Athletic PerformanceWBPBM-PSCNCT07224646
Whole-Body Photobiomodulation Use in Professional Soccer Players During a State Championship
A study testing Whole-Body Photobiomodulation (PBM) (Active PBM) in people with Athletic Performance and Muscle Fatigue, run by Universidade Federal de Sao Carlos at 1 site in Brazil.
Trial summary
This study aims to investigate the effects of whole-body photobiomodulation on professional soccer players during a state championship. The primary question is whether photobiomodulation improves recovery, reduces muscle fatigue, and enhances performance compared to standard training without photobiomodulation. Read more about this study
- Who is it for?
- Ages 18 to 35 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Athletic Performance, Muscle Fatigue, Muscle Strength
- What is being tested?
- Whole-Body Photobiomodulation (PBM) (Active PBM)
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 24 participants
- Where
- 1 siteBrazil
- Study dates
- 4 Sep 2025to Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Male professional soccer players currently competing in the championship
- Age 18-35 years
- Training frequency ≥5 times per week
- Able to attend all PBM/sham sessions and all assessments during the 8-week intervention
- Signed informed consent
Who cannot join
- Lower-limb musculoskeletal injury in the last 6 months or currently receiving treatment
- Current use of phototherapy or any other recovery-enhancing modality
- Chronic medical conditions that may affect performance or recovery
- Known sensitivity or contraindication to light-based therapies
- Inability to comply with the intervention or training schedule
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Brazil1 site, 1 recruiting
- Recruiting
Desportivo Brasil Training Center
Porto Feliz, São Paulo, 18546412
Italo A Oliveira, MSc, +55 19 997190361, italoao@estudante.ufscar.br
Italo A Oliveira, MSc
About this study
This study aims to investigate the effects of whole-body photobiomodulation on professional soccer players during a state championship. The primary question is whether photobiomodulation improves recovery, reduces muscle fatigue, and enhances performance compared to standard training without photobiomodulation.
Read the detailed description
Detailed Description:
This randomized, controlled clinical trial aims to evaluate the effects of whole-body photobiomodulation (PBM) on recovery and performance in professional soccer players during a state championship.
The intervention will be performed twice weekly on non-consecutive days for 8 weeks, in combination with each athlete's standard training routine. Participants will be allocated to either an active PBM group or a sham PBM group, both following identical procedures to maintain blinding.
Throughout the study, participants will complete scheduled assessments at baseline, during, and after the 8-week period to monitor performance, muscle soreness, and hematological responses. Data will be analyzed using appropriate statistical tests, with a significance level of 5% (two-tailed).
- Conditions
- Athletic Performance, Muscle Fatigue, Muscle Strength, Sports
- Being tested
- Whole-Body Photobiomodulation (PBM) (Active PBM), Sham PBM
- Keywords
- Phototherapy, Laser therapy, Muscle fatigue, Muscle damage, Soccer
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Whole-Body Photobiomodulation (PBM) (Active PBM)Radiation
This intervention consists of whole-body photobiomodulation delivered using a full-body PBM device. Sessions are performed twice weekly on non-consecutive days for 8 weeks, coinciding with the athletes' standard training. The device emits therapeutic light at specified wavelengths and power, targeting the entire body. The protocol is standardized according to prior research, ensuring consistent exposure for all participants in the active arm. The intervention aims to improve muscle performance and recovery while reducing delayed onset muscle soreness (DOMS).
Sham PBMRadiation
Intervention Description (Sham PBM):
Participants receive a sham photobiomodulation intervention using the same device and schedule, but without emission of therapeutic light. The procedure mimics the active intervention to maintain blinding while allowing comparison of outcomes, including muscle performance, DOMS, and blood markers.
| Study group | Role | What they receive |
|---|---|---|
| Active PBM | Experimental | Whole-body PBM delivered with a Joovv Elite System (6 LED panels; 660±10 nm red and 850±10 nm near-infrared; total panel area ≈12,193 cm²). Athlete stands ~20 cm from panels, wearing eye protection. Two exposures per session: 450 s anterior + 450 s posterior (total 15 min). Measured average irradiance ≈81.62 mW/cm² and energy density per region ≈25.71 J/cm² at 20 cm. Two sessions/week on non-consecutive days for 8 weeks, after routine training. Receives: Radiation: Whole-Body Photobiomodulation (PBM) (Active PBM) |
| Sham PBM | Placebo comparator | Identical setup and schedule, but with therapeutic light disabled (placebo light only). Eye protection and blinding procedures identical to active PBM. Receives: Radiation: Sham PBM |
What is being measured
The primary outcome is the main question the study is designed to answer.
