Musculoskeletal Pain - Acute and Subacute ConditionsNCT07220200
MOVE Protocol - Movement-Oriented Velocity of Engagement
A study testing MOVE Rehabilitation Protocol in people with Musculoskeletal Pain - Acute and Subacute Conditions, run by MMSx Authority Institute for Movement Mechanics & Biomechanics Research Inc. at 4 sites in 2 countries.
Trial summary
A Prospective, Multi-Site, Interventional Case-Series Evaluating the MOVE (Movement-Oriented Velocity of Engagement) Protocol for Musculoskeletal Pain Recovery Read more about this study
- Who is it for?
- Ages 18 to 70 years
- Conditions the study is for
- Musculoskeletal Pain - Acute and Subacute Conditions
- What is being tested?
- MOVE Rehabilitation Protocol
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 52 participants
- Where
- 4 sitesin 2 countries
- Study dates
- 15 Jun 2024to 17 Oct 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- • Adults aged 18-65 years diagnosed with acute or subacute musculoskeletal pain or movement restriction (≤12 weeks duration).
- Capable of performing supervised rehabilitation and daily movement tasks.
- Able to provide informed consent and comply with study assessments.
- Baseline pain score ≥4 on the Numerical Rating Scale (NRS).
Who cannot join
- Chronic pain (>12 weeks) or neurological disorders affecting movement control.
- Post-surgical cases or fractures within the past 3 months.
- Cardiopulmonary or systemic illness contraindicating exercise participation.
- Pregnancy or conditions limiting safe participation in physical rehabilitation.
- Refusal to sign informed consent.
Trial locations and contacts
4 sites in 2 countries.
4 sites in 2 countries
United States2 sites
BodyGNTX Fitness Institute
Columbus, Ohio, 43220
MMSx AUTHORITY (COORDINATING CENTER)
Powell, Ohio, 43065
India2 sites
Indian Institute of Kinesiology & Biomechanics Science (IIKBS)
Burhānpur, Madhya Pradesh, 450331
GFFI Fitness Academy
New Delhi, National Capital Territory of Delhi, 110026
About this study
Official title: A Prospective, Multi-Site, Interventional Case-Series Evaluating the MOVE (Movement-Oriented Velocity of Engagement) Protocol for Musculoskeletal Pain Recovery
A Prospective, Multi-Site, Interventional Case-Series Evaluating the MOVE (Movement-Oriented Velocity of Engagement) Protocol for Musculoskeletal Pain Recovery
Read the detailed description
The MOVE Protocol is a structured, biomechanics-based rehabilitation framework designed to accelerate recovery from musculoskeletal pain conditions through progressive mobilization and neuromuscular control. This interventional case-series involved multiple clinical and training centers (BodyGNTX, GFFI, IIKBS, ASFU) and applied standardized MOVE sessions under the supervision of certified movement specialists. Assessments included pain scoring (NRS), functional mobility (LEFS/UEFI), and balance control, measured at baseline, week 2, week 4, and week 8. The protocol followed ICH-GCP E6(R2) and Helsinki 2013 guidelines, with institutional ethics approval from MMSx Authority IREB. The study demonstrated safe and effective early-movement outcomes across diverse populations, emphasizing mobility, load optimization, and neuromuscular revalidation.
- Being tested
- MOVE Rehabilitation Protocol
- Keywords
- Rehabilitation, Biomechanics, Early Mobilization, Movement Therapy, Functional Recovery, Pain Management, Physical Therapy
- Medical subject headings
- Agnosia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
MOVE Rehabilitation ProtocolBehavioural
The MOVE (Movement-Oriented Velocity of Engagement) protocol is a biomechanics-based rehabilitation approach targeting early mobilization and functional recovery for musculoskeletal pain conditions. The structured program includes four key phases: Mobilize, Optimize Load, Validate Neural Control, and Energize Recovery, applied over 8 weeks under therapist supervision.
