Parkinson DiseaseNCT07244900
Conventional Physical Therapy Action Observation Therapy on Freezing of Gait and Functional Mobility in Parkinson's Disease
A study testing Conventional Physical Therapy and Action Observation plus conventional Physical Therapy in people with Parkinson Disease and Neuro-Degenerative Disease, run by University of Lahore at 1 site in Pakistan.
Trial summary
The goal of this study is to determine the effects of action observation therapy with conventional physical therapy on freezing gait and functional limitation in participants with Parkinson's disease. Read more about this study
- Who is it for?
- Ages 50 to 80 years
- Conditions the study is for
- Parkinson Disease, Neuro-Degenerative Disease
- What is being tested?
- Conventional Physical Therapy and Action Observation plus conventional Physical Therapy
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 42 participants
- Where
- 1 sitePakistan
- Study dates
- 1 Jun 2023to 1 Jul 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 to 80 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
None listed.
Who cannot join
- The exclusion criteria were
- systemic diseases such as diabetes, sepsis, systemic lupus erythematosus
- Uncontrolled hypertension or hypotension
- 2. neurological issues that could affect the assessment and outcomes of treatment, 3. implantation for deep brain stimulation 4. visual or acoustic limitations.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effects Of Conventional Physical Therapy With And Without Action Observation Therapy On Freezing Of Gait And Functional Mobility In Participants With Parkinson's Disease: A Randomised Clinical Trial
The goal of this study is to determine the effects of action observation therapy with conventional physical therapy on freezing gait and functional limitation in participants with Parkinson's disease.
Read the detailed description
Parkinson's disease is a neurodegenerative disorder that is characterized by rigidity, tremors, and bradykinesia, along with non-motor dysfunction. The exercise rehabilitation has a positive impact on motor and non-motor functions in individuals with Parkinson's disease. Conventional physical therapy (CPT) that involves isometric exercises, stretching techniques, and strength and balance training is useful to improve the severity of functional mobility and freezing of gait. In action observation therapy (AOT), small video clips of different goal-directed tasks were added to rehabilitation to determine the combined effects on outcome.
- Conditions
- Parkinson Disease, Neuro-Degenerative Disease
- Being tested
- Conventional Physical Therapy, Action Observation plus conventional Physical Therapy
- Keywords
- Parkinson's Disease, Balance, Freezing of Gait, Mobility, Function
- Medical subject headings
- Parkinson Disease
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Conventional Physical TherapyOther
Group A received conventional physical therapy treatment. The CPT program consists of isometric exercises, stretching, and strength training based on the patient's physical condition and the severity of functional mobility and freezing of Gait.
Action Observation plus conventional Physical TherapyOther
Group B was given action observation therapy with conventional physical therapy treatment. In AOT, the therapist showed small video clips of different goal-directed tasks to participants, and they were asked to follow every step and movement. The therapist maintained the patient's attention with verbal feedback
| Study group | Role | What they receive |
|---|---|---|
| Conventional Physiotherapy Group | Active comparator | This group included conventional physical therapy that contains isometric exercise, stretching techniques, and strength and balance training. Receives: Other: Conventional Physical Therapy |
| Experimental Group | Experimental | This group included action observation therapy in addition to conventional physical therapy, in which small videos containing specific task will be made available to follow to the participants. Receives: Other: Action Observation plus conventional Physical Therapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in functional mobility
The TUG is an efficient test that measures mobility and balance, requiring participants to rise from a chair, walk 3 meters, turn, walk back, and sit down. The time taken to complete this sequence is recorded, with longer times indicating potential mobility issues. A score of more than or equal to fourteen seconds indicates a high risk of falls.
Measured: The assessment was made at baseline before the treatment session, and any change in mobility status was observed at the end of 6th week and 12th week after the intervention.
Change in Freezing of gait
The FOG-Q is a reliable tool for evaluating the effectiveness of treatment intervention on FOG for Parkinson's disease. The questionnaire consists of 6 items designed to assess the severity of freezing of gait. Each item is rated on a five-point Likert scale, with '0' indicating no symptoms and '4' indicating the most severe symptoms. The total score can range from 0 to 24, with higher scores indicating greater severity of freezing of gait.
Measured: The freezing of gait was assessed at baseline, and any change in it was measured at the end of 6th week and 12th week after the intervention.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Nov 2025
- Study start1 Jun 2023
- Primary completion1 Jun 2024
- Study completion1 Jul 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Parkinson DiseaseStudies of the same condition, open and under way.
- More trials run by University of LahoreThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- This study follows a parallel group design, involving two groups: a control group and an experimental group. Participants in both groups will receive treatment concurrently but under different conditions. The control group will receive the standard or conventional intervention, while the experimental group will receive the modified or additional treatment being investigated. Comparisons between the groups will be made to evaluate the effectiveness of the experimental intervention.
