Single Recession Defects (RT2)NCT07239180
Clinical Evaluation Comparing Tunneled Coronally Advanced Flap and Modified Coronally Advanced Tunnel With Connective Tissue Graft for Managing Single Gum Recession
A study testing Modified Coronally Advanced Tunnel with Connective Tissue Graft and Tunneled Coronally Advance Flap with Connective Tissue Graft in people with Single Recession Defects (RT2), run by Cairo University.
Trial summary
The technique under investigation aims to provide effective root coverage while offering the advantage of being less invasive. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Single Recession Defects (RT2)
- What is being tested?
- Modified Coronally Advanced Tunnel with Connective Tissue Graft and Tunneled Coronally Advance Flap with Connective Tissue Graft
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 24 participants
- Where
- No sites listed yet
- Study dates
- 14 Dec 2025to 30 Aug 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients with single RT2 gingival recession defect ≥ 2 mm
- Age >18 years old.
- Systemically healthy patients with no contraindications for periodontal surgeries.
- Gingival and plaque index less than 20%.
- No previous surgeries at the defect site.
- Accepts 6 months follow-up period (compliant patients).
Who cannot join
- RT1 gingival recession.
- Smokers >10 cigarettes a day a contraindicating for any plastic periodontal surgery.
- Poor oral hygiene.
- Active periodontitis patients.
- Patients on medications causing gingival enlargement.
- Pregnancy.
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- Teeth mobility ≥ 1 mm.
- Patients using fixed or removable orthodontic appliances.
- Restoration and/or periapical radiolucency at the defect site.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Clinical Evaluation of Tunneled Coronally Advance Flap (TCAF) Versus Modified Coronally Advanced Tunnel With Connective Tissue Graft in Management of Single Recession Defects (RT2): A Randomized Clinical Trial
The technique under investigation aims to provide effective root coverage while offering the advantage of being less invasive.
Read the detailed description
Limited RCTs have been found in the literature comparing the root coverage capacity of the tunneled coronally advanced flap versus modified coronally advanced tunnel combined with connective tissue graft in single RT2 defects. So, this trial aims to fill this gap of knowledge.
- Conditions
- Single Recession Defects (RT2)
- Being tested
- Modified Coronally Advanced Tunnel with Connective Tissue Graft, Tunneled Coronally Advance Flap with Connective Tissue Graft
- Keywords
- Single Recession defects (RT2), TCAF, MCAT, Clinical performance, Root Coverage, Gingival Recession
- Medical subject headings
- Gingival Recession
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Modified Coronally Advanced Tunnel with Connective Tissue GraftProcedure or surgery
Modified coronally advanced tunnel with connective tissue graft without vertical releasing incisions
Tunneled Coronally Advance Flap with Connective Tissue GraftProcedure or surgery
Tunneled coronally advance flap with connective tissue graft with one vertical releasing incision
| Study group | Role | What they receive |
|---|---|---|
| Modified Coronally Advanced Tunnel with Connective Tissue Graft | Active comparator | Not described Receives: Procedure: Modified Coronally Advanced Tunnel with Connective Tissue Graft |
| Tunneled Coronally Advance Flap (TCAF) with Connective Tissue Graft | Experimental | Not described Receives: Procedure: Tunneled Coronally Advance Flap with Connective Tissue Graft |
What is being measured
The primary outcome is the main question the study is designed to answer.
Gingival Recession Depth (GRD)
Measuring gingival recession depth (GRD) using UNC Periodontal probe in millimeter (mm)
Measured: 6 months
Secondary outcomes (12)
The Percentage of Mean Root Coverage (MRC %)
Measuring the percentage of mean root coverage (MRC %) using UNC Periodontal Probe in percentage (%)
Measured: 6 months
Complete Root Coverage (CRC)
Measuring the complete root coverage (CRC) visually (Yes/No)
Measured: 6 months
Root Coverage Esthetic Score (RES)
Measuring the root coverage esthetic score (RES) visually with score (0 "minimum" - 10 "maximum")
Measured: 6 months
The Distance between the contact point and the top of the papilla (DCP)
Measuring the distance between the contact point and the top of the papilla (DCP) using UNC periodontal probe in millimeter (mm)
Measured: 6 months
Gingival Recession Width (RW)
Measuring the gingival recession width (RW) using UNC periodontal probe in Millimeter (mm)
Measured: 6 months
Probing Pocket Depth (PPD)
Measuring the probing pocket depth (PPD) using UNC periodontal probe in Millimeter (mm)
Measured: 6 months
Clinical Attachment Level (CAL)
Measuring the clinical attachment level (CAL) using UNC periodontal probe in Millimeter (mm)
Measured: 6 months
Gingival Index (GI)
Measuring the gingival index (GI) using UNC periodontal probe with score (0 "minimum" - 3 "maximum")
Measured: 6 months
Plaque Index (PI)
Measuring the plaque index (PI) using UNC periodontal probe with score (0 "minimum" - 3 "maximum")
Measured: 6 months
Keratinized Tissue Width (KTW)
Measuring the keratinized tissue width (KTW) using UNC periodontal probe in Millimeter (mm)
Measured: 6 months
Gingival Thickness (GT)
Measuring the gingival thickness (GT) using endodontic file in Millimeter (mm)
Measured: 6 months
Postoperative Patient Satisfaction (Visual Analogue Scale)
Measuring the postoperative patient satisfaction (Visual Analogue Scale) using Patient's questionnaire with score (0 "minimum" -10 "maximum")
Measured: 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Nov 2025
- Study start14 Dec 2025 (estimated)
- Primary completion30 Mar 2026 (estimated)
- Study completion30 Aug 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Single Recession Defects (RT2)Studies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind
- Who is masked
- Participant, Care provider, Investigator, Outcomes assessor
- Enrolment
- 24 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Khaled Hashem Kamal, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07239180
- Sponsor's protocol ID
- CairoU PhD protocol for Khaled
- Status last verified
- Nov 2025
- First submitted
- 16 Nov 2025
- Last updated
- 26 Nov 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Limited RCTs have been found in the literature comparing the root coverage capacity of the tunneled coronally advanced flap versus modified coronally advanced tunnel combined with connective tissue graft in single RT2 defects. So, this trial aims to fill this gap of knowledge.
