Uterus AbsentNCT07228351
Comparison of the Effects of Vaginal Cuff Closure Sexual Function in Laparoscopic Hysterectomy
A study testing The effect of the vaginal cuff closure technique on women's sexual life and urogenital functions and ultrasound in people with Uterus Absent, run by Acibadem Kent Hospital at 1 site in Turkey (Türkiye).
Trial summary
Aim: Laparoscopic hysterectomy is the vaginal removal of the uterus with the help of laparoscopy. After the uterus is removed after hysterectomy, vaginal length is shortened by cuff suturing, resulting in conditions such as dyspareunia and sexual dysfunction . Read more about this study
- Who is it for?
- Ages 18 to 65 years, women only
- Conditions the study is for
- Uterus Absent
- What is being tested?
- The effect of the vaginal cuff closure technique on women's sexual life and urogenital functions and ultrasound
- Type of treatment
- Medical device, Lifestyle or therapy programme
- How many people
- Not given
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- Start not givento not given
- Phase
- Expanded access
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- Women only
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Perimenopausal period
- Having undergone surgery for benign gynecological indications
- Complete and accurate patient registration information.
- Volunteering to participate in the study.
Who cannot join
- Uterus size greater than 14 weeks' gestation
- Pelvic organ prolapse in the preoperative period
- Urinary incontinence in the preoperative period
- Cases with intraoperative complications
- Having undergone another concurrent surgery (urinary incontinence surgery, bowel surgery, etc.)
- History of endometriosis
- History of pelvic inflammatory disease
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
- Available
İzmir Kent Acibadem Hospital
Izmir
merve ecem albayrak, 05544691774, mecem_albayrak@yahoo.com.tr
About this study
Official title: Comparison of the Effects of Vaginal Cuff Closure Techniques on Vaginal Length and Sexual Function in Laparoscopic Hysterectomy
Aim: Laparoscopic hysterectomy is the vaginal removal of the uterus with the help of laparoscopy. After the uterus is removed after hysterectomy, vaginal length is shortened by cuff suturing, resulting in conditions such as dyspareunia and sexual dysfunction . Hysterectomy may also affect women physically and psychologically, as well as causing changes in sexual functions . In patients planned to undergo hysterectomy; Changes that may occur in sexual functions cause serious concerns during the preoperative period. However, physicians often miss these important points and do not discuss these issues adequately with patients. In this study; We aimed to compare the effects of vaginal cuff closure techniques in laparoscopic hysterectomy on vaginal length and women's sexual life. We used the Arizona Sexual Experience Scale to assess women's sexual life.
Read the detailed description
Hysterectomy, defined as the surgical removal of the uterus, is one of the most commonly performed gynecological operations worldwide. Indications for hysterectomy, which is frequently performed on women of reproductive age and menopause, are emphasized in the literature as including pelvic masses (uterine myomas), abnormal bleeding (menorrhagia, menometrorrhagia, dysfunctional uterine bleeding), ovarian cysts, endometriosis, pelvic pain, pelvic prolapse, and urinary incontinence. Currently, there are many approaches to hysterectomy. The uterus can be removed abdominally, vaginally, laparoscopically, or robotically. Due to the advantages of minimally invasive surgery, laparoscopic and robotic hysterectomies are on the rise, while the rate of vaginal and abdominal hysterectomies is decreasing. Laparoscopic hysterectomy is the vaginal removal of the uterus using laparoscopy. Advantages include rapid postoperative recovery, short hospital stay, reduced need for analgesia, and improved visualization of the pelvic organs. Hysterectomy can lead to bleeding, infection, thromboembolic events, and gastrointestinal and urinary complications. Due to the removal of the uterus after hysterectomy, vaginal length shortens, leading to conditions such as dyspareunia and sexual dysfunction. Hysterectomy can also affect women physically and psychologically, as well as alter sexual function. Sexual function after hysterectomy can be affected by physiological factors (reduced tissue quality, neural stimulation, and pelvic blood flow due to anatomical changes in pelvic tissue), hormonal factors (reduced ovarian blood flow or decreased estrogen and progesterone levels due to the removal of the ovaries along with hysterectomy), psychological factors (depression, altered body image, and perception of femininity), and factors related to the hysterectomy technique. There are conflicting opinions regarding the effect of the uterus on sexual function. Some authors suggest that uterine contractions play an important role in the orgasmic phase, while others suggest that hysterectomy causes vaginal shortening or damage to autonomic nerve endings in the cervicovaginal area, leading to sexual dysfunction. The causal relationship between hysterectomy and decreased sexual function has been linked to shortened vaginal length and the emergence of postoperative dyspareunia. This is influenced by the vaginal cuff closure techniques used during hysterectomy.
