Musculoskeletal PainNCT07218757
A Pragmatic Trial of EAET for Veterans With Chronic Pain
A study testing Emotional Awareness and Expression Therapy (EAET) and Cognitive Behavioral Therapy for Chronic Pain (CBT-CP) in people with Musculoskeletal Pain, run by University of California, Los Angeles at 1 site in United States.
Trial summary
About one in three Veterans lives with long-term (chronic) pain, and many of them also struggle with past trauma and mental health issues like depression, anxiety, or PTSD. Emotional Awareness and Expression Therapy (EAET) is a type of talk therapy that helps people understand and express their emotions, especially… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Musculoskeletal Pain
- What is being tested?
- Emotional Awareness and Expression Therapy (EAET) and Cognitive Behavioral Therapy for Chronic Pain (CBT-CP)
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 672 participants
- Where
- 1 siteUnited States
- Study dates
- 2 Jan 2026to Jul 2030
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Veteran at one of 7 VA healthcare systems;
- Age 18 years or older;
- At least 3 months of musculoskeletal pain, defined using International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) diagnostic codes, which include the following M-code diagnoses: back pain, fibromyalgia, limb pain, neck pain; R-code diagnoses: pelvic and perineal pain, jaw pain; and G-code diagnoses: tension headaches; and
- Pain of at least moderate severity, defined as ≥4 "on average" on the 0-10 Numeric Pain Rating Scale
Who cannot join
- Poorly controlled major psychiatric illness (e.g., schizophrenia, bipolar I disorder with acute psychotic symptoms, severe manic or depressive episode listed as active in CPRS);
- Active suicide or violence risk (e.g., currently suicidal or homicidal ideation, intent, or plans);
- Active severe drug/alcohol use disorder (e.g., drinking more than intended, tried to stop but couldn't, spent significant time drinking or being sick from aftereffects, wanted drink so badly you couldn't think of anything else, interference with home or work life, continued to drink despite problems, given up on activities, dangerous situations, withdrawal and/or tolerance); and
- Current participation in CBT-CP or EAET, or participation in either intervention in the last 6 months, via clinical care or another research study.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
University of California, Los Angeles
Los Angeles, California, 90095
Brandon C Yarns C Yarns, MD, MS, 310 268 3304, VAChronicPainMultiStudy@va.gov
About this study
Official title: A Pragmatic Trial of Emotional Awareness and Expression Therapy for Veterans With Chronic Pain: Phase 1
About one in three Veterans lives with long-term (chronic) pain, and many of them also struggle with past trauma and mental health issues like depression, anxiety, or PTSD. Emotional Awareness and Expression Therapy (EAET) is a type of talk therapy that helps people understand and express their emotions, especially those linked to past trauma. This therapy has been shown to help reduce pain and improve mental health.
So far, multiple studies have tested EAET in both Veterans and civilians, and the results have been promising. EAET has helped people feel less pain, move better, and experience fewer mental health symptoms. Because of these strong results, the U.S. Department of Health \& Human Services named EAET a Best Practice for managing pain in 2019.
Read more
Two earlier studies at a VA hospital in Los Angeles found that EAET worked even better than another well-known therapy called cognitive behavioral therapy for chronic pain (CBT-CP) for older Veterans. However, those studies were done in tightly controlled settings. Now, researchers want to see if EAET works just as well when it's used in everyday healthcare settings, by different types of doctors and therapists.
Doctors and therapists at up to 7 VA hospitals across the country will be trained to use EAET. They will then try it out with Veterans to see how well it works and how easy it is to use in real clinics. Veterans, doctors, and other staff will be asked for feedback to learn what helps or gets in the way of using EAET.
