PeriodontitisNCT07213752

Diode Laser-Assisted Periodontal Therapy Enhances Clinical Outcomes for Deep Periodontal Pockets in Smokers

A study testing Diode Laser Application in Deep Periodontal Pockets, Professional Mechanical Plaque Removal and Scaling and Root Planing in people with Periodontitis and Periodontitis Stage III, run by Selcuk University at 1 site in Turkey (Türkiye).

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record

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Trial summary

Who is it for?: Ages 18 years and olderHealthy volunteers can take part
Conditions the study is for: Periodontitis, Periodontitis Stage III, Periodontal Disease
What is being tested?: Diode Laser Application in Deep Periodontal Pockets, Professional Mechanical Plaque Removal and Scaling and Root Planing
Type of treatment: Medical device, Surgery or procedure
Could I receive a placebo?: No, everyone receives an active treatment
How many people: 33 participants
Where: 1 siteTurkey (Türkiye)
Study dates: 10 Dec 2023to 5 Jun 2025
Phase: Interventional
Are there results?: None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 18 years and older
All sexes
Healthy volunteers accepted
Adult, Older adult

Who may be able to join

no periodontal treatment within the previous 6 months;
no use of antibiotics within the previous 3 months;
no systemic disease and alcohol drinkers, or drug users;
no use of anti-inflammatory drugs within the past 3 months;
no pregnancy;
no use of hormonal contraceptives; and
current smokers with a history of smoking ≥10 cigarettes per day for at least one year.

Who cannot join

Patients with <20 teeth, grade III tooth mobility, partial dentures, or fixed prostheses were excluded. Additionally, those with dental implants or peri-implant diseases were also excluded.

Trial locations and contacts

1 site in 1 country.

Turkey (Türkiye)1 site

Selcuk University Faculty of Dentistry Department of Periodontology
Konya, Selçuklu, 42250

Other trials in Turkey (Türkiye)

About this study

Official title: Diode Laser-Assisted Periodontal Therapy Enhances Clinical Outcomes for Deep Periodontal Pockets in Smokers: A Randomized Clinical Trial

This study investigated the adjunctive effects of diode laser therapy in smokers with severe periodontitis. Thirty-three patients were randomized to non-surgical periodontal therapy (SRP) with or without diode laser. Clinical parameters and salivary oxidative stress markers (MDA, 8-OHdG) were assessed at baseline, 1, and 3 months. Both groups showed improvements, but SRP+DL resulted in significantly greater reductions in deep pockets, PISA, PESA, PI, and MDA at 3 months. These findings suggest that diode laser therapy may enhance conventional treatment by improving clinical outcomes and reducing oxidative stress in smokers with severe periodontitis.

Conditions: Periodontitis, Periodontitis Stage III, Periodontal Disease, Diode Laser Therapy, Smoking, Malondialdehyde
Being tested: Diode Laser Application in Deep Periodontal Pockets, Professional Mechanical Plaque Removal, Scaling and Root Planing
Keywords: adjunctive periodontal treatment, diode laser therapy, non-surgical periodontal therapy, smokers with periodontitis, malondialdehyde, 8-hydroxy-2'-deoxyguanosine
Medical subject headings: Periodontitis, Periodontal Diseases, Smoking

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Diode Laser Application in Deep Periodontal PocketsDevice
A 940 nm indium-gallium-aluminum-phosphate diode laser (Ezlase, Biolase, USA) with a 400 μm fiber was used in contact mode at 1.5 W, pulse 20/20 ms, 20 s/cm², power density 1.061 W/cm², and 15 J/cm² energy in deep periodontal pockets.
Professional Mechanical Plaque RemovalProcedure or surgery
Professional mechanical removal of supragingival plaque and calculus
Scaling and Root PlaningProcedure or surgery
Subgingival scaling and root planing

Study groups in NCT07213752
Study group	Role	What they receive
Stage III Grade C :Non surgical periodontal therapy and an adjunct diode laser use	Experimental	Not described Receives: Device: Diode Laser Application in Deep Periodontal Pockets; Procedure: Professional Mechanical Plaque Removal; Procedure: Scaling and Root Planing
Stage III Grade C :Non surgical periodontal therapy	Experimental	Not described Receives: Procedure: Professional Mechanical Plaque Removal; Procedure: Scaling and Root Planing

What is being measured

The primary outcome is the main question the study is designed to answer.

