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Chest PainTrIAje ProjectNCT07247669

Evaluation and Optimization of Telephone Triage Using Artificial Intelligence (AI) Models for the Detection of Demands for Time-dependent Pathology at the Emergency and Urgent Care Coordination Center (CCUE).

An observational study of Chest Pain and Stroke Acute, run by Centro de Emergencias Sanitarias 061 Andalucía at 1 site in Spain.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
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Trial summary

Improving Telephone Triage in Emergency Calls with AI The Coordinating Centre for Urgencies and Emergencies in Andalusia (CCUE) handles thousands of calls every day. Each call needs to be assessed based on the information given over the phone to determine how serious the case is. Read more about this study

Who is it for?
Any age
Conditions the study is for
Chest Pain, Stroke Acute, Respiratory Failure
How many people
5,000,000 participants
Where
1 siteSpain
Study dates
1 Mar 2025to 31 Dec 2027
Phase
Observational
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages Any age
  • All sexes
  • No healthy volunteers
  • Child, Adult, Older adult

Study population: All patients who have requested telephone assistance in the last five years to the Medical Dispatch Center in Andalusia.

Who may be able to join

  • Telephone calls recorded with codes A36 + A58 (unconsciousness/cardiorespiratory arrest), A16 (respiratory distress), A23 (non-traumatic chest pain) and A54 (stroke).

Who cannot join

  • Demands with relevant information about the patient or the event incomplete or absent.

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

María José MJ Dr. Luque Hernández, MD PhD contact

0034 617563352

mariajose.luque.sspa@juntadeandalucia.es

Spain1 site, 1 recruiting
  • Centro de Emergencias Sanitarias 061

    Málaga, Málaga, 29590

    María José MJ Luque-Hernández, MD PhD, +34 617563352, mariajose.luque.sspa@juntadeandalucia.es

    María José Luque Hernández, Doctor of Medicine, PhD

    Recruiting

Other trials in Spain

About this study

Official title: Proyecto "trIAje": evaluación y optimización Del Triaje telefónico Mediante Modelos de Inteligencia Artificial (IA) Para la detección de Demandas Por patología Tiempo-dependiente en el Centro Coordinador de Urgencias y Emergencias (CCUE).

Improving Telephone Triage in Emergency Calls with AI The Coordinating Centre for Urgencies and Emergencies in Andalusia (CCUE) handles thousands of calls every day. Each call needs to be assessed based on the information given over the phone to determine how serious the case is. The reasons for calling range from minor health issues to life-threatening emergencies like cardiac arrest (CPA).

This project focuses on improving telephone triage for four key emergency situations that often indicate severe or life-threatening conditions:

Read more

Unconsciousness / Cardiac arrest Difficulty breathing Chest pain (non-traumatic, possible heart-related issues) Stroke symptoms Our goal is to make telephone triage more accurate and efficient by using advanced Artificial Intelligence (AI) techniques, including Machine Learning (ML) and Natural Language Processing (NLP). These tools will help CCUE operators make better and faster decisions, ensuring that patients receive the right care as quickly as possible.

How it will be done:

The investigators will analyze anonymized historical call data from the emergency coordination system (CCR) and digital clinical records (HCDM). This includes:

Structured data: Predefined fields, such as answers to standard triage questions.

Unstructured data: Free-text notes and other information recorded during the call.

A hybrid AI approach will be used, combining:

Traditional AI methods (supervised learning and deep learning) to classify cases.

Generative AI techniques (advanced language models) to extract useful insights from free-text data.

Building the Best Prediction Model

To find the most effective AI model, we will test different machine learning techniques, including:

Decision Trees Random Forests Support Vector Machines (SVM) XGBoost Ensemble methods Neural Networks We will also analyze which questions and variables are the most important in predicting the severity of a case. Based on this, we will suggest improvements to the current triage questions to enhance accuracy.

Measuring Success

We will evaluate the AI model using key performance metrics, including:

Accuracy (overall correctness) Sensitivity (ability to detect real emergencies) Specificity (ability to avoid false alarms) False Positive \& False Negative Rates (how often the system makes mistakes) Likelihood Ratios (how well the system distinguishes between urgent and non-urgent cases) F1-Score \& ROC Curve (overall performance indicators) Why This Matters This project will assess how effective the current telephone triage system is and develop a new AI-powered model to improve it. The goal is to help emergency operators quickly identify the most serious cases, reducing response times and improving patient outcomes. In the future, the investigators aim to integrate this improved AI model into the CCUE system to enhance emergency response across Andalusia.

Read the detailed description

The Emergency and Urgent Care Coordination Center in Andalusia (CCUE) receives thousands of calls daily, during which each case must be classified by severity level based on the information provided over the phone. The conditions for which citizens seek help span a wide range-from minor ailments to cardiac arrest. This project addresses the challenge of telephone triage in out-of-hospital emergencies for several frequent reasons for care requests that may indicate emergent and potentially life-threatening medical conditions: unconsciousness/cardiac arrest, respiratory distress, non-traumatic chest pain, and stroke.