Read the detailed description
Chronic pain is present in nearly one-third of Veterans and is frequently accompanied by comorbid trauma and mental health symptoms. Emotional awareness and expression therapy (EAET) is an evidence-based psychological treatment for chronic pain that was developed to directly target comorbid trauma and mental health symptoms with the goal of reducing or eliminating chronic pain. Multiple controlled and uncontrolled efficacy trials of EAET in Veterans and civilians have shown EAET can produce robust effects on improving outcomes that include pain severity, pain interference, depression, anxiety, and post-traumatic stress disorder (PTSD) symptoms. Consequently, EAET was recommended as a Pain Management Best Practice by the U.S. Department of Health \& Human Services in 2019. Moreover, in two single-site efficacy trials conducted at VA Greater Los Angeles Healthcare System, EAET was found to be superior on several outcomes to gold- standard cognitive behavioral therapy for chronic pain (CBT-CP) among older Veterans with chronic pain. Yet these more tightly controlled trials may not reflect the true effectiveness of EAET when implemented by diverse clinicians. The overall goal of the proposed project is to conduct a rigorous and comprehensive evaluation of EAET delivered in usual care settings. The project will proceed in two phases: During a 1-year UG3 phase, clinicians at up to 7 geographically diverse VA healthcare systems will be trained in EAET via an EAET learning collaborative, and a pilot randomized clinical trial of EAET and CBT-CP will be performed at each site to confirm feasibility. In addition, a formative evaluation will be conducted to engage clinicians, administrators, and Veterans and to identify barriers and facilitators to implementation. In Phase 2, we are conducting a pragmatic multisite randomized clinical trial.
- Conditions
- Musculoskeletal Pain
- Being tested
- Emotional Awareness and Expression Therapy (EAET), Cognitive Behavioral Therapy for Chronic Pain (CBT-CP)
- Keywords
- Chronic Pain, Psychotherapy, Musculoskeletal Disease, Mental Health
- Medical subject headings
- Musculoskeletal Pain, Chronic Pain, Musculoskeletal Diseases, Psychological Well-Being
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Emotional Awareness and Expression Therapy (EAET)Behavioural
Talk therapy that helps people understand and express their feelings, especially emotions linked to past stress or trauma. The goal is to help reduce long-term pain by dealing with hidden emotional struggles that may be affecting the body.
Cognitive Behavioral Therapy for Chronic Pain (CBT-CP)Behavioural
Talk therapy that helps people learn how their thoughts, feelings, and behaviors affect their pain. It teaches skills to manage pain, reduce stress, and improve daily life.
| Study group | Role | What they receive |
|---|---|---|
| Emotional awareness and expression therapy (EAET) | Experimental | Seeks to reduce physical (e.g., pain) and emotional (e.g., depression, anxiety) symptoms by helping individuals become aware of their emotions, express them, and resolve emotional conflicts. It will use techniques such as writing about stress, role playing how to handle difficult relationships, recognizing and expressing anger and other feelings, and being more open with others. Receives: Behavioral: Emotional Awareness and Expression Therapy (EAET) |
| Cognitive behavioral therapy for chronic pain (CBT-CP) | Active comparator | Seeks to help individuals function better and improve symptoms by teaching various cognitive and behavioral skills to manage symptoms. It will use techniques such as relaxation training, engaging in pleasant activities, pacing yourself, and changing unhelpful ways of thinking. Receives: Behavioral: Cognitive Behavioral Therapy for Chronic Pain (CBT-CP) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in "pain severity" from baseline to 10 weeks, 6 months, and 12 months post baseline
Brief Pain Inventory (BPI) Pain Severity. Average of four self report items: current pain, worst pain over the last 7 days, least pain over the last 7 days, and average pain over the last 7 days. Each item is scored 0-10 (0 = no pain; 10 = pain as bad as can be).
Measured: Baseline, along with 10 weeks, 6 months, and 12 months post baseline
Secondary outcomes (12)
Change in "pain Interference" from baseline to 10 weeks, 6 months, and 12 months post baseline
BPI Pain Interference. Average of seven self-report items: general activity, mood, walking ability, normal work, relations with other people, sleep, and enjoyment of life. Each item is scored 0-10 (0 = does not interfere; 10 = completely interferes).
Measured: Baseline, along with 10 weeks, 6 months, and 12 months post baseline
Change in "total pain impact" from baseline to 10 weeks, 6 months, and 12 months post baseline
Pain, Enjoyment of Life and General Activity scale. Average of three self-report items: average pain intensity, interference with enjoyment of life, and interference with general activity over the past week. Each item is scored 0-10 (0 = no pain or no interference; 10 = pain as bad as you can imagine or completely interferes).
