Primary Progressive Aphasia(PPA)Multi-PANCT07219680
Intervention for Communication Quality of Life in Primary Progressive Aphasia
A study testing Multicomponent Lexical Retrieval Cascade Training and Multicomponent Video Implemented Script Training in Aphasia in people with Primary Progressive Aphasia(PPA) and Semantic Dementia, run by Maya Henry at 1 site in United States.
Trial summary
The goal of this clinical trial is to learn whether a personalized, multi-component, virtual speech language treatment program can improve communication and quality of life for adults with primary progressive aphasia (PPA) and their primary communication partners. Read more about this study
- Who is it for?
- Ages 40 years and older
- Conditions the study is for
- Primary Progressive Aphasia(PPA), Semantic Dementia, Logopenic Progressive Aphasia (LPA)
- What is being tested?
- Multicomponent Lexical Retrieval Cascade Training and Multicomponent Video Implemented Script Training in Aphasia
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Apr 2026to Aug 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- A PPA (Gorno-Tempini et al., 2011) or "PPA-plus" (Mesulam et al., 2001) diagnosis
- MMSE score of 15 or higher and must be able to produce single monosyllabic words intelligibly
- Must speak English, Spanish or both languages (i.e., bilingual speakers of English or Spanish)
- Hearing and vision adequate for participation in teleconference meetings
- Must have a study partner available (someone who will commit to attending teleconference sessions, as needed, during assessment and treatment phases)
- Partners must express willingness to attend and participate in assessment and treatment sessions, including those targeting dyadic communication goals
Show all 9Show fewer
- Partners must speak English, Spanish or both languages (i.e., bilingual speakers of English or Spanish)
- Partner's hearing and vision should be adequate for participation in teleconference meetings
- The participant and/or study partner must have basic experience using a computer.
Who cannot join
- Other central nervous system or medical diagnosis that can account for symptoms
- Psychiatric diagnosis that can account for symptoms
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
University of Texas
Austin, Texas, 78712
Carly M Millanski, MS, 512-471-3420, aphasialab@austin.utexas.edu
Camille Wagner Rodriguez, MS, wagner.camille@austin.utexas.edu
About this study
Official title: Intervention to Promote Communication Quality of Life for Persons With Language-Led Dementia and Their Partners: A Randomized Pilot Trial
The goal of this clinical trial is to learn whether a personalized, multi-component, virtual speech language treatment program can improve communication and quality of life for adults with primary progressive aphasia (PPA) and their primary communication partners. The study will enroll participants who speak English and/or Spanish.
The main questions the study aims to answer are:
Read more
- Is the telerehabilitation program feasible and acceptable for people with PPA and their study partners?
- Do participants with PPA and study partners find treatment beneficial?
- What patterns of treatment response are seen in participants?
- Which outcome measures are most useful for evaluating changes in communication and quality of life?
Researchers will compare participants who receive intervention immediately to participants assigned to a waitlist control group (who will receive treatment after a delay) to see whether participation in the treatment program is associated with improvements in communication and quality of life.
Participants will:
- Take part in speech language therapy sessions delivered by video visit that combine restorative, compensatory, and partner-focused communication strategies. Treatment may take place after a waiting period.
- Receive education and communication training together with their partner.
- Complete speech, language, and cognitive assessments.
- Complete questionnaires about communication abilities, daily functioning, and quality of life.
- Conditions
- Primary Progressive Aphasia(PPA), Semantic Dementia, Logopenic Progressive Aphasia (LPA), Nonfluent Aphasia, Progressive, Progressive Aphasia, Semantic Variant Primary Progressive Aphasia (svPPA)
- Being tested
- Multicomponent Lexical Retrieval Cascade Training, Multicomponent Video Implemented Script Training in Aphasia
- Keywords
- speech-language pathology, neurodegenerative disease, logopenic, nonfluent, semantic, script training, teletherapy, remote, multimodal communication training, partner training, augmentative and alternative communication, AAC, Communication Book, bilingual, Spanish, Hispanic, Latino
- Medical subject headings
- Aphasia, Primary Progressive, Frontotemporal Dementia, Primary Progressive Nonfluent Aphasia, Aphasia, Neurodegenerative Diseases
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Multicomponent Lexical Retrieval Cascade TrainingBehavioural
Also called Multi-LRCT
In person or via teletherapy: A multi-component treatment incorporating elements of restitutive, compensatory, and care-partner focused interventions. Participants work on producing names of personally relevant targets in multiple communication modalities. Biweekly (45-90 minute) sessions with a clinician target multimodal communication and the use of strategies to support word retrieval. These skills are also trained via daily independent practice. The participant meets six times during the course of treatment with a study partner (e.g., spouse) for communication counseling, education, and practice of communication strategies.
