribution The load ratio transferred to the right and left lower extremities during walking.
Measurement Unit: %
Measured: From enrollment to the end of treatment at 8 weeks
Pressure distribution (foot pressure patterns)
The DIERS device is an advanced technology system used in clinics and research for gait analysis, posture assessment, and spinal measurements. General Features of the DIERS System Uses an optical 3D/4D scanning method → does not expose the body to radiation. It is non-invasive; there is no need to attach sensors to the child or adult. It provides detailed data on posture, spinal alignment, pressure, and gait in a short time (within seconds).
Gait Analysis
With DIERS' pedogait or gaitlab systems:
Pressure distribution (foot pressure patterns) Pressure distribution on the sole of the foot using the DIERS pedogait system. Unit of Measurement: kPa
Measured: From enrollment to the end of treatment at 8 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Oct 2025
- Study startNov 2025 (estimated)
- Primary completionApr 2026 (estimated)
- Study completionSep 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Hemophilia A Without InhibitorStudies of the same condition, open and under way.
- More trials run by Hacettepe UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- The cases included in the study will be randomly divided into two groups using the web-based www.randomizer.org application. Group 1 is the virtual reality group, and Group 2 is the home-based exercise group.
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 20 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Hacettepe University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Duygu Turker, Hacettepe University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07200609
- Sponsor's protocol ID
- E2-25-10575
- Status last verified
- Sep 2025
- First submitted
- 11 Sep 2025
- Last updated
- 1 Oct 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 1 Oct 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effects of a Virtual Reality-Based Gamified Rehabilitation Program on Body Structure and Function, Activity, and Participation in Children With Hemophilia: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07200609
- Acronym / sponsor ID
- E2-25-10575
- Conditions
- Hemophilia A Without Inhibitor
- Keywords
- virtual reality, home-based exercise, joint health, body structure and function, activity, participation
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 20 participants (estimated)
- Lead sponsor
- Hacettepe UniversityUniversity, hospital or other
- Study start
- Nov 2025 (estimated)
- Primary completion
- Apr 2026 (estimated)
- Study completion
- Sep 2026 (estimated)
- First posted
- 1 Oct 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Hemophilia is an inherited bleeding disorder caused by deficiencies or low levels of clotting factors VIII (hemophilia A) and IX (hemophilia B). It is a chronic disease that negatively affects physical function, mobility, and quality of life by causing damage to joint and muscle structures due to bleeding disorders. Traditional rehabilitation methods can sometimes be boring for children and lead to a loss of motivation. Therefore, there is a need for innovative methods that will increase treatment compliance and improve children's physical activity levels.
Virtual reality (VR) technology provides a realistic and interactive environment that enables children to actively participate in the rehabilitation process. Combined with gamification elements, VR offers a fun learning and practice environment that supports the development of motor skills, reduces fear of movement, and can increase motivation for repetitive exercises.
This randomized controlled trial will evaluate the effects of virtual reality-based gamified rehabilitation on joint health, pain, posture, gait function, proprioception, and quality of life. Additionally, the contribution of this intervention to changes in activity and participation levels will be demonstrated using the International Classification of Functioning, Disability, and Health (ICF) model.
This study has the potential to guide future clinical practice by offering a more enjoyable and effective rehabilitation alternative for children with hemophilia. The widespread adoption of virtual reality-supported programs will be an important step in reducing physical disabilities associated with hemophilia.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- The cases included in the study will be randomly divided into two groups using the web-based www.randomizer.org application. Group 1 is the virtual reality group, and Group 2 is the home-based exercise group.
| Arm | Type | Receives |
|---|---|---|
| Virtual reality group | Experimental | Other: Virtual Reality InterventionInclusion criteria: Diagnosed with Hemophilia A by a pediatric hematologist Aged 6-18 years With moderate to severe hemophilia Not regularly exercising No active bleeding complaints Children who are willing to participate in the study and continue prophylactic treatment Exclusion criteria: Children with active bleeding complaints Children who have undergone lower extremity surgery Children with neurological, orthopedic, or psychological conditions that affect functional performance |
| Home-Based Exercise Group | Active comparator | Other: Home-Based Exercise InterventionInclusion criteria: Diagnosed with Hemophilia A by a pediatric hematologist Aged 6-18 years With moderate to severe hemophilia Not regularly exercising No active bleeding complaints Children who are willing to participate in the study and continue prophylactic treatment Exclusion criteria: Children with active bleeding complaints Children who have undergone lower extremity surgery Children with neurological, orthopedic, or psychological conditions that affect functional performance |
Who may qualify
- Ages
- 6 to 18 years
- Sex
- Male only
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult
Key inclusion criteria (9 listed)
- Hemophilia A diagnosed by a pediatric hematologist
- Boys aged 6-18
- Have moderate to severe hemophilia
- Do not exercise regularly
- Be able to move independently or with minimal support (ambulatory)
Key exclusion criteria (4 listed)
- Children with active bleeding
- Those who have had lower extremity surgery
- Those with mental retardation
- Children with neurological, orthopedic, or psychological illnesses that may affect functional performance
