HealthyNCT07209904
Economic Evaluation of Mindline.sg
A study testing mindline.sg in people with Healthy, run by Centre for Evidence and Implementation Singapore Ltd at 1 site in Singapore.
Trial summary
This study aims to evaluate the effectiveness of mindline.sg, a digital mental health platform, in improving mental health literacy, emotional wellbeing, quality of life, and economic outcomes among adults in Singapore. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Healthy
- What is being tested?
- mindline.sg
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 242 participants
- Where
- 1 siteSingapore
- Study dates
- 20 Nov 2025to 30 May 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Aged at least 21 years or at least 18 years old if National of University student
- Have lived in Singapore for at least 2 years
- Have not received a formal diagnosis of a psychiatric disorder
- Not currently receiving any form of mental health treatment (e.g., counselling)
- Fluent in English
- Participants from screening whose DASS-21 scores are mild or moderate for any one of the sub scales.
Who cannot join
- Those who do not meet the inclusion criteria will be screened and excluded.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Study on Understanding the Overall Effectiveness of Mindline.sg on Improving Mental Health Literacy, Quality of Life and Economic Outcomes
This study aims to evaluate the effectiveness of mindline.sg, a digital mental health platform, in improving mental health literacy, emotional wellbeing, quality of life, and economic outcomes among adults in Singapore. We will conduct a randomized controlled trial (RCT) with two phases: an initial screening and a 1-month intervention. Eligible participants, identified based on mental health symptom scores, will be randomly assigned to either an intervention group using mindline.sg or a control group receiving standard mental health information.
The intervention group will receive weekly prompts to engage with key features of the platform, including psychoeducation, positive psychology tools, emotion regulation exercises, and access to digital navigation for mental health services. Participants in both groups will complete surveys at baseline, post-intervention, and two months post-intervention, measuring outcomes such as mental health symptoms, resilience, wellbeing, emotion regulation, mental health literacy, and work performance. We expect mindline.sg users to show greater improvements across mental health and quality of life indicators, increased mental health literacy, and better work productivity compared to controls. This study will provide evidence on the utility of digital mental health tools in supporting population mental wellbeing and inform future digital mental health strategies in Singapore and similar contexts.
Read the detailed description
The primary hypothesis is:
- Participants in the intervention group using mindline.sg will show significantly greater improvements in mental health outcomes, quality of life, and work productivity at post-intervention (T1) and 3-month follow-up (T2), compared to the control group.
Secondary hypotheses include:
- Intervention participants will demonstrate increased resilience, better emotion regulation, and more positive attitudes and behaviors toward mental health help-seeking compared to the control group.
- Participants in the intervention group will show higher usage and engagement with digital mental health features and report higher perceived helpfulness of tools.
- The mindline.sg intervention will be cost-effective compared to the control condition, considering improvements in mental health and productivity outcomes relative to platform costs.
The study will use a randomized controllled trial design. Participants will be assigned to either: (1) A control group (receiving a mental health information pamphlet), or (2) An intervention group (using mindline.sg). Primary outcomes include mental health status, quality of life, economic and productivity measures, and user engagement metrics.
Trial participation will last 3 months. We aim to screen 5,000 adults from the general population who are aged 21 and above, have lived in Singapore for at least two years, have no psychiatric history, and are not currently receiving mental health treatment.
Participants from screening whose DASS-21 scores are mild to moderate for any one of the following sub scales will be recruited for the subsequent phase of the study.
Participants will be randomly assigned to either the control or intervention group. In the control group, participants will receive mental health literacy materials based on standard materials given out in Singapore (e.g., from the Health Promotion Board). In the intervention group, participants will be encouraged to use Mindline.sg for four weeks.
The intervention includes weekly prompts to engage with different platform features, for example:
- Week 1: Mental health literacy (Self-assessment tools and psychoeducation modules e.g. 'understand stress', 'find perspective')
- Week 2: Positive psychology and meditation exercises through Wysa AI chat (Completion of at least 4 exercises, e.g. 'Feel more control', 'be grateful', 'think motivation', 'identify your strengths', 'be kind to yourself', 'offload your worries', 'talk about your day'). Do note that Wysa's AI materials are carefully assessed for mental health appropriateness. Users can access the Wysa AI chat directly through the mindline platform without any further registration or account creation.