Study at a glance
From the registry record, last updated by the sponsor on 26 Nov 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Clinical Evaluation of Tunneled Coronally Advance Flap (TCAF) Versus Modified Coronally Advanced Tunnel With Connective Tissue Graft in Management of Single Recession Defects (RT2): A Randomized Clinical Trial
- ClinicalTrials.gov ID
- NCT07239180
- Acronym / sponsor ID
- CairoU PhD protocol for Khaled
- Conditions
- Single Recession Defects (RT2)
- Keywords
- Single Recession defects (RT2), TCAF, MCAT, Clinical performance, Root Coverage, Gingival Recession
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 24 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 14 Dec 2025 (estimated)
- Primary completion
- 30 Mar 2026 (estimated)
- Study completion
- 30 Aug 2026 (estimated)
- First posted
- 20 Nov 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The technique under investigation aims to provide effective root coverage while offering the advantage of being less invasive.
Detailed description
Limited RCTs have been found in the literature comparing the root coverage capacity of the tunneled coronally advanced flap versus modified coronally advanced tunnel combined with connective tissue graft in single RT2 defects. So, this trial aims to fill this gap of knowledge.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind (participant, care provider, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Modified Coronally Advanced Tunnel with Connective Tissue Graft | Active comparator | Procedure: Modified Coronally Advanced Tunnel with Connective Tissue Graft |
| Tunneled Coronally Advance Flap (TCAF) with Connective Tissue Graft | Experimental | Procedure: Tunneled Coronally Advance Flap with Connective Tissue Graft |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Patients with single RT2 gingival recession defect ≥ 2 mm
- Age >18 years old.
- Systemically healthy patients with no contraindications for periodontal surgeries.
- Gingival and plaque index less than 20%.
- No previous surgeries at the defect site.
Key exclusion criteria (9 listed)
- RT1 gingival recession.
- Smokers >10 cigarettes a day a contraindicating for any plastic periodontal surgery.
- Poor oral hygiene.
- Active periodontitis patients.
- Patients on medications causing gingival enlargement.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Modified Coronally Advanced Tunnel with Connective Tissue GraftModified coronally advanced tunnel with connective tissue graft without vertical releasing incisions | Procedure or surgery | Modified Coronally Advanced Tunnel with Connective Tissue Graft |
| Tunneled Coronally Advance Flap with Connective Tissue GraftTunneled coronally advance flap with connective tissue graft with one vertical releasing incision | Procedure or surgery | Tunneled Coronally Advance Flap (TCAF) with Connective Tissue Graft |
Primary outcome
Gingival Recession Depth (GRD)
Time frame: 6 months
Measuring gingival recession depth (GRD) using UNC Periodontal probe in millimeter (mm)
12 secondary outcomes
The Percentage of Mean Root Coverage (MRC %)
Time frame: 6 months
Complete Root Coverage (CRC)
Time frame: 6 months
Root Coverage Esthetic Score (RES)
Time frame: 6 months
The Distance between the contact point and the top of the papilla (DCP)
Time frame: 6 months
Gingival Recession Width (RW)
Time frame: 6 months
Probing Pocket Depth (PPD)
Time frame: 6 months
Clinical Attachment Level (CAL)
Time frame: 6 months
Gingival Index (GI)
Time frame: 6 months
Plaque Index (PI)
Time frame: 6 months
Keratinized Tissue Width (KTW)
Time frame: 6 months
Gingival Thickness (GT)
Time frame: 6 months
Postoperative Patient Satisfaction (Visual Analogue Scale)
Time frame: 6 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Nov 2025.
- Related InfoLink provided by the sponsor.
- Individual participant dataSharing planned: Yes. Limited RCTs have been found in the literature comparing the root coverage capacity of the tunneled coronally advanced flap versus modified coronally advanced tunnel combined with connective tissue graft in single RT2 defects. So, this trial aims to fill this gap of knowledge.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing Modified Coronally Advanced Tunnel with Connective Tissue Graft and Tunneled Coronally Advance Flap with Connective Tissue Graft in people with Single Recession Defects (RT2), run by Cairo University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 26 Nov 2025. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Khaled Hashem Kamal, Masters Degree (00201281033350, khaled.hashem@dentistry.cu.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Gingival Recession Depth (GRD) (time frame: 6 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Nov 2025.