Measured: Baseline, along with 10 weeks, 6 months, and 12 months post baseline
Change in "physical functioning" from baseline to 10 weeks, 6 months, and 12 months post baseline
PROMIS Physical Functioning Short Form 6b. Total of six self-report items assessing ability to perform daily physical activities such as carrying groceries, climbing stairs, walking, and self-care. Each item is scored on a 5-point scale (1 = unable to do; 5 = without any difficulty), with higher scores indicating better physical functioning.
Measured: Baseline, along with 10 weeks, 6 months, and 12 months post baseline
Change in "sleep" from baseline to 10 weeks, 6 months, and 12 months post baseline
PROMIS Sleep Disturbance 6a. Total of six self-report items assessing perceptions of sleep quality, difficulty falling asleep, and sleep satisfaction over the past 7 days. Each item is scored on a 5-point scale (e.g., 1 = not at all; 5 = very much), with higher scores indicating greater sleep disturbance.
Measured: Baseline, along with 10 weeks, 6 months, and 12 months post baseline
Change in "fatigue" from baseline to 10 weeks, 6 months, and 12 months post baseline
PROMIS Fatigue 7a. Total of seven self-report items assessing the frequency and impact of fatigue over the past 7 days, including tiredness, energy level, and how fatigue interferes with daily activities. Each item is scored on a 5-point scale (e.g., 1 = not at all; 5 = very much), with higher scores indicating greater fatigue.
Measured: Baseline, along with 10 weeks, 6 months, and 12 months post baseline
Change in "pain catastrophizing" from baseline to 10 weeks, 6 months, and 12 months post baseline
Pain Catastrophizing Scale-Short Form-6 Item. Total of six self-report items assessing catastrophic thinking related to pain, including rumination, magnification, and helplessness. Each item is scored 0-4 (0 = not at all; 4 = all the time), with higher scores indicating greater pain catastrophizing.
Measured: Baseline, along with 10 weeks, 6 months, and 12 months post baseline
Change in "depression symptoms" from baseline to 10 weeks, 6 months, and 12 months post baseline
Patient Health Questionnaire-8 Item. Total of eight self-report items assessing symptoms of depression over the past 2 weeks, including mood, interest, sleep, energy, appetite, self-worth, concentration, and psychomotor changes. Each item is scored 0-3 (0 = not at all; 3 = nearly every day), yielding a total score between 0 and 24, with higher scores indicating more severe depressive symptoms.
Measured: Baseline, along with 10 weeks, 6 months, and 12 months post baseline
Change in "anxiety symptoms" from baseline to 10 weeks, 6 months, and 12 months post baseline
Generalized Anxiety Disorder Scale-7 Item. Total of seven self-report items assessing symptoms of generalized anxiety over the past 2 weeks, including nervousness, uncontrollable worry, excessive worry, trouble relaxing, restlessness, irritability, and fear of something awful happening. Each item is scored 0-3 (0 = not at all; 3 = nearly every day), yielding a total score between 0 and 21, with higher scores indicating more severe anxiety symptoms.
Measured: Baseline, along with 10 weeks, 6 months, and 12 months post baseline
Change in "PTSD symptoms" from baseline to 10 weeks, 6 months, and 12 months post baseline
PTSD Checklist for DSM-5 (PCL-5). Total of 20 self-report items assessing PTSD symptoms over the past month, including intrusion, avoidance, negative alterations in cognition and mood, and alterations in arousal and reactivity. Each item is scored 0-4 (0 = not at all; 4 = extremely), yielding a total score between 0 and 80, with higher scores indicating greater PTSD symptom severity.
Measured: Baseline, along with 10 weeks, 6 months, and 12 months post baseline
Change in "substance use screener" from baseline to 10 weeks, 6 months, and 12 months post baseline
Tobacco, Alcohol, Prescription Medication, and Other Substance use first stage screener (TAPS-1). Single self-report item assessing frequency of use for tobacco, alcohol, prescription medications, and other substances over the past 12 months or since the last assessment point. Each item is scored on a scale from 0 to 5 (0 = never; 5 = daily or almost daily), with higher scores indicating greater substance use frequency.