Delayed Onset Muscle Soreness (DOMS)
Pain intensity measured using the Numeric Rating Scale (NRS; 0-10 points; higher scores = worse pain) during a maximal voluntary knee-extension contraction in sitting. Pain location/extent captured with a standardized pain drawing (exploratory). Primary analysis uses NRS.
Measured: Baseline (T1), weekly (T2, weeks 1-8), and end of week 8 (T3).
Secondary outcomes (3)
Knee Extensor Strength (Hand-Held Dynamometry)
Peak force of dominant-leg knee extensors measured with a handheld dynamometer in standardized seated position; mean of two MVC attempts used for analysis.
Measured: Baseline (T1), weekly (T2, weeks 1-8), end of week 8 (T3)
Squat Jump (SJ) Height
Vertical jump height (cm) from Squat Jump (SJ) with hands on hips; mean of two trials; flight-time method on contact device.
Measured: Baseline (T1), weekly (T2, weeks 1-8), end of week 8 (T3) Unit: cm
Countermovement Jump (CMJ) Height
Vertical jump height (cm) from Countermovement Jump (CMJ) with hands on hips; mean of two trials; flight-time method on contact device.
Measured: Baseline (T1), weekly (T2, weeks 1-8), end of week 8 (T3)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Nov 2025
- Study start4 Sep 2025
- Primary completionAug 2026 (estimated)
- Study completionDec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (27)Papers the sponsor has linked to this study.
- Other trials for Athletic PerformanceStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Model Description: Participants are randomly assigned to two parallel groups: an Active Photobiomodulation (PBM) group and a Sham PBM group. Both groups undergo the same training schedule and assessment timeline, but only the active group receives therapeutic light exposure. There is no crossover between groups throughout the 8-week intervention period.
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 24 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Universidade Federal de Sao Carlos
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Italo Amaral de Oliveira, Universidade Federal de Sao Carlos
- Investigators
- Italo A Oliveira, MSc, Principal investigator, UFSCAR
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07224646
- Sponsor's protocol ID
- 84660524.7.0000.5504
- Acronym
- WBPBM-PSC
- Status last verified
- Nov 2025
- First submitted
- 4 Sep 2025
- Last updated
- 24 Nov 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- Yes
- Individual data sharing
- No: At this time, the plan for sharing individual participant data (IPD) has not been determined. Decisions regarding data sharing will be made after study completion, considering participant privacy, ethical approvals, and applicable institutional policies.
Publications
Zagatto AM, Dutra YM, Lira FS, Antunes BM, Faustini JB, Malta ES, Lopes VHF, de Poli RAB, Brisola GMP, Dos Santos GV, Rodrigues FM, Ferraresi C. Full Body Photobiomodulation Therapy to Induce Faster Muscle Recovery in Water Polo Athletes: Preliminary Results. Photobiomodul Photomed Laser Surg. 2020 Dec;38(12):766-772. doi: 10.1089/photob.2020.4803.
PubMed 33332232Vanin AA, Verhagen E, Barboza SD, Costa LOP, Leal-Junior ECP. Photobiomodulation therapy for the improvement of muscular performance and reduction of muscular fatigue associated with exercise in healthy people: a systematic review and meta-analysis. Lasers Med Sci. 2018 Jan;33(1):181-214. doi: 10.1007/s10103-017-2368-6. Epub 2017 Oct 31.
PubMed 29090398Van Hooren B, Zolotarjova J. The Difference Between Countermovement and Squat Jump Performances: A Review of Underlying Mechanisms With Practical Applications. J Strength Cond Res. 2017 Jul;31(7):2011-2020. doi: 10.1519/JSC.0000000000001913.
PubMed 28640774Thong ISK, Jensen MP, Miro J, Tan G. The validity of pain intensity measures: what do the NRS, VAS, VRS, and FPS-R measure? Scand J Pain. 2018 Jan 26;18(1):99-107. doi: 10.1515/sjpain-2018-0012.
PubMed 29794282Rochkind S, Geuna S, Shainberg A. Chapter 25: Phototherapy in peripheral nerve injury: effects on muscle preservation and nerve regeneration. Int Rev Neurobiol. 2009;87:445-64. doi: 10.1016/S0074-7742(09)87025-6.
