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Oral CancerNCT07237672

AI Based Physiotherapy 3- and 9-Month Follow-Up in Oral Cancer Patients

A study testing AI-based physiotherapy follow-up assessments and conventional physiotherapy follow-up assessments in people with Oral Cancer, run by National Taiwan University Hospital at 1 site in Taiwan.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
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Trial summary

This follow-up clinical study aims to evaluate the sustained effects of two rehabilitation programs (AI-based physiotherapy vs. conventional physiotherapy) for oral cancer patients. Read more about this study

Who is it for?
Ages 20 to 70 years
Conditions the study is for
Oral Cancer
What is being tested?
AI-based physiotherapy follow-up assessments and conventional physiotherapy follow-up assessments
Could I receive a placebo?
No, everyone receives an active treatment
How many people
65 participants
Where
1 siteTaiwan
Study dates
6 Dec 2025to Dec 2027
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 20 to 70 years
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Participants who completed the intervention phase of the previous trial (202411044RINC)
  • Age 20-65 years
  • Able to attend follow-up assessments at 3 and 9 months

Who cannot join

  • Withdrawal from the original trial
  • Cancer recurrence or new cancer-related treatment interfering with functional assessment
  • Unable to communicate or comply with follow-up visits

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

Yueh-Hsia Chen, Ph.D. contact

+886-2-33668133

yuehhsiachen@ntu.edu.tw

Taiwan1 site, 1 recruiting

  • School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan

    Taipei, 100

    Yueh-Hsia Chen, Ph.D

    Yueh-Hsia Chen, Ph.D

    Recruiting

Other trials in Taiwan

About this study

Official title: Effects of AI Based Physiotherapy on Mandibular Mobility Shoulder Function Whole Body Physical Function Quality of Life and Return to Work in Oral Cancer Patients: 3- and 9-Month Postintervention Follow-Up

This follow-up clinical study aims to evaluate the sustained effects of two rehabilitation programs (AI-based physiotherapy vs. conventional physiotherapy) for oral cancer patients. Participants who completed the original intervention trial (ClinicalTrials.gov ID: 202411044RINC) will be assessed at 3 and 9 months post-intervention. Outcomes include mandibular mobility, shoulder joint range of motion, functional performance, quality of life, pain, and return-to-work status.

Read the detailed description

This study is a continuation of our prior trial (ClinicalTrials.gov ID: 202411044RINC), which investigated the short-term effects of AI-based physiotherapy compared with conventional physiotherapy in oral cancer patients.

The current follow-up phase evaluates both groups at 3 and 9 months post-intervention to determine whether initial improvements are maintained and whether they translate into better long-term physical function, quality of life, and return-to-work outcomes. No additional interventions will be delivered; only follow-up assessments are planned.

Conditions
Oral Cancer
Being tested
AI-based physiotherapy follow-up assessments, conventional physiotherapy follow-up assessments
Keywords
Artificial intelligence, Oral cancer, Maximum interincisal opening, Physical function, Prehabilitation, Physiotherapy
Medical subject headings
Mouth Neoplasms

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • AI-based physiotherapy follow-up assessmentsOther

    AI-based physiotherapy and 3 and 9 months follow-up assessments

  • conventional physiotherapy follow-up assessmentsOther

    conventional physiotherapy and 3 and 9 months follow-up assessments

Study groups in NCT07237672
Study groupRoleWhat they receive
Experimental group (Follow-up)ExperimentalParticipants who originally received AI-based physiotherapy will undergo follow-up assessments at 3 and 9 months post-intervention.
Receives: Other: AI-based physiotherapy follow-up assessments
Control group (Follow-up)Active comparatorParticipants who originally received conventional physiotherapy will undergo follow-up assessments at 3 and 9 months post-intervention.
Receives: Other: conventional physiotherapy follow-up assessments

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Disabilities of the Arm, Shoulder, and Hand outcome questionnaire

    A total scale from 1 to 100. Higher scores indicate greater disability

    Measured: 3 months, 9 months post-intervention

  2. EORTC QLQ-C30 questionnaire

    A total scale from 1 to 100. Higher scores indicate greater function

    Measured: 3 months, 9 months post-intervention

Secondary outcomes (1)

  1. Return-to-work status

    yes/no, time to return, % returned

    Measured: 3 months, 9 months post-intervention

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted20 Nov 2025
  2. Study start6 Dec 2025
  3. Primary completionDec 2027 (estimated)
  4. Study completionDec 2027 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Non-randomised
Intervention model
Parallel groups
Masking
None (open label)
Enrolment
65 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07237672
Sponsor's protocol ID
202412109RIND
Status last verified
Oct 2025
First submitted
2 Oct 2025
Last updated
16 Dec 2025
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No

Publications

  • Badiola-Bengoa A, Mendez-Zorrilla A. A Systematic Review of the Application of Camera-Based Human Pose Estimation in the Field of Sport and Physical Exercise. Sensors (Basel). 2021 Sep 7;21(18):5996. doi: 10.3390/s21185996.

    PubMed 34577204

  • Baranano CF, Rosenthal EL, Morgan BA, McColloch NL, Magnuson JS. Dynasplint for the management of trismus after treatment of upper aerodigestive tract cancer: a retrospective study. Ear Nose Throat J. 2011 Dec;90(12):584-90. doi: 10.1177/014556131109001209.

