Hand Burnhand burnNCT07228780
Impact of Resistance Training With and Without Venous Occlusion on Strength and Function Post (Hand Burn)
A study testing resistance exercise with venous occlusion and traditional resistance exercises in people with Hand Burn, run by Cairo University at 1 site in Egypt.
Trial summary
It will be hypothesized that There is There is no difference between resistance training with and without venous occlusion on hand strength and function post hand burn. Read more about this study
- Who is it for?
- Any ageHealthy volunteers can take part
- Conditions the study is for
- Hand Burn
- What is being tested?
- resistance exercise with venous occlusion and traditional resistance exercises
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 34 participants
- Where
- 1 siteEgypt
- Study dates
- 20 Nov 2025to 30 Jan 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Who may be able to join
- Patients of all age groups and both sexes having less than sixty percent TBSA thermal burns and involves the hand.
- Patients with second-degree (superficial or deep) burn on the hand.
- Patients with third-degree burns
- Patients with complete wound healing
- Patients without any defects at tendons
- Patients without burning at cubital fossa (cuff placement)
Show all 9Show fewer
- participants were required to have a resting (systolic and diastolic) blood pressure of <140/90 mmHg and a resting heart rate of <90 bpm
- A decreased grip strength.
- Patients without cognitive impairments and actively cooperating with treatment and measurements
Who cannot join
- Any patient who has previous injury or congenital deformity of the hand with restricted hand function.
- Resting systolic BP (BP) <140 mmHg and/or diastolic BP< 90 mmHg
- Self-reported cardiovascular, metabolic, or pulmonary conditions or signs and symptoms suggestive of these diseases
- Associated injuries affecting participation in exercise training, including fracture, amputation, acquired brain injury or peripheral neural injury or any pre-existing medical condition which may affect exercise participation.
- patients that had fourth degree burns
- patients that had first degree burns
Show all 11Show fewer
- Patients with burn at cubital fossa (cuff placement)
- Patients without complete wound healing
- patient who is taking medications that affect hemodynamic responses
- Patients with severe hand burns leading to muscle and tendon damage, or those who have undergone finger amputation surgery
- Patients who were not compliant for following up for at least once a month following discharge from hospital.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Impact of Resistance Training With and Without Venous Occlusion on Strength and Function Post Hand Burn
It will be hypothesized that There is There is no difference between resistance training with and without venous occlusion on hand strength and function post hand burn.
Read the detailed description
The purpose of the study is to evaluate the difference between resistance training with and without venous occlusion on hand strength and function post hand burn.
This study will be designed to evaluate the difference between resistance training with and without venous occlusion on hand strength and function post hand burn.
- Conditions
- Hand Burn
- Being tested
- resistance exercise with venous occlusion, traditional resistance exercises
- Keywords
- hand burn-hand grip
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
resistance exercise with venous occlusionOther
patients with hand burn who will receive conventional treatment for burn which included: positioning, range of motion, stretch, joint mobilization and strength exercise for hand grip for 3 days per week for 4 weeks
traditional resistance exercisesOther
This group will include 17 patients with hand burn who will receive conventional treatment for burn which included: positioning, range of motion, stretch, joint mobilization and strength exercise for hand grip for 3 days per week for 4 weeks
| Study group | Role | What they receive |
|---|---|---|
| study group (aspirin Group) | Experimental | Resistance exercises with venous occlusion This group will include 17 patients with hand burn who will receive treatment for burn which included: positioning, range of motion, stretch, joint mobilization and strength exercise for hand grip with blood flow restriction3 days per week for 4 weeks Receives: Other: resistance exercise with venous occlusion |
| control | Experimental | This group will include 17 patients with hand burn who will receive treatment for burn which included: positioning, range of motion, stretch, joint mobilization and strength exercise for hand grip with blood flow restriction3 days per week for 4 weeks Receives: Other: traditional resistance exercises |
What is being measured
The primary outcome is the main question the study is designed to answer.
hand grip strength
Hand grip will be assessed by digital Hand Dynamometer
Measured: twice first before beginning treatment from day 1 of treatment second after complete treatment after 1 month Assessment will be for 1 minute For assessment hand grip strength
Secondary outcomes (1)
upper limb function
Function of hand will be assessed by quick disabilities of arm, shoulder and hand questionnaire which asks patient about symptoms as well as ability to perform certain activities This scale which which assess upper limb function and high score means high disability and bad results and low score means low disability and good results
Measured: twice first pre treatment at 1 day for almost 5 minutes to assess all functions of upper limb function second after complete treatment after 1 month to assess upper limb function after treatment for 5 minutes
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Nov 2025
- Study start20 Nov 2025
- Primary completion1 Jan 2026
- Study completion30 Jan 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (33)Papers the sponsor has linked to this study.
