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Post-operative Knee StiffnessNCT07204119

Comparison of GT With TF Technique in Patient With Post-Operative Knee Stiffness

A study testing Tissue Flossing Technique and Graston Technique in people with Post-operative Knee Stiffness, run by Riphah International University at 1 site in Pakistan.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
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Trial summary

The purpose of this study was to compare the effects of Graston Technique and Tissue Flossing Technique in patients with post-operative knee stiffness on pain, range of motion, and functional outcomes. A randomized controlled trial was conducted at Benazir Bhutto Hospital, Rawalpindi. Read more about this study

Who is it for?
Ages 20 to 40 years
Conditions the study is for
Post-operative Knee Stiffness
What is being tested?
Tissue Flossing Technique and Graston Technique
Could I receive a placebo?
No, everyone receives an active treatment
How many people
48 participants
Where
1 sitePakistan
Study dates
12 Feb 2025to 25 Dec 2025
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 20 to 40 years
  • All sexes
  • No healthy volunteers
  • Adult

Who may be able to join

  • Age group between 20 to 40 years.
  • Both male and female.
  • Patients with 6 weeks post-operative following open reduction and internal fixation (ORIF) of femur, tibia, or fibula shaft fracture
  • Decreased in knee Flexion \& Extension (A minimum of 20° or above).

Who cannot join

  • Those patients who have allergies to latex
  • Malignant or metabolic cause of knee fracture
  • Venous Thrombotic disease/ Varicose veins.
  • Cardiopulmonary illness and hypertension.
  • Skin diseases/ metabolic disorders.
  • Patient with arthroplasty and arthroscopy.
  • Patellar fracture/ ACL/ PCL/ MCL/ LCL rupture/ injuries.
  • Any pathological condition having effects on knees.

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

imran amjad, PhD contact

03324390125

imran.amjad@riphah.edu.pk

Pakistan1 site, 1 recruiting
  • Banazir Bhutto Hospital,

    Rawalpindi, Punjab Province, 46000

    Sidra Zaib, MSPT-OMPT, 03070501563, sidrazaib1129@gmail.com

    Lal Gul Khan, MScPT, 03002146287, lalgul.khan@riphah.edu.pk

    Recruiting

Other trials in Pakistan

About this study

Official title: Official Title: Comparison of Graston Technique With Tissue Flossing Technique in Patient With Post-Operative Knee Stiffness

The purpose of this study was to compare the effects of Graston Technique and Tissue Flossing Technique in patients with post-operative knee stiffness on pain, range of motion, and functional outcomes. A randomized controlled trial was conducted at Benazir Bhutto Hospital, Rawalpindi. The total sample size was 48, divided into three groups. The study duration was six months. Purposive sampling was applied for recruitment, and group randomization was performed by lottery method. Only patients with post-operative knee stiffness meeting the inclusion criteria were enrolled. Outcome measures included goniometer, Functional Independence Measure (FIM), and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaires. Data was collected at baseline and after interventions, and analysis was performed using SPSS version 23.

Read the detailed description

Stiffness has been defined as a decrease in postoperative range of motion (ROM), including flexion contracture, accompanied by persistent pain and/or functional compromise (1). Post-traumatic stiffness may result from dense intra-articular adhesions and fibrotic transformation of periarticular structures (2). The knee joint, crucial for lower-limb biomechanics, is the most frequently injured joint in the lower extremities (3). Post-traumatic knee stiffness and loss of ROM are common complications following knee injuries. The normal ROM of the knee joint is generally accepted to be 0° (full extension) to 135° (full flexion). A stiff knee is defined as one with a total ROM of less than 50°, while an ankylosed knee is characterized by a ROM of less than 30° (4). Knee joint stiffness may result from several factors, including periarticular surgeries, traumatic injuries, inflammatory or infectious joint diseases, fractures, prolonged immobilization, and scar formation due to burns or trauma. Post-surgical procedures such as open reduction and internal fixation (ORIF) may also contribute to stiffness through scar tissue formation and reduced joint mobility (5). The choice of fixation method for femoral or tibial fractures depends on the fracture type and anatomical location. For femoral shaft fractures, intramedullary (IM) nailing is considered the gold standard. Stabilization of femoral or tibial fractures can also be achieved through ORIF using screws, plates, or rods. In cases with compromised skin integrity at the fracture site, external fixation provides a temporary solution, using external frames to align the bones (6) Diagnosis of post-operative knee stiffness is based on reduced knee flexion and extension after surgery, commonly following ORIF of femur, tibia, or fibula fractures. Literature defines stiffness as total knee ROM <50° and ankylosis when <30°. Clinical judgment with goniometric assessment and functional evaluation using WOMAC and FIM questionnaires provides valid measures. Previous studies suggest intra-articular adhesions, fibrotic changes, and prolonged immobilization as primary contributors to post-operative knee stiffness.