    PubMed 22180114

  • Chen CC, Lin CC, Hsieh HP, Fu YC, Chen YJ, Lu TW. In vivo three-dimensional mandibular kinematics and functional point trajectories during temporomandibular activities using 3d fluoroscopy. Dentomaxillofac Radiol. 2021 Feb 1;50(2):20190464. doi: 10.1259/dmfr.20190464. Epub 2020 Aug 12.

    PubMed 32783637

  • Chen SC, Huang BS, Hung TM, Lin CY, Chang YL. Impact of physical and psychosocial dysfunction on return to work in survivors of oral cavity cancer. Psychooncology. 2019 Sep;28(9):1910-1917. doi: 10.1002/pon.5173. Epub 2019 Jul 23.

    PubMed 31291694

  • Chen YH, Liang WA, Lin CR, Huang CY. A randomized controlled trial of scapular exercises with electromyography biofeedback in oral cancer patients with accessory nerve dysfunction. Support Care Cancer. 2022 Oct;30(10):8241-8250. doi: 10.1007/s00520-022-07263-4. Epub 2022 Jul 11.

    PubMed 35821447

  • Chen YH, Huang CY, Liang WA, Lin CR, Chao YH. Effects of Conscious Control of Scapular Orientation in Oral Cancer Survivors With Scapular Dyskinesis: A Randomized Controlled Trial. Integr Cancer Ther. 2021 Jan-Dec;20:15347354211040827. doi: 10.1177/15347354211040827.

    PubMed 34412536

  • Chen YH, Lin CR, Liang WA, Huang CY. Motor control integrated into muscle strengthening exercises has more effects on scapular muscle activities and joint range of motion before initiation of radiotherapy in oral cancer survivors with neck dissection: A randomized controlled trial. PLoS One. 2020 Aug 6;15(8):e0237133. doi: 10.1371/journal.pone.0237133. eCollection 2020.

    PubMed 32760097

  • Chen YH, Liang WA, Hsu CY, Guo SL, Lien SH, Tseng HJ, Chao YH. Functional outcomes and quality of life after a 6-month early intervention program for oral cancer survivors: a single-arm clinical trial. PeerJ. 2018 Feb 21;6:e4419. doi: 10.7717/peerj.4419. eCollection 2018.

    PubMed 29492348

  • Cocks K, Wells JR, Johnson C, Schmidt H, Koller M, Oerlemans S, Velikova G, Pinto M, Tomaszewski KA, Aaronson NK, Exall E, Finbow C, Fitzsimmons D, Grant L, Groenvold M, Tolley C, Wheelwright S, Bottomley A; European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group. Content validity of the EORTC quality of life questionnaire QLQ-C30 for use in cancer. Eur J Cancer. 2023 Jan;178:128-138. doi: 10.1016/j.ejca.2022.10.026. Epub 2022 Nov 1.

    PubMed 36436330

  • Cohen EE, LaMonte SJ, Erb NL, Beckman KL, Sadeghi N, Hutcheson KA, Stubblefield MD, Abbott DM, Fisher PS, Stein KD, Lyman GH, Pratt-Chapman ML. American Cancer Society Head and Neck Cancer Survivorship Care Guideline. CA Cancer J Clin. 2016 May;66(3):203-39. doi: 10.3322/caac.21343. Epub 2016 Mar 22.

    PubMed 27002678

  • Dijkstra PU, Huisman PM, Roodenburg JL. Criteria for trismus in head and neck oncology. Int J Oral Maxillofac Surg. 2006 Apr;35(4):337-42. doi: 10.1016/j.ijom.2005.08.001. Epub 2005 Nov 8.

    PubMed 16280237

  • Falz R, Bischoff C, Thieme R, Lassing J, Mehdorn M, Stelzner S, Busse M, Gockel I. Effects and duration of exercise-based prehabilitation in surgical therapy of colon and rectal cancer: a systematic review and meta-analysis. J Cancer Res Clin Oncol. 2022 Sep;148(9):2187-2213. doi: 10.1007/s00432-022-04088-w. Epub 2022 Jun 13.

    PubMed 35695931

  • Furtado DA, Pereira AA, Andrade Ade O, Bellomo DP Jr, da Silva MR. A specialized motion capture system for real-time analysis of mandibular movements using infrared cameras. Biomed Eng Online. 2013 Feb 22;12:17. doi: 10.1186/1475-925X-12-17.

    PubMed 23433470

  • Jehn P, Spalthoff S, Lentge F, Zeller AN, Tavassol F, Neuhaus MT, Eckstein FM, Kruskemper G, Gellrich NC, Korn P. Postoperative quality of life and therapy-related impairments of oral cancer in relation to time-distance since treatment. J Cancer Surviv. 2022 Dec;16(6):1366-1378. doi: 10.1007/s11764-021-01118-3. Epub 2021 Oct 5.

    PubMed 34609700

  • Johnson J, Johansson M, Ryden A, Houltz E, Finizia C. Impact of trismus on health-related quality of life and mental health. Head Neck. 2015 Nov;37(11):1672-9. doi: 10.1002/hed.23816. Epub 2015 Jan 27.

    PubMed 24985733

Questions about this trial

What is this clinical trial studying?

A study testing AI-based physiotherapy follow-up assessments and conventional physiotherapy follow-up assessments in people with Oral Cancer, run by National Taiwan University Hospital at 1 site in Taiwan.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 16 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Yueh-Hsia Chen, Ph.D. (+886-2-33668133, yuehhsiachen@ntu.edu.tw), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Disabilities of the Arm, Shoulder, and Hand outcome questionnaire (time frame: 3 months, 9 months post-intervention). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07237672, which also lists 25 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Dec 2025.

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