Implant DentistryNCT07212985
Horizontal Anterior Maxillary Ridge Augmentation Using Autogenous Ring Block Grafts Combined With Particulate Xenogeneic Bone Versus Biphasic Beta-tri-calcium Phosphate Sulphate EthOss Graft: A Clinical Study
A study testing Autogenous Bone Block + Xenograft + Collagen Membrane in people with Implant Dentistry, run by Al-Azhar University at 1 site in Egypt.
Trial summary
. Group A, received ABG cylinders obtained from the chin and organic bovine bone mineral particles (Bio-Oss xenograft) along with an absorbable collagen membrane. ABG cylinders from the chin and biphasic alloplastic (EthOss) grafting material made of CS (35%) and TCP (65%) were given to Group B. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Implant Dentistry
- What is being tested?
- Autogenous Bone Block + Xenograft + Collagen Membrane
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteEgypt
- Study dates
- 5 Jan 2023to 18 Jun 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Adults ≥18 years requiring implant-supported restoration in the anterior maxilla
- Horizontal alveolar bone deficiency <4 mm (Cawood \& Howell Class III-IV)
- Satisfactory oral hygiene
- No previous bone augmentation at study site
Who cannot join
- Uncontrolled systemic diseases
- History of head/neck irradiation or immunosuppression
- Oral lesions (e.g., lichen planus)
- Ongoing or recent IV bisphosphonate therapy
- Untreated periodontitis or poor oral hygiene
- Parafunctional habits, pregnancy, psychiatric disorders
- Recent tobacco use
Trial locations and contacts
1 site in 1 country.
Egypt1 site
Faculty of Oral and Dental Medicine, Nahda University,Taibah University
Cairo
About this study
. Group A, received ABG cylinders obtained from the chin and organic bovine bone mineral particles (Bio-Oss xenograft) along with an absorbable collagen membrane. ABG cylinders from the chin and biphasic alloplastic (EthOss) grafting material made of CS (35%) and TCP (65%) were given to Group B. CBCT scans were conducted before bone augmentation surgery, one week and 6 months postoperatively
Read the detailed description
Two groups of forty patients participated in this prospective, controlled, randomized clinical investigation. Group A, received ABG cylinders obtained from the chin and organic bovine bone mineral particles (Bio-Oss xenograft) along with an absorbable collagen membrane. ABG cylinders from the chin and biphasic alloplastic (EthOss) grafting material made of CS (35%) and TCP (65%) were given to Group B. CBCT scans were conducted before bone augmentation surgery, one week and 6 months postoperatively
- Conditions
- Implant Dentistry
- Being tested
- Autogenous Bone Block + Xenograft + Collagen Membrane
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Autogenous Bone Block + Xenograft + Collagen MembraneProcedure or surgery
Autogenous chin bone block graft combined with particulate bovine xenograft (Bio-Oss, Geistlich Pharma AG) and covered with an absorbable collagen membrane (Bio-Gide).