Multicomponent Video Implemented Script Training in AphasiaBehavioural
Also called Multi-VISTA
In person or via teletherapy: A multi-component treatment incorporating elements of restitutive, compensatory, and care-partner focused interventions. Treatment focuses on production of individually-tailored, personally relevant scripts. The participant completes 30 minutes per day of independent practice, during which they speak in unison with a video model. Biweekly (45-90 minute) sessions with a clinician target clear and accurate script production, memorization, and conversational usage, as well as multimodal communication. The participant meets six times during the course of treatment with a study partner (e.g., spouse) for communication counseling, education, and practice of communication strategies.
| Study group | Role | What they receive |
|---|---|---|
| Waitlist Control | Other | Individuals in the waitlist-control group will undergo initial assessment followed by a waiting interval of 12 (Multi-VISTA) or 13 (Multi-LRCT) weeks. Following the waiting period, they will again complete baseline assessments prior to the treatment phase (co-development of training materials and Multi-VISTA or Multi-LRCT treatment). Receives: Behavioral: Multicomponent Lexical Retrieval Cascade Training; Behavioral: Multicomponent Video Implemented Script Training in Aphasia |
| Immediate Treatment | Experimental | Individuals in the immediate treatment group will undergo initial assessment followed immediately by the treatment phase (co-development of training materials and Multi-VISTA or Multi-LRCT treatment). Receives: Behavioral: Multicomponent Lexical Retrieval Cascade Training; Behavioral: Multicomponent Video Implemented Script Training in Aphasia |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in spoken naming of trained/untrained items
Percent correctly named trained/untrained pictures
Measured: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
Change in script production accuracy
Percent correct intelligible, scripted words for trained/untrained scripts
Measured: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
Change in barriers and facilitators in dyad conversation
Number of conversation barriers and facilitators observed in conversation
Measured: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
Communication Modality Inventory
A likert-type survey characterizing frequency and type of communication modalities used in conversation, administered to both the person with PPA and their conversation partner.
Measured: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
Secondary outcomes (5)
Change on Quick Aphasia Battery
A standardized aphasia assessment.
Measured: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
Change on Aphasia Impact Questionnaire
A psychosocial questionnaire for individuals with aphasia. Scores range from 0-84, with higher scores indicating greater impact of aphasia.
Measured: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
Acceptability and Perception of Change Survey
A survey characterizing acceptability of and perceived response to treatment.
Measured: post-treatment (approximately 12-13 weeks after treatment onset)
Change on Adult Carers Quality of Life Questionnaire
A measure evaluating quality of life for caregivers. Scores range from 0-100, with higher scores indicating greater quality of life.
Measured: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
Change on Brief - Coping Orientation to Problems Experienced Inventory (Brief-COPE)
A survey characterizing care partner use of coping strategies.
Measured: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Oct 2025
- Study start1 Apr 2026
- Primary completionAug 2027 (estimated)
- Study completionAug 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Primary Progressive Aphasia(PPA)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants in Arm 1, the immediate treatment group, will proceed immediately to initial assessments followed by the treatment phase (co-development of training materials and Multi-VISTA or Multi-LRCT treatment). Participants in Arm 2, the waitlist control group, will undergo initial assessment followed by a waiting interval of 12 (Multi-VISTA) or 13 (Multi-LRCT) weeks. Following the waiting period, they will be reassessed for cognitive-linguistic and participant-reported outcome measures prior to the treatment phase (co-development of training materials and Multi-VISTA or Multi-LRCT treatment).
- Masking
- None (open label)
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Maya Henry
- Sponsor type
- University, hospital or other
- Collaborators
- National Institutes of Health (NIH), National Institute on Aging (NIA)
- Responsible party
- Sponsor-investigator, Maya Henry, University of Texas at Austin
- Investigators
- Maya L Henry, PhD, Principal investigator, University of Texas at AustinStephanie M Grasso, PhD, Principal investigator, University of Texas at Austin
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07219680
- Sponsor's protocol ID
- R61AG089318
- Acronym
- Multi-PA
- Status last verified
- Apr 2026
- First submitted
- 20 Oct 2025
- Last updated
- 21 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: Because of the possibility of deductive disclosure of subjects with unusual characteristics and the sensitive nature of the protected health information obtained in this trial, we will make decisions about data sharing on request, with IRB oversight.
Publications
Henry ML, Hubbard HI, Grasso SM, Mandelli ML, Wilson SM, Sathishkumar MT, Fridriksson J, Daigle W, Boxer AL, Miller BL, Gorno-Tempini ML. Retraining speech production and fluency in non-fluent/agrammatic primary progressive aphasia. Brain. 2018 Jun 1;141(6):1799-1814. doi: 10.1093/brain/awy101.