Various therapeutic interventions have been developed to address this issue, myofascial compression technique, i.e., Graston Technique and tissue flossing emerging as promising approaches. The Graston Technique (GT) is a therapeutic approach known as instrument-assisted soft tissue mobilization (IASTM). GT uses specialized tools to massage and scrape the skin, reducing pain and targeting tissue restrictions that cause dysfunction. The Graston Technique supports soft tissue healing by enhancing blood flow (vasodilation) to the affected area, which can accelerate recovery and reduce stiffness (7).

The Graston Technique, instrument-assisted soft tissue mobilization (IASTM), has shown efficacy in improving range of motion and reducing pain in various musculoskeletal conditions. Studies have demonstrated its effectiveness in treating chronic low back pain, with significant improvements in pain reduction and increased range of motion compared to general exercise alone (8).

The technique has also been found to be beneficial in addressing postoperative elbow stiffness, showing greater improvements in pain reduction and patient-specific function compared to other soft tissue mobilization techniques (9)

. For instance, a study on patients with anterior knee pain found that IASTM techniques, including the Graston Technique, were as effective as stretching exercises in reducing pain, improving flexibility, and enhancing lower extremity function in patients with iliotibial band tightness (10).

Similarly, compressive myofascial release techniques have demonstrated effectiveness in increasing ankle dorsiflexion range of motion (11).

Tissue flossing, on the other hand, utilizes a floss band that is elastic rubber band designed to wrap around joints or muscle groups before or during exercise or stretching. The primary mechanism involves blood flow restriction (BFR), creating temporary tissue ischemia, followed by blood flow reperfusion upon removal, which can boost metabolic responses (3).

Tissue flossing is a novel technique gaining popularity in athletic training and rehabilitation for its potential effects on joint range of motion (ROM) and muscle function. Studies have shown that floss band application on limbs, soft tissues, or joints with approximately 50% tension wrapping pressure can have small to medium effects on ROM, muscle stiffness, and strength (12).

Research on the effects of tissue flossing on joint stiffness has produced mixed results. Some studies have reported positive outcomes, such as increased ankle ROM and improved jump and sprint performance in recreational athletes (13).

The Graston Technique and tissue flossing are two techniques that aim to improve soft tissue mobility and joint function through distinct mechanisms. The former employs specialized instruments for soft tissue mobilization, while the latter uses compression and subsequent modulation of blood flow.

The lack of direct comparisons between these techniques underscores the potential significance of study investigating their comparative efficacy in treating post-operative knee stiffness. Such research could substantially contribute to the existing body of knowledge regarding soft tissue mobilization techniques and their applications across various musculoskeletal conditions, thereby providing clinicians with valuable insights.

Being tested
Tissue Flossing Technique, Graston Technique, Control group
Keywords
Post-operative knee stiffness, Graston Technique, Range of Motion, Tissue Flossing

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Tissue Flossing TechniqueOther

    Hot pack: 10 minutes, PNF (hold-relax with agonist contraction), CPM: 10 minutes, Self-stretching: End range position for 30 seconds, repeat twice. 1 to 2 minutes for Tissue Flossing Technique Description: Active and passive movement with knee wrapped in a high-quality floss band (208×5×0.15 cm), Wrapped from upper gastrocnemius to lower quadriceps and hamstring muscles using a 50% overlapping pattern with a 25% elongation stretch, Series of active and passive exercises (knee flexion and extension) with 3 repetitions.

  • Graston TechniqueOther

    Hot pack: 10 minutes, PNF (hold-relax with agonist contraction), CPM: 10 minutes, Self-stretching: End range position for 30 seconds, repeat twice.

    2 minutes for Graston Technique Technique Description: Participant lies supine with hip and knee straight, Water-based gel used to reduce friction.

