Apical PeriodontitisNCT07243353
Examination of the Effect of Nd:YAG Laser on Oxidative Stress and Matrix Metalloproteinase-9 in Teeth With Apical Periodontitis
An observational study of Apical Periodontitis and Oxidative Stress, run by Kırıkkale University at 1 site in Turkey (Türkiye).
Trial summary
The objective of this clinical investigation is to examine the impact of Nd:YAG laser therapy on oxidative stress and matrix metalloproteinase-9 (MMP-9) levels in teeth afflicted with apical periodontitis. Read more about this study
- Who is it for?
- Ages 25 to 50 years
- Conditions the study is for
- Apical Periodontitis, Oxidative Stress
- How many people
- 58 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Feb 2024to 8 Nov 2024
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 25 to 50 years
- All sexes
- No healthy volunteers
- Adult
Study population: The study groups comprised of patients who had applied to the Department of Endodontics at the Faculty of Dentistry at Kırıkkale University and that underwent endodontic treatment from 15 February 2024 to 15 October 2024.
Who may be able to join
- Patients aged between 25 and 50 years and classified as American Society of Anesthesiologists (ASA) I. The maxillar and mandibular incisors and premolars with chronic apical periodontitis of a PAI score of 3 or 4 were included.
Who cannot join
- Patients with American Society of Anesthesiologists (ASA) classification II or higher, pregnant, patients with localised or generalised periodontitis, patients who had used antibiotics in the last month and anti-inflammatory drugs in the last week, smokers, and teeth with internal or external root resorption, swelling, palpation pain or fistula in the relevant area, root fracture or incomplete root formation, and teeth that could not be isolated with rubber dam were not included in the study.
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Kırıkkale Üniversitesi Diş Hekimliği Fakültesi
Kirikkale
About this study
The objective of this clinical investigation is to examine the impact of Nd:YAG laser therapy on oxidative stress and matrix metalloproteinase-9 (MMP-9) levels in teeth afflicted with apical periodontitis. Samples were collected from patients who had undergone treatment with the Nd:YAG laser and compared with samples collected from patients who had not received this treatment. The study commenced with a sample of 60 patients. However, the study was completed with 58 patients. The study concluded with the following finding: the use of Nd:YAG lasers was not found to be superior.
- Conditions
- Apical Periodontitis, Oxidative Stress
- Keywords
- Apical periodontitis, Matrix metalloproteinase-9, Nd:YAG laser, Oxidative stress
- Medical subject headings
- Periapical Periodontitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Nd:YAG laser group | Group treated with Nd:YAG laser | |
| Control group | Group not treated with Nd:YAG laser |
What is being measured
The primary outcome is the main question the study is designed to answer.
Measurement of TOS, TAOC and MMP-9 levels in periapical exudate and GCF
TOS, TAOC and MMP-9 levels were measured by ELISA in periapical exudate and GCF samples collected during routine root canal treatment in patients with apical periodontitis. No significant difference was detected in the change in biomarker levels between the group treated with the Nd:YAG laser and the control group.
Measured: The initial and seventh days of the treatment period
Secondary outcomes (1)
Determination of the correlation relationship between TOS, TAOC and MMP-9 levels in periapical exudate and GCF samples
The present study investigated the correlation between periapical exudate and GCF samples. The findings revealed a unidirectional and strong relationship between TOS and TAOC.
Measured: The initial and seventh days of the treatment period
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Nov 2025
- Study start1 Feb 2024
- Primary completion1 Nov 2024
- Study completion8 Nov 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Apical PeriodontitisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Prospective
- Enrolment
- 58 participants (actual)
Sponsor and investigators
- Lead sponsor
- Kırıkkale University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ali Turkyilmaz, Kırıkkale University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07243353
- Sponsor's protocol ID
- 2024/046
- Status last verified
- Nov 2025
- First submitted
- 17 Nov 2025
- Last updated
- 15 Dec 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 15 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Examination of the Effect of Nd:YAG Laser on Oxidative Stress and Matrix Metalloproteinase-9 in Teeth With Apical Periodontitis
- ClinicalTrials.gov ID
- NCT07243353
- Acronym / sponsor ID
- 2024/046
- Conditions
- Apical Periodontitis, Oxidative Stress
- Keywords
- Apical periodontitis, Matrix metalloproteinase-9, Nd:YAG laser, Oxidative stress
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 58 participants (actual)
- Lead sponsor
- Kırıkkale UniversityUniversity, hospital or other
- Study start
- 1 Feb 2024 (actual)
- Primary completion
- 1 Nov 2024 (actual)
- Study completion
- 8 Nov 2024 (actual)
- First posted
- 21 Nov 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The objective of this clinical investigation is to examine the impact of Nd:YAG laser therapy on oxidative stress and matrix metalloproteinase-9 (MMP-9) levels in teeth afflicted with apical periodontitis. Samples were collected from patients who had undergone treatment with the Nd:YAG laser and compared with samples collected from patients who had not received this treatment. The study commenced with a sample of 60 patients. However, the study was completed with 58 patients. The study concluded with the following finding: the use of Nd:YAG lasers was not found to be superior.
Study design
- Observational model
- Case-control
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Nd:YAG laser group | – | –Group treated with Nd:YAG laser |
| Control group | – | –Group not treated with Nd:YAG laser |
Who may qualify
- Ages
- 25 to 50 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
- Study population
- The study groups comprised of patients who had applied to the Department of Endodontics at the Faculty of Dentistry at Kırıkkale University and that underwent endodontic treatment from 15 February 2024 to 15 October 2024.
Key inclusion criteria (1 listed)
- Patients aged between 25 and 50 years and classified as American Society of Anesthesiologists (ASA) I. The maxillar and mandibular incisors and premolars with chronic apical periodontitis of a PAI score of 3 or 4 were included.
Key exclusion criteria (1 listed)
- Patients with American Society of Anesthesiologists (ASA) classification II or higher, pregnant, patients with localised or generalised periodontitis, patients who had used antibiotics in the last month and anti-inflammatory drugs in the last week, smokers, and teeth with internal or external root resorption, swelling, palpation pain or fistula in the relevant area, root fracture or incomplete root formation, and teeth that could not be isolated with rubber dam were not included in the study.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Measurement of TOS, TAOC and MMP-9 levels in periapical exudate and GCF
Time frame: The initial and seventh days of the treatment period
TOS, TAOC and MMP-9 levels were measured by ELISA in periapical exudate and GCF samples collected during routine root canal treatment in patients with apical periodontitis. No significant difference was detected in the change in biomarker levels between the group treated with the Nd:YAG laser and the control group.
1 secondary outcome
Determination of the correlation relationship between TOS, TAOC and MMP-9 levels in periapical exudate and GCF samples
Time frame: The initial and seventh days of the treatment period
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Dec 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Apical Periodontitis and Oxidative Stress, run by Kırıkkale University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 15 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Measurement of TOS, TAOC and MMP-9 levels in periapical exudate and GCF (time frame: The initial and seventh days of the treatment period). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Dec 2025.