OcclusionNCT07215208
Abutment Analysis of Metallic Denture Frameworks in Mandibular Kenedy Class III Cases
A study testing CAD/CAM metallic partial denture frameworks and Conventional metallic partial denture frameworks in people with Occlusion and Prosthesis Durability, run by Cairo University.
Trial summary
This study is aimed to compare CAD/CAM (digitally fabricated) metallic partial denture frameworks to conventionally fabricated metallic partial denture frameworks in mandibular Kennedy class-III arches in terms of abutment health and occlusal analysis Read more about this study
- Who is it for?
- Any ageHealthy volunteers can take part
- Conditions the study is for
- Occlusion, Prosthesis Durability
- What is being tested?
- CAD/CAM metallic partial denture frameworks and Conventional metallic partial denture frameworks
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 22 participants
- Where
- No sites listed yet
- Study dates
- Oct 2025to Jan 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Who may be able to join
- Patients with unilateral bounded saddles in the mandible (Kennedy class III).
- Opposing dentition is fully intact or restored.
- Sufficient inter-arch space.
- Angle's class I maxilla-mandibular relationship.
Who cannot join
- Periodontal affection of the abutment teeth.
- Skeletal mal-relation.
- Unmotivated patients to maintain adequate oral hygiene to follow up.
- Patients with neuromuscular and Psychiatric disorders.
- Systematic disease affecting bone and periodontal health.
- Insufficient inter-arch space.
- Patients with physical disabilities that could affect follow up.
About this study
Official title: Abutment Health and Occlusal Analysis of CAD-CAM and Conventional Metallic Partial Denture Framework in Mandibular Kenedy Class III Cases: A Randomized Cross Over Clinical Trial
This study is aimed to compare CAD/CAM (digitally fabricated) metallic partial denture frameworks to conventionally fabricated metallic partial denture frameworks in mandibular Kennedy class-III arches in terms of abutment health and occlusal analysis
Read the detailed description
Traditional metallic partial dentures with cobalt-chromium frameworks and clasps considered a reliable choice because they're affordable, durable and have a resistance to distortion. However, the fabrication of traditional metallic partial dentures involves several manual steps, like pouring of the stone casts, surveying the hard tissue and soft tissue undercuts to choose the best path of insertion, and meticulously waxing each component (major and minor connectors, rests, clasps, and denture base retainers) directly onto the cast. This hands-on process can result in some fabrication errors, which by in turn can increase the stresses on the teeth supporting the denture (abutments) and even other non-abutment teeth.
CAD/CAM technology is increasingly being used for the fabrication of metallic partial denture frameworks; it has been highlighting in several investigations. The workflow starts with an intra oral digital scan of the oral cavity, to generate a 3D digital model, that allows for electronic surveying. The metallic partial denture frameworks are then designed virtually using specialized software, after which a wax pattern is created by milling or rapid prototyping. Then the wax pattern would be casted conventionally into metallic partial denture frameworks. The key advantages are simplifying the fabrication process, enhance the accuracy of fit, and reduce the stresses on abutment teeth, significant time savings, and reduction of the potential errors inherent in traditional multi-step lab procedures
- Conditions
- Occlusion, Prosthesis Durability
- Being tested
- CAD/CAM metallic partial denture frameworks, Conventional metallic partial denture frameworks
- Medical subject headings
- Bites and Stings, Prosthesis Failure
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
CAD/CAM metallic partial denture frameworksOther
The CAD/CAM workflow starts with scanning of the physical model (master cast) to create a 3D virtual representation. Dental professionals then digitally analyze this virtual model and design the metallic partial denture frameworks using specialized computer software. Once the design is finalized, a wax pattern of the framework is either milled or 3D printed. Then proceeding with this wax pattern to fabricate the final metal partial denture framework, either by conventional casting process, or milling of the metallic framework
Conventional metallic partial denture frameworksOther
The metallic partial denture frameworks have proven to be affordable and convenient treatment option for partially dentate patients for it is rigidity and durability. It can be used in thin sections and provide high strength and stiffness. However, metallic partial denture frameworks also come with several drawbacks. A significant concern for some patients is the metallic display, which can lead to poor esthetics. Other disadvantages include increased prosthesis weight, a potential metallic taste, and a tendency for plaque accumulation. Additionally, they can induce stresses on the abutment teeth
| Study group | Role | What they receive |
|---|---|---|
| CAD/CAM metallic partial denture frameworks | Experimental | The digital technology makes it much easier in fabricating the prosthesis, so by the aid of this technology we can make accurate occlusal scan and jaw relation without annoying of the patient with the impression material. The software makes it much easier in designing and planning for proper established removable metallic partial denture, with one tap we can print the designed wax pattern and continue in the conventional steps of manufacturing the metallic partial denture Receives: Other: CAD/CAM metallic partial denture frameworks |
| Conventional metallic partial denture frameworks | Active comparator | The conventional fabricated metallic partial dentures have been the standard method for fabricating the metallic frameworks. It is a reliable treatment option for the partially edentulous patients and the most commonly used for it is advantageous. The advantages of conventional metallic partial dentures are it considered to be more rigid even if in thin sections, has higher stiffness and strength, thanks to good thermal conductivity of metal it can conduct heat and cold, can be designed to minimize tissue coverage Receives: Other: Conventional metallic partial denture frameworks |
What is being measured
The primary outcome is the main question the study is designed to answer.
Abutment health mobility
Periotest, Periotest value (PTV) which ranges from -8 to +50
Measured: 3 months
Secondary outcomes (1)
Gingival bleeding index
Löe and Silness Gingival Index (GI), GI scale (scores) 0 -3 (with 0 being normal and 3 being severe inflammation)
Measured: 3 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Oct 2025
- Study startOct 2025 (estimated)
- Primary completionJan 2026 (estimated)
- Study completionJan 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for OcclusionStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- \- Prospective, randomized controlled, two-phase, crossover trial.
