Heavy Metal Exposure From VapingNCT07215065
Examining Heavy Metal Exposure and Respiratory Health in Young Adult Electronic Cigarette Users
An observational study of Heavy Metal Exposure From Vaping, run by Ohio State University Comprehensive Cancer Center at 1 site in United States.
Trial summary
This study investigates heavy metal exposure in young adults who use electronic cigarettes. Read more about this study
- Who is it for?
- Ages 18 to 29 yearsHealthy volunteers can take part
- Conditions the study is for
- Heavy Metal Exposure From Vaping
- What is being tested?
- Non-Interventional Study
- How many people
- 58 participants
- Where
- 1 siteUnited States
- Study dates
- 22 Oct 2025to 27 Feb 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 29 years
- All sexes
- Healthy volunteers accepted
- Adult
Study population: Young adults (aged 18 - 29 years) who are established and current EC users.
Who may be able to join
- Aged 18-29 years
- Established electronic cigarette (EC) user (participant uses ECs on a daily/weekly basis [used on ≥ 5 days in past 30-days] for the past 3 months)
- Willing to abstain from nicotine for at least 12 hours before the laboratory visit
- Willing to not eat food or drink water/beverages for at least 30 minutes before the laboratory visit [required for salivary collection]
- Utilize 4th generation EC products (pod-mod or disposable EC products; e.g., JUUL, Hyde)
- Must be able to read and write in English
Who cannot join
- Recently COVID-19+ (defined as a positive test in the past 30 days) or a recent COVID-19 hospitalization (within the past 6 months)
- Attempting to quit the use of ECs
- Is pregnant, planning on becoming pregnant and/or breastfeeding [will be verified using a urine pregnancy test]
- Self-reported severe or significant psychological and/or psychiatric conditions [e.g., not currently receiving treatment/medication; only past and/or stable conditions will be allowed]
- A history of cardiac events and/or distress within the past 3 months
- Diagnosed with a chronic, serious lung disease or current infection (e.g., pneumonia, pulmonary edema)
- Are deaf, hard of hearing, or have a severe motor disability
Trial locations and contacts
1 site in 1 country.
United States1 site
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210
About this study
This study investigates heavy metal exposure in young adults who use electronic cigarettes.
Read the detailed description
PRIMARY OBJECTIVES:
- Identify and quantify heavy metals (HM) concentration in the saliva of e-cigarette users.
II. Examine changes in pulmonary functioning and HM concentration pre/post vaping.
III. Examine the association between vaping intensity and HM concentration in the saliva of e-cigarette users.
OUTLINE: This is an observational study.
Participants vape their own electronic cigarette device as much or as little as they like over 30 minutes on study. Participants also undergo saliva sample collection, spirometry to measure respiratory function, and complete questionnaires.
- Conditions
- Heavy Metal Exposure From Vaping
- Being tested
- Non-Interventional Study
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Non-Interventional StudyOther
Also called Non-Interventional Observational Study
Non-Interventional Study
| Study group | Role | What they receive |
|---|---|---|
| Observational | Participants vape their own electronic cigarette device as much or as little as they like over 30 minutes on study. Participants also undergo saliva sample collection, spirometry to measure respiratory function, and complete questionnaires. Receives: Other: Non-Interventional Study |
What is being measured
The primary outcome is the main question the study is designed to answer.
Heavy metal concentration in the saliva of e-cigarette users
Identify and quantify HM concentrations in the saliva among all participants in the sample before and after their 30 minute vaping session.
Measured: Baseline, Immediately Following Vaping Session
Spirometry to Measure the Change From Baseline in Forced Vital Capacity (FVC)
Participants will complete spirometry (a pulmonary function test) before and immediately after the completion of the 30 minute vaping session.
Measured: Baseline, Immediately Following Vaping Session
Spirometry to Measure the Change From Baseline in Forced Expiratory Volume in One Second (FEV1)
Participants will complete spirometry (a pulmonary function test) before and immediately after the completion of the 30 minute vaping session.
Measured: Baseline, Immediately Following Vaping Session
E-cigarette puffing behavior
E-cigarette puffing behavior will be measured with a topography device that records frequency, duration, and flow rate of e-cigarette puffs. These measures are combined to inform the overall measure of e-cigarette puffing behavior.
Measured: Up to 30 minutes
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Oct 2025
- Study start22 Oct 2025
- Primary completion27 Feb 2026
- Study completion27 Feb 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Heavy Metal Exposure From VapingStudies of the same condition, open and under way.