- Week 3: Emotion regulation exercises on mindline.sg platform (eg: tackling emotional burnout, overcoming insecurity, overcoming low mood and regaining motivation)
- Week 4: Help-seeking and personalized toolkit (explore service wayfinding tools for further mental health resources, mindline.sg live chat).
Participants will not be required to download any third party app. They are also not required to disclose any personal data during registration or use of the mindline.sg platform. Weekly activities will likely take between 10 - 30 mins, depending on the activities. Participants can exit and come back to the website later and continue their activities at their own pace. Each week, participants will receive weekly reminders via phone (e.g. messenger app) or email. This will contain infographics explaining the features.
Additionally, to ensure compliance, participants will be given a quiz at the end of each week with reimbursements for quiz completion. At the end of each week, they will also be asked to report on their use of site features (frequency and feature(s) used, and perceived helpfulness of feature), as well as their mood (three visual-analogue scales tracking: overall mood, stress, and ability to cope with challenges during the week). The quizzes will focus on participants' engagement with the platform, user experience, satisfaction, and feedback on specific features-such as what they liked or didn't like, and what worked well or didn't work. There are no "right" or "wrong" answers.
Reimbursement will be based on completeness of the quiz, not correctness-so as long as participants complete all the questions, they will be eligible.
The peer support forum feature (Let's Talk) on the mindline platform will not be part of the package as there is a separate study to evaluate it specifically.
At the end-of-study debrief, control group participants will be directed to the mindline.sg website so they too can benefit from it.
(b) Participants will also complete measures at three time-points: baseline (T0), immediately after the intervention (T1), and 2-months post-intervention. Across the three measurement timepoints, participants will be asked to complete a questionnaire to measure primary and secondary outcomes.
To provide further context, we will analyse aggregated and anonymised administrative data from the platform during the study period, including:
- Referrals: Referrals (self-reported) from mineline.sg to offline mental health services;
- Costs of mindline, including: Development and operational costs.
Please note that this project is a collaborative initiative between the Behavioural and Implementation Sciences Interventions (BISI) at YLLSoM, NUS, the Centre for Evidence and Implementation (CEI), and Ministry of Health Office for Healthcare Transformation (MOHT) formalized through a project contract signed among the three organisations. The project is supported with funding from MOHT.
- Conditions
- Healthy
- Being tested
- mindline.sg
- Keywords
- digital mental health
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
mindline.sgBehavioural
mindline.sg is a polydigital mental health platform with resources, wayfinding, and peer support via a forum. The website was built by the MOH Office for Healthcare Transformation together with Ministry of Social and Family Development, National Council of Social Service and Institute of Mental health. The content was cureated by the mindline.sg team and vetted by a clinical review panel which included clinicians from IMH and Fei Yue Community Services.
| Study group | Role | What they receive |
|---|---|---|
| Control | No intervention | In the control group, participants will receive mental health literacy materials based on standard materials given out in Singapore. At the end-of-study debrief, control group participants will be directed to the mindline.sg website so they can benefit from it. |
| Intervention | Experimental | In the intervention group, participants will be encouraged to use Mindline.sg for four weeks. Each week, participants will receive a reminder to complete certain activities on the website and a quiz to measure completion of activities. Receives: Behavioral: mindline.sg |
What is being measured
The primary outcome is the main question the study is designed to answer.
Mental health symptoms by 21-item Depression, Anxiety and Stress Scale (DASS-21)
The Depression, Anxiety and Stress Scale - 21 Items (DASS-21) is a set of three self-report scales designed to measure the emotional states of depression, anxiety and stress. Each of the three DASS-21 scales contains 7 items, divided into subscales with similar content. The depression scale assesses dysphoria, hopelessness, devaluation of life, self-deprecation, lack of interest / involvement, anhedonia and inertia. The anxiety scale assesses autonomic arousal, skeletal muscle effects, situational anxiety, and subjective experience of anxious affect. The stress scale is sensitive to levels of chronic non-specific arousal. It assesses difficulty relaxing, nervous arousal, and being easily upset / agitated, irritable / over-reactive and impatient. Scores for depression, anxiety and stress are calculated by summing the scores for the relevant items. Higher scores indicate higher severity of symptoms.