| Study group | Role | What they receive |
|---|---|---|
| Move Protocol | Experimental | Participants received the MOVE (Movement-Oriented Velocity of Engagement) rehabilitation protocol, consisting of four progressive phases: Mobilize, Optimize Load, Validate Neural Control, and Energize Recovery. The program emphasized functional movement restoration, load tolerance, and neuromuscular coordination. Receives: Behavioral: MOVE Rehabilitation Protocol |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pain Reduction (NRS Score)
Change in Numeric Rating Scale (NRS) for pain intensity from baseline to week 8 following the MOVE (Movement-Oriented Velocity of Engagement) rehabilitation program. Participants rated pain on a 0-10 scale where 0 = no pain and 10 = worst possible pain.
Measured: Baseline, Week 2, Week 4, and Week 8
Secondary outcomes (3)
Functional Improvement (LEFS / UEFI Score)
Change in Lower Extremity Functional Scale (LEFS) or Upper Extremity Functional Index (UEFI) from baseline to week 8, reflecting mobility and activity performance improvement post-MOVE intervention.
Measured: Baseline, Week 2, Week 4, Week 8
Balance and Postural Stability (Timed Single-Leg Stance Test)
Improvement in single-leg stance duration and balance control across sessions as measured by standardized postural tests.
Measured: Baseline, Week 4, Week 8
Participant Perceived Recovery (Global Rating of Change Scale)
Participants rate overall improvement on a 7-point Global Rating of Change (GROC) scale at week 8 to capture subjective recovery perception.
Measured: Week 8
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Oct 2025
- Study start15 Jun 2024
- Primary completion10 Oct 2024
- Study completion17 Oct 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Musculoskeletal Pain - Acute and Subacute ConditionsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- This was a multi-site, single-arm interventional case-series evaluating the MOVE (Movement-Oriented Velocity of Engagement) rehabilitation protocol for acute and subacute musculoskeletal pain. Forty participants across four international centers completed an 8-week standardized intervention consisting of four progressive phases: Mobilize, Optimize Load, Validate Neural Control, and Energize Recovery. The study aimed to assess safety, functional recovery, and pain reduction outcomes following the MOVE protocol.
- Masking
- None (open label)
- Enrolment
- 52 participants (actual)
Sponsor and investigators
- Lead sponsor
- MMSx Authority Institute for Movement Mechanics & Biomechanics Research Inc.
- Sponsor type
- University, hospital or other
- Collaborators
- Indian Institute of Kinesiology and Biomechanics Science (IIKBS), BodyGNTX Fitness Institute, ASFU (American Sports & Fitness University), GFFI Fitness Academy
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07220200
- Sponsor's protocol ID
- MOVE-001/2025
- Status last verified
- Oct 2025
- First submitted
- 22 Oct 2025
- Last updated
- 12 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: De-identified participant data are stored securely at MMSx Authority Clinical Research Division and affiliated academic centers (BodyGNTX USA, GFFI India, IIKBS). Data will not be shared publicly but may be used in aggregate form for institutional publications.
