Mild Cognitive ImpairmentNCT07248709
Comparison of High-Intensity Interval Training and Moderate-Intensity Continuous Training in Mild Cognitive Impairment
A study testing High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training in people with Mild Cognitive Impairment, run by Riphah International University at 2 sites in Pakistan.
Trial summary
This study aims to determine the effects of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) on cognitive and physical fitness in community-dwelling adults diagnosed with Mild Cognitive Impairment (MCI). Read more about this study
- Who is it for?
- Ages 60 years and older
- Conditions the study is for
- Mild Cognitive Impairment
- What is being tested?
- High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 68 participants
- Where
- 2 sitesPakistan
- Study dates
- 5 Nov 2025to 30 Apr 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 60 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- older adults who had been diagnosed with MCI according to Peterson's criteria [Montreal Cognitive Assessment (MoCA) score <26 for those with 12 years or more of education and <25 for those with less than 12 years of education; activity of daily living scale ≤23; no clinical diagnosis of dementia]
- older adults who are physically normal (the six-item Katz Activities of Daily Living Scale should all be evaluated as "independent")
Who cannot join
- Participants who have medical problems or co-morbidities that interdict their participation in the study.
- Unable to walk without an assistive device
- Diagnosed with neurodegenerative diseases such as Alzheimer's disease
- Having regular exercise habits (defined as exercise for ≥150 min per week).
- Participating in other ongoing intervention study
Trial locations and contacts
2 sites in 1 country.
Pakistan2 sites
Khursheed Oldage Home and Nursing Care
Lahore, Punjab Province, 64350
Alara Healthcare Clinic
Lahore, Punjab Province
About this study
Official title: Comparison of High-Intensity Interval Training and Moderate-Intensity Continuous Training on Executive Functions, Cardiorespiratory and Physical Fitness in Older Adults With Mild Cognitive Impairment
This study aims to determine the effects of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) on cognitive and physical fitness in community-dwelling adults diagnosed with Mild Cognitive Impairment (MCI).
A double-blinded randomized clinical trial will be conducted for ten months at Ruhama Welfare Foundation Society Lahore and Kainat Patient Care and Old Age Home, Lahore. The sample size is calculated through G-power and 68 participants will be recruited through the non-probability convenience sampling technique. Those who meet the inclusion criteria will be randomized into two groups through the online randomizer tool. Both experimental groups will undergo an 8-week intervention, consisting of three sessions per week with alternate-day training of 38 minutes. The HIIT group will perform exercise with each session consisting of four 4-minute intervals at 85-95% of their maximum heart rate, with 3-minute active recovery periods, while the MICT group will engage in continuous exercise for 28 minutes at 70-75% of their maximum heart rate. Assessment will be done at baseline, after the 4th week, 8th week, and follow-up at 12th week.
Read the detailed description
Mild cognitive impairment is a syndrome defined as cognitive decline greater than expected for an individual's age and education level but that does not interfere notably with activities of daily life. Prevalence in population-based epidemiological studies ranges from 3% to 19% in adults older than 65 years. Some people with mild cognitive impairment seem to remain stable or return to normal over time, but more than half progress to dementia within 5 years. Mild cognitive impairment can thus be regarded as a risk state for dementia. The amnestic subtype of mild cognitive impairment has a high risk of progression to Alzheimer's disease, and it could constitute a prodromal stage of this disorder. One of the main causes of disability and dependency in older adults globally, dementia ranks as the seventh most common cause of all disorders. Globally, there were 55 million dementia sufferers in 2021; by 2030, that figure is expected to rise to 78 million, and by 2050, it will reach 139 million. Thankfully, there is a chance that postponing dementia onset by five years could cut its prevalence in half globally. Compared to just 3% of the age-matched group, 46% of people with mild cognitive impairment (MCI), an intermediate stage between normal cognition and dementia, will develop dementia within three years. As a result, MCI is a crucial phase in stopping dementia from getting worse. The multi-cognitive function of subjects with MCI declines.
HIIT can enhance cognitive performance through increased blood flow to the brain, promoting neurogenesis and synaptic plasticity, which are crucial for cognitive tasks. MICT also supports cognitive function. HIIT often produces superior results in a shorter time frame. HIIT involves short bursts of high-intensity exercise followed by rest or low-intensity periods, leading to significant cardiovascular adaptations such as increased VO2 max and improved heart efficiency. MICT, while beneficial, requires longer durations to achieve comparable gains in cardiorespiratory fitness (CRF). Engaging in regular physical exercise has been shown to delay age-related physiological and cognitive decline, reduce the risk of common diseases, and improve the subjective quality of life. Meanwhile, a large proportion of older adults are insufficiently physically active, potentially increasing societal health-related challenges connected to a growing older population. It is, therefore, important to provide both effective and attractive exercise methods adapted for this group. One of the proposed key factors in maximizing exercise effects is to exercise beyond moderate intensities, as in high-intensity interval training (HIIT). Although aerobic moderate-intensity continuous training (MICT) is performed at intensities below the anaerobic threshold, HIIT is broadly defined as short, repeated work intervals at an external intensity close to (80%-100%), or above (>100%) the intensity that elicits maximum oxygen uptake (Vo2 max), with passive or low intensity recovery between intervals.
