HealthyMoViBlocNCT07203807
Study of the Optimal Number of Repetitions to Investigate the Cerebral Activity by fNIRS During a Voluntary Movement and an Illusory Movement Induced by Vibration
An observational study of Healthy, run by Centre Hospitalier Régional d'Orléans at 1 site in France.
Trial summary
The purpose of this study is to investigate the cerebral activation of healthy participants during a voluntary movement and an illusory movement induced by vibration. This will be done by repeating both tasks 20 times for 10 seconds. Read more about this study
- Who is it for?
- Ages 18 to 40 years
- Conditions the study is for
- Healthy
- What is being tested?
- Voluntary movement and illusory movement of the right upper limb induced by TVS.
- How many people
- 29 participants
- Where
- 1 siteFrance
- Study dates
- 27 Oct 2025to 31 Oct 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Adult
Study population: Healthy young adult aged 18 to 40
Who may be able to join
- Healthy volunteers aged 18 to 40
- Right-handed: Edinburgh laterality test short format QL > 60 (Veale et al., 2014).
- Sufficient command of the French language to understand instructions
- No known neurological medical history
Who cannot join
- Allergy to neoprene (fNIRS cap material)
- Hair volume preventing the cap from fitting and/or access to the scalp
- Injury to right upper limb causing pain during mobilization
- Protected person (under guardianship or trusteeship)
- Person under court protection
- Persons deprived of liberty
Show all 9Show fewer
- Persons not affiliated to a social security scheme
- Pregnant or breast-feeding women
- Volunteers opposed to the study
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Methodological Study on the Minimum Number of Blocks in fNIRS: Brain Activity During Voluntary Movement and During Illusory Movement Induced by Vibratory Tendon Stimulation of the Right Distal Upper Limb in Healthy Right-handed Participants
The purpose of this study is to investigate the cerebral activation of healthy participants during a voluntary movement and an illusory movement induced by vibration.
This will be done by repeating both tasks 20 times for 10 seconds.
The study aims to determine the minimum number of repetitions (blocks) required to maximize cerebral activity.
Read the detailed description
Functional near-infrared spectroscopy (fNIRS) is a non-invasive method that measures cortical hemodynamic responses by measuring variations in oxyhemoglobin (HbO) and deoxyhemoglobin (HbR). Thanks to its portability, ease of use, and low cost, fNIRS is particularly well suited to the study of neurological populations such as stroke patients.
To obtain a robust hemodynamic response, fNIRS studies use a block-design experimental paradigm, alternating between periods of task performance and rest. However, there is considerable heterogeneity in the number of blocks used in the literature, making it difficult to construct an optimal paradigm. Among the methodological issues, knowledge of the minimum number of blocks for which the cerebral response is maximal appears to be a key point.
It is generally acknowledged that increasing the number of blocks reduces intra-individual variability and improves the detection of task-specific responses. However, increasing the number of blocks increases the acquisition time, which can lead to fatigue or discomfort, particularly in elderly participants or participants with neurological disorders. A compromise must be found between methodological precision and clinical tolerance in the construction of future experimental paradigms, particularly those involving a motor task in a neurological rehabilitation context.
To date, the literature does not recommend a specific number of blocks based on the actual motor task (voluntary movement) or illusory task (induced by tendon vibration stimulation (TVS)), as both modalities are used in rehabilitation. Improving our understanding of the relationship between the number of blocks and the hemodynamic response measured by fNIRS depending on the type of task would enable us to move towards standardizing experimental paradigms.
The aim of this study is to identify the minimum number of blocks required to obtain a maximal cerebral hemodynamic response (variations in HbO and HbR), measured by fNIRS during a unilateral hand motor task and an illusory movement induced by TVS in healthy participants. Ultimately, these results will help optimize fNIRS experimental paradigms by ensuring reliable capture of task-related brain activity in a minimum of time, compatible with a pathological population.
The protocol comprises two different modalities: Voluntary movement and illusory movement of the right upper limb induced by TVS. This experiment will be conducted on young, healthy participants aged 18 to 40.