Measured: Screening, baseline, 4 weeks after baseline, 12 weeks after baseline
Quality of Life by 6-item EQ-5D-5L scale
The 5-level EQ-5D version (EQ-5D-5L) was introduced by the EuroQol Group in 2009 to improve the instrument's sensitivity and to reduce ceiling effects, as compared to the EQ-5D-3L. The EQ-5D-5L essentially consists of 2 pages: the EQ-5D descriptive system and the EQ visual analogue scale (EQ VAS). The descriptive system comprises five dimensions: mobility, self-care, usual activities, pain/discomfort and anxiety/depression. Each dimension has 5 levels: no problems, slight problems, moderate problems, severe problems and extreme problems. The patient is asked to indicate his/her health state by ticking the box next to the most appropriate statement in each of the five dimensions. This decision results in a 1-digit number that expresses the level selected for that dimension. The digits for the five dimensions can be combined into a 5-digit number that describes the patient's health state.
Measured: Baseline, 4 weeks after baseline, 12 weeks after baseline
Work productivity by WHO-HPQ measure of absenteeism and presenteeism
Absenteeism questions included both sickness absence and non-sickness absence. The questions asked about the number of days in the past 1 year that participants were absent due to health-related problem and non-health-related conditions separately. The questions about presenteeism asked the number of days in the past 1 year that participants had come to work while sick, felt they should take sick leave or were incapable of working with full performance.
Measured: 4 weeks after baseline, 12 weeks after baseline
Secondary outcomes (6)
Resilience by 10-item Connor-Davidson Resilience Scale
The scale has been developed and tested as (i) a measure of degree of resilience, (ii) as a predictor of outcome to treatment with medication or psychotherapy, stress management and resilience-building; (iii) as a marker of progress during treatment; (iv) as a marker of biological (i.e. physical) changes in the brain. The scale also has promise as a method to screen people for high, intermediate or low resilience. For the CD-RISC-10, the total score ranges from 0-40.
Measured: Baseline, 4 weeks after baseline, 12 weeks after baseline
Attitudes, knowledge and behaviours regarding mental health and help-seeking by the Mental Help Seeking Attitudes Scale (MHSAS)
The MHSAS is a 9-item instrument designed to measure respondents' overall evaluation (unfavorable vs. favorable) of their seeking help from a mental health professional if they found themselves to be dealing with a mental health concern. A higher score indicates a more positive attitude toward seeking help. The MHSAS score is a measure of help seeking attitude (Hammer, Parent, \& Spiker, 2018), as it is known in the literature on professional mental health treatment seeking behavior. More precisely, the MHSAS score is a numerical quantification of the degree to which a person reports having a negative versus positive attitude toward their seeking help from a mental health professional.
Measured: Baseline, 4 weeks after baseline, 12 weeks after baseline
Positive psychology by the Cantril Ladder and the WHO-5 Wellbeing Index
The Cantril Ladder is a question that measures life satisfaction and well-being by asking individuals to rate their current life on a scale of 0 to 10, with 10 being the best possible life and 0 being the worst.
The WHO-5 is a self-report instrument measuring mental well-being. It consists of five statements relating to the past two weeks. Respondents rate their experiences over the past two weeks on a 6-point scale, and the total score is multiplied by 4 to create a 0-100 scale, where higher scores indicate better well-being.
Measured: Baseline, 4 weeks after baseline, 12 weeks after baseline
Emotion regulation by DERS-18
DERS-18 is a brief version of the Difficulties in Emotion Regulation Scale, with 18 items, and is a brief version of the original 36 item DERS. This scale measures an integrative conceptualization of emotion regulation as involving not just the modulation of emotional arousal, but also the awareness, understanding, and acceptance of emotions, and the ability to act in desired ways regardless of emotional state. The DERS-18 can be used to facilitate understanding of how emotion dysregulation is associated with psychiatric symptoms and treatment progress; it can help track changes in a client's ability to self-regulate throughout the course of treatment. Respondents rate how often they experience the statements listed (e.g., "I pay attention to how I feel") on a scale from "Almost never" to "Almost always".