Research on the relationship between hysterectomy and postoperative urinary incontinence or urogenital complaints has yielded mixed results. Studies report varying effects of hysterectomy on urinary incontinence. However, it is unclear whether postoperative urinary incontinence is due to the hysterectomy itself, influenced by the technique, or due to preoperative factors. The possibility of deterioration in sexual function and urinary dysfunction in patients undergoing hysterectomy raises serious concerns during the preoperative period. However, physicians often overlook these important points and fail to adequately discuss them with patients. In this study, we aimed to investigate the effects of the vaginal cuff closure technique in laparoscopic hysterectomy on women's sexual life and urogenital functions. We used the Arizona Sexual Experiences Scale and vaginal length measurement to assess women's sexual life, and the Urogenital Distress Inventory to assess urogenital functions. Patients who underwent laparoscopic hysterectomy at the Obstetrics and Gynecology Department of Abant İzzet Baysal University Faculty of Medicine will be included in this study. Patients who underwent total laparoscopic hysterectomy will be divided into two groups based on the vaginal cuff closure technique: laparoscopic and vaginal. Patients will be recorded and evaluated based on their age, gender, parity, body mass index, presenting complaints, ultrasonography findings, probe curettage results, Pap smear results, surgical indications, current chronic diseases, and past surgical history. Data obtained in the study will be analyzed using SPSS. During total laparoscopic hysterectomy, vaginal cuff closure techniques will be used to divide the patients into two groups: laparoscopic and vaginal closure.
- Conditions
- Uterus Absent
- Being tested
- The effect of the vaginal cuff closure technique on women's sexual life and urogenital functions, ultrasound
- Keywords
- hysterectomy, laparoscopy, suturation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
The effect of the vaginal cuff closure technique on women's sexual life and urogenital functionsBehavioural
The Arizona Sexual Experiences Scale is a 6-point Likert-type scale consisting of 5 questions. The lowest possible score is 5, and the highest is 30. Scores of 11 or more are considered sexual dysfunction.
ultrasoundDevice
Vaginal length measurement accompanied by ultrasound
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Nov 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Uterus AbsentStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Expanded access
Sponsor and investigators
- Lead sponsor
- Acibadem Kent Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, merve ecem albayrak, Acibadem Kent Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07228351
- Sponsor's protocol ID
- AcibademKentH
- Status last verified
- Nov 2025
- First submitted
- 10 Nov 2025
- Last updated
- 14 Nov 2025
- Results posted
- No
Publications
Turner LC, Shepherd JP, Wang L, Bunker CH, Lowder JL. Hysterectomy surgery trends: a more accurate depiction of the last decade? Am J Obstet Gynecol. 2013 Apr;208(4):277.e1-7. doi: 10.1016/j.ajog.2013.01.022. Epub 2013 Jan 17.
PubMed 23333543
Study at a glance
From the registry record, last updated by the sponsor on 14 Nov 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of the Effects of Vaginal Cuff Closure Techniques on Vaginal Length and Sexual Function in Laparoscopic Hysterectomy
- ClinicalTrials.gov ID
- NCT07228351
- Acronym / sponsor ID
- AcibademKentH
- Conditions
- Uterus Absent
- Keywords
- hysterectomy, laparoscopy, suturation
- Study type
- Expanded access
- Recruitment status
- Available
- Lead sponsor
- Acibadem Kent HospitalUniversity, hospital or other
- First posted
- 14 Nov 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Aim: Laparoscopic hysterectomy is the vaginal removal of the uterus with the help of laparoscopy. After the uterus is removed after hysterectomy, vaginal length is shortened by cuff suturing, resulting in conditions such as dyspareunia and sexual dysfunction . Hysterectomy may also affect women physically and psychologically, as well as causing changes in sexual functions . In patients planned to undergo hysterectomy; Changes that may occur in sexual functions cause serious concerns during the preoperative period. However, physicians often miss these important points and do not discuss these issues adequately with patients. In this study; We aimed to compare the effects of vaginal cuff closure techniques in laparoscopic hysterectomy on vaginal length and women's sexual life. We used the Arizona Sexual Experience Scale to assess women's sexual life.