Probing Pocket Dept (PPD)
The probing pocket dept was assessed on six tooth surfaces, inluding the mesiobuccal, buccal, distobuccal, mesiolingual, lingual and distolingual areas of each tooth.
Measured: Through study completion, an average of 3 months.
Periodontal Epithelial Surface Area (PESA)
PESA represents the total epithelial surface area in periodontal pockets.
Measured: Through study completion, an average of 3 months.
Periodontal Inflamed Surface Area (PISA)
PISA quantifies the inflamed portion of this surface area by integrating only sites exhibiting BOP, both measured in mm2.
Measured: Through study completion, an average of 3 months.
Salivary Malondialdehyde Levels
Evaluation of salivary malondialdehyde levels.
Measured: Through study completion, an average of 3 months.
Salivary 8-hydroxy-2'-deoxyguanosine Levels
Evaluation of salivary 8-hydroxy-2'-deoxyguanosine levels.
Measured: Through study completion, an average of 3 months.
PPD ≥4 mm, site-specific PPD (ssPPD)
For sites with PPD ≥4 mm, site-specific PPD (ssPPD) values was calculated.
Measured: Through study completion, an average of 3 months.
PPD ≥4 mm, site spesific CAL (ssCAL)
For sites with PPD ≥4 mm, site spesific CAL (ssCAL) values were also calculated.
Measured: Through study completion, an average of 3 months.
PPD ≥4 mm, site-specific PISA (ssPISA)
For sites with PPD ≥4 mm, site-specific PISA (ssPISA) values were calculated.
Measured: Through study completion, an average of 3 months.
PPD ≥4 mm, site-specific PESA (ssPESA)
For sites with PPD ≥4 mm, site-specific PESA (ssPESA) values were calculated.
Measured: Through study completion, an average of 3 months.

Secondary outcomes (4)

Plaque Index (PI)
The plaque index was assessed on six tooth surfaces, inluding the mesiobuccal, buccal, distobuccal, mesiolingual, lingual and distolingual areas of each tooth.
Measured: Through study completion, an average of 3 months.
Bleeding on Probing (BOP)
The bleeding on probing index was assessed on six tooth surfaces, inluding the mesiobuccal, buccal, distobuccal, mesiolingual, lingual and distolingual areas of each tooth.
Measured: Through study completion, an average of 3 months.
Clinical Attachment Level (CAL)
The clinical attachment level was assessed on six tooth surfaces, inluding the mesiobuccal, buccal, distobuccal, mesiolingual, lingual and distolingual areas of each tooth.
Measured: Through study completion, an average of 3 months.
Gingival Index (GI)
The gingival index was assessed on six tooth surfaces, inluding the mesiobuccal, buccal, distobuccal, mesiolingual, lingual and distolingual areas of each tooth.
Measured: Through study completion, an average of 3 months.

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

10 Dec 20235 Jun 2025

First posted9 Oct 2025
Study start10 Dec 2023
Primary completion21 Jan 2025
Study completion5 Jun 2025

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Other trials for PeriodontitisStudies of the same condition, open and under way.
More trials run by Selcuk UniversityThe sponsor's other registered studies.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase N/A
Primary purpose: Treatment
Allocation: Randomised
Intervention model: Parallel groups
Masking: Single blind
Who is masked: Outcomes assessor
Enrolment: 33 participants (actual)

IDs, dates and publications

ClinicalTrials.gov ID: NCT07213752
Sponsor's protocol ID: SU-DIAE-01
Status last verified: Dec 2023
First submitted: 29 Sep 2025
Last updated: 9 Oct 2025
Results posted: No
Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: Yes

Want to know more?

The sponsor has not listed a contact. The official record may have more details.