- Other trials for Hand BurnStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 34 participants (actual)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Hadeer Gamal Fouad Eltelemy, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07228780
- Sponsor's protocol ID
- P.T.REC/012/006079
- Acronym
- hand burn
- Status last verified
- Apr 2026
- First submitted
- 13 Nov 2025
- Last updated
- 14 Apr 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: it is considered privacy of patients and privacy of my research
Publications
Araujo, B. F., do Nascimento, C. M., Busarello, F. O., Moreira, N. B., Baroni, M. P., de Carvalho, A. R., & Bertolini, G. R. F. (2012). Assessment of handgrip strength after neural mobilization. Revista Brasileira de Medicina do Esporte, 18(4), 242-245.
Ahmed, A. M., Hassan, Y. S., Azer, S. Z., & Abd EL-All, H. A. E. R. (2019). Effect of range of motion exercise program on improving upper-arm region joints function for burned patients. Assiut Scientific Nursing Journal, 7(19), 61-69.
Watzinger N, Hecker A, Petschnig D, Tran J, Glantschnig C, Moshammer M, Pignet AL, Ellersdorfer AM, Kamolz LP. Long-Term Functional Outcomes after Hand Burns: A Monocentric Controlled Cohort Study. J Clin Med. 2024 Jun 15;13(12):3509. doi: 10.3390/jcm13123509.
PubMed 38930038Watson R, Sullivan B, Stone A, Jacobs C, Malone T, Heebner N, Noehren B. Blood Flow Restriction Therapy: An Evidence-Based Approach to Postoperative Rehabilitation. JBJS Rev. 2022 Oct 3;10(10). doi: 10.2106/JBJS.RVW.22.00062. eCollection 2022 Oct 1.
PubMed 36191086Tehreem, Z., Kazmi, Y., Khalid, M. U., Mansha, H., Hassan, M., & Majeed, R. (2022). Comparison of soft tissue mobilization versus static stretching in post-burn contractures at elbow and wrist, A pilot study. Journal of University Medical & Dental College, 13(3), 408-411.
Serghiou M, Cowan A, Whitehead C. Rehabilitation after a burn injury. Clin Plast Surg. 2009 Oct;36(4):675-86. doi: 10.1016/j.cps.2009.05.008.
PubMed 19793561Schoenfeld BJ. The mechanisms of muscle hypertrophy and their application to resistance training. J Strength Cond Res. 2010 Oct;24(10):2857-72. doi: 10.1519/JSC.0b013e3181e840f3.
PubMed 20847704Salwa, F., KHATTAB, A. S., MOHAMMED, M. M., & NASER, M. A. (2020). Validity and reliability of the Arabic version of the quick-dash questionnaire for upper extremity disorders. The Medical Journal of Cairo University, 88(December), 2037-2043
Reina-Ruiz AJ, Martinez-Cal J, Molina-Torres G, Romero-Galisteo RP, Galan-Mercant A, Carrasco-Vega E, Gonzalez-Sanchez M. Effectiveness of Blood Flow Restriction on Functionality, Quality of Life and Pain in Patients with Neuromusculoskeletal Pathologies: A Systematic Review. Int J Environ Res Public Health. 2023 Jan 12;20(2):1401. doi: 10.3390/ijerph20021401.
PubMed 36674158Prolonge, R. (2022). Hand and Wrist Mobilizations. In: Mesplié, G. (eds) Hand and Wrist Therapy. Springer, Cham. https://doi.org/10.1007/978-3-030-94942-6_5
Procter F. Rehabilitation of the burn patient. Indian J Plast Surg. 2010 Sep;43(Suppl):S101-13. doi: 10.4103/0970-0358.70730.
PubMed 21321643Perera, A. D., Perera, C., & Karunanayake, A. L. (2017). Effectiveness of early stretching exercises for range of motion in the shoulder joint and quality of functional recovery in patients with burns-a randomized control trial.