Detailed description
Hysterectomy, defined as the surgical removal of the uterus, is one of the most commonly performed gynecological operations worldwide. Indications for hysterectomy, which is frequently performed on women of reproductive age and menopause, are emphasized in the literature as including pelvic masses (uterine myomas), abnormal bleeding (menorrhagia, menometrorrhagia, dysfunctional uterine bleeding), ovarian cysts, endometriosis, pelvic pain, pelvic prolapse, and urinary incontinence. Currently, there are many approaches to hysterectomy. The uterus can be removed abdominally, vaginally, laparoscopically, or robotically. Due to the advantages of minimally invasive surgery, laparoscopic and robotic hysterectomies are on the rise, while the rate of vaginal and abdominal hysterectomies is decreasing. Laparoscopic hysterectomy is the vaginal removal of the uterus using laparoscopy. Advantages include rapid postoperative recovery, short hospital stay, reduced need for analgesia, and improved visualization of the pelvic organs. Hysterectomy can lead to bleeding, infection, thromboembolic events, and gastrointestinal and urinary complications. Due to the removal of the uterus after hysterectomy, vaginal length shortens, leading to conditions such as dyspareunia and sexual dysfunction. Hysterectomy can also affect women physically and psychologically, as well as alter sexual function. Sexual function after hysterectomy can be affected by physiological factors (reduced tissue quality, neural stimulation, and pelvic blood flow due to anatomical changes in pelvic tissue), hormonal factors (reduced ovarian blood flow or decreased estrogen and progesterone levels due to the removal of the ovaries along with hysterectomy), psychological factors (depression, altered body image, and perception of femininity), and factors related to the hysterectomy technique. There are conflicting opinions regarding the effect of the uterus on sexual function. Some authors suggest that uterine contractions play an important role in the orgasmic phase, while others suggest that hysterectomy causes vaginal shortening or damage to autonomic nerve endings in the cervicovaginal area, leading to sexual dysfunction. The causal relationship between hysterectomy and decreased sexual function has been linked to shortened vaginal length and the emergence of postoperative dyspareunia. This is influenced by the vaginal cuff closure techniques used during hysterectomy.
Research on the relationship between hysterectomy and postoperative urinary incontinence or urogenital complaints has yielded mixed results. Studies report varying effects of hysterectomy on urinary incontinence. However, it is unclear whether postoperative urinary incontinence is due to the hysterectomy itself, influenced by the technique, or due to preoperative factors. The possibility of deterioration in sexual function and urinary dysfunction in patients undergoing hysterectomy raises serious concerns during the preoperative period. However, physicians often overlook these important points and fail to adequately discuss them with patients. In this study, we aimed to investigate the effects of the vaginal cuff closure technique in laparoscopic hysterectomy on women's sexual life and urogenital functions. We used the Arizona Sexual Experiences Scale and vaginal length measurement to assess women's sexual life, and the Urogenital Distress Inventory to assess urogenital functions. Patients who underwent laparoscopic hysterectomy at the Obstetrics and Gynecology Department of Abant İzzet Baysal University Faculty of Medicine will be included in this study. Patients who underwent total laparoscopic hysterectomy will be divided into two groups based on the vaginal cuff closure technique: laparoscopic and vaginal. Patients will be recorded and evaluated based on their age, gender, parity, body mass index, presenting complaints, ultrasonography findings, probe curettage results, Pap smear results, surgical indications, current chronic diseases, and past surgical history. Data obtained in the study will be analyzed using SPSS. During total laparoscopic hysterectomy, vaginal cuff closure techniques will be used to divide the patients into two groups: laparoscopic and vaginal closure.
Study design
Who may qualify
- Ages
- 18 to 65 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Perimenopausal period
- Having undergone surgery for benign gynecological indications
- Complete and accurate patient registration information.
- Volunteering to participate in the study.
Key exclusion criteria (7 listed)
- Uterus size greater than 14 weeks' gestation
- Pelvic organ prolapse in the preoperative period
- Urinary incontinence in the preoperative period
- Cases with intraoperative complications
- Having undergone another concurrent surgery (urinary incontinence surgery, bowel surgery, etc.)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| The effect of the vaginal cuff closure technique on women's sexual life and urogenital functionsThe Arizona Sexual Experiences Scale is a 6-point Likert-type scale consisting of 5 questions. The lowest possible score is 5, and the highest is 30. Scores of 11 or more are considered sexual dysfunction. | Behavioural | – |
| ultrasoundVaginal length measurement accompanied by ultrasound | Device | – |
Primary outcome
Not reported in the source record.
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Nov 2025.
- Results publication: PubMed 23333543Turner LC, Shepherd JP, Wang L, Bunker CH, Lowder JL. Hysterectomy surgery trends: a more accurate depiction of the last decade? Am J Obstet Gynecol. 2013 Apr;208(4):277.e1-7. doi: 10.1016/j.ajog.2013.01.022. Epub 2013 Jan 17.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing The effect of the vaginal cuff closure technique on women's sexual life and urogenital functions and ultrasound in people with Uterus Absent, run by Acibadem Kent Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 14 Nov 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact merve albayrak (05544691774, mecem_albayrak@yahoo.com.tr), or a site near the patient. AzTrials does not enrol participants or take referrals.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07228351, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Nov 2025.