Talk to your doctor first and take this page with you. Only the study team can confirm whether you can join.

Questions to ask the study team

What is the study trying to find out?
What would I need to do, and how often would I visit?
Could I receive a placebo instead of the treatment?
What are the possible risks and benefits for me?
Will it cost me anything? Are travel or time paid for?
Can I keep seeing my own doctor during the study?
What happens when the study ends?

See locations

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Effect of Cryotherapeutic and Nanotherapeutic Sodium Hypochlorite on Post-Operative Endodontic Pain.
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A Retrospective Comparative Evaluation of Omega-3 and Resveratrol Supplementation in Patients With Periodontitis
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Probiotics Versus Antibiotics as an Adjuvant to Non-surgical Periodontal Treatment Among Smokers With Stage II, Grade B Periodontitis
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All Periodontitis trials

Study at a glance

From the registry record, last updated by the sponsor on 9 Oct 2025. Recruitment status is as the sponsor reported it: confirm with the study team.

Official title: Diode Laser-Assisted Periodontal Therapy Enhances Clinical Outcomes for Deep Periodontal Pockets in Smokers: A Randomized Clinical Trial
ClinicalTrials.gov ID: NCT07213752
Acronym / sponsor ID: SU-DIAE-01
Conditions: Periodontitis, Periodontitis Stage III, Periodontal Disease, Diode Laser Therapy, Smoking, Malondialdehyde
Keywords: adjunctive periodontal treatment, diode laser therapy, non-surgical periodontal therapy, smokers with periodontitis, malondialdehyde, 8-hydroxy-2'-deoxyguanosine
Study type: Interventional
Recruitment status: Completed
Enrolment: 33 participants (actual)
Lead sponsor: Selcuk UniversityUniversity, hospital or other
Collaborators: The Scientific and Technological Research Council of Turkey
Study start: 10 Dec 2023 (actual)
Primary completion: 21 Jan 2025 (actual)
Study completion: 5 Jun 2025 (actual)
First posted: 9 Oct 2025 (actual)
Results: Not posted in the source record

Clinical summary

The research question as the sponsor registered it. This describes what the study plans to test, not what it found.

Study design

Primary purpose: Treatment
Allocation: Randomised
Intervention model: Parallel groups
Masking: Single blind (outcomes assessor)
Number of arms: 2

Arm	Type	Receives
Stage III Grade C :Non surgical periodontal therapy and an adjunct diode laser use	Experimental	Device: Diode Laser Application in Deep Periodontal Pockets, Procedure: Professional Mechanical Plaque Removal, Procedure: Scaling and Root Planing
Stage III Grade C :Non surgical periodontal therapy	Experimental	Procedure: Professional Mechanical Plaque Removal, Procedure: Scaling and Root Planing

Who may qualify

Ages: 18 years and older
Sex: All
Healthy volunteers: Accepted
Age groups: Adult, Older adult

Key inclusion criteria (7 listed)

no periodontal treatment within the previous 6 months;
no use of antibiotics within the previous 3 months;
no systemic disease and alcohol drinkers, or drug users;
no use of anti-inflammatory drugs within the past 3 months;
no pregnancy;

Key exclusion criteria (1 listed)

Patients with <20 teeth, grade III tooth mobility, partial dentures, or fixed prostheses were excluded. Additionally, those with dental implants or peri-implant diseases were also excluded.

Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.

Interventions

Intervention	Type	Arms
Diode Laser Application in Deep Periodontal PocketsA 940 nm indium-gallium-aluminum-phosphate diode laser (Ezlase, Biolase, USA) with a 400 μm fiber was used in contact mode at 1.5 W, pulse 20/20 ms, 20 s/cm², power density 1.061 W/cm², and 15 J/cm² energy in deep periodontal pockets.	Device	Stage III Grade C :Non surgical periodontal therapy and an adjunct diode laser use
Professional Mechanical Plaque RemovalProfessional mechanical removal of supragingival plaque and calculus	Procedure or surgery	Stage III Grade C :Non surgical periodontal therapy, Stage III Grade C :Non surgical periodontal therapy and an adjunct diode laser use
Scaling and Root PlaningSubgingival scaling and root planing	Procedure or surgery	Stage III Grade C :Non surgical periodontal therapy, Stage III Grade C :Non surgical periodontal therapy and an adjunct diode laser use

