EEGNCT07240870
Age-dependent EEG Characteristics During Desflurane Anesthesia From Adults to Elderlies
An observational study of EEG and Aging, run by Chinese PLA General Hospital at 1 site in China.
Trial summary
This study is a prospective cohort study that records bilateral frontal EEG data from patients undergoing elective non-cardiac or non-neurosurgical surgeries and divides them into different age groups based on age. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- EEG, Aging, Desflurane Anesthesia
- What is being tested?
- Age
- How many people
- 47 participants
- Where
- 1 siteChina
- Study dates
- 24 Apr 2025to 30 Jun 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Adult, Older adult
Study population: Patients from a tertiary hospital
Who may be able to join
- Age ≥ 18 years old, male or female not limited
- Patients who undergo elective non cardiac surgery or non neurosurgical surgery;
- ASA classification levels 1-3
Who cannot join
- Individuals with central nervous system disorders such as autism, attention deficit/hyperactivity disorder, epilepsy, or any congenital mental illness;
- Patients with any contraindications to the use of desflurane, such as those with a history of malignant hyperthermia (MH), allergies to halogenated anesthetics, and patients with significantly elevated intracranial pressure (ICP);
- Patients with unstable clinical conditions, such as severe hypotension or circulatory failure
Trial locations and contacts
1 site in 1 country.
China1 site
First Medical center of Chinese PLA General Hospital
Beijing, Beijing Municipality, 100853
About this study
Official title: Age-dependent EEG Coupling, Periodic and Aperiodic Characteristics During Desflurane Anesthesia From Adults to Elderlies
This study is a prospective cohort study that records bilateral frontal EEG data from patients undergoing elective non-cardiac or non-neurosurgical surgeries and divides them into different age groups based on age. All patients received maintenance of general anesthesia with desflurane, and the periodic and aperiodic components, permutation cross mutual information (PCMI), and phase lag entropy (PLE) of EEG data were analyzed under different states of wakefulness, general anesthesia, and recovery. Professional correlation analysis methods were used to analyze the EEG spectrum.
Read the detailed description
This study investigates how the aging brain responds to general anesthesia (GA). As global populations grow older, an increasing number of elderly patients require surgery with GA. However, the aging brain undergoes significant changes, such as a reduction in brain volume (atrophy) and a decreased ability to metabolize drugs. These factors can make anesthesia riskier for older adults, potentially leading to complications like delayed recovery or post-operative cognitive dysfunction. Currently, most anesthesia monitoring systems are designed based on data from younger, healthier adults and may not accurately reflect the brain state of an elderly patient. This study aims to address this critical gap by analyzing the brain's electrical signals (via EEG) across different age groups to understand how aging influences the brain's response to anesthesia.
The research team enrolled 47 patients, aged between 19 and 82 years, who were scheduled for surgery requiring general anesthesia with desflurane. Participants were divided into three age groups for comparison: young adults (18-40 years), middle-aged adults (40-65 years), and older adults (over 65 years). The investigators analyzed the periodic and aperiodic component, permutation cross mutual information (PCMI) and phase lag entropy (PLE) of EEG data in the states of awake, GA, and recovery.
- Conditions
- EEG, Aging, Desflurane Anesthesia
- Being tested
- Age
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
AgeOther
Divided into three age groups based on the age of the included patients
| Study group | Role | What they receive |
|---|---|---|
| 18-40 years age group | 18-40 years Receives: Other: Age | |
| 40-65 years age group | 40-65 years Receives: Other: Age | |
| >65 years age group | >65 years Receives: Other: Age |
What is being measured
The primary outcome is the main question the study is designed to answer.
Electroencephalogram-derived Features
The following quantitative features will be extracted and assessed from the electroencephalogram (EEG) recordings:
Periodic Component: The oscillatory power within standard frequency bands: Delta (1-4 Hz), Theta (4-8 Hz), Alpha (8-13 Hz), Beta (13-30 Hz), and Gamma (30-45 Hz).
Aperiodic Component: The offset and exponent of the background '1/f' activity, extracted via spectral parameterization.
Permutation Cross Mutual Information (PCMI): A measure to assess nonlinear coupling and directional information flow between different brain regions.
Phase Lag Entropy (PLE): A measure to evaluate the dynamic stability of functional brain connectivity.
Measured: Assessed from 2-minute EEG segments at each of three states: Baseline, Under General Anesthesia, and Recovery.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Nov 2025
- Study start24 Apr 2025
- Primary completion30 Jun 2025
- Study completion30 Jun 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for EEGStudies of the same condition, open and under way.