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Virtual Reality InterventionThe virtual reality training group will have sessions lasting 40 minutes, 3 days a week for 8 weeks. * A 30-minute VR-based training session using Kinect Xbox (5 min warm-up, 30 min VR, 5 min cool-down) * The device has an infrared camera sensor (Kinect sensor) that detects the participant's movement in real time * Even if the user's movement is not performed correctly in the game settings, the user receives visual and auditory sensory feedback about movement errors. * All games are provided to engage participants' interest in the topics and require the use of the person's lower extremities. * Each game will be played for 10 minutes during the 30-minute training session. (A total of 3 games will be played) * Participants in VR programs typically perform active hip flexion, hip abduction, hip external and internal rotation, knee flexion and extension, ankle dorsiflexion, and plantar flexion while standing. * Game content: Kinect Sports, Kinect Adventures and Kinect Sports Rivals. | Other | Virtual reality group |
| Home-Based Exercise Intervention* Home-based exercise training group will also be given online exercises 3 days a week for 8 weeks. * Active/passive stretching exercises within pain limits * Patients will perform exercises at home under a supervised exercise program * They will perform exercises matching the virtual reality group in terms of exercise sequence, intensity, duration, and mode, incorporating open and closed kinetic chain movements * A 20-second stretch followed by a 20-second relaxation performed five times per session for each muscle * Light resistance exercises targeting muscle groups in the lower extremities, with a 5-second contraction followed by a 5-second relaxation, performed five times per session * Bodyweight exercises * Balance exercises * Posture exercises | Other | Home-Based Exercise Group |
Primary outcome
Hemophilia Joint Health Score (HJHS)
Time frame: From enrollment to the end of treatment at 8 weeks
HJHS is a commonly used clinical assessment scale developed to evaluate joint health in patients with hemophilia. It aims to detect hemophilia-related joint damage early, particularly in children and adolescents. Purpose of development: To detect hemophilic arthropathy (joint damage) through physical examination without the need for radiological methods. Scope: The elbow, knee, and ankle joints, which are the most commonly affected joints in hemophilia patients, are evaluated. Target group: Although initially developed for children aged 4-18, it is now also used in adults. The following joint characteristics are scored in the HJHS: Joint swelling (acute/chronic) Muscle atrophy Joint pain Loss of joint range of motion (ROM) Crepitus (sound or friction sensation during joint movement) Gait (walking) assessment Scoring: These parameters are evaluated for each joint using a specific scoring system. A total score of 0 = normal joint health, a higher score = more joint damage.
Physical Activity Questionnaire for Children (PAQ-C)
Time frame: From enrollment to the end of treatment at 8 weeks
Target group: Children and adolescents. Objective: To determine the level of physical activity performed through play, sports, and exercise in daily life. Method: The child is asked to indicate how many times they performed the activities on the list (e.g., jumping rope, running, cycling, walking, skating, games) in the last 7 days. Answer options: Never done it = 0 points 1-2 times = 1 point 3-4 times = 2 points 5-6 times = 3 points 7 times and above = 4 points Points awarded for all activities (e.g., jumping rope, running, cycling, walking, skating, tag, etc.) are added together. This total gives the child's total physical activity score for the last 7 days.
CHO-KLAT (Canadian Hemophilia Outcomes-Kids' Life Assessment Tool)
Time frame: From enrollment to the end of treatment at 8 weeks
Purpose of development: To measure the daily life experiences, social participation, and quality of life of children with hemophilia. Age group: Child version (8-18 years) → Completed by the child. Parent version (for ages 0-7 and 8-18) → Based on parental observation. Includes questions that relate conditions specific to hemophilia (e.g., bleeding, treatment burden, physical limitations) to quality of life. CHO-KLAT assesses the child's life from a physical, social, and emotional perspective. The question topics are generally: School and social activities (participation, friendships, involvement in games) Physical activities (sports, games, ability to exercise) Daily living activities (mobility, care, freedom of movement) Emotional state (anxiety, feelings about illness) Experiences related to treatment (injections, access to healthcare) Each item is scored between 0 and 4 (0 = strongly disagree, 4 = strongly agree). All scores are then added up and converted to a 0-100 range.
12 secondary outcomes
Stability Index
Time frame: From enrollment to the end of treatment at 8 weeks
Posture
Time frame: From enrollment to the end of treatment at 8 weeks
Multidimensional Hemophilia Pain
Time frame: From enrollment to the end of treatment at 8 weeks
Proprioception
Time frame: From enrollment to the end of treatment at 8 weeks
Functional Independence Score in Hemophilia (FISH)
Time frame: From enrollment to the end of treatment at 8 weeks
Postural Sway
Time frame: From enrollment to the end of treatment at 8 weeks
Weight Distribution
Time frame: From enrollment to the end of treatment at 8 weeks
Dynamic Balance Test
Time frame: From enrollment to the end of treatment at 8 weeks
Step Length and Step Width
Time frame: From enrollment to the end of treatment at 8 weeks
Cadence (Steps per Minute)
Time frame: From enrollment to the end of treatment at 8 weeks
Right/left load distribution
Time frame: From enrollment to the end of treatment at 8 weeks
Pressure distribution (foot pressure patterns)
Time frame: From enrollment to the end of treatment at 8 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 Oct 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
A study testing Virtual Reality Intervention and Home-Based Exercise Intervention in people with Hemophilia A Without Inhibitor, run by Hacettepe University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 1 Oct 2025. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Hemophilia Joint Health Score (HJHS) (time frame: From enrollment to the end of treatment at 8 weeks). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Oct 2025.