Study at a glance
From the registry record, last updated by the sponsor on 12 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Prospective, Multi-Site, Interventional Case-Series Evaluating the MOVE (Movement-Oriented Velocity of Engagement) Protocol for Musculoskeletal Pain Recovery
- ClinicalTrials.gov ID
- NCT07220200
- Acronym / sponsor ID
- MOVE-001/2025
- Keywords
- Rehabilitation, Biomechanics, Early Mobilization, Movement Therapy, Functional Recovery, Pain Management, Physical Therapy
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 52 participants (actual)
- Lead sponsor
- MMSx Authority Institute for Movement Mechanics & Biomechanics Research Inc.University, hospital or other
- Collaborators
- Indian Institute of Kinesiology and Biomechanics Science (IIKBS), BodyGNTX Fitness Institute, ASFU (American Sports & Fitness University), GFFI Fitness Academy
- Study start
- 15 Jun 2024 (actual)
- Primary completion
- 10 Oct 2024 (actual)
- Study completion
- 17 Oct 2025 (actual)
- First posted
- 23 Oct 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
A Prospective, Multi-Site, Interventional Case-Series Evaluating the MOVE (Movement-Oriented Velocity of Engagement) Protocol for Musculoskeletal Pain Recovery
Detailed description
The MOVE Protocol is a structured, biomechanics-based rehabilitation framework designed to accelerate recovery from musculoskeletal pain conditions through progressive mobilization and neuromuscular control. This interventional case-series involved multiple clinical and training centers (BodyGNTX, GFFI, IIKBS, ASFU) and applied standardized MOVE sessions under the supervision of certified movement specialists. Assessments included pain scoring (NRS), functional mobility (LEFS/UEFI), and balance control, measured at baseline, week 2, week 4, and week 8. The protocol followed ICH-GCP E6(R2) and Helsinki 2013 guidelines, with institutional ethics approval from MMSx Authority IREB. The study demonstrated safe and effective early-movement outcomes across diverse populations, emphasizing mobility, load optimization, and neuromuscular revalidation.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- This was a multi-site, single-arm interventional case-series evaluating the MOVE (Movement-Oriented Velocity of Engagement) rehabilitation protocol for acute and subacute musculoskeletal pain. Forty participants across four international centers completed an 8-week standardized intervention consisting of four progressive phases: Mobilize, Optimize Load, Validate Neural Control, and Energize Recovery. The study aimed to assess safety, functional recovery, and pain reduction outcomes following the MOVE protocol.
| Arm | Type | Receives |
|---|---|---|
| Move Protocol | Experimental | Behavioral: MOVE Rehabilitation ProtocolParticipants received the MOVE (Movement-Oriented Velocity of Engagement) rehabilitation protocol, consisting of four progressive phases: Mobilize, Optimize Load, Validate Neural Control, and Energize Recovery. The program emphasized functional movement restoration, load tolerance, and neuromuscular coordination. |
Who may qualify
- Ages
- 18 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- • Adults aged 18-65 years diagnosed with acute or subacute musculoskeletal pain or movement restriction (≤12 weeks duration).
Key exclusion criteria (5 listed)
- Chronic pain (>12 weeks) or neurological disorders affecting movement control.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| MOVE Rehabilitation ProtocolThe MOVE (Movement-Oriented Velocity of Engagement) protocol is a biomechanics-based rehabilitation approach targeting early mobilization and functional recovery for musculoskeletal pain conditions. The structured program includes four key phases: Mobilize, Optimize Load, Validate Neural Control, and Energize Recovery, applied over 8 weeks under therapist supervision. | Behavioural | Move Protocol |
Primary outcome
Pain Reduction (NRS Score)
Time frame: Baseline, Week 2, Week 4, and Week 8
Change in Numeric Rating Scale (NRS) for pain intensity from baseline to week 8 following the MOVE (Movement-Oriented Velocity of Engagement) rehabilitation program. Participants rated pain on a 0-10 scale where 0 = no pain and 10 = worst possible pain.
3 secondary outcomes
Functional Improvement (LEFS / UEFI Score)
Time frame: Baseline, Week 2, Week 4, Week 8
Balance and Postural Stability (Timed Single-Leg Stance Test)
Time frame: Baseline, Week 4, Week 8
Participant Perceived Recovery (Global Rating of Change Scale)
Time frame: Week 8
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Aug 2026.
- Individual participant dataSharing planned: No. De-identified participant data are stored securely at MMSx Authority Clinical Research Division and affiliated academic centers (BodyGNTX USA, GFFI India, IIKBS). Data will not be shared publicly but may be used in aggregate form for institutional publications.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
4 sites in 2 countries: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing MOVE Rehabilitation Protocol in people with Musculoskeletal Pain - Acute and Subacute Conditions, run by MMSx Authority Institute for Movement Mechanics & Biomechanics Research Inc. at 4 sites in 2 countries.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 12 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 4 sites in United States, India. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pain Reduction (NRS Score) (time frame: Baseline, Week 2, Week 4, and Week 8). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Aug 2026.