Effect of Piezocision and Injectable Platelets Rich Fibrin on Tooth MovementPhase 1NCT07239024
Evaluation of Piezocision Versus Injectable Platelet-rich Fibrin During Orthodontic Canine Retraction Orthodontic Canine Retraction: A Comparative Clinical Study
A Phase 1 study testing Iprf and piezocision in people with Effect of Piezocision and Injectable Platelets Rich Fibrin on Tooth Movement, run by Al-Azhar University at 1 site in Egypt.
Trial summary
Comparison of piezocisin and injectable platelets rich fibrin during canine retraction Read more about this study
- Who is it for?
- Ages 14 to 22 yearsHealthy volunteers can take part
- Conditions the study is for
- Effect of Piezocision and Injectable Platelets Rich Fibrin on Tooth Movement
- What is being tested?
- Iprf and piezocision
- Type of treatment
- Injection or infusion, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 16 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Dec 2025to 20 Apr 2026
- Phase
- Phase 1
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 14 to 22 years
- All sexes
- Healthy volunteers accepted
- Child, Adult
Inclusion Criteria:. An age ranges from 14-22 years. 2. Crowding or protrusion that require 1st premolars extraction, followed by symmetrical canine retractions.
- All permanent teeth present, 3rd molars aren't considered. 4. Good oral hygiene. 5. No systemic disease and/or medication that could interfere with orthodontic tooth movement. 6. No previous orthodontic treatment. 7. No evidence of craniofacial anomalies, such as cleft lip and palate or previous history of trauma, bruxism, or parafunction. 8. No tooth size, shape, or root abnormalities visible on patient's radiographic records.
-
Exclusion Criteria:Patients diagnosed to have an indication for non-extraction approach.
- Poor oral hygiene or periodontally compromised patient.
- 3. Previous orthodontic treatment. 4. Any implanted assistive (e.g., pacemakers, cochlear implants, etc.). 5. Any skeletal dysplasia or craniofacial malformation. 6. Patients with root resorption, impacted canine or dental anomalies. 7. Any systemic diseases or medications that could interfere with orthodontic tooth movement.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Evaluation of Piezocision Versus Injectable Platelet-rich Fibrin During Orthodontic Canine Retraction: A Comparative Clinical Stud
Comparison of piezocisin and injectable platelets rich fibrin during canine retraction
Read the detailed description
Evaluation of piezocision versus injectable platelet-rich fibrin during orthodontic canine retraction: A comparative clinical study
- Being tested
- Iprf and piezocision
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Iprf and piezocisionProcedure or surgery
Injection of iprf and piezocisin
| Study group | Role | What they receive |
|---|---|---|
| Iprf experimental side | Experimental | Injection of platelet rich fibrin Receives: Procedure: Iprf and piezocision |
| iPrf control side | No intervention | Not described |
| Piezocisin experimental side | Experimental | Flapless incision Receives: Procedure: Iprf and piezocision |
| Piezocision control sode | No intervention | Not described |
What is being measured
The primary outcome is the main question the study is designed to answer.
Rate of canine retraction
Measured: 4 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Nov 2025
- Study start1 Dec 2025 (estimated)
- Primary completion1 Apr 2026 (estimated)
- Study completion20 Apr 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Effect of Piezocision and Injectable Platelets Rich Fibrin on Tooth MovementStudies of the same condition, open and under way.
- More trials run by Al-Azhar UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 1
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Factorial
- Masking
- None (open label)
- Enrolment
- 16 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Al-Azhar University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, farouk ahmed hussein, Al-Azhar University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07239024
- Sponsor's protocol ID
- 1250/5544
- Status last verified
- Nov 2025
- First submitted
- 16 Nov 2025
- Last updated
- 20 Nov 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 20 Nov 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of Piezocision Versus Injectable Platelet-rich Fibrin During Orthodontic Canine Retraction: A Comparative Clinical Stud
- ClinicalTrials.gov ID
- NCT07239024
- Acronym / sponsor ID
- 1250/5544
- Phase
- Phase 1
- Study type
- Interventional
- Recruitment status
- Enrolling by invitation
- Enrolment
- 16 participants (estimated)
- Lead sponsor
- Al-Azhar UniversityUniversity, hospital or other
- Study start
- 1 Dec 2025 (estimated)
- Primary completion
- 1 Apr 2026 (estimated)
- Study completion
- 20 Apr 2026 (estimated)
- First posted
- 20 Nov 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Comparison of piezocisin and injectable platelets rich fibrin during canine retraction
Detailed description
Evaluation of piezocision versus injectable platelet-rich fibrin during orthodontic canine retraction: A comparative clinical study
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Factorial
- Masking
- None (open label)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Iprf experimental side | Experimental | Procedure: Iprf and piezocisionInjection of platelet rich fibrin |
| iPrf control side | No intervention | – |
| Piezocisin experimental side | Experimental | Procedure: Iprf and piezocisionFlapless incision |
| Piezocision control sode | No intervention | – |
Who may qualify
- Ages
- 14 to 22 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Iprf and piezocisionInjection of iprf and piezocisin | Procedure or surgery | Iprf experimental side, Piezocisin experimental side |
Primary outcome
Rate of canine retraction
Time frame: 4 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Nov 2025.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 1 study testing Iprf and piezocision in people with Effect of Piezocision and Injectable Platelets Rich Fibrin on Tooth Movement, run by Al-Azhar University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 20 Nov 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 1 studies test a treatment in a small group of people for the first time or in a new way, mainly to check safety and find the right dose.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Rate of canine retraction (time frame: 4 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Nov 2025.