Measured: Baseline, 4 weeks after baseline, 12 weeks after baseline
Self-reported usage patterns of mindline.sg
Frequency and features used
Measured: Baseline, during intervention, 4 weeks after baseline, 12 weeks after baseline
Cost-effectiveness of mindline.sg
The costs of the mindline.sg intervention will be cost-effective compared to the control condition, considering improvements in mental health and productivity outcomes relative to platform costs.
Measured: Baseline, 4 weeks after baseline, 12 weeks after baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Oct 2025
- Study start20 Nov 2025
- Primary completion30 May 2026
- Study completion30 May 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for HealthyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants will be randomly assigned to either the control or intervention group. * Control Group: In the control group, participants will receive mental health literacy materials based on standard materials given out in Singapore (e.g., from the Health Promotion Board). * Intervention Group: In the intervention group, participants will be encouraged to use Mindline.sg for four weeks. The intervention includes weekly prompts to engage with different platform features,
- Masking
- Double blind
- Who is masked
- Participant, Care provider
- Enrolment
- 242 participants (actual)
Sponsor and investigators
- Lead sponsor
- Centre for Evidence and Implementation Singapore Ltd
- Sponsor type
- University, hospital or other
- Collaborators
- Ministry of Health, Singapore
- Responsible party
- Principal investigator, Jean Liu, Centre for Evidence and Implementation Singapore Ltd
- Investigators
- Jean Liu, PhD, Principal investigator, National University of Singapore, Yong Loo Lin School of Medicine.
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07209904
- Sponsor's protocol ID
- NUS-IRB-2025-228
- Status last verified
- Jun 2026
- First submitted
- 29 Sep 2025
- Last updated
- 12 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Saw YE, Tan EY, Liu JS, Liu JC. Predicting Public Uptake of Digital Contact Tracing During the COVID-19 Pandemic: Results From a Nationwide Survey in Singapore. J Med Internet Res. 2021 Feb 3;23(2):e24730. doi: 10.2196/24730.
PubMed 33465034Tan EY, Wee RR, Saw YE, Heng KJ, Chin JW, Tong EM, Liu JC. Tracking Private WhatsApp Discourse About COVID-19 in Singapore: Longitudinal Infodemiology Study. J Med Internet Res. 2021 Dec 23;23(12):e34218. doi: 10.2196/34218.
PubMed 34881720Barsova T, Cheong ZG, Mak AR, Liu JC. Predicting Psychological Symptoms When Facebook's Digital Well-being Features Are Used: Cross-sectional Survey Study. JMIR Form Res. 2022 Aug 29;6(8):e39387. doi: 10.2196/39387.
PubMed 36036971Erdembileg, S., Asplund, C. L., & Liu, J. C. J. (in preparation). Engagement with Taylor Swift's music and social media content predicts mental health outcomes in youths: Cross-sectional survey study.
Study at a glance
From the registry record, last updated by the sponsor on 12 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Study on Understanding the Overall Effectiveness of Mindline.sg on Improving Mental Health Literacy, Quality of Life and Economic Outcomes
- ClinicalTrials.gov ID
- NCT07209904
- Acronym / sponsor ID
- NUS-IRB-2025-228
- Conditions
- Healthy
- Keywords
- digital mental health
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 242 participants (actual)
- Lead sponsor
- Centre for Evidence and Implementation Singapore LtdUniversity, hospital or other
- Collaborators
- Ministry of Health, Singapore
- Study start
- 20 Nov 2025 (actual)
- Primary completion
- 30 May 2026 (actual)
- Study completion
- 30 May 2026 (actual)
- First posted
- 7 Oct 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to evaluate the effectiveness of mindline.sg, a digital mental health platform, in improving mental health literacy, emotional wellbeing, quality of life, and economic outcomes among adults in Singapore. We will conduct a randomized controlled trial (RCT) with two phases: an initial screening and a 1-month intervention. Eligible participants, identified based on mental health symptom scores, will be randomly assigned to either an intervention group using mindline.sg or a control group receiving standard mental health information.