    Superior and inferior longitudinal strokes delivered with GT-4 instrument at a 45° angle to soft tissues Sequence includes strokes from above patella to anterior inferior iliac spine (AIIS) and back, maintaining a 2-second cadence

  • Control groupOther

    Hot pack: 10 minutes, PNF (hold-relax with agonist contraction): Gentle stretch of knee muscle for 10 seconds Isometric contraction for 6 seconds. Flex knee with therapist assistance. Hold position for 10 seconds, repeat 3 times, CPM: 10 minutes, Self-stretching: End range position for 30 seconds, repeat twice

Study groups in NCT07204119
Study groupRoleWhat they receive
Tissue Flossing TechniqueExperimentalHot pack: 10 minutes, PNF (hold-relax with agonist contraction), CPM: 10 minutes, Self-stretching: End range position for 30 seconds, repeat twice. 1 to 2 minutes for Tissue Flossing Technique Description: Active and passive movement with knee wrapped in a high-quality floss band (208×5×0.15 cm), Wrapped from upper gastrocnemius to lower quadriceps and hamstring muscles using a 50% overlapping pattern with a 25% elongation stretch, Series of active and passive exercises (knee flexion and extension) with 3 repetitions.
Receives: Other: Tissue Flossing Technique
Graston TechniqueExperimentalHot pack: 10 minutes, PNF (hold-relax with agonist contraction), CPM: 10 minutes, Self-stretching: End range position for 30 seconds, repeat twice. 2 minutes for Graston Technique Technique Description: Participant lies supine with hip and knee straight, Water-based gel used to reduce friction. Superior and inferior longitudinal strokes delivered with GT-4 instrument at a 45° angle to soft tissues Sequence includes strokes from above patella to anterior inferior iliac spine (AIIS) and back, maintaining a 2-second cadence
Receives: Other: Graston Technique
Control groupActive comparatorHot pack: 10 minutes * PNF (hold-relax with agonist contraction): Gentle stretch of knee muscle for 10 seconds Isometric contraction for 6 seconds. Flex knee with therapist assistance. Hold position for 10 seconds, repeat 3 times * CPM: 10 minutes * Self-stretching: End range position for 30 seconds, repeat twice
Receives: Other: Control group

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Range of Motion:

    Range of motion (ROM) is the extent of movement possible at a joint or body part. It's the arc of motion a joint can travel, typically measured in degrees using a goniometer. Healthy ROM allows for comfortable movement, while limitations can lead to pain and reduced function.

    Measured: 2 weeks

Secondary outcomes (3)
  1. Numerated Pain Rating Scale:

    The Numeric Rating Scale (NRS), also known as the Numeric Pain Rating Scale (NPRS), is a simple, validated tool used to measure pain intensity by having a person rate their pain on a scale, typically from 0 to 10, where 0 means no pain and 10 means the worst possible pain.

    Measured: 2 weeks

  2. Western Ontario and McMaster Universities Osteoarthritis Index

    WOMAC stands for the Western Ontario and McMaster Universities Osteoarthritis Index, a self-administered questionnaire used by health professionals to assess osteoarthritis (OA) of the hip and knee. It measures pain, stiffness, and physical function through 24 items across three subscales, with higher scores indicating increased difficulty.

    Measured: 2 weeks

  3. Functional Independence Measure:

    The Functional Independence Measure (FIM) is an assessment tool used in rehabilitation to evaluate a patient's ability to perform daily activities by measuring the degree of assistance required.

    Measured: 2 weeks

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted2 Oct 2025
  2. Study start12 Feb 2025
  3. Primary completion15 Dec 2025 (estimated)
  4. Study completion25 Dec 2025 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Single blind
Who is masked
Participant
Enrolment
48 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07204119
Sponsor's protocol ID
Riphah/RCRS/REC/02181
Status last verified
Sep 2025
First submitted
25 Sep 2025
Last updated
2 Oct 2025
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Publications

  • Manrique J, Gomez MM, Parvizi J. Stiffness after total knee arthroplasty. J Knee Surg. 2015 Apr;28(2):119-26. doi: 10.1055/s-0034-1396079. Epub 2014 Dec 16.

    PubMed 25513992
  • Galvez-Sirvent E, Ibarzabal-Gil A, Rodriguez-Merchan EC. Complications of the surgical treatment of fractures of the tibial plateau: prevalence, causes, and management. EFORT Open Rev. 2022 Aug 4;7(8):554-568. doi: 10.1530/EOR-22-0004.

