Hematopoietic and Lymphatic System NeoplasmNCT07216534
Virtual Reality Viewing of Unaltered Streetscape Versus Digitally Manipulated Opposite Streetscape to Assess Psychosocial Response in Participants
A study testing Survey Administration and Virtual Technology Intervention in people with Hematopoietic and Lymphatic System Neoplasm and Malignant Solid Neoplasm, run by Ohio State University Comprehensive Cancer Center at 1 site in United States.
Trial summary
This clinical trial compares virtual reality viewing of an unaltered streetscape versus a digitally manipulated opposite streetscape to assess the psychosocial response in participants. Visible measures of neighborhood factors might be associated with health outcomes and risk factors of those outcomes. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm, Psychiatric Disorder
- What is being tested?
- Survey Administration and Virtual Technology Intervention
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 32 participants
- Where
- 1 siteUnited States
- Study dates
- 15 Jan 2027to 31 Jan 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Adults 18+
- Must currently live (4+ night/week) at the residence being studied. Only one resident per household will be selected
- Must understand and be able to read English
- Must agree to have residence photographed
- Must be able to wear a VR head mounted display
- Must live in neighborhood that has been selected for study
- Must be willing and able to attend an approximately 2 hour in-person visit on Ohio State University (OSU) campus
Who cannot join
- Pregnant women
- Visual or mobility impairment
- Cannot have epilepsy or other condition that would inhibit them from being able to use a VR headset
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
The Ohio State University Comprehensive Cancer Center contact
United States1 site, 1 recruiting
- Recruiting
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210
Jesse Plascak, PhD, MPH, 614-293-8024
Jesse Plascak, PhD, MPH
About this study
Official title: Piloting a Virtual Reality-Based, Randomized Controlled Trial of Psychosocial Responses to Neighborhood Physical Disorder
This clinical trial compares virtual reality viewing of an unaltered streetscape versus a digitally manipulated opposite streetscape to assess the psychosocial response in participants. Visible measures of neighborhood factors might be associated with health outcomes and risk factors of those outcomes. Short-term exposure to virtual reality environments representing very high or very low levels of neighborhood physical disorder - presence or absence of garbage/litter, presence or absence of graffiti, presence or absence of an abandoned building, presence or absence of large dumpsters, poor or very well-kept building conditions, poor or very well-kept yard conditions, poor or very well-kept road verge conditions may be a safe and effective way to assess psychosocial response in participants.
Read the detailed description
PRIMARY OBJECTIVES:
- Compare sympathetic autonomic measures (heart rate variability and skin conductance) between participants viewing, in virtual reality, their streetscape as a digitally manipulated opposite version with respect to physical disorder indicators versus participants viewing their streetscape as a digital twin with respect to physical disorder indicators.
II. Compare self-report measures (Self-Assessment Manikin and state anxiety ratings) between participants viewing, in virtual reality, their streetscape as a digitally manipulated opposite version with respect to physical disorder indicators versus participants viewing their streetscape as a digital twin with respect to physical disorder indicators.
III. Record side effects of interacting within a virtual reality environment over short periods of time (3-5 min):
IIIa. Quantify frequency of side effects; IIIb. Explore whether side effects increase across subsequent VR sessions of the cross-over study; IIIc. Explore whether side effects vary by VR intervention arm (digital twin of own streetscape or digitally manipulated opposite indicators of physical disorder of own streetscape).
IV. Analyze impact of covariates on study outcomes.
EXPLORATORY OBJECTIVES:
- Compare eye gaze density between participants viewing, in virtual reality, their streetscape as a digitally manipulated opposite version with respect to physical disorder indicators versus participants viewing their streetscape as a digital twin with respect to physical disorder indicators.
II. Compare self-report measures (neighborhood social cohesion and neighborhood disorder) between participants viewing, in virtual reality, their streetscape as a digitally manipulated opposite version with respect to physical disorder indicators versus participants viewing their streetscape as a digital twin with respect to physical disorder indicators.
OUTLINE: Participants are randomized within their residing neighborhood to 1 of 2 arms.