- More trials run by Ohio State University Comprehensive Cancer CenterThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Cross-sectional
- Enrolment
- 58 participants (actual)
Sponsor and investigators
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Alayna Tackett, Ohio State University Comprehensive Cancer Center
- Investigators
- Alayna P Tackett, PhD, Principal investigator, Ohio State University Comprehensive Cancer Center
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07215065
- Sponsor's protocol ID
- OSU-25119
- Other IDs
- NCI-2025-06572
- Status last verified
- May 2026
- First submitted
- 8 Oct 2025
- Last updated
- 20 May 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 20 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Examining Heavy Metal Exposure and Respiratory Health in Young Adult Electronic Cigarette Users
- ClinicalTrials.gov ID
- NCT07215065
- Acronym / sponsor ID
- OSU-25119
- Conditions
- Heavy Metal Exposure From Vaping
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 58 participants (actual)
- Lead sponsor
- Ohio State University Comprehensive Cancer CenterUniversity, hospital or other
- Study start
- 22 Oct 2025 (actual)
- Primary completion
- 27 Feb 2026 (actual)
- Study completion
- 27 Feb 2026 (actual)
- First posted
- 10 Oct 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study investigates heavy metal exposure in young adults who use electronic cigarettes.
Detailed description
PRIMARY OBJECTIVES:
- Identify and quantify heavy metals (HM) concentration in the saliva of e-cigarette users.
II. Examine changes in pulmonary functioning and HM concentration pre/post vaping.
III. Examine the association between vaping intensity and HM concentration in the saliva of e-cigarette users.
OUTLINE: This is an observational study.
Participants vape their own electronic cigarette device as much or as little as they like over 30 minutes on study. Participants also undergo saliva sample collection, spirometry to measure respiratory function, and complete questionnaires.
Study design
- Observational model
- Case only
- Time perspective
- Cross-sectional
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Observational | – | Other: Non-Interventional StudyParticipants vape their own electronic cigarette device as much or as little as they like over 30 minutes on study. Participants also undergo saliva sample collection, spirometry to measure respiratory function, and complete questionnaires. |
Who may qualify
- Ages
- 18 to 29 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
- Study population
- Young adults (aged 18 - 29 years) who are established and current EC users.
Key inclusion criteria (6 listed)
- Aged 18-29 years
- Established electronic cigarette (EC) user (participant uses ECs on a daily/weekly basis [used on ≥ 5 days in past 30-days] for the past 3 months)
- Willing to abstain from nicotine for at least 12 hours before the laboratory visit
- Willing to not eat food or drink water/beverages for at least 30 minutes before the laboratory visit [required for salivary collection]
- Utilize 4th generation EC products (pod-mod or disposable EC products; e.g., JUUL, Hyde)
Key exclusion criteria (7 listed)
- Recently COVID-19+ (defined as a positive test in the past 30 days) or a recent COVID-19 hospitalization (within the past 6 months)
- Attempting to quit the use of ECs
- Is pregnant, planning on becoming pregnant and/or breastfeeding [will be verified using a urine pregnancy test]
- Self-reported severe or significant psychological and/or psychiatric conditions [e.g., not currently receiving treatment/medication; only past and/or stable conditions will be allowed]
- A history of cardiac events and/or distress within the past 3 months
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Non-Interventional StudyAlso: Non-Interventional Observational StudyNon-Interventional Study | Other | Observational |
Primary outcome
Heavy metal concentration in the saliva of e-cigarette users
Time frame: Baseline, Immediately Following Vaping Session
Identify and quantify HM concentrations in the saliva among all participants in the sample before and after their 30 minute vaping session.
Spirometry to Measure the Change From Baseline in Forced Vital Capacity (FVC)
Time frame: Baseline, Immediately Following Vaping Session
Participants will complete spirometry (a pulmonary function test) before and immediately after the completion of the 30 minute vaping session.
Spirometry to Measure the Change From Baseline in Forced Expiratory Volume in One Second (FEV1)
Time frame: Baseline, Immediately Following Vaping Session
Participants will complete spirometry (a pulmonary function test) before and immediately after the completion of the 30 minute vaping session.
E-cigarette puffing behavior
Time frame: Up to 30 minutes
E-cigarette puffing behavior will be measured with a topography device that records frequency, duration, and flow rate of e-cigarette puffs. These measures are combined to inform the overall measure of e-cigarette puffing behavior.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 May 2026.
- The JameslineLink provided by the sponsor.
- Individual participant dataSharing planned: No
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Alayna P Tackett, PhD principal investigator
Ohio State University Comprehensive Cancer Center
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Heavy Metal Exposure From Vaping, run by Ohio State University Comprehensive Cancer Center at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 20 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Heavy metal concentration in the saliva of e-cigarette users (time frame: Baseline, Immediately Following Vaping Session). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 May 2026.