Measured: Baseline, along with 10 weeks, 6 months, and 12 months post baseline
Change in "World Health Organization Quality of life" from baseline to 10 weeks, 6 months, and 12 months post baseline
World Health Organization-Quality of Life (WHOQOL-2). Two self-report items assessing overall quality of life and general health. Each item is scored on a 5-point scale (e.g., 1 = very poor/very dissatisfied; 5 = very good/very satisfied), with higher scores indicating better quality of life.
Measured: Baseline, along with 10 weeks, 6 months, and 12 months post baseline
"Patient Global Impression of Change" at 10 weeks, 6 months, and 12 months post baseline
Patient Global Impression of Change (PGIC). A single self report item assessing the Patient Global Impression of Change as a result of treatment. Items range from 1-7 (1 = No change (or condition has gotten worse); 7 = A great deal better and a considerable improvement that has made all the difference).
Measured: 10 weeks, 6 months, and 12 months post baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Oct 2025
- Study start2 Jan 2026
- Primary completionJul 2030 (estimated)
- Study completionJul 2030 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Musculoskeletal PainStudies of the same condition, open and under way.
- More trials run by University of California, Los AngelesThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants will be randomized 1:1 either to emotional awareness and expression therapy (EAET) or cognitive behavioral therapy for chronic pain (CBT-CP). The randomization sequence will be generated at the start of the study by the study statistician using a computer randomizer to create seven sets of condition assignments (i.e., stratified by site) in blocks of 12 participants, resulting in 2 experimental groups of 6 participants after each block has been fully allocated. We consider 6 participants optimal because it is large enough to maintain group status even if someone drops out but small enough to provide individualized attention, facilitate scheduling a common group time, and keep the size of the pool to be randomized manageable.
- Masking
- None (open label)
- Enrolment
- 672 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of California, Los Angeles
- Sponsor type
- University, hospital or other
- Collaborators
- National Center for Complementary and Integrative Health (NCCIH), University of Texas Health Science Center at San Antonio (South Texas) ADRC, University of Colorado, Denver, University of Utah, VA Greater Los Angeles Healthcare System, Yale University, Greater Los Angeles Veterans Research and Education Foundation
- Responsible party
- Principal investigator, Brandon C. Yarns, MD, MS, BME, University of California, Los Angeles
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07218757
- Sponsor's protocol ID
- UG3/UH3AT013497
- Other IDs
- 1UG3AT013497-01, 4UH3AT03497-02
- Status last verified
- Aug 2026
- First submitted
- 16 Oct 2025
- Last updated
- 24 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 24 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Pragmatic Trial of Emotional Awareness and Expression Therapy for Veterans With Chronic Pain: Phase 1
- ClinicalTrials.gov ID
- NCT07218757
- Acronym / sponsor ID
- UG3/UH3AT013497
- Conditions
- Musculoskeletal Pain
- Keywords
- Chronic Pain, Psychotherapy, Musculoskeletal Disease, Mental Health
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 672 participants (estimated)
- Lead sponsor
- University of California, Los AngelesUniversity, hospital or other
- Collaborators
- National Center for Complementary and Integrative Health (NCCIH), University of Texas Health Science Center at San Antonio (South Texas) ADRC, University of Colorado, Denver, University of Utah, VA Greater Los Angeles Healthcare System, Yale University, Greater Los Angeles Veterans Research and Education Foundation
- Study start
- 2 Jan 2026 (actual)
- Primary completion
- Jul 2030 (estimated)
- Study completion
- Jul 2030 (estimated)
- First posted
- 20 Oct 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
About one in three Veterans lives with long-term (chronic) pain, and many of them also struggle with past trauma and mental health issues like depression, anxiety, or PTSD. Emotional Awareness and Expression Therapy (EAET) is a type of talk therapy that helps people understand and express their emotions, especially those linked to past trauma. This therapy has been shown to help reduce pain and improve mental health.
So far, multiple studies have tested EAET in both Veterans and civilians, and the results have been promising. EAET has helped people feel less pain, move better, and experience fewer mental health symptoms. Because of these strong results, the U.S. Department of Health \& Human Services named EAET a Best Practice for managing pain in 2019.
Two earlier studies at a VA hospital in Los Angeles found that EAET worked even better than another well-known therapy called cognitive behavioral therapy for chronic pain (CBT-CP) for older Veterans. However, those studies were done in tightly controlled settings. Now, researchers want to see if EAET works just as well when it's used in everyday healthcare settings, by different types of doctors and therapists.