ARM I: Participants have their streetscape photographed. Participants view a standard residential streetscape using virtual reality (VR) for up to 5 minutes. Patients then view a digital twin of their streetscape with identical physical disorder using VR for up to 5 minutes followed by viewing their streetscape with the opposite physical disorder using VR for up to 5 minutes.
ARM II: Participants have their streetscape photographed. Participants view a standard residential streetscape using VR for up to 5 minutes. Patients then view their streetscape with the opposite physical disorder using VR for up to 5 minutes followed by viewing a digital twin of their streetscape with identical physical disorder using VR for up to 5 minutes.
- Conditions
- Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm, Psychiatric Disorder
- Being tested
- Survey Administration, Virtual Technology Intervention
- Medical subject headings
- Mental Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Survey AdministrationOther
Ancillary studies
Virtual Technology InterventionOther
Also called Virtual Reality Intervention, Virtual Technology
View standard streetscape
Virtual Technology InterventionOther
Also called Virtual Reality Intervention, Virtual Technology
View digital twin of streetscape
Virtual Technology InterventionOther
Also called Virtual Reality Intervention, Virtual Technology
View opposite digital streetscape
| Study group | Role | What they receive |
|---|---|---|
| Arm I (twin followed by opposite streetscape) | Experimental | Participants have their streetscape photographed. Participants view a standard residential streetscape using VR for up to 5 minutes. Patients then view a digital twin of their streetscape with identical physical disorder using VR for up to 5 minutes followed by viewing their streetscape with the opposite physical disorder using VR for up to 5 minutes. Receives: Other: Survey Administration; Other: Virtual Technology Intervention |
| Arm II (opposite followed by twin streetscape) | Experimental | Participants have their streetscape photographed. Participants view a standard residential streetscape using VR for up to 5 minutes. Patients then view their streetscape with the opposite physical disorder using VR for up to 5 minutes followed by viewing a digital twin of their streetscape with identical physical disorder using VR for up to 5 minutes. Receives: Other: Survey Administration; Other: Virtual Technology Intervention |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in heart rate variability
Mean heart rate variability over the entire session of each VR condition will be calculated from electrocardiograph data. Will compare the difference between two VR conditions (viewing opposite neighborhood image versus viewing twin neighborhood image) using a crossover design. Analyses of outcomes will be conducted using generalized linear mixed model approaches.
Measured: From baseline to completion of virtual reality (VR) viewings, up to 1 day
Change in skin conductance
Skin conductance, measured as microsiemens, will be calculated as the mean value over each VR condition. Will compare the difference between two VR conditions (viewing opposite neighborhood image versus viewing twin neighborhood image) using a crossover design. Analyses of outcomes will be conducted using generalized linear mixed model approaches.
Measured: From baseline to completion of VR viewings, up to 1 day
Affective reaction
Assessed via Self-assessment Manikin. Will compare the difference between two VR conditions (viewing opposite neighborhood image versus viewing twin neighborhood image) using a crossover design. Analyses of outcomes will be conducted using generalized linear mixed model approaches.
Measured: After completion of VR viewings, up to 1 day
Anxiety
Assessed via Spielberger State-Trait Anxiety Inventory short form. Will compare the difference between two VR conditions (viewing opposite neighborhood image versus viewing twin neighborhood image) using a crossover design. Analyses of outcomes will be conducted using generalized linear mixed model approaches.
Measured: After completion of VR viewings, up to 1 day
Participant reported discomfort
This is an open-ended outcome measure. Discomfort reported by participants will be recorded by study staff.
Measured: After completion of VR viewings, up to 1 day
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Oct 2025
- Study start15 Jan 2027 (estimated)
- Primary completion31 Jan 2028 (estimated)
- Study completion31 Jan 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Hematopoietic and Lymphatic System NeoplasmStudies of the same condition, open and under way.