Mohammadabadi, H. D., Azizi, S., Dadarkhah, A., & Soltani, Z. R. (2018). Evaluation of effectiveness of the wrist mobilization compared with local corticosteroid injection in treatment of moderate carpal tunnel syndrome. Annals of Military and Health Sciences Research, 16(2), e83335.
Machek, S. B., Harris, D. R., Heileson, J. L., Wilburn, D. T., Forsse, J. S., & Willoughby, D. S. (2023). Impacts of varying blood flow restriction cuff size and material on arterial, venous and calf muscle pump-mediated blood flow. Oxygen, 3(2), 190-202
Kara S, Seyhan N, Oksuz S. Effectiveness of early rehabilitation in hand burns. Ulus Travma Acil Cerrahi Derg. 2023 Jun;29(6):691-697. doi: 10.14744/tjtes.2023.22780.
PubMed 37278077
Study at a glance
From the registry record, last updated by the sponsor on 14 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Impact of Resistance Training With and Without Venous Occlusion on Strength and Function Post Hand Burn
- ClinicalTrials.gov ID
- NCT07228780
- Acronym / sponsor ID
- hand burn / P.T.REC/012/006079
- Conditions
- Hand Burn
- Keywords
- hand burn-hand grip
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 34 participants (actual)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 20 Nov 2025 (actual)
- Primary completion
- 1 Jan 2026 (actual)
- Study completion
- 30 Jan 2026 (actual)
- First posted
- 14 Nov 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
It will be hypothesized that There is There is no difference between resistance training with and without venous occlusion on hand strength and function post hand burn.
Detailed description
The purpose of the study is to evaluate the difference between resistance training with and without venous occlusion on hand strength and function post hand burn.
This study will be designed to evaluate the difference between resistance training with and without venous occlusion on hand strength and function post hand burn.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| study group (aspirin Group) | Experimental | Other: resistance exercise with venous occlusionResistance exercises with venous occlusion This group will include 17 patients with hand burn who will receive treatment for burn which included: positioning, range of motion, stretch, joint mobilization and strength exercise for hand grip with blood flow restriction3 days per week for 4 weeks |
| control | Experimental | Other: traditional resistance exercisesThis group will include 17 patients with hand burn who will receive treatment for burn which included: positioning, range of motion, stretch, joint mobilization and strength exercise for hand grip with blood flow restriction3 days per week for 4 weeks |
Who may qualify
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (9 listed)
- Patients of all age groups and both sexes having less than sixty percent TBSA thermal burns and involves the hand.
Key exclusion criteria (11 listed)
- Any patient who has previous injury or congenital deformity of the hand with restricted hand function.
- Resting systolic BP (BP) <140 mmHg and/or diastolic BP< 90 mmHg
- Self-reported cardiovascular, metabolic, or pulmonary conditions or signs and symptoms suggestive of these diseases
- Associated injuries affecting participation in exercise training, including fracture, amputation, acquired brain injury or peripheral neural injury or any pre-existing medical condition which may affect exercise participation.
- patients that had fourth degree burns
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| resistance exercise with venous occlusionpatients with hand burn who will receive conventional treatment for burn which included: positioning, range of motion, stretch, joint mobilization and strength exercise for hand grip for 3 days per week for 4 weeks | Other | study group (aspirin Group) |
| traditional resistance exercisesThis group will include 17 patients with hand burn who will receive conventional treatment for burn which included: positioning, range of motion, stretch, joint mobilization and strength exercise for hand grip for 3 days per week for 4 weeks | Other | control |
Primary outcome
hand grip strength
Time frame: twice first before beginning treatment from day 1 of treatment second after complete treatment after 1 month Assessment will be for 1 minute For assessment hand grip strength
Hand grip will be assessed by digital Hand Dynamometer
1 secondary outcome
upper limb function
Time frame: twice first pre treatment at 1 day for almost 5 minutes to assess all functions of upper limb function second after complete treatment after 1 month to assess upper limb function after treatment for 5 minutes
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Apr 2026.
- Results publicationAraujo, B. F., do Nascimento, C. M., Busarello, F. O., Moreira, N. B., Baroni, M. P., de Carvalho, A. R., & Bertolini, G. R. F. (2012). Assessment of handgrip strength after neural mobilization. Revista Brasileira de Medicina do Esporte, 18(4), 242-245.