Doctors and therapists at up to 7 VA hospitals across the country will be trained to use EAET. They will then try it out with Veterans to see how well it works and how easy it is to use in real clinics. Veterans, doctors, and other staff will be asked for feedback to learn what helps or gets in the way of using EAET.
Detailed description
Chronic pain is present in nearly one-third of Veterans and is frequently accompanied by comorbid trauma and mental health symptoms. Emotional awareness and expression therapy (EAET) is an evidence-based psychological treatment for chronic pain that was developed to directly target comorbid trauma and mental health symptoms with the goal of reducing or eliminating chronic pain. Multiple controlled and uncontrolled efficacy trials of EAET in Veterans and civilians have shown EAET can produce robust effects on improving outcomes that include pain severity, pain interference, depression, anxiety, and post-traumatic stress disorder (PTSD) symptoms. Consequently, EAET was recommended as a Pain Management Best Practice by the U.S. Department of Health \& Human Services in 2019. Moreover, in two single-site efficacy trials conducted at VA Greater Los Angeles Healthcare System, EAET was found to be superior on several outcomes to gold- standard cognitive behavioral therapy for chronic pain (CBT-CP) among older Veterans with chronic pain. Yet these more tightly controlled trials may not reflect the true effectiveness of EAET when implemented by diverse clinicians. The overall goal of the proposed project is to conduct a rigorous and comprehensive evaluation of EAET delivered in usual care settings. The project will proceed in two phases: During a 1-year UG3 phase, clinicians at up to 7 geographically diverse VA healthcare systems will be trained in EAET via an EAET learning collaborative, and a pilot randomized clinical trial of EAET and CBT-CP will be performed at each site to confirm feasibility. In addition, a formative evaluation will be conducted to engage clinicians, administrators, and Veterans and to identify barriers and facilitators to implementation. In Phase 2, we are conducting a pragmatic multisite randomized clinical trial.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Participants will be randomized 1:1 either to emotional awareness and expression therapy (EAET) or cognitive behavioral therapy for chronic pain (CBT-CP). The randomization sequence will be generated at the start of the study by the study statistician using a computer randomizer to create seven sets of condition assignments (i.e., stratified by site) in blocks of 12 participants, resulting in 2 experimental groups of 6 participants after each block has been fully allocated. We consider 6 participants optimal because it is large enough to maintain group status even if someone drops out but small enough to provide individualized attention, facilitate scheduling a common group time, and keep the size of the pool to be randomized manageable.
| Arm | Type | Receives |
|---|---|---|
| Emotional awareness and expression therapy (EAET) | Experimental | Behavioral: Emotional Awareness and Expression Therapy (EAET)Seeks to reduce physical (e.g., pain) and emotional (e.g., depression, anxiety) symptoms by helping individuals become aware of their emotions, express them, and resolve emotional conflicts. It will use techniques such as writing about stress, role playing how to handle difficult relationships, recognizing and expressing anger and other feelings, and being more open with others. |
| Cognitive behavioral therapy for chronic pain (CBT-CP) | Active comparator | Behavioral: Cognitive Behavioral Therapy for Chronic Pain (CBT-CP)Seeks to help individuals function better and improve symptoms by teaching various cognitive and behavioral skills to manage symptoms. It will use techniques such as relaxation training, engaging in pleasant activities, pacing yourself, and changing unhelpful ways of thinking. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Veteran at one of 7 VA healthcare systems;
- Age 18 years or older;
- At least 3 months of musculoskeletal pain, defined using International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) diagnostic codes, which include the following M-code diagnoses: back pain, fibromyalgia, limb pain, neck pain; R-code diagnoses: pelvic and perineal pain, jaw pain; and G-code diagnoses: tension headaches; and
- Pain of at least moderate severity, defined as ≥4 "on average" on the 0-10 Numeric Pain Rating Scale
Key exclusion criteria (4 listed)
- Poorly controlled major psychiatric illness (e.g., schizophrenia, bipolar I disorder with acute psychotic symptoms, severe manic or depressive episode listed as active in CPRS);