PubMed 19682654Oliveira FS, Pinfildi CE, Parizoto NA, Liebano RE, Bossini PS, Garcia EB, Ferreira LM. Effect of low level laser therapy (830 nm) with different therapy regimes on the process of tissue repair in partial lesion calcaneous tendon. Lasers Surg Med. 2009 Apr;41(4):271-6. doi: 10.1002/lsm.20760.
PubMed 19347936Medeiros DM, Aimi M, Vaz MA, Baroni BM. Effects of low-level laser therapy on hamstring strain injury rehabilitation: A randomized controlled trial. Phys Ther Sport. 2020 Mar;42:124-130. doi: 10.1016/j.ptsp.2020.01.006. Epub 2020 Jan 10.
PubMed 31991284Lesnak J, Anderson D, Farmer B, Katsavelis D, Grindstaff TL. VALIDITY OF HAND-HELD DYNAMOMETRY IN MEASURING QUADRICEPS STRENGTH AND RATE OF TORQUE DEVELOPMENT. Int J Sports Phys Ther. 2019 Apr;14(2):180-187.
PubMed 30997270Higashi RH, Toma RL, Tucci HT, Pedroni CR, Ferreira PD, Baldini G, Aveiro MC, Borghi-Silva A, de Oliveira AS, Renno AC. Effects of low-level laser therapy on biceps braquialis muscle fatigue in young women. Photomed Laser Surg. 2013 Dec;31(12):586-94. doi: 10.1089/pho.2012.3388.
PubMed 24320801Mechanisms of low level light therapy Michael R. Hamblin, Tatiana N Demidova
Hamblin, M. R., Ferraresi, C., Huang, Y.-Y., Freitas, L. F. de, & Carroll, J. D. (2018). Low-level light therapy: Photobiomodulation. SPIE Press. ISBN 9781510614154
Ferreira-Valente MA, Pais-Ribeiro JL, Jensen MP. Validity of four pain intensity rating scales. Pain. 2011 Oct;152(10):2399-2404. doi: 10.1016/j.pain.2011.07.005.
PubMed 21856077Ferraresi C, Huang YY, Hamblin MR. Photobiomodulation in human muscle tissue: an advantage in sports performance? J Biophotonics. 2016 Dec;9(11-12):1273-1299. doi: 10.1002/jbio.201600176. Epub 2016 Nov 22.
PubMed 27874264Ferraresi C, Hamblin MR, Parizotto NA. Low-level laser (light) therapy (LLLT) on muscle tissue: performance, fatigue and repair benefited by the power of light. Photonics Lasers Med. 2012 Nov 1;1(4):267-286. doi: 10.1515/plm-2012-0032.
PubMed 23626925Ferraresi C, Bertucci D, Schiavinato J, Reiff R, Araujo A, Panepucci R, Matheucci E Jr, Cunha AF, Arakelian VM, Hamblin MR, Parizotto N, Bagnato V. Effects of Light-Emitting Diode Therapy on Muscle Hypertrophy, Gene Expression, Performance, Damage, and Delayed-Onset Muscle Soreness: Case-control Study with a Pair of Identical Twins. Am J Phys Med Rehabil. 2016 Oct;95(10):746-57. doi: 10.1097/PHM.0000000000000490.
PubMed 27088469
Study at a glance
From the registry record, last updated by the sponsor on 24 Nov 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Whole-Body Photobiomodulation Use in Professional Soccer Players During a State Championship
- ClinicalTrials.gov ID
- NCT07224646
- Acronym / sponsor ID
- WBPBM-PSC / 84660524.7.0000.5504
- Conditions
- Athletic Performance, Muscle Fatigue, Muscle Strength, Sports
- Keywords
- Phototherapy, Laser therapy, Muscle fatigue, Muscle damage, Soccer
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 24 participants (estimated)
- Lead sponsor
- Universidade Federal de Sao CarlosUniversity, hospital or other
- Study start
- 4 Sep 2025 (actual)
- Primary completion
- Aug 2026 (estimated)
- Study completion
- Dec 2026 (estimated)
- First posted
- 5 Nov 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to investigate the effects of whole-body photobiomodulation on professional soccer players during a state championship. The primary question is whether photobiomodulation improves recovery, reduces muscle fatigue, and enhances performance compared to standard training without photobiomodulation.
