OverweightSCEX-ADCRPNCT07230873
The Impact of Stationary Combined Exercise on Adiponectin and Hs-CRP Levels in Overweight Women
A study testing Combined Exercise Group and No Structured Exercise in people with Overweight and Obesity, run by Xianjie Zheng at 1 site in China.
Trial summary
This study looked at whether a specific exercise program can improve inflammatory markers in overweight young women. We tested an eight-week, circuit-style exercise program that combines aerobic and resistance activities (e.g., sit-ups, step jumps, push-ups, jump rope, jumping jacks, medicine-ball lifts). Read more about this study
- Who is it for?
- Ages 20 to 30 years, women only
- Conditions the study is for
- Overweight, Obesity, Inflammation, Low-Grade
- What is being tested?
- Combined Exercise Group and No Structured Exercise
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 22 participants
- Where
- 1 siteChina
- Study dates
- 20 Jan 2024to 10 Apr 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 30 years
- Women only
- No healthy volunteers
- Adult
Who may be able to join
- Female sex Age 20 to 30 years BMI 25 to 31 kg/m² Body weight 63 to 87 kg Generally healthy, without diagnosed chronic illness Willing and able to provide written informed consent Willing to refrain from vigorous physical activity for 48 hours before blood sampling Able to attend 4 supervised training sessions per week for 8 weeks (if assigned to intervention)
Who cannot join
- History of cardiovascular disease, hypertension, or diabetes Current smoking or tobacco use Current use of medications or supplements that affect metabolism or inflammatory markers Pregnancy or breastfeeding Contraindications to moderate-to-high intensity exercise on screening Participation in regular vigorous exercise training within the past 6 months Inability or unwillingness to comply with study procedures (e.g., missing >2 consecutive training sessions)
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Impact of Stationary Combined Exercise on Adiponectin and High-Sensitivity C-Reactive Protein Levels in Overweight Women
This study looked at whether a specific exercise program can improve inflammatory markers in overweight young women. We tested an eight-week, circuit-style exercise program that combines aerobic and resistance activities (e.g., sit-ups, step jumps, push-ups, jump rope, jumping jacks, medicine-ball lifts). Participants exercised four times per week at a moderate-to-high intensity, with a warm-up and cool-down at each session.
Twenty-two women (ages 20-30 years; BMI 25-31 kg/m²) were randomly assigned to one of two groups: (1) the exercise group completed the training program; (2) the control group continued usual daily activities without a structured program. Before starting and 48 hours after finishing the program, we took fasting blood samples to measure two markers: adiponectin (a hormone made by fat tissue that supports healthy metabolism and has anti-inflammatory effects) and high-sensitivity C-reactive protein (hs-CRP) (a blood marker of inflammation and cardiovascular risk).
Read more
The main outcomes were the changes in adiponectin and hs-CRP from before to after the 8-week period. We also recorded weight, body mass index (BMI), body fat percentage, and fitness (VO₂max). The study was conducted at the Exercise Physiology Laboratory, College of Physical Education and Health, Chongqing College of International Business and Economics (Chongqing, China). The research ethics committee approved the protocol, and all participants provided written informed consent.
Recruitment and data collection are complete. Findings suggest that this circuit-based exercise program can increase adiponectin and lower hs-CRP, alongside improvements in body composition, in overweight young women.
- Being tested
- Combined Exercise Group, No Structured Exercise
- Keywords
- Adiponectin, inflammation, combined station training, hs-CRP
- Medical subject headings
- Overweight, Obesity, Inflammation, Cardiovascular Diseases
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Combined Exercise GroupBehavioural
Also called High-Intensity Circuit-Based Combined Exercise, Combined Stationary Exercise, SCEX Program (Stationary Combined Exercise)
Participants completed an eight-week circuit-based combined exercise program, four sessions per week, at an intensity of 70-90% of maximum heart rate. Each session began with a 10-15 minute warm-up (stretching and light jogging) and ended with a 5-10 minute cool-down (walking and stretching). The main exercise protocol included six stations (sit-ups, step jumps, push-ups, jump rope, jumping jacks, and medicine ball lifting), performed in three rounds. The duration at each station progressively increased from 60 seconds (weeks 1-2) to 150 seconds (weeks 7-8), with rest intervals of 30-50 seconds between stations and 3-5 minutes between rounds. Exercise intensity was monitored with a Polar heart rate monitor to ensure participants stayed within the target zone.