- More trials run by Chinese PLA General HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 47 participants (actual)
Sponsor and investigators
- Lead sponsor
- Chinese PLA General Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Weidong Mi, Chinese PLA General Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07240870
- Sponsor's protocol ID
- PLAGH-Des-EEG
- Status last verified
- Nov 2025
- First submitted
- 29 Sep 2025
- Last updated
- 21 Nov 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 21 Nov 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Age-dependent EEG Coupling, Periodic and Aperiodic Characteristics During Desflurane Anesthesia From Adults to Elderlies
- ClinicalTrials.gov ID
- NCT07240870
- Acronym / sponsor ID
- PLAGH-Des-EEG
- Conditions
- EEG, Aging, Desflurane Anesthesia
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 47 participants (actual)
- Lead sponsor
- Chinese PLA General HospitalUniversity, hospital or other
- Study start
- 24 Apr 2025 (actual)
- Primary completion
- 30 Jun 2025 (actual)
- Study completion
- 30 Jun 2025 (actual)
- First posted
- 21 Nov 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study is a prospective cohort study that records bilateral frontal EEG data from patients undergoing elective non-cardiac or non-neurosurgical surgeries and divides them into different age groups based on age. All patients received maintenance of general anesthesia with desflurane, and the periodic and aperiodic components, permutation cross mutual information (PCMI), and phase lag entropy (PLE) of EEG data were analyzed under different states of wakefulness, general anesthesia, and recovery. Professional correlation analysis methods were used to analyze the EEG spectrum.
Detailed description
This study investigates how the aging brain responds to general anesthesia (GA). As global populations grow older, an increasing number of elderly patients require surgery with GA. However, the aging brain undergoes significant changes, such as a reduction in brain volume (atrophy) and a decreased ability to metabolize drugs. These factors can make anesthesia riskier for older adults, potentially leading to complications like delayed recovery or post-operative cognitive dysfunction. Currently, most anesthesia monitoring systems are designed based on data from younger, healthier adults and may not accurately reflect the brain state of an elderly patient. This study aims to address this critical gap by analyzing the brain's electrical signals (via EEG) across different age groups to understand how aging influences the brain's response to anesthesia.
The research team enrolled 47 patients, aged between 19 and 82 years, who were scheduled for surgery requiring general anesthesia with desflurane. Participants were divided into three age groups for comparison: young adults (18-40 years), middle-aged adults (40-65 years), and older adults (over 65 years). The investigators analyzed the periodic and aperiodic component, permutation cross mutual information (PCMI) and phase lag entropy (PLE) of EEG data in the states of awake, GA, and recovery.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| 18-40 years age group | – | Other: Age18-40 years |
| 40-65 years age group | – | Other: Age40-65 years |
| >65 years age group | – | Other: Age>65 years |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Age groups
- Adult, Older adult
- Study population
- Patients from a tertiary hospital
Key inclusion criteria (3 listed)
- Age ≥ 18 years old, male or female not limited
- Patients who undergo elective non cardiac surgery or non neurosurgical surgery;
- ASA classification levels 1-3
Key exclusion criteria (3 listed)
- Individuals with central nervous system disorders such as autism, attention deficit/hyperactivity disorder, epilepsy, or any congenital mental illness;
- Patients with any contraindications to the use of desflurane, such as those with a history of malignant hyperthermia (MH), allergies to halogenated anesthetics, and patients with significantly elevated intracranial pressure (ICP);
- Patients with unstable clinical conditions, such as severe hypotension or circulatory failure
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| AgeDivided into three age groups based on the age of the included patients | Other | 18-40 years age group, 40-65 years age group, >65 years age group |
Primary outcome
Electroencephalogram-derived Features
Time frame: Assessed from 2-minute EEG segments at each of three states: Baseline, Under General Anesthesia, and Recovery.
The following quantitative features will be extracted and assessed from the electroencephalogram (EEG) recordings: Periodic Component: The oscillatory power within standard frequency bands: Delta (1-4 Hz), Theta (4-8 Hz), Alpha (8-13 Hz), Beta (13-30 Hz), and Gamma (30-45 Hz). Aperiodic Component: The offset and exponent of the background '1/f' activity, extracted via spectral parameterization. Permutation Cross Mutual Information (PCMI): A measure to assess nonlinear coupling and directional information flow between different brain regions. Phase Lag Entropy (PLE): A measure to evaluate the dynamic stability of functional brain connectivity.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Nov 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of EEG and Aging, run by Chinese PLA General Hospital at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 21 Nov 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Electroencephalogram-derived Features (time frame: Assessed from 2-minute EEG segments at each of three states: Baseline, Under General Anesthesia, and Recovery.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Nov 2025.