The experiment will begin and end with a one-minute rest period. Participants will be asked to open and close their right hand 20 times in 10 seconds. Similarly, they will experience 10 seconds of TVS-induced illusory movement 20 times. Each task epoch will be preceded by a 12-20 second resting period.
Both conditions will be randomized and counterbalanced. Participants can start with either the voluntary movement task or the illusory.
The fNIRS devices that will be used are the Brite MKII and Brite MKIII (Artinis Medical Systems, the Netherlands).
The vibration tool is a VibraMoov vibrator from Technoconcept in Mane, France.
- Conditions
- Healthy
- Being tested
- Voluntary movement and illusory movement of the right upper limb induced by TVS.
- Keywords
- fNIRS, Blocks, Movement, Illusion
- Medical subject headings
- Bites and Stings, Illusions
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Voluntary movement and illusory movement of the right upper limb induced by TVS.Other
The protocol comprises two different modalities: Voluntary movement and illusory movement of the right upper limb induced by TVS.
The experiment will begin and end with a one-minute rest period. Participants will be asked to open and close their right hand 20 times in 10 seconds. Similarly, they will experience 10 seconds of TVS-induced illusory movement 20 times. Each task epoch will be preceded by a 12-20 second resting period.
Both conditions will be randomized and counterbalanced. Participants can start with either the voluntary movement task or the illusory.
| Study group | Role | What they receive |
|---|---|---|
| Healthy young | Healthy young participants aged 18 to 40 Receives: Other: Voluntary movement and illusory movement of the right upper limb induced by TVS. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Cerebral hemodynamic variations in the sensorimotor areas assessed by fNIRS with 42 long channels and 4 short channels.
HbO will be considered as the primary outcome measure of the cerebral activity through the hemodynamic response
Measured: Day 0
Cerebral hemodynamic variations in the frontoparietal areas assessed by fNIRS with 42 long channels and 4 short channels
HbO will be considered as the primary outcome measure of the cerebral activity through the hemodynamic response
Measured: Day 0
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Oct 2025
- Study start27 Oct 2025
- Primary completion31 Oct 2025
- Study completion31 Oct 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (5)Papers the sponsor has linked to this study.
- Other trials for HealthyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Cross-sectional
- Enrolment
- 29 participants (actual)
Sponsor and investigators
- Lead sponsor
- Centre Hospitalier Régional d'Orléans
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07203807
- Sponsor's protocol ID
- CHUO-2025-17
- Acronym
- MoViBloc
- Status last verified
- Jan 2026
- First submitted
- 25 Sep 2025
- Last updated
- 8 Jan 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Edin BB, Vallbo AB. Dynamic response of human muscle spindle afferents to stretch. J Neurophysiol. 1990 Jun;63(6):1297-306. doi: 10.1152/jn.1990.63.6.1297.
PubMed 2141632Herold F, Wiegel P, Scholkmann F, Thiers A, Hamacher D, Schega L. Functional near-infrared spectroscopy in movement science: a systematic review on cortical activity in postural and walking tasks. Neurophotonics. 2017 Oct;4(4):041403. doi: 10.1117/1.NPh.4.4.041403. Epub 2017 Aug 1.
PubMed 28924563Naito E, Morita T, Amemiya K. Body representations in the human brain revealed by kinesthetic illusions and their essential contributions to motor control and corporeal awareness. Neurosci Res. 2016 Mar;104:16-30. doi: 10.1016/j.neures.2015.10.013. Epub 2015 Nov 10.
PubMed 26562333Pinti P, Tachtsidis I, Hamilton A, Hirsch J, Aichelburg C, Gilbert S, Burgess PW. The present and future use of functional near-infrared spectroscopy (fNIRS) for cognitive neuroscience. Ann N Y Acad Sci. 2020 Mar;1464(1):5-29. doi: 10.1111/nyas.13948. Epub 2018 Aug 7.