The intervention group will receive weekly prompts to engage with key features of the platform, including psychoeducation, positive psychology tools, emotion regulation exercises, and access to digital navigation for mental health services. Participants in both groups will complete surveys at baseline, post-intervention, and two months post-intervention, measuring outcomes such as mental health symptoms, resilience, wellbeing, emotion regulation, mental health literacy, and work performance. We expect mindline.sg users to show greater improvements across mental health and quality of life indicators, increased mental health literacy, and better work productivity compared to controls. This study will provide evidence on the utility of digital mental health tools in supporting population mental wellbeing and inform future digital mental health strategies in Singapore and similar contexts.
Detailed description
The primary hypothesis is:
- Participants in the intervention group using mindline.sg will show significantly greater improvements in mental health outcomes, quality of life, and work productivity at post-intervention (T1) and 3-month follow-up (T2), compared to the control group.
Secondary hypotheses include:
- Intervention participants will demonstrate increased resilience, better emotion regulation, and more positive attitudes and behaviors toward mental health help-seeking compared to the control group.
- Participants in the intervention group will show higher usage and engagement with digital mental health features and report higher perceived helpfulness of tools.
- The mindline.sg intervention will be cost-effective compared to the control condition, considering improvements in mental health and productivity outcomes relative to platform costs.
The study will use a randomized controllled trial design. Participants will be assigned to either: (1) A control group (receiving a mental health information pamphlet), or (2) An intervention group (using mindline.sg). Primary outcomes include mental health status, quality of life, economic and productivity measures, and user engagement metrics.
Trial participation will last 3 months. We aim to screen 5,000 adults from the general population who are aged 21 and above, have lived in Singapore for at least two years, have no psychiatric history, and are not currently receiving mental health treatment.
Participants from screening whose DASS-21 scores are mild to moderate for any one of the following sub scales will be recruited for the subsequent phase of the study.
Participants will be randomly assigned to either the control or intervention group. In the control group, participants will receive mental health literacy materials based on standard materials given out in Singapore (e.g., from the Health Promotion Board). In the intervention group, participants will be encouraged to use Mindline.sg for four weeks.
The intervention includes weekly prompts to engage with different platform features, for example:
- Week 1: Mental health literacy (Self-assessment tools and psychoeducation modules e.g. 'understand stress', 'find perspective')
- Week 2: Positive psychology and meditation exercises through Wysa AI chat (Completion of at least 4 exercises, e.g. 'Feel more control', 'be grateful', 'think motivation', 'identify your strengths', 'be kind to yourself', 'offload your worries', 'talk about your day'). Do note that Wysa's AI materials are carefully assessed for mental health appropriateness. Users can access the Wysa AI chat directly through the mindline platform without any further registration or account creation.
- Week 3: Emotion regulation exercises on mindline.sg platform (eg: tackling emotional burnout, overcoming insecurity, overcoming low mood and regaining motivation)
- Week 4: Help-seeking and personalized toolkit (explore service wayfinding tools for further mental health resources, mindline.sg live chat).
Participants will not be required to download any third party app. They are also not required to disclose any personal data during registration or use of the mindline.sg platform. Weekly activities will likely take between 10 - 30 mins, depending on the activities. Participants can exit and come back to the website later and continue their activities at their own pace. Each week, participants will receive weekly reminders via phone (e.g. messenger app) or email. This will contain infographics explaining the features.
Additionally, to ensure compliance, participants will be given a quiz at the end of each week with reimbursements for quiz completion. At the end of each week, they will also be asked to report on their use of site features (frequency and feature(s) used, and perceived helpfulness of feature), as well as their mood (three visual-analogue scales tracking: overall mood, stress, and ability to cope with challenges during the week). The quizzes will focus on participants' engagement with the platform, user experience, satisfaction, and feedback on specific features-such as what they liked or didn't like, and what worked well or didn't work. There are no "right" or "wrong" answers.