PubMed 29718131Henry ML, Hubbard HI, Grasso SM, Dial HR, Beeson PM, Miller BL, Gorno-Tempini ML. Treatment for Word Retrieval in Semantic and Logopenic Variants of Primary Progressive Aphasia: Immediate and Long-Term Outcomes. J Speech Lang Hear Res. 2019 Aug 15;62(8):2723-2749. doi: 10.1044/2018_JSLHR-L-18-0144. Epub 2019 Aug 7.
PubMed 31390290Dial HR, Hinshelwood HA, Grasso SM, Hubbard HI, Gorno-Tempini ML, Henry ML. Investigating the utility of teletherapy in individuals with primary progressive aphasia. Clin Interv Aging. 2019 Feb 25;14:453-471. doi: 10.2147/CIA.S178878. eCollection 2019.
PubMed 30880927
Study at a glance
From the registry record, last updated by the sponsor on 21 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Intervention to Promote Communication Quality of Life for Persons With Language-Led Dementia and Their Partners: A Randomized Pilot Trial
- ClinicalTrials.gov ID
- NCT07219680
- Acronym / sponsor ID
- Multi-PA / R61AG089318
- Conditions
- Primary Progressive Aphasia(PPA), Semantic Dementia, Logopenic Progressive Aphasia (LPA), Nonfluent Aphasia, Progressive, Progressive Aphasia, Semantic Variant Primary Progressive Aphasia (svPPA)
- Keywords
- speech-language pathology, neurodegenerative disease, logopenic, nonfluent, semantic, script training, teletherapy, remote
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Maya HenryUniversity, hospital or other
- Collaborators
- National Institutes of Health (NIH), National Institute on Aging (NIA)
- Study start
- 1 Apr 2026 (actual)
- Primary completion
- Aug 2027 (estimated)
- Study completion
- Aug 2027 (estimated)
- First posted
- 22 Oct 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to learn whether a personalized, multi-component, virtual speech language treatment program can improve communication and quality of life for adults with primary progressive aphasia (PPA) and their primary communication partners. The study will enroll participants who speak English and/or Spanish.
The main questions the study aims to answer are:
- Is the telerehabilitation program feasible and acceptable for people with PPA and their study partners?
- Do participants with PPA and study partners find treatment beneficial?
- What patterns of treatment response are seen in participants?
- Which outcome measures are most useful for evaluating changes in communication and quality of life?
Researchers will compare participants who receive intervention immediately to participants assigned to a waitlist control group (who will receive treatment after a delay) to see whether participation in the treatment program is associated with improvements in communication and quality of life.
Participants will:
- Take part in speech language therapy sessions delivered by video visit that combine restorative, compensatory, and partner-focused communication strategies. Treatment may take place after a waiting period.
- Receive education and communication training together with their partner.
- Complete speech, language, and cognitive assessments.
- Complete questionnaires about communication abilities, daily functioning, and quality of life.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Participants in Arm 1, the immediate treatment group, will proceed immediately to initial assessments followed by the treatment phase (co-development of training materials and Multi-VISTA or Multi-LRCT treatment). Participants in Arm 2, the waitlist control group, will undergo initial assessment followed by a waiting interval of 12 (Multi-VISTA) or 13 (Multi-LRCT) weeks. Following the waiting period, they will be reassessed for cognitive-linguistic and participant-reported outcome measures prior to the treatment phase (co-development of training materials and Multi-VISTA or Multi-LRCT treatment).