PubMed 30085354Schneider C, Marquis R, Johr J, Lopes da Silva M, Ryvlin P, Serino A, De Lucia M, Diserens K. Disentangling the percepts of illusory movement and sensory stimulation during tendon vibration in the EEG. Neuroimage. 2021 Nov 1;241:118431. doi: 10.1016/j.neuroimage.2021.118431. Epub 2021 Jul 28.
PubMed 34329723
Study at a glance
From the registry record, last updated by the sponsor on 8 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Methodological Study on the Minimum Number of Blocks in fNIRS: Brain Activity During Voluntary Movement and During Illusory Movement Induced by Vibratory Tendon Stimulation of the Right Distal Upper Limb in Healthy Right-handed Participants
- ClinicalTrials.gov ID
- NCT07203807
- Acronym / sponsor ID
- MoViBloc / CHUO-2025-17
- Conditions
- Healthy
- Keywords
- fNIRS, Blocks, Movement, Illusion
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 29 participants (actual)
- Lead sponsor
- Centre Hospitalier Régional d'OrléansUniversity, hospital or other
- Study start
- 27 Oct 2025 (actual)
- Primary completion
- 31 Oct 2025 (actual)
- Study completion
- 31 Oct 2025 (actual)
- First posted
- 2 Oct 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to investigate the cerebral activation of healthy participants during a voluntary movement and an illusory movement induced by vibration.
This will be done by repeating both tasks 20 times for 10 seconds.
The study aims to determine the minimum number of repetitions (blocks) required to maximize cerebral activity.
Detailed description
Functional near-infrared spectroscopy (fNIRS) is a non-invasive method that measures cortical hemodynamic responses by measuring variations in oxyhemoglobin (HbO) and deoxyhemoglobin (HbR). Thanks to its portability, ease of use, and low cost, fNIRS is particularly well suited to the study of neurological populations such as stroke patients.
To obtain a robust hemodynamic response, fNIRS studies use a block-design experimental paradigm, alternating between periods of task performance and rest. However, there is considerable heterogeneity in the number of blocks used in the literature, making it difficult to construct an optimal paradigm. Among the methodological issues, knowledge of the minimum number of blocks for which the cerebral response is maximal appears to be a key point.
It is generally acknowledged that increasing the number of blocks reduces intra-individual variability and improves the detection of task-specific responses. However, increasing the number of blocks increases the acquisition time, which can lead to fatigue or discomfort, particularly in elderly participants or participants with neurological disorders. A compromise must be found between methodological precision and clinical tolerance in the construction of future experimental paradigms, particularly those involving a motor task in a neurological rehabilitation context.
To date, the literature does not recommend a specific number of blocks based on the actual motor task (voluntary movement) or illusory task (induced by tendon vibration stimulation (TVS)), as both modalities are used in rehabilitation. Improving our understanding of the relationship between the number of blocks and the hemodynamic response measured by fNIRS depending on the type of task would enable us to move towards standardizing experimental paradigms.
The aim of this study is to identify the minimum number of blocks required to obtain a maximal cerebral hemodynamic response (variations in HbO and HbR), measured by fNIRS during a unilateral hand motor task and an illusory movement induced by TVS in healthy participants. Ultimately, these results will help optimize fNIRS experimental paradigms by ensuring reliable capture of task-related brain activity in a minimum of time, compatible with a pathological population.
The protocol comprises two different modalities: Voluntary movement and illusory movement of the right upper limb induced by TVS. This experiment will be conducted on young, healthy participants aged 18 to 40.
The experiment will begin and end with a one-minute rest period. Participants will be asked to open and close their right hand 20 times in 10 seconds. Similarly, they will experience 10 seconds of TVS-induced illusory movement 20 times. Each task epoch will be preceded by a 12-20 second resting period.
Both conditions will be randomized and counterbalanced. Participants can start with either the voluntary movement task or the illusory.
The fNIRS devices that will be used are the Brite MKII and Brite MKIII (Artinis Medical Systems, the Netherlands).