    PubMed 35924649
  • Wu SY, Tsai YH, Wang YT, Chang WD, Lee CL, Kuo CA, Chang NJ. Acute Effects of Tissue Flossing Coupled with Functional Movements on Knee Range of Motion, Static Balance, in Single-Leg Hop Distance, and Landing Stabilization Performance in Female College Students. Int J Environ Res Public Health. 2022 Jan 27;19(3):1427. doi: 10.3390/ijerph19031427.

    PubMed 35162447
  • Pirato F, Rosso F, Dettoni F, Bonasia DE, Bruzzone M, Rossi R. How to manage a native stiff knee. EFORT Open Rev. 2024 May 10;9(5):363-374. doi: 10.1530/EOR-24-0034.

    PubMed 38726987
  • Phruetthiphat OA, Zampogna B, Vasta S, Tassanawipas B, Gao Y, Callaghan JJ. TKR after posttraumatic and primary knee osteoarthritis: a comparative study. J Orthop Surg Res. 2021 Mar 4;16(1):173. doi: 10.1186/s13018-021-02322-8.

    PubMed 33663576
  • Mckivigan JM, Tulimero G. An Analysis Of Graston Technique® For Soft-Tissue Therapy. Rehabilitation Science. 2020;5(4):31. 2020.

  • 26, Kangra Rm. Effectiveness Of Instrument Assisted Soft Tissue Mobilization (Iastm) On Post-Operative Knee Stiffness: A Case Study. International Journal Of Scientific Research. 2024 Jun; 13(5).

  • Lee JH, Lee DK, Oh JS. The effect of Graston technique on the pain and range of motion in patients with chronic low back pain. J Phys Ther Sci. 2016 Jun;28(6):1852-5. doi: 10.1589/jpts.28.1852. Epub 2016 Jun 28.

    PubMed 27390432
  • Bhosale P, Kolke Pt S. Effectiveness of instrument assisted soft tissue mobilization (IASTM) and muscle energy technique (MET) on post-operative elbow stiffness: a randomized clinical trial. J Man Manip Ther. 2023 Oct;31(5):340-348. doi: 10.1080/10669817.2022.2122372. Epub 2022 Sep 28.

    PubMed 36171728
  • Lim, J.-Y., Nam, S.-H., & Kim, K.-D. (2022). Effect of Active Stretching and Instrument-Assisted Soft Tissue Mobilization on the Hip Joint Range of Motion and Stiffness of the Tensor Fascia Lata in Subjects with Shortened Tensor Fascia Lata. Journal of Musculoskeletal Science and Technology, 6(2), 43-50.

  • Stanek J, Sullivan T, Davis S. Comparison of Compressive Myofascial Release and the Graston Technique for Improving Ankle-Dorsiflexion Range of Motion. J Athl Train. 2018 Feb;53(2):160-167. doi: 10.4085/1062-6050-386-16. Epub 2018 Jan 26.

    PubMed 29373060
  • Jianhong, G., Seng, T. J., Samsudin, S., Soon, C. C., & Zaremohzzabieh, Z. (2021). The Effect of Tissue Flossing Technique on Sports and Injury Prevention and Rehabilitation: A Systematic Review of Recent Research. International Journal of Human Movement and Sports Sciences, 9(6), 1157-1173.

  • Mills B, Mayo B, Tavares F, Driller M. The Effect of Tissue Flossing on Ankle Range of Motion, Jump, and Sprint Performance in Elite Rugby Union Athletes. J Sport Rehabil. 2020 Mar 1;29(3):282-286. doi: 10.1123/jsr.2018-0302.

    PubMed 30676229
  • Cheatham SW, Kolber MJ, Mokha M, Hanney WJ. Concurrent validity of pain scales in individuals with myofascial pain and fibromyalgia. J Bodyw Mov Ther. 2018 Apr;22(2):355-360. doi: 10.1016/j.jbmt.2017.04.009. Epub 2017 Apr 27.

    PubMed 29861234
  • Hancock GE, Hepworth T, Wembridge K. Accuracy and reliability of knee goniometry methods. J Exp Orthop. 2018 Oct 19;5(1):46. doi: 10.1186/s40634-018-0161-5.

    PubMed 30341552

Questions about this trial

What is this clinical trial studying?

A study testing Tissue Flossing Technique and Graston Technique in people with Post-operative Knee Stiffness, run by Riphah International University at 1 site in Pakistan.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 4 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 2 Oct 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact imran amjad, PhD (03324390125, imran.amjad@riphah.edu.pk), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Range of Motion: (time frame: 2 weeks). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07204119, which also lists 18 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Oct 2025.

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