The goal is to improve the accuracy and efficiency of telephone triage using advanced Artificial Intelligence (AI) techniques-both symbolic and generative-including machine learning (ML) and natural language processing (NLP). This will enable CCUE CES-061 Andalucía operators to make faster, more informed decisions to provide timely and appropriate care.

The investigators will collect anonymized historical data from calls related to these four care request categories, extracted from the relational database systems of the Networked Coordination Centers (CCR) and the Mobile Digital Health Record (HCDM) of CES-061 Andalucía. The analysis will include both structured data (predefined fields with specific formats, including triage questions asked during the call) and unstructured data (free text and other formats) generated during demand management, encompassing coordination and care delivery aspects.

The investigators will implement a hybrid approach that integrates classical AI techniques (supervised and deep learning for classification) with generative AI (large language models to analyze and extract valuable insights from unstructured data). Various classification algorithms-such as decision trees, random forests, SVM, XGBoost, ensemble methods, and neural networks-will be tested to build the most accurate predictive model.

Through feature importance analysis, we will identify the most predictive questions and variables, proposing modifications to the current triage questions to enhance prediction accuracy.

The model will be evaluated using multiple metrics (including accuracy, sensitivity, specificity, positive and negative likelihood ratios, false positive rate [alarm failure], false negative rate [omission failure], area under the ROC curve, and F1-score). These metrics will help assess the model's ability to correctly predict final diagnoses-maximizing detection of truly urgent cases (high sensitivity, high positive likelihood ratio, and low false negative rate) while avoiding excessive false positives (high specificity, low false positive rate, and low negative likelihood ratio).

The aim of this project is to assess the effectiveness of the current CCUE telephone triage model and develop a new AI-based model to improve it. We aim to provide a solid foundation for future implementation of the improved model within CCUEs, helping personnel to quickly identify and prioritize the most severe cases, ultimately reducing response times and improving health outcomes.

Keywords
Emergency Medical Communication Center, Triage Telephone, Emergency Medical Services, Priority, Machine Learning, Artificial Intelligence
Medical subject headings
Chest Pain, Stroke, Respiratory Insufficiency, Heart Arrest, Coma

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Detection of critical severity from Medical Dispatch Center

    the medical dispatch center has to Detect a Time dependent pathology (the ones that are life-threatening emergencies).Minutes from call receipt to recognition of a life-threatening emergency (time dependent pathology)

    Measured: 24 hours. From the call receipt to medical team dispatch

Secondary outcomes (3)
  1. Effectiveness

    Effectiveness of the current telephone triage system for these demands in the CCUE of Andalusia, using clinically relevant performance metrics, especially under-triage and over-triage (including accuracy, sensitivity, specificity, positive and negative likelihood ratios, false positive and false negative rates, area under the ROC curve and F1-score).

    Measured: one year

  2. Artificial Intelligence Model Design

    Engineers have to develop and validate an Artificial Intelligence (AI) model that integrates classical AI and generative AI techniques to improve the accuracy and efficiency of telephone triage of users requesting assistance for unconsciousness/cardiorespiratory arrest (registered in the system as types of demands A36 and A58 respectively), respiratory distress (A16), non-traumatic chest pain (A23) and stroke (A54) in the Emergency and Urgency Coordination Centres (CCUE) of Andalusia.

    Measured: 2 years

  3. Performance of Artificial Intelligence (AI) models in dispatch medical center

    Engineers have to performance different AI algorithms in predicting the severity of telephone calls for unconsciousness/cardiopulmonary arrest, respiratory distress, non-traumatic chest pain, and stroke, using structured and unstructured data from the CCR and HCDM databases.

    Measured: 2 years

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted25 Nov 2025
  2. Study start1 Mar 2025
  3. Primary completion1 Jun 2026 (estimated)
  4. Study completion31 Dec 2027 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Retrospective
Enrolment
5,000,000 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07247669
Sponsor's protocol ID
2025_CES_061_IA_TRIAJE_V5
Other IDs
SICEIA-2024-002592
Acronym
TrIAje Project
Status last verified
May 2026
First submitted
30 Sep 2025
Last updated
13 May 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
Undecided

Publications

  • Luque-Hernandez MJ, Romero-Oloriz C, Ritore-Hidalgo A, Serrano Alarcon A, Lopez Lopez C, Caballero-Garcia A, Armengol de La Hoz MA. trIAje project: protocol for a retrospective cohort study to optimise AI-assisted telephone triage of time-sensitive conditions in emergency medical services. BMJ Open. 2026 Sep 28;16(9):e113242. doi: 10.1136/bmjopen-2025-113242.

    PubMed 42805668

Questions about this trial

What is this clinical trial studying?

An observational study of Chest Pain and Stroke Acute, run by Centro de Emergencias Sanitarias 061 Andalucía at 1 site in Spain.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 13 May 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Spain. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact María José MJ Dr. Luque Hernández, MD PhD (0034 617563352, mariajose.luque.sspa@juntadeandalucia.es), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Detection of critical severity from Medical Dispatch Center (time frame: 24 hours. From the call receipt to medical team dispatch). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07247669, which also lists 1 linked publication.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 May 2026.

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