Reimbursement will be based on completeness of the quiz, not correctness-so as long as participants complete all the questions, they will be eligible.
The peer support forum feature (Let's Talk) on the mindline platform will not be part of the package as there is a separate study to evaluate it specifically.
At the end-of-study debrief, control group participants will be directed to the mindline.sg website so they too can benefit from it.
(b) Participants will also complete measures at three time-points: baseline (T0), immediately after the intervention (T1), and 2-months post-intervention. Across the three measurement timepoints, participants will be asked to complete a questionnaire to measure primary and secondary outcomes.
To provide further context, we will analyse aggregated and anonymised administrative data from the platform during the study period, including:
- Referrals: Referrals (self-reported) from mineline.sg to offline mental health services;
- Costs of mindline, including: Development and operational costs.
Please note that this project is a collaborative initiative between the Behavioural and Implementation Sciences Interventions (BISI) at YLLSoM, NUS, the Centre for Evidence and Implementation (CEI), and Ministry of Health Office for Healthcare Transformation (MOHT) formalized through a project contract signed among the three organisations. The project is supported with funding from MOHT.
Study design
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, care provider)
- Number of arms
- 2
- Model description
- Participants will be randomly assigned to either the control or intervention group. * Control Group: In the control group, participants will receive mental health literacy materials based on standard materials given out in Singapore (e.g., from the Health Promotion Board). * Intervention Group: In the intervention group, participants will be encouraged to use Mindline.sg for four weeks. The intervention includes weekly prompts to engage with different platform features,
| Arm | Type | Receives |
|---|---|---|
| Control | No intervention | –In the control group, participants will receive mental health literacy materials based on standard materials given out in Singapore. At the end-of-study debrief, control group participants will be directed to the mindline.sg website so they can benefit from it. |
| Intervention | Experimental | Behavioral: mindline.sgIn the intervention group, participants will be encouraged to use Mindline.sg for four weeks. Each week, participants will receive a reminder to complete certain activities on the website and a quiz to measure completion of activities. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Aged at least 21 years or at least 18 years old if National of University student
- Have lived in Singapore for at least 2 years
- Have not received a formal diagnosis of a psychiatric disorder
- Not currently receiving any form of mental health treatment (e.g., counselling)
- Fluent in English
Key exclusion criteria (1 listed)
- Those who do not meet the inclusion criteria will be screened and excluded.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| mindline.sgmindline.sg is a polydigital mental health platform with resources, wayfinding, and peer support via a forum. The website was built by the MOH Office for Healthcare Transformation together with Ministry of Social and Family Development, National Council of Social Service and Institute of Mental health. The content was cureated by the mindline.sg team and vetted by a clinical review panel which included clinicians from IMH and Fei Yue Community Services. | Behavioural | Intervention |
Primary outcome
Mental health symptoms by 21-item Depression, Anxiety and Stress Scale (DASS-21)
Time frame: Screening, baseline, 4 weeks after baseline, 12 weeks after baseline
The Depression, Anxiety and Stress Scale - 21 Items (DASS-21) is a set of three self-report scales designed to measure the emotional states of depression, anxiety and stress. Each of the three DASS-21 scales contains 7 items, divided into subscales with similar content. The depression scale assesses dysphoria, hopelessness, devaluation of life, self-deprecation, lack of interest / involvement, anhedonia and inertia. The anxiety scale assesses autonomic arousal, skeletal muscle effects, situational anxiety, and subjective experience of anxious affect. The stress scale is sensitive to levels of chronic non-specific arousal. It assesses difficulty relaxing, nervous arousal, and being easily upset / agitated, irritable / over-reactive and impatient. Scores for depression, anxiety and stress are calculated by summing the scores for the relevant items. Higher scores indicate higher severity of symptoms.