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 42 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Lahore
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Ishfaq Ahmed, PhD Physiotherapy, Study director, University of Lahore
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07244900
- Sponsor's protocol ID
- Kiran Maqsood
- Status last verified
- Nov 2025
- First submitted
- 17 Nov 2025
- Last updated
- 16 Jun 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: De-identified individual participant data (IPD) that underlie the results reported in the study will be shared.
Study at a glance
From the registry record, last updated by the sponsor on 16 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects Of Conventional Physical Therapy With And Without Action Observation Therapy On Freezing Of Gait And Functional Mobility In Participants With Parkinson's Disease: A Randomised Clinical Trial
- ClinicalTrials.gov ID
- NCT07244900
- Acronym / sponsor ID
- Kiran Maqsood
- Conditions
- Parkinson Disease, Neuro-Degenerative Disease
- Keywords
- Parkinson's Disease, Balance, Freezing of Gait, Mobility, Function
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 42 participants (actual)
- Lead sponsor
- University of LahoreUniversity, hospital or other
- Study start
- 1 Jun 2023 (actual)
- Primary completion
- 1 Jun 2024 (actual)
- Study completion
- 1 Jul 2024 (actual)
- First posted
- 24 Nov 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this study is to determine the effects of action observation therapy with conventional physical therapy on freezing gait and functional limitation in participants with Parkinson's disease.
Detailed description
Parkinson's disease is a neurodegenerative disorder that is characterized by rigidity, tremors, and bradykinesia, along with non-motor dysfunction. The exercise rehabilitation has a positive impact on motor and non-motor functions in individuals with Parkinson's disease. Conventional physical therapy (CPT) that involves isometric exercises, stretching techniques, and strength and balance training is useful to improve the severity of functional mobility and freezing of gait. In action observation therapy (AOT), small video clips of different goal-directed tasks were added to rehabilitation to determine the combined effects on outcome.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- This study follows a parallel group design, involving two groups: a control group and an experimental group. Participants in both groups will receive treatment concurrently but under different conditions. The control group will receive the standard or conventional intervention, while the experimental group will receive the modified or additional treatment being investigated. Comparisons between the groups will be made to evaluate the effectiveness of the experimental intervention.
| Arm | Type | Receives |
|---|---|---|
| Conventional Physiotherapy Group | Active comparator | Other: Conventional Physical TherapyThis group included conventional physical therapy that contains isometric exercise, stretching techniques, and strength and balance training. |
| Experimental Group | Experimental | Other: Action Observation plus conventional Physical TherapyThis group included action observation therapy in addition to conventional physical therapy, in which small videos containing specific task will be made available to follow to the participants. |
Who may qualify
- Ages
- 50 to 80 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (0 listed)
Key exclusion criteria (4 listed)
- The exclusion criteria were
- systemic diseases such as diabetes, sepsis, systemic lupus erythematosus
- Uncontrolled hypertension or hypotension
- 2. neurological issues that could affect the assessment and outcomes of treatment, 3. implantation for deep brain stimulation 4. visual or acoustic limitations.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Conventional Physical TherapyGroup A received conventional physical therapy treatment. The CPT program consists of isometric exercises, stretching, and strength training based on the patient's physical condition and the severity of functional mobility and freezing of Gait. | Other | Conventional Physiotherapy Group |
| Action Observation plus conventional Physical TherapyGroup B was given action observation therapy with conventional physical therapy treatment. In AOT, the therapist showed small video clips of different goal-directed tasks to participants, and they were asked to follow every step and movement. The therapist maintained the patient's attention with verbal feedback | Other | Experimental Group |
Primary outcome
Change in functional mobility
Time frame: The assessment was made at baseline before the treatment session, and any change in mobility status was observed at the end of 6th week and 12th week after the intervention.
The TUG is an efficient test that measures mobility and balance, requiring participants to rise from a chair, walk 3 meters, turn, walk back, and sit down. The time taken to complete this sequence is recorded, with longer times indicating potential mobility issues. A score of more than or equal to fourteen seconds indicates a high risk of falls.
Change in Freezing of gait
Time frame: The freezing of gait was assessed at baseline, and any change in it was measured at the end of 6th week and 12th week after the intervention.
The FOG-Q is a reliable tool for evaluating the effectiveness of treatment intervention on FOG for Parkinson's disease. The questionnaire consists of 6 items designed to assess the severity of freezing of gait. Each item is rated on a five-point Likert scale, with '0' indicating no symptoms and '4' indicating the most severe symptoms. The total score can range from 0 to 24, with higher scores indicating greater severity of freezing of gait.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Jun 2026.
- Individual participant dataSharing planned: Yes. De-identified individual participant data (IPD) that underlie the results reported in the study will be shared.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Ishfaq Ahmed, PhD Physiotherapy study director
University of Lahore
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Conventional Physical Therapy and Action Observation plus conventional Physical Therapy in people with Parkinson Disease and Neuro-Degenerative Disease, run by University of Lahore at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 0 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 16 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in functional mobility (time frame: The assessment was made at baseline before the treatment session, and any change in mobility status was observed at the end of 6th week and 12th week after the intervention.). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Jun 2026; AzTrials last refreshed its copy on 7 Nov 2026.