Primary outcome

Probing Pocket Dept (PPD)
Time frame: Through study completion, an average of 3 months.
The probing pocket dept was assessed on six tooth surfaces, inluding the mesiobuccal, buccal, distobuccal, mesiolingual, lingual and distolingual areas of each tooth.
Periodontal Epithelial Surface Area (PESA)
Time frame: Through study completion, an average of 3 months.
PESA represents the total epithelial surface area in periodontal pockets.
Periodontal Inflamed Surface Area (PISA)
Time frame: Through study completion, an average of 3 months.
PISA quantifies the inflamed portion of this surface area by integrating only sites exhibiting BOP, both measured in mm2.
Salivary Malondialdehyde Levels
Time frame: Through study completion, an average of 3 months.
Evaluation of salivary malondialdehyde levels.
Salivary 8-hydroxy-2'-deoxyguanosine Levels
Time frame: Through study completion, an average of 3 months.
Evaluation of salivary 8-hydroxy-2'-deoxyguanosine levels.
PPD ≥4 mm, site-specific PPD (ssPPD)
Time frame: Through study completion, an average of 3 months.
For sites with PPD ≥4 mm, site-specific PPD (ssPPD) values was calculated.
PPD ≥4 mm, site spesific CAL (ssCAL)
Time frame: Through study completion, an average of 3 months.
For sites with PPD ≥4 mm, site spesific CAL (ssCAL) values were also calculated.
PPD ≥4 mm, site-specific PISA (ssPISA)
Time frame: Through study completion, an average of 3 months.
For sites with PPD ≥4 mm, site-specific PISA (ssPISA) values were calculated.
PPD ≥4 mm, site-specific PESA (ssPESA)
Time frame: Through study completion, an average of 3 months.
For sites with PPD ≥4 mm, site-specific PESA (ssPESA) values were calculated.

4 secondary outcomes

Plaque Index (PI)
Time frame: Through study completion, an average of 3 months.
Bleeding on Probing (BOP)
Time frame: Through study completion, an average of 3 months.
Clinical Attachment Level (CAL)
Time frame: Through study completion, an average of 3 months.
Gingival Index (GI)
Time frame: Through study completion, an average of 3 months.

Results and safety

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

Research links

Official record on ClinicalTrials.govLast updated by the sponsor 9 Oct 2025.

Related trials for Periodontitis

Recruiting
Effect of Cryotherapeutic and Nanotherapeutic Sodium Hypochlorite on Post-Operative Endodontic Pain.
Symptomatic Irreversible Pulpitis, Symptomatic Apical Periodontitis
Active, not recruitingObservational study
A Retrospective Comparative Evaluation of Omega-3 and Resveratrol Supplementation in Patients With Periodontitis
Periodontitis
Recruiting
Probiotics Versus Antibiotics as an Adjuvant to Non-surgical Periodontal Treatment Among Smokers With Stage II, Grade B Periodontitis
Probiotics, Antibiotics
Recruiting
Effects of Different Activation Techniques on Antimicrobial Photodynamic Therapy in Apical Periodontitis
Apical Periodontitis, Endodontic Retreatment
Recruiting
Ozone Gel Versus Chlorohexidine Gel as an Adjunct to Non-Surgical Treatment of Stage II Periodontitis Grade B Among Smokers Patients
Ozone Gel, Chlorohexidine Gel

Referral and contact

AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.

The record lists no contact. Use the official record to reach the sponsor.

1 site in 1 country: see every site and its status.

Questions about this trial

What is this clinical trial studying?

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 7 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 9 Oct 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Probing Pocket Dept (PPD) (time frame: Through study completion, an average of 3 months.). The study lists 9 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07213752.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Oct 2025.