| Arm | Type | Receives |
|---|---|---|
| Waitlist Control | Other | Behavioral: Multicomponent Lexical Retrieval Cascade Training, Behavioral: Multicomponent Video Implemented Script Training in AphasiaIndividuals in the waitlist-control group will undergo initial assessment followed by a waiting interval of 12 (Multi-VISTA) or 13 (Multi-LRCT) weeks. Following the waiting period, they will again complete baseline assessments prior to the treatment phase (co-development of training materials and Multi-VISTA or Multi-LRCT treatment). |
| Immediate Treatment | Experimental | Behavioral: Multicomponent Lexical Retrieval Cascade Training, Behavioral: Multicomponent Video Implemented Script Training in AphasiaIndividuals in the immediate treatment group will undergo initial assessment followed immediately by the treatment phase (co-development of training materials and Multi-VISTA or Multi-LRCT treatment). |
Who may qualify
- Ages
- 40 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (9 listed)
- A PPA (Gorno-Tempini et al., 2011) or "PPA-plus" (Mesulam et al., 2001) diagnosis
- MMSE score of 15 or higher and must be able to produce single monosyllabic words intelligibly
- Must speak English, Spanish or both languages (i.e., bilingual speakers of English or Spanish)
- Hearing and vision adequate for participation in teleconference meetings
- Must have a study partner available (someone who will commit to attending teleconference sessions, as needed, during assessment and treatment phases)
Key exclusion criteria (2 listed)
- Other central nervous system or medical diagnosis that can account for symptoms
- Psychiatric diagnosis that can account for symptoms
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Multicomponent Lexical Retrieval Cascade TrainingAlso: Multi-LRCTIn person or via teletherapy: A multi-component treatment incorporating elements of restitutive, compensatory, and care-partner focused interventions. Participants work on producing names of personally relevant targets in multiple communication modalities. Biweekly (45-90 minute) sessions with a clinician target multimodal communication and the use of strategies to support word retrieval. These skills are also trained via daily independent practice. The participant meets six times during the course of treatment with a study partner (e.g., spouse) for communication counseling, education, and practice of communication strategies. | Behavioural | Immediate Treatment, Waitlist Control |
| Multicomponent Video Implemented Script Training in AphasiaAlso: Multi-VISTAIn person or via teletherapy: A multi-component treatment incorporating elements of restitutive, compensatory, and care-partner focused interventions. Treatment focuses on production of individually-tailored, personally relevant scripts. The participant completes 30 minutes per day of independent practice, during which they speak in unison with a video model. Biweekly (45-90 minute) sessions with a clinician target clear and accurate script production, memorization, and conversational usage, as well as multimodal communication. The participant meets six times during the course of treatment with a study partner (e.g., spouse) for communication counseling, education, and practice of communication strategies. | Behavioural | Immediate Treatment, Waitlist Control |
Primary outcome
Change in spoken naming of trained/untrained items
Time frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
Percent correctly named trained/untrained pictures
Change in script production accuracy
Time frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
Percent correct intelligible, scripted words for trained/untrained scripts
Change in barriers and facilitators in dyad conversation
Time frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
Number of conversation barriers and facilitators observed in conversation
Communication Modality Inventory
Time frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
A likert-type survey characterizing frequency and type of communication modalities used in conversation, administered to both the person with PPA and their conversation partner.
5 secondary outcomes
Change on Quick Aphasia Battery
Time frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
Change on Aphasia Impact Questionnaire
Time frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
Acceptability and Perception of Change Survey
Time frame: post-treatment (approximately 12-13 weeks after treatment onset)
Change on Adult Carers Quality of Life Questionnaire
Time frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
Change on Brief - Coping Orientation to Problems Experienced Inventory (Brief-COPE)
Time frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Apr 2026.
- Background: PubMed 29718131Henry ML, Hubbard HI, Grasso SM, Mandelli ML, Wilson SM, Sathishkumar MT, Fridriksson J, Daigle W, Boxer AL, Miller BL, Gorno-Tempini ML. Retraining speech production and fluency in non-fluent/agrammatic primary progressive aphasia. Brain. 2018 Jun 1;141(6):1799-1814. doi: 10.1093/brain/awy101.
- Background: PubMed 31390290Henry ML, Hubbard HI, Grasso SM, Dial HR, Beeson PM, Miller BL, Gorno-Tempini ML. Treatment for Word Retrieval in Semantic and Logopenic Variants of Primary Progressive Aphasia: Immediate and Long-Term Outcomes. J Speech Lang Hear Res. 2019 Aug 15;62(8):2723-2749. doi: 10.1044/2018_JSLHR-L-18-0144. Epub 2019 Aug 7.
- Background: PubMed 30880927Dial HR, Hinshelwood HA, Grasso SM, Hubbard HI, Gorno-Tempini ML, Henry ML. Investigating the utility of teletherapy in individuals with primary progressive aphasia. Clin Interv Aging. 2019 Feb 25;14:453-471. doi: 10.2147/CIA.S178878. eCollection 2019.
- University of Texas Aphasia Research and Treatment LabLink provided by the sponsor.
- University of Texas Aphasia Multilingual Aphasia and Dementia Research LabLink provided by the sponsor.
- Individual participant dataSharing planned: Undecided. Because of the possibility of deductive disclosure of subjects with unusual characteristics and the sensitive nature of the protected health information obtained in this trial, we will make decisions about data sharing on request, with IRB oversight.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Maya L Henry, PhD principal investigator
University of Texas at Austin
Stephanie M Grasso, PhD principal investigator
University of Texas at Austin
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Multicomponent Lexical Retrieval Cascade Training and Multicomponent Video Implemented Script Training in Aphasia in people with Primary Progressive Aphasia(PPA) and Semantic Dementia, run by Maya Henry at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 21 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Henry Lab Research Coordinator (512-471-3420, aphasialab@austin.utexas.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in spoken naming of trained/untrained items (time frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07219680, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Apr 2026.