Detailed description
Detailed Description:
This randomized, controlled clinical trial aims to evaluate the effects of whole-body photobiomodulation (PBM) on recovery and performance in professional soccer players during a state championship.
The intervention will be performed twice weekly on non-consecutive days for 8 weeks, in combination with each athlete's standard training routine. Participants will be allocated to either an active PBM group or a sham PBM group, both following identical procedures to maintain blinding.
Throughout the study, participants will complete scheduled assessments at baseline, during, and after the 8-week period to monitor performance, muscle soreness, and hematological responses. Data will be analyzed using appropriate statistical tests, with a significance level of 5% (two-tailed).
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
- Model description
- Model Description: Participants are randomly assigned to two parallel groups: an Active Photobiomodulation (PBM) group and a Sham PBM group. Both groups undergo the same training schedule and assessment timeline, but only the active group receives therapeutic light exposure. There is no crossover between groups throughout the 8-week intervention period.
| Arm | Type | Receives |
|---|---|---|
| Active PBM | Experimental | Radiation: Whole-Body Photobiomodulation (PBM) (Active PBM)Whole-body PBM delivered with a Joovv Elite System (6 LED panels; 660±10 nm red and 850±10 nm near-infrared; total panel area ≈12,193 cm²). Athlete stands ~20 cm from panels, wearing eye protection. Two exposures per session: 450 s anterior + 450 s posterior (total 15 min). Measured average irradiance ≈81.62 mW/cm² and energy density per region ≈25.71 J/cm² at 20 cm. Two sessions/week on non-consecutive days for 8 weeks, after routine training. |
| Sham PBM | Placebo comparator | Radiation: Sham PBMIdentical setup and schedule, but with therapeutic light disabled (placebo light only). Eye protection and blinding procedures identical to active PBM. |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Male professional soccer players currently competing in the championship
- Age 18-35 years
- Training frequency ≥5 times per week
- Able to attend all PBM/sham sessions and all assessments during the 8-week intervention
- Signed informed consent
Key exclusion criteria (5 listed)
- Lower-limb musculoskeletal injury in the last 6 months or currently receiving treatment
- Current use of phototherapy or any other recovery-enhancing modality
- Chronic medical conditions that may affect performance or recovery
- Known sensitivity or contraindication to light-based therapies
- Inability to comply with the intervention or training schedule
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Whole-Body Photobiomodulation (PBM) (Active PBM)This intervention consists of whole-body photobiomodulation delivered using a full-body PBM device. Sessions are performed twice weekly on non-consecutive days for 8 weeks, coinciding with the athletes' standard training. The device emits therapeutic light at specified wavelengths and power, targeting the entire body. The protocol is standardized according to prior research, ensuring consistent exposure for all participants in the active arm. The intervention aims to improve muscle performance and recovery while reducing delayed onset muscle soreness (DOMS). | Radiation | Active PBM |
| Sham PBMIntervention Description (Sham PBM): Participants receive a sham photobiomodulation intervention using the same device and schedule, but without emission of therapeutic light. The procedure mimics the active intervention to maintain blinding while allowing comparison of outcomes, including muscle performance, DOMS, and blood markers. | Radiation | Sham PBM |
Primary outcome
Delayed Onset Muscle Soreness (DOMS)
Time frame: Baseline (T1), weekly (T2, weeks 1-8), and end of week 8 (T3).
Pain intensity measured using the Numeric Rating Scale (NRS; 0-10 points; higher scores = worse pain) during a maximal voluntary knee-extension contraction in sitting. Pain location/extent captured with a standardized pain drawing (exploratory). Primary analysis uses NRS.
3 secondary outcomes
Knee Extensor Strength (Hand-Held Dynamometry)
Time frame: Baseline (T1), weekly (T2, weeks 1-8), end of week 8 (T3)
Squat Jump (SJ) Height
Time frame: Baseline (T1), weekly (T2, weeks 1-8), end of week 8 (T3) Unit: cm
Countermovement Jump (CMJ) Height
Time frame: Baseline (T1), weekly (T2, weeks 1-8), end of week 8 (T3)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Nov 2025.
- Background: PubMed 33332232Zagatto AM, Dutra YM, Lira FS, Antunes BM, Faustini JB, Malta ES, Lopes VHF, de Poli RAB, Brisola GMP, Dos Santos GV, Rodrigues FM, Ferraresi C. Full Body Photobiomodulation Therapy to Induce Faster Muscle Recovery in Water Polo Athletes: Preliminary Results. Photobiomodul Photomed Laser Surg. 2020 Dec;38(12):766-772. doi: 10.1089/photob.2020.4803.