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 22 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Samah Ahmed Abdallah Sharaka, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07215208
- Sponsor's protocol ID
- Abutment analysis CAD-CAM
- Status last verified
- Sep 2025
- First submitted
- 2 Oct 2025
- Last updated
- 10 Oct 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 10 Oct 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Abutment Health and Occlusal Analysis of CAD-CAM and Conventional Metallic Partial Denture Framework in Mandibular Kenedy Class III Cases: A Randomized Cross Over Clinical Trial
- ClinicalTrials.gov ID
- NCT07215208
- Acronym / sponsor ID
- Abutment analysis CAD-CAM
- Conditions
- Occlusion, Prosthesis Durability
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 22 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- Oct 2025 (estimated)
- Primary completion
- Jan 2026 (estimated)
- Study completion
- Jan 2026 (estimated)
- First posted
- 10 Oct 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study is aimed to compare CAD/CAM (digitally fabricated) metallic partial denture frameworks to conventionally fabricated metallic partial denture frameworks in mandibular Kennedy class-III arches in terms of abutment health and occlusal analysis
Detailed description
Traditional metallic partial dentures with cobalt-chromium frameworks and clasps considered a reliable choice because they're affordable, durable and have a resistance to distortion. However, the fabrication of traditional metallic partial dentures involves several manual steps, like pouring of the stone casts, surveying the hard tissue and soft tissue undercuts to choose the best path of insertion, and meticulously waxing each component (major and minor connectors, rests, clasps, and denture base retainers) directly onto the cast. This hands-on process can result in some fabrication errors, which by in turn can increase the stresses on the teeth supporting the denture (abutments) and even other non-abutment teeth.
CAD/CAM technology is increasingly being used for the fabrication of metallic partial denture frameworks; it has been highlighting in several investigations. The workflow starts with an intra oral digital scan of the oral cavity, to generate a 3D digital model, that allows for electronic surveying. The metallic partial denture frameworks are then designed virtually using specialized software, after which a wax pattern is created by milling or rapid prototyping. Then the wax pattern would be casted conventionally into metallic partial denture frameworks. The key advantages are simplifying the fabrication process, enhance the accuracy of fit, and reduce the stresses on abutment teeth, significant time savings, and reduction of the potential errors inherent in traditional multi-step lab procedures
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
- Model description
- - Prospective, randomized controlled, two-phase, crossover trial.
| Arm | Type | Receives |
|---|---|---|
| CAD/CAM metallic partial denture frameworks | Experimental | Other: CAD/CAM metallic partial denture frameworksThe digital technology makes it much easier in fabricating the prosthesis, so by the aid of this technology we can make accurate occlusal scan and jaw relation without annoying of the patient with the impression material. The software makes it much easier in designing and planning for proper established removable metallic partial denture, with one tap we can print the designed wax pattern and continue in the conventional steps of manufacturing the metallic partial denture |
| Conventional metallic partial denture frameworks | Active comparator | Other: Conventional metallic partial denture frameworksThe conventional fabricated metallic partial dentures have been the standard method for fabricating the metallic frameworks. It is a reliable treatment option for the partially edentulous patients and the most commonly used for it is advantageous. The advantages of conventional metallic partial dentures are it considered to be more rigid even if in thin sections, has higher stiffness and strength, thanks to good thermal conductivity of metal it can conduct heat and cold, can be designed to minimize tissue coverage |
Who may qualify
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (4 listed)
- Patients with unilateral bounded saddles in the mandible (Kennedy class III).
- Opposing dentition is fully intact or restored.
- Sufficient inter-arch space.
- Angle's class I maxilla-mandibular relationship.
Key exclusion criteria (7 listed)
- Periodontal affection of the abutment teeth.
- Skeletal mal-relation.
- Unmotivated patients to maintain adequate oral hygiene to follow up.
- Patients with neuromuscular and Psychiatric disorders.
- Systematic disease affecting bone and periodontal health.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| CAD/CAM metallic partial denture frameworksThe CAD/CAM workflow starts with scanning of the physical model (master cast) to create a 3D virtual representation. Dental professionals then digitally analyze this virtual model and design the metallic partial denture frameworks using specialized computer software. Once the design is finalized, a wax pattern of the framework is either milled or 3D printed. Then proceeding with this wax pattern to fabricate the final metal partial denture framework, either by conventional casting process, or milling of the metallic framework | Other | CAD/CAM metallic partial denture frameworks |
| Conventional metallic partial denture frameworksThe metallic partial denture frameworks have proven to be affordable and convenient treatment option for partially dentate patients for it is rigidity and durability. It can be used in thin sections and provide high strength and stiffness. However, metallic partial denture frameworks also come with several drawbacks. A significant concern for some patients is the metallic display, which can lead to poor esthetics. Other disadvantages include increased prosthesis weight, a potential metallic taste, and a tendency for plaque accumulation. Additionally, they can induce stresses on the abutment teeth | Other | Conventional metallic partial denture frameworks |
Primary outcome
Abutment health mobility
Time frame: 3 months
Periotest, Periotest value (PTV) which ranges from -8 to +50
1 secondary outcome
Gingival bleeding index
Time frame: 3 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Oct 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
A study testing CAD/CAM metallic partial denture frameworks and Conventional metallic partial denture frameworks in people with Occlusion and Prosthesis Durability, run by Cairo University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 10 Oct 2025. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Abutment health mobility (time frame: 3 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Oct 2025.