- Active suicide or violence risk (e.g., currently suicidal or homicidal ideation, intent, or plans);
- Active severe drug/alcohol use disorder (e.g., drinking more than intended, tried to stop but couldn't, spent significant time drinking or being sick from aftereffects, wanted drink so badly you couldn't think of anything else, interference with home or work life, continued to drink despite problems, given up on activities, dangerous situations, withdrawal and/or tolerance); and
- Current participation in CBT-CP or EAET, or participation in either intervention in the last 6 months, via clinical care or another research study.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Emotional Awareness and Expression Therapy (EAET)Talk therapy that helps people understand and express their feelings, especially emotions linked to past stress or trauma. The goal is to help reduce long-term pain by dealing with hidden emotional struggles that may be affecting the body. | Behavioural | Emotional awareness and expression therapy (EAET) |
| Cognitive Behavioral Therapy for Chronic Pain (CBT-CP)Talk therapy that helps people learn how their thoughts, feelings, and behaviors affect their pain. It teaches skills to manage pain, reduce stress, and improve daily life. | Behavioural | Cognitive behavioral therapy for chronic pain (CBT-CP) |
Primary outcome
Change in "pain severity" from baseline to 10 weeks, 6 months, and 12 months post baseline
Time frame: Baseline, along with 10 weeks, 6 months, and 12 months post baseline
Brief Pain Inventory (BPI) Pain Severity. Average of four self report items: current pain, worst pain over the last 7 days, least pain over the last 7 days, and average pain over the last 7 days. Each item is scored 0-10 (0 = no pain; 10 = pain as bad as can be).
12 secondary outcomes
Change in "pain Interference" from baseline to 10 weeks, 6 months, and 12 months post baseline
Time frame: Baseline, along with 10 weeks, 6 months, and 12 months post baseline
Change in "total pain impact" from baseline to 10 weeks, 6 months, and 12 months post baseline
Time frame: Baseline, along with 10 weeks, 6 months, and 12 months post baseline
Change in "physical functioning" from baseline to 10 weeks, 6 months, and 12 months post baseline
Time frame: Baseline, along with 10 weeks, 6 months, and 12 months post baseline
Change in "sleep" from baseline to 10 weeks, 6 months, and 12 months post baseline
Time frame: Baseline, along with 10 weeks, 6 months, and 12 months post baseline
Change in "fatigue" from baseline to 10 weeks, 6 months, and 12 months post baseline
Time frame: Baseline, along with 10 weeks, 6 months, and 12 months post baseline
Change in "pain catastrophizing" from baseline to 10 weeks, 6 months, and 12 months post baseline
Time frame: Baseline, along with 10 weeks, 6 months, and 12 months post baseline
Change in "depression symptoms" from baseline to 10 weeks, 6 months, and 12 months post baseline
Time frame: Baseline, along with 10 weeks, 6 months, and 12 months post baseline
Change in "anxiety symptoms" from baseline to 10 weeks, 6 months, and 12 months post baseline
Time frame: Baseline, along with 10 weeks, 6 months, and 12 months post baseline
Change in "PTSD symptoms" from baseline to 10 weeks, 6 months, and 12 months post baseline
Time frame: Baseline, along with 10 weeks, 6 months, and 12 months post baseline
Change in "substance use screener" from baseline to 10 weeks, 6 months, and 12 months post baseline
Time frame: Baseline, along with 10 weeks, 6 months, and 12 months post baseline
Change in "World Health Organization Quality of life" from baseline to 10 weeks, 6 months, and 12 months post baseline
Time frame: Baseline, along with 10 weeks, 6 months, and 12 months post baseline
"Patient Global Impression of Change" at 10 weeks, 6 months, and 12 months post baseline
Time frame: 10 weeks, 6 months, and 12 months post baseline
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Aug 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Emotional Awareness and Expression Therapy (EAET) and Cognitive Behavioral Therapy for Chronic Pain (CBT-CP) in people with Musculoskeletal Pain, run by University of California, Los Angeles at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 24 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Brandon C Yarns, MD, MS (310 268 3304, VAChronicPainMultiStudy@va.gov), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in "pain severity" from baseline to 10 weeks, 6 months, and 12 months post baseline (time frame: Baseline, along with 10 weeks, 6 months, and 12 months post baseline). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Aug 2026.