- More trials run by Ohio State University Comprehensive Cancer CenterThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 32 participants (estimated)
Sponsor and investigators
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Jesse Plascak, Ohio State University Comprehensive Cancer Center
- Investigators
- Jesse Plascak, PhD, MPH, Principal investigator, Ohio State University Comprehensive Cancer Center
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07216534
- Sponsor's protocol ID
- OSU-25170
- Other IDs
- NCI-2025-07331
- Status last verified
- Oct 2026
- First submitted
- 10 Oct 2025
- Last updated
- 16 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 16 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Piloting a Virtual Reality-Based, Randomized Controlled Trial of Psychosocial Responses to Neighborhood Physical Disorder
- ClinicalTrials.gov ID
- NCT07216534
- Acronym / sponsor ID
- OSU-25170
- Conditions
- Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm, Psychiatric Disorder
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 32 participants (estimated)
- Lead sponsor
- Ohio State University Comprehensive Cancer CenterUniversity, hospital or other
- Study start
- 15 Jan 2027 (estimated)
- Primary completion
- 31 Jan 2028 (estimated)
- Study completion
- 31 Jan 2028 (estimated)
- First posted
- 14 Oct 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This clinical trial compares virtual reality viewing of an unaltered streetscape versus a digitally manipulated opposite streetscape to assess the psychosocial response in participants. Visible measures of neighborhood factors might be associated with health outcomes and risk factors of those outcomes. Short-term exposure to virtual reality environments representing very high or very low levels of neighborhood physical disorder - presence or absence of garbage/litter, presence or absence of graffiti, presence or absence of an abandoned building, presence or absence of large dumpsters, poor or very well-kept building conditions, poor or very well-kept yard conditions, poor or very well-kept road verge conditions may be a safe and effective way to assess psychosocial response in participants.
Detailed description
PRIMARY OBJECTIVES:
- Compare sympathetic autonomic measures (heart rate variability and skin conductance) between participants viewing, in virtual reality, their streetscape as a digitally manipulated opposite version with respect to physical disorder indicators versus participants viewing their streetscape as a digital twin with respect to physical disorder indicators.
II. Compare self-report measures (Self-Assessment Manikin and state anxiety ratings) between participants viewing, in virtual reality, their streetscape as a digitally manipulated opposite version with respect to physical disorder indicators versus participants viewing their streetscape as a digital twin with respect to physical disorder indicators.
III. Record side effects of interacting within a virtual reality environment over short periods of time (3-5 min):
IIIa. Quantify frequency of side effects; IIIb. Explore whether side effects increase across subsequent VR sessions of the cross-over study; IIIc. Explore whether side effects vary by VR intervention arm (digital twin of own streetscape or digitally manipulated opposite indicators of physical disorder of own streetscape).
IV. Analyze impact of covariates on study outcomes.
EXPLORATORY OBJECTIVES:
- Compare eye gaze density between participants viewing, in virtual reality, their streetscape as a digitally manipulated opposite version with respect to physical disorder indicators versus participants viewing their streetscape as a digital twin with respect to physical disorder indicators.
II. Compare self-report measures (neighborhood social cohesion and neighborhood disorder) between participants viewing, in virtual reality, their streetscape as a digitally manipulated opposite version with respect to physical disorder indicators versus participants viewing their streetscape as a digital twin with respect to physical disorder indicators.
OUTLINE: Participants are randomized within their residing neighborhood to 1 of 2 arms.
ARM I: Participants have their streetscape photographed. Participants view a standard residential streetscape using virtual reality (VR) for up to 5 minutes. Patients then view a digital twin of their streetscape with identical physical disorder using VR for up to 5 minutes followed by viewing their streetscape with the opposite physical disorder using VR for up to 5 minutes.