| Study group | Role | What they receive |
|---|---|---|
| ABG + Xenograft + Collagen Membrane | Experimental | Patients receive autogenous bone block graft (from chin) combined with particulate bovine xenograft (Bio-Oss, Geistlich Pharma AG) and covered with absorbable collagen membrane (Bio-Gide). Receives: Procedure: Autogenous Bone Block + Xenograft + Collagen Membrane |
| ABG + EthOss (Synthetic Graft) | Experimental | Patients receive autogenous bone block graft (from chin) combined with EthOss, a biphasic synthetic graft material (35% calcium sulfate, 65% β-tricalcium phosphate). Receives: Procedure: Autogenous Bone Block + Xenograft + Collagen Membrane |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in horizontal alveolar ridge width
Measured: Baseline, 1 week, and 6 months post-surgery
Secondary outcomes (1)
Postoperative complications
Measured: Up to 6 months post-surgery
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Oct 2025
- Study start5 Jan 2023
- Primary completion5 Jun 2024
- Study completion18 Jun 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Implant DentistryStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 40 participants (actual)
Sponsor and investigators
- Lead sponsor
- Al-Azhar University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Nora Abdelgawad Mohamed, Al-Azhar University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07212985
- Sponsor's protocol ID
- REC-PD-24-22
- Status last verified
- Oct 2025
- First submitted
- 1 Oct 2025
- Last updated
- 8 Oct 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 8 Oct 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Horizontal Anterior Maxillary Ridge Augmentation Using Autogenous Ring Block Grafts Combined With Particulate Xenogeneic Bone Versus Biphasic Beta-tri-calcium Phosphate Sulphate EthOss Graft: A Clinical Study
- ClinicalTrials.gov ID
- NCT07212985
- Acronym / sponsor ID
- REC-PD-24-22
- Conditions
- Implant Dentistry
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 40 participants (actual)
- Lead sponsor
- Al-Azhar UniversityUniversity, hospital or other
- Study start
- 5 Jan 2023 (actual)
- Primary completion
- 5 Jun 2024 (actual)
- Study completion
- 18 Jun 2024 (actual)
- First posted
- 8 Oct 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
. Group A, received ABG cylinders obtained from the chin and organic bovine bone mineral particles (Bio-Oss xenograft) along with an absorbable collagen membrane. ABG cylinders from the chin and biphasic alloplastic (EthOss) grafting material made of CS (35%) and TCP (65%) were given to Group B. CBCT scans were conducted before bone augmentation surgery, one week and 6 months postoperatively
Detailed description
Two groups of forty patients participated in this prospective, controlled, randomized clinical investigation. Group A, received ABG cylinders obtained from the chin and organic bovine bone mineral particles (Bio-Oss xenograft) along with an absorbable collagen membrane. ABG cylinders from the chin and biphasic alloplastic (EthOss) grafting material made of CS (35%) and TCP (65%) were given to Group B. CBCT scans were conducted before bone augmentation surgery, one week and 6 months postoperatively
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| ABG + Xenograft + Collagen Membrane | Experimental | Procedure: Autogenous Bone Block + Xenograft + Collagen MembranePatients receive autogenous bone block graft (from chin) combined with particulate bovine xenograft (Bio-Oss, Geistlich Pharma AG) and covered with absorbable collagen membrane (Bio-Gide). |
| ABG + EthOss (Synthetic Graft) | Experimental | Procedure: Autogenous Bone Block + Xenograft + Collagen MembranePatients receive autogenous bone block graft (from chin) combined with EthOss, a biphasic synthetic graft material (35% calcium sulfate, 65% β-tricalcium phosphate). |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Adults ≥18 years requiring implant-supported restoration in the anterior maxilla
- Horizontal alveolar bone deficiency <4 mm (Cawood \& Howell Class III-IV)
- Satisfactory oral hygiene
- No previous bone augmentation at study site
Key exclusion criteria (7 listed)
- Uncontrolled systemic diseases
- History of head/neck irradiation or immunosuppression
- Oral lesions (e.g., lichen planus)
- Ongoing or recent IV bisphosphonate therapy
- Untreated periodontitis or poor oral hygiene
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Autogenous Bone Block + Xenograft + Collagen MembraneAutogenous chin bone block graft combined with particulate bovine xenograft (Bio-Oss, Geistlich Pharma AG) and covered with an absorbable collagen membrane (Bio-Gide). | Procedure or surgery | ABG + EthOss (Synthetic Graft), ABG + Xenograft + Collagen Membrane |
Primary outcome
Change in horizontal alveolar ridge width
Time frame: Baseline, 1 week, and 6 months post-surgery
1 secondary outcome
Postoperative complications
Time frame: Up to 6 months post-surgery
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Oct 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Autogenous Bone Block + Xenograft + Collagen Membrane in people with Implant Dentistry, run by Al-Azhar University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 8 Oct 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in horizontal alveolar ridge width (time frame: Baseline, 1 week, and 6 months post-surgery). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Oct 2025.