Quality of Life by 6-item EQ-5D-5L scale
Time frame: Baseline, 4 weeks after baseline, 12 weeks after baseline
The 5-level EQ-5D version (EQ-5D-5L) was introduced by the EuroQol Group in 2009 to improve the instrument's sensitivity and to reduce ceiling effects, as compared to the EQ-5D-3L. The EQ-5D-5L essentially consists of 2 pages: the EQ-5D descriptive system and the EQ visual analogue scale (EQ VAS). The descriptive system comprises five dimensions: mobility, self-care, usual activities, pain/discomfort and anxiety/depression. Each dimension has 5 levels: no problems, slight problems, moderate problems, severe problems and extreme problems. The patient is asked to indicate his/her health state by ticking the box next to the most appropriate statement in each of the five dimensions. This decision results in a 1-digit number that expresses the level selected for that dimension. The digits for the five dimensions can be combined into a 5-digit number that describes the patient's health state.
Work productivity by WHO-HPQ measure of absenteeism and presenteeism
Time frame: 4 weeks after baseline, 12 weeks after baseline
Absenteeism questions included both sickness absence and non-sickness absence. The questions asked about the number of days in the past 1 year that participants were absent due to health-related problem and non-health-related conditions separately. The questions about presenteeism asked the number of days in the past 1 year that participants had come to work while sick, felt they should take sick leave or were incapable of working with full performance.
6 secondary outcomes
Resilience by 10-item Connor-Davidson Resilience Scale
Time frame: Baseline, 4 weeks after baseline, 12 weeks after baseline
Attitudes, knowledge and behaviours regarding mental health and help-seeking by the Mental Help Seeking Attitudes Scale (MHSAS)
Time frame: Baseline, 4 weeks after baseline, 12 weeks after baseline
Positive psychology by the Cantril Ladder and the WHO-5 Wellbeing Index
Time frame: Baseline, 4 weeks after baseline, 12 weeks after baseline
Emotion regulation by DERS-18
Time frame: Baseline, 4 weeks after baseline, 12 weeks after baseline
Self-reported usage patterns of mindline.sg
Time frame: Baseline, during intervention, 4 weeks after baseline, 12 weeks after baseline
Cost-effectiveness of mindline.sg
Time frame: Baseline, 4 weeks after baseline, 12 weeks after baseline
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Jun 2026.
- Background: PubMed 33465034Saw YE, Tan EY, Liu JS, Liu JC. Predicting Public Uptake of Digital Contact Tracing During the COVID-19 Pandemic: Results From a Nationwide Survey in Singapore. J Med Internet Res. 2021 Feb 3;23(2):e24730. doi: 10.2196/24730.
- Background: PubMed 34881720Tan EY, Wee RR, Saw YE, Heng KJ, Chin JW, Tong EM, Liu JC. Tracking Private WhatsApp Discourse About COVID-19 in Singapore: Longitudinal Infodemiology Study. J Med Internet Res. 2021 Dec 23;23(12):e34218. doi: 10.2196/34218.
- Background: PubMed 36036971Barsova T, Cheong ZG, Mak AR, Liu JC. Predicting Psychological Symptoms When Facebook's Digital Well-being Features Are Used: Cross-sectional Survey Study. JMIR Form Res. 2022 Aug 29;6(8):e39387. doi: 10.2196/39387.
- BackgroundErdembileg, S., Asplund, C. L., & Liu, J. C. J. (in preparation). Engagement with Taylor Swift's music and social media content predicts mental health outcomes in youths: Cross-sectional survey study.
- Intervention websiteLink provided by the sponsor.
- Individual participant dataSharing planned: No
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Metabolic Impact of VLCPUFA-Rich Fish Oil: A Clinical Study on Omega-3 Index Enhancement in Healthy Individuals
Fatty Acids, Omega-3, Fish Oils
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Jean Liu, PhD principal investigator
National University of Singapore, Yong Loo Lin School of Medicine.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing mindline.sg in people with Healthy, run by Centre for Evidence and Implementation Singapore Ltd at 1 site in Singapore.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 12 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Singapore. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Mental health symptoms by 21-item Depression, Anxiety and Stress Scale (DASS-21) (time frame: Screening, baseline, 4 weeks after baseline, 12 weeks after baseline). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07209904, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Jun 2026.