While exercise is a promising intervention for cognitive health, the comparative efficacy of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) in older adults with MCI remains underexplored. This research seeks to provide useful insights examining the effects of HIIT and MICT on executive functions, cardiorespiratory fitness, and overall physical fitness. HIIT's potential time efficiency and physiological benefits may offer significant advantages over traditional exercise methods. The findings could inform clinical practice, shape public health guidelines, and lead to more effective exercise interventions, ultimately enhancing the quality of life for older adults at risk of cognitive decline.
- Conditions
- Mild Cognitive Impairment
- Being tested
- High-Intensity Interval Training (HIIT), Moderate-Intensity Continuous Training
- Keywords
- High-Intensity Interval Training, Moderate-Intensity Continuous Training, Mild Cognitive Impairment, Executive Function, Physical Fitness, Cardiorespiratory Fitness
- Medical subject headings
- Cognitive Dysfunction
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
High-Intensity Interval Training (HIIT)Other
The HIIT group will engage in 28 min of alternating high-intensity and low-intensity exercise, where the high-intensity phase will be at 85-90% of maximum heart rate for 4 min, followed by a 3-min recovery period at 50-60% of maximum heart rate, repeated four times on a treadmill or stationary bicycle. (RPE ~16 on Borg scale) Total duration will be 38 minutes including warm up and cool down period.
Moderate-Intensity Continuous TrainingOther
The MICT group's training will consist of continuous aerobic exercise for 28 min at 60-70% of maximum heart rate on a treadmill or stationary bicycle. (RPE ~13 on Borg scale) Total duration will be 38 minutes including warm up and cool down period.
| Study group | Role | What they receive |
|---|---|---|
| Group A | Experimental | The High-Intensity Interval Training Group (HIIT) Receives: Other: High-Intensity Interval Training (HIIT) |
| Group B | Experimental | Moderate-Intensity Continuous Training (MICT) Receives: Other: Moderate-Intensity Continuous Training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Montreal Cognitive Assessment (MoCA)
The Montreal Cognitive Assessment (MoCA) is a one-page, 30-point cognitive screening measurement scale that takes about 10 minutes to administer. There are 12 subtasks in the MoCA test that include memory, visuospatial orientation, executive functioning, phonemic fluency, and two-item abstract thinking task, attention, concentration, and working memory, language, orientation to time and place. A score of 26 is a cutoff score to differentiate between normal and abnormal. It has been extensively validated for its reliability and effectiveness in detecting cognitive deficits.
Measured: Assessment at baseline, after the 4th week, 8th week, and follow-up at 12th week.
Secondary outcomes (3)
Trail Making Test
The Trail Making Test (TMT) is a widely used neuropsychological assessment tool that evaluates cognitive flexibility, executive function, and processing speed. It consists of two parts: TMT-A and TMT-B, each designed to measure different cognitive abilities. TMT-A: This part requires the participant to connect a series of numbered circles in ascending order (1-2-3-4...). It primarily assesses visuoperceptual abilities, such as visual scanning and motor speed. TMT-B: In this part, participants alternate between numbers and letters (1-A-2-B-3-C...), which adds complexity by requiring task-switching and working memory. This portion reflects higher-order executive functions, including cognitive flexibility and the ability to shift attention between tasks.
Measured: Assessment at baseline, after the 4th week, 8th week, and follow-up at 12th week.
The Short Physical Performance Battery (SPPB)
The Short Physical Performance Battery (SPPB) is an objective assessment tool used to evaluate lower extremity functioning and physical performance in older adults including those with mild cognitive impairment (MCI). It consists of three tests: Balance test, Gait speed test and Chair stand test. Each test is scored from 0-4 points. Total SPPB score ranges from 0 (worst performance) to 12 (best performance).
Measured: Assessment at baseline, after the 4th week, 8th week, and follow-up at 12th week.
6-Minute Walk Test (6MWT)
The 6-Minute Walk Test (6MWT) aims to determine how far a person can walk in 6 minutes on a flat, hard surface. The test evaluates the integrated response of multiple bodily systems during exercise, including the respiratory, cardiovascular, and musculoskeletal systems. The person walks back and forth along a measured course, typically 30 meters long. They are instructed to cover as much distance as possible in 6 minutes. Participants can slow down or rest if needed but should resume walking when able.
Measured: Assessment at baseline, after the 4th week, 8th week, and follow-up at 12th week.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Nov 2025
- Study start5 Nov 2025
- Primary completion12 Apr 2026
- Study completion30 Apr 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (5)Papers the sponsor has linked to this study.
- Other trials for Mild Cognitive ImpairmentStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 68 participants (actual)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Aruba Saeed, PhD, Principal investigator, Riphah International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07248709
- Sponsor's protocol ID
- REC/0268 Sadia Khalid
- Status last verified
- Jun 2026
- First submitted
- 18 Nov 2025
- Last updated
- 3 Jun 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Shao Z, Huang J, Feng H, Hu M. Optimizing the physical activity intervention for older adults with mild cognitive impairment: a factorial