No Structured ExerciseBehavioural
Also called Usual Activity, No Exercise Program
Participants in the control group will not receive any structured exercise program during the eight-week study period. They will be instructed to maintain their usual daily routines and refrain from initiating any new organized exercise or training programs beyond their routine physical education classes and everyday activities.
| Study group | Role | What they receive |
|---|---|---|
| Combined Exercise Group | Experimental | Arm 1 reflects the circuit-based combined exercise intervention. Receives: Behavioral: Combined Exercise Group |
| Control Group | Experimental | Arm 2 reflects the no structured exercise condition. Receives: Behavioral: No Structured Exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Serum Adiponectin Concentration
Serum adiponectin (µg/mL) quantified by ELISA in the fasting state; difference from baseline to 48 hours after completion of the 8-week exercise program.
Measured: Baseline and 48 hours post-intervention (end of week 8).
Secondary outcomes (1)
Change in Serum Adiponectin Concentration
Serum adiponectin (µg/mL) quantified by ELISA in the fasting state; difference from baseline to 48 hours after completion of the 8-week exercise program.
Measured: Baseline and 48 hours post-intervention (end of week 8).
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Nov 2025
- Study start20 Jan 2024
- Primary completion10 Apr 2024
- Study completion10 Apr 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for OverweightStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 22 participants (actual)
Sponsor and investigators
- Lead sponsor
- Xianjie Zheng
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Xianjie Zheng, Chongqing Medical University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07230873
- Sponsor's protocol ID
- College of Physical Education
- Other IDs
- K2016038
- Acronym
- SCEX-ADCRP
- Status last verified
- Nov 2025
- First submitted
- 13 Sep 2025
- Last updated
- 19 Nov 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 19 Nov 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Impact of Stationary Combined Exercise on Adiponectin and High-Sensitivity C-Reactive Protein Levels in Overweight Women
- ClinicalTrials.gov ID
- NCT07230873
- Acronym / sponsor ID
- SCEX-ADCRP / College of Physical Education
- Keywords
- Adiponectin, inflammation, combined station training, hs-CRP
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 22 participants (actual)
- Lead sponsor
- Xianjie ZhengUniversity, hospital or other
- Study start
- 20 Jan 2024 (actual)
- Primary completion
- 10 Apr 2024 (actual)
- Study completion
- 10 Apr 2024 (actual)
- First posted
- 17 Nov 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study looked at whether a specific exercise program can improve inflammatory markers in overweight young women. We tested an eight-week, circuit-style exercise program that combines aerobic and resistance activities (e.g., sit-ups, step jumps, push-ups, jump rope, jumping jacks, medicine-ball lifts). Participants exercised four times per week at a moderate-to-high intensity, with a warm-up and cool-down at each session.
Twenty-two women (ages 20-30 years; BMI 25-31 kg/m²) were randomly assigned to one of two groups: (1) the exercise group completed the training program; (2) the control group continued usual daily activities without a structured program. Before starting and 48 hours after finishing the program, we took fasting blood samples to measure two markers: adiponectin (a hormone made by fat tissue that supports healthy metabolism and has anti-inflammatory effects) and high-sensitivity C-reactive protein (hs-CRP) (a blood marker of inflammation and cardiovascular risk).
The main outcomes were the changes in adiponectin and hs-CRP from before to after the 8-week period. We also recorded weight, body mass index (BMI), body fat percentage, and fitness (VO₂max). The study was conducted at the Exercise Physiology Laboratory, College of Physical Education and Health, Chongqing College of International Business and Economics (Chongqing, China). The research ethics committee approved the protocol, and all participants provided written informed consent.