The vibration tool is a VibraMoov vibrator from Technoconcept in Mane, France.
Study design
- Observational model
- Other
- Time perspective
- Cross-sectional
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Healthy young | – | Other: Voluntary movement and illusory movement of the right upper limb induced by TVS.Healthy young participants aged 18 to 40 |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Age groups
- Adult
- Study population
- Healthy young adult aged 18 to 40
Key inclusion criteria (4 listed)
- Healthy volunteers aged 18 to 40
- Right-handed: Edinburgh laterality test short format QL > 60 (Veale et al., 2014).
- Sufficient command of the French language to understand instructions
- No known neurological medical history
Key exclusion criteria (9 listed)
- Allergy to neoprene (fNIRS cap material)
- Hair volume preventing the cap from fitting and/or access to the scalp
- Injury to right upper limb causing pain during mobilization
- Protected person (under guardianship or trusteeship)
- Person under court protection
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Voluntary movement and illusory movement of the right upper limb induced by TVS.The protocol comprises two different modalities: Voluntary movement and illusory movement of the right upper limb induced by TVS. The experiment will begin and end with a one-minute rest period. Participants will be asked to open and close their right hand 20 times in 10 seconds. Similarly, they will experience 10 seconds of TVS-induced illusory movement 20 times. Each task epoch will be preceded by a 12-20 second resting period. Both conditions will be randomized and counterbalanced. Participants can start with either the voluntary movement task or the illusory. | Other | Healthy young |
Primary outcome
Cerebral hemodynamic variations in the sensorimotor areas assessed by fNIRS with 42 long channels and 4 short channels.
Time frame: Day 0
HbO will be considered as the primary outcome measure of the cerebral activity through the hemodynamic response
Cerebral hemodynamic variations in the frontoparietal areas assessed by fNIRS with 42 long channels and 4 short channels
Time frame: Day 0
HbO will be considered as the primary outcome measure of the cerebral activity through the hemodynamic response
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Jan 2026.
- Background: PubMed 2141632Edin BB, Vallbo AB. Dynamic response of human muscle spindle afferents to stretch. J Neurophysiol. 1990 Jun;63(6):1297-306. doi: 10.1152/jn.1990.63.6.1297.
- Background: PubMed 28924563Herold F, Wiegel P, Scholkmann F, Thiers A, Hamacher D, Schega L. Functional near-infrared spectroscopy in movement science: a systematic review on cortical activity in postural and walking tasks. Neurophotonics. 2017 Oct;4(4):041403. doi: 10.1117/1.NPh.4.4.041403. Epub 2017 Aug 1.
- Background: PubMed 26562333Naito E, Morita T, Amemiya K. Body representations in the human brain revealed by kinesthetic illusions and their essential contributions to motor control and corporeal awareness. Neurosci Res. 2016 Mar;104:16-30. doi: 10.1016/j.neures.2015.10.013. Epub 2015 Nov 10.
- Background: PubMed 30085354Pinti P, Tachtsidis I, Hamilton A, Hirsch J, Aichelburg C, Gilbert S, Burgess PW. The present and future use of functional near-infrared spectroscopy (fNIRS) for cognitive neuroscience. Ann N Y Acad Sci. 2020 Mar;1464(1):5-29. doi: 10.1111/nyas.13948. Epub 2018 Aug 7.
- Background: PubMed 34329723Schneider C, Marquis R, Johr J, Lopes da Silva M, Ryvlin P, Serino A, De Lucia M, Diserens K. Disentangling the percepts of illusory movement and sensory stimulation during tendon vibration in the EEG. Neuroimage. 2021 Nov 1;241:118431. doi: 10.1016/j.neuroimage.2021.118431. Epub 2021 Jul 28.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Healthy, run by Centre Hospitalier Régional d'Orléans at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 8 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Cerebral hemodynamic variations in the sensorimotor areas assessed by fNIRS with 42 long channels and 4 short channels. (time frame: Day 0). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07203807, which also lists 5 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Jan 2026.