- Results publicationAhmed, A. M., Hassan, Y. S., Azer, S. Z., & Abd EL-All, H. A. E. R. (2019). Effect of range of motion exercise program on improving upper-arm region joints function for burned patients. Assiut Scientific Nursing Journal, 7(19), 61-69.
- Results publication: PubMed 38930038Watzinger N, Hecker A, Petschnig D, Tran J, Glantschnig C, Moshammer M, Pignet AL, Ellersdorfer AM, Kamolz LP. Long-Term Functional Outcomes after Hand Burns: A Monocentric Controlled Cohort Study. J Clin Med. 2024 Jun 15;13(12):3509. doi: 10.3390/jcm13123509.
- Results publication: PubMed 36191086Watson R, Sullivan B, Stone A, Jacobs C, Malone T, Heebner N, Noehren B. Blood Flow Restriction Therapy: An Evidence-Based Approach to Postoperative Rehabilitation. JBJS Rev. 2022 Oct 3;10(10). doi: 10.2106/JBJS.RVW.22.00062. eCollection 2022 Oct 1.
- Results publicationTehreem, Z., Kazmi, Y., Khalid, M. U., Mansha, H., Hassan, M., & Majeed, R. (2022). Comparison of soft tissue mobilization versus static stretching in post-burn contractures at elbow and wrist, A pilot study. Journal of University Medical & Dental College, 13(3), 408-411.
- Results publication: PubMed 19793561Serghiou M, Cowan A, Whitehead C. Rehabilitation after a burn injury. Clin Plast Surg. 2009 Oct;36(4):675-86. doi: 10.1016/j.cps.2009.05.008.
- Results publication: PubMed 20847704Schoenfeld BJ. The mechanisms of muscle hypertrophy and their application to resistance training. J Strength Cond Res. 2010 Oct;24(10):2857-72. doi: 10.1519/JSC.0b013e3181e840f3.
- Results publicationSalwa, F., KHATTAB, A. S., MOHAMMED, M. M., & NASER, M. A. (2020). Validity and reliability of the Arabic version of the quick-dash questionnaire for upper extremity disorders. The Medical Journal of Cairo University, 88(December), 2037-2043
- Results publication: PubMed 36674158Reina-Ruiz AJ, Martinez-Cal J, Molina-Torres G, Romero-Galisteo RP, Galan-Mercant A, Carrasco-Vega E, Gonzalez-Sanchez M. Effectiveness of Blood Flow Restriction on Functionality, Quality of Life and Pain in Patients with Neuromusculoskeletal Pathologies: A Systematic Review. Int J Environ Res Public Health. 2023 Jan 12;20(2):1401. doi: 10.3390/ijerph20021401.
- Results publicationProlonge, R. (2022). Hand and Wrist Mobilizations. In: Mesplié, G. (eds) Hand and Wrist Therapy. Springer, Cham. https://doi.org/10.1007/978-3-030-94942-6_5
- Results publication: PubMed 21321643Procter F. Rehabilitation of the burn patient. Indian J Plast Surg. 2010 Sep;43(Suppl):S101-13. doi: 10.4103/0970-0358.70730.
- Results publicationPerera, A. D., Perera, C., & Karunanayake, A. L. (2017). Effectiveness of early stretching exercises for range of motion in the shoulder joint and quality of functional recovery in patients with burns-a randomized control trial.
- Individual participant dataSharing planned: No. it is considered privacy of patients and privacy of my research
Related trials for Hand Burn
Recruiting
Hand Function Outcome After the Application of Transfer Energy Capacitive and Resistive on Post-burn Patients Presented With Carpal Tunnel Syndrome
Carpal Tunnel Syndrome (CTS) Post-burn
Not yet recruitingObservational study
Validity and Reliability of Arabic Version of Michigan Hand Questionnaire in Assessment of Hand Function Post-burn
Burns
RecruitingObservational study
Turkish Adaptation and Validation of the Burnt Hand Outcome Tool (BHOT)
Hand Burn, Hand Injuries
RecruitingObservational study
Changes in Function of the Upper Limb With Physiotherapy
Burn of Upper Limb, Except Wrist and Hand
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing resistance exercise with venous occlusion and traditional resistance exercises in people with Hand Burn, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 14 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
hand grip strength (time frame: twice first before beginning treatment from day 1 of treatment second after complete treatment after 1 month Assessment will be for 1 minute For assessment hand grip strength). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07228780, which also lists 33 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Apr 2026.