Recruitment and data collection are complete. Findings suggest that this circuit-based exercise program can increase adiponectin and lower hs-CRP, alongside improvements in body composition, in overweight young women.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Combined Exercise Group | Experimental | Behavioral: Combined Exercise GroupArm 1 reflects the circuit-based combined exercise intervention. |
| Control Group | Experimental | Behavioral: No Structured ExerciseArm 2 reflects the no structured exercise condition. |
Who may qualify
- Ages
- 20 to 30 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Female sex Age 20 to 30 years BMI 25 to 31 kg/m² Body weight 63 to 87 kg Generally healthy, without diagnosed chronic illness Willing and able to provide written informed consent Willing to refrain from vigorous physical activity for 48 hours before blood sampling Able to attend 4 supervised training sessions per week for 8 weeks (if assigned to intervention)
Key exclusion criteria (1 listed)
- History of cardiovascular disease, hypertension, or diabetes Current smoking or tobacco use Current use of medications or supplements that affect metabolism or inflammatory markers Pregnancy or breastfeeding Contraindications to moderate-to-high intensity exercise on screening Participation in regular vigorous exercise training within the past 6 months Inability or unwillingness to comply with study procedures (e.g., missing >2 consecutive training sessions)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Combined Exercise GroupAlso: High-Intensity Circuit-Based Combined Exercise, Combined Stationary Exercise, SCEX Program (Stationary Combined Exercise)Participants completed an eight-week circuit-based combined exercise program, four sessions per week, at an intensity of 70-90% of maximum heart rate. Each session began with a 10-15 minute warm-up (stretching and light jogging) and ended with a 5-10 minute cool-down (walking and stretching). The main exercise protocol included six stations (sit-ups, step jumps, push-ups, jump rope, jumping jacks, and medicine ball lifting), performed in three rounds. The duration at each station progressively increased from 60 seconds (weeks 1-2) to 150 seconds (weeks 7-8), with rest intervals of 30-50 seconds between stations and 3-5 minutes between rounds. Exercise intensity was monitored with a Polar heart rate monitor to ensure participants stayed within the target zone. | Behavioural | Combined Exercise Group |
| No Structured ExerciseAlso: Usual Activity, No Exercise ProgramParticipants in the control group will not receive any structured exercise program during the eight-week study period. They will be instructed to maintain their usual daily routines and refrain from initiating any new organized exercise or training programs beyond their routine physical education classes and everyday activities. | Behavioural | Control Group |
Primary outcome
Change in Serum Adiponectin Concentration
Time frame: Baseline and 48 hours post-intervention (end of week 8).
Serum adiponectin (µg/mL) quantified by ELISA in the fasting state; difference from baseline to 48 hours after completion of the 8-week exercise program.
1 secondary outcome
Change in Serum Adiponectin Concentration
Time frame: Baseline and 48 hours post-intervention (end of week 8).
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Nov 2025.
- Individual participant dataSharing planned: No
Related trials for Overweight
RecruitingObservational study
Endoscopic Sleeve Gastroplasty (ESG) Prospective Trial for Obesity (EGO-Trial)
Obesity
Active, not recruitingPhase 4
Effects of Sequential Therapy With Mexidol® (Intravenous) and Mexidol® FORTE 250 (Oral) on Functional Brain Activity Assessed by Functional Magnetic Resonance Imaging and Biochemical Parameters in Patients With Chronic Cerebral Ischemia: A Comparison of Patients With and Without Metabolic Disorders
Metabolic Abnormalities, Obesity & Overweight
Recruiting
Exercise Training and Vitamin D Metabolism
Obesity & Overweight, Vitamin D
Recruiting
Metabolic Health, Bones and Nuts During Weight Loss in Adults
Weight Loss, Bone Density
Active, not recruiting
Effect of Probiotics on Insulin Sensitivity in Overweight and Obese Pregnancy
Obesity & Overweight, Gestational Diabetes Mellitus (GDM)
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Combined Exercise Group and No Structured Exercise in people with Overweight and Obesity, run by Xianjie Zheng at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 19 Nov 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Serum Adiponectin Concentration (time frame: Baseline and 48 hours post-intervention (end of week 8).). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Nov 2025.