- Background: PubMed 29090398Vanin AA, Verhagen E, Barboza SD, Costa LOP, Leal-Junior ECP. Photobiomodulation therapy for the improvement of muscular performance and reduction of muscular fatigue associated with exercise in healthy people: a systematic review and meta-analysis. Lasers Med Sci. 2018 Jan;33(1):181-214. doi: 10.1007/s10103-017-2368-6. Epub 2017 Oct 31.
- Background: PubMed 28640774Van Hooren B, Zolotarjova J. The Difference Between Countermovement and Squat Jump Performances: A Review of Underlying Mechanisms With Practical Applications. J Strength Cond Res. 2017 Jul;31(7):2011-2020. doi: 10.1519/JSC.0000000000001913.
- Background: PubMed 29794282Thong ISK, Jensen MP, Miro J, Tan G. The validity of pain intensity measures: what do the NRS, VAS, VRS, and FPS-R measure? Scand J Pain. 2018 Jan 26;18(1):99-107. doi: 10.1515/sjpain-2018-0012.
- Background: PubMed 19682654Rochkind S, Geuna S, Shainberg A. Chapter 25: Phototherapy in peripheral nerve injury: effects on muscle preservation and nerve regeneration. Int Rev Neurobiol. 2009;87:445-64. doi: 10.1016/S0074-7742(09)87025-6.
- Background: PubMed 19347936Oliveira FS, Pinfildi CE, Parizoto NA, Liebano RE, Bossini PS, Garcia EB, Ferreira LM. Effect of low level laser therapy (830 nm) with different therapy regimes on the process of tissue repair in partial lesion calcaneous tendon. Lasers Surg Med. 2009 Apr;41(4):271-6. doi: 10.1002/lsm.20760.
- Background: PubMed 31991284Medeiros DM, Aimi M, Vaz MA, Baroni BM. Effects of low-level laser therapy on hamstring strain injury rehabilitation: A randomized controlled trial. Phys Ther Sport. 2020 Mar;42:124-130. doi: 10.1016/j.ptsp.2020.01.006. Epub 2020 Jan 10.
- Background: PubMed 30997270Lesnak J, Anderson D, Farmer B, Katsavelis D, Grindstaff TL. VALIDITY OF HAND-HELD DYNAMOMETRY IN MEASURING QUADRICEPS STRENGTH AND RATE OF TORQUE DEVELOPMENT. Int J Sports Phys Ther. 2019 Apr;14(2):180-187.
- Background: PubMed 24320801Higashi RH, Toma RL, Tucci HT, Pedroni CR, Ferreira PD, Baldini G, Aveiro MC, Borghi-Silva A, de Oliveira AS, Renno AC. Effects of low-level laser therapy on biceps braquialis muscle fatigue in young women. Photomed Laser Surg. 2013 Dec;31(12):586-94. doi: 10.1089/pho.2012.3388.
- BackgroundMechanisms of low level light therapy Michael R. Hamblin, Tatiana N Demidova
- BackgroundHamblin, M. R., Ferraresi, C., Huang, Y.-Y., Freitas, L. F. de, & Carroll, J. D. (2018). Low-level light therapy: Photobiomodulation. SPIE Press. ISBN 9781510614154
- Background: PubMed 21856077Ferreira-Valente MA, Pais-Ribeiro JL, Jensen MP. Validity of four pain intensity rating scales. Pain. 2011 Oct;152(10):2399-2404. doi: 10.1016/j.pain.2011.07.005.
- Individual participant dataSharing planned: No. At this time, the plan for sharing individual participant data (IPD) has not been determined. Decisions regarding data sharing will be made after study completion, considering participant privacy, ethical approvals, and applicable institutional policies.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Italo A Oliveira, MSc principal investigator
UFSCAR
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Whole-Body Photobiomodulation (PBM) (Active PBM) in people with Athletic Performance and Muscle Fatigue, run by Universidade Federal de Sao Carlos at 1 site in Brazil.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 24 Nov 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Brazil. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Italo A Oliveira, MSc (+55 19 997190361, italoao@estudante.ufscar.br), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Delayed Onset Muscle Soreness (DOMS) (time frame: Baseline (T1), weekly (T2, weeks 1-8), and end of week 8 (T3).). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07224646, which also lists 27 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Nov 2025.