ARM II: Participants have their streetscape photographed. Participants view a standard residential streetscape using VR for up to 5 minutes. Patients then view their streetscape with the opposite physical disorder using VR for up to 5 minutes followed by viewing a digital twin of their streetscape with identical physical disorder using VR for up to 5 minutes.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Arm I (twin followed by opposite streetscape) | Experimental | Other: Survey Administration, Other: Virtual Technology InterventionParticipants have their streetscape photographed. Participants view a standard residential streetscape using VR for up to 5 minutes. Patients then view a digital twin of their streetscape with identical physical disorder using VR for up to 5 minutes followed by viewing their streetscape with the opposite physical disorder using VR for up to 5 minutes. |
| Arm II (opposite followed by twin streetscape) | Experimental | Other: Survey Administration, Other: Virtual Technology InterventionParticipants have their streetscape photographed. Participants view a standard residential streetscape using VR for up to 5 minutes. Patients then view their streetscape with the opposite physical disorder using VR for up to 5 minutes followed by viewing a digital twin of their streetscape with identical physical disorder using VR for up to 5 minutes. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (7 listed)
- Adults 18+
- Must currently live (4+ night/week) at the residence being studied. Only one resident per household will be selected
- Must understand and be able to read English
- Must agree to have residence photographed
- Must be able to wear a VR head mounted display
Key exclusion criteria (3 listed)
- Pregnant women
- Visual or mobility impairment
- Cannot have epilepsy or other condition that would inhibit them from being able to use a VR headset
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Survey AdministrationAncillary studies | Other | Arm I (twin followed by opposite streetscape), Arm II (opposite followed by twin streetscape) |
| Virtual Technology InterventionAlso: Virtual Reality Intervention, Virtual TechnologyView standard streetscape | Other | Arm I (twin followed by opposite streetscape), Arm II (opposite followed by twin streetscape) |
| Virtual Technology InterventionAlso: Virtual Reality Intervention, Virtual TechnologyView digital twin of streetscape | Other | Arm I (twin followed by opposite streetscape), Arm II (opposite followed by twin streetscape) |
| Virtual Technology InterventionAlso: Virtual Reality Intervention, Virtual TechnologyView opposite digital streetscape | Other | Arm I (twin followed by opposite streetscape), Arm II (opposite followed by twin streetscape) |
Primary outcome
Change in heart rate variability
Time frame: From baseline to completion of virtual reality (VR) viewings, up to 1 day
Mean heart rate variability over the entire session of each VR condition will be calculated from electrocardiograph data. Will compare the difference between two VR conditions (viewing opposite neighborhood image versus viewing twin neighborhood image) using a crossover design. Analyses of outcomes will be conducted using generalized linear mixed model approaches.
Change in skin conductance
Time frame: From baseline to completion of VR viewings, up to 1 day
Skin conductance, measured as microsiemens, will be calculated as the mean value over each VR condition. Will compare the difference between two VR conditions (viewing opposite neighborhood image versus viewing twin neighborhood image) using a crossover design. Analyses of outcomes will be conducted using generalized linear mixed model approaches.
Affective reaction
Time frame: After completion of VR viewings, up to 1 day
Assessed via Self-assessment Manikin. Will compare the difference between two VR conditions (viewing opposite neighborhood image versus viewing twin neighborhood image) using a crossover design. Analyses of outcomes will be conducted using generalized linear mixed model approaches.
Anxiety
Time frame: After completion of VR viewings, up to 1 day
Assessed via Spielberger State-Trait Anxiety Inventory short form. Will compare the difference between two VR conditions (viewing opposite neighborhood image versus viewing twin neighborhood image) using a crossover design. Analyses of outcomes will be conducted using generalized linear mixed model approaches.
Participant reported discomfort
Time frame: After completion of VR viewings, up to 1 day
This is an open-ended outcome measure. Discomfort reported by participants will be recorded by study staff.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Oct 2026.
- The JameslineLink provided by the sponsor.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The Ohio State University Comprehensive Cancer Center contact
Jesse Plascak, PhD, MPH principal investigator
Ohio State University Comprehensive Cancer Center
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Survey Administration and Virtual Technology Intervention in people with Hematopoietic and Lymphatic System Neoplasm and Malignant Solid Neoplasm, run by Ohio State University Comprehensive Cancer Center at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 16 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact The Ohio State University Comprehensive Cancer Center (800-293-5066, OSUCCCClinicaltrials@osumc.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in heart rate variability (time frame: From baseline to completion of virtual reality (VR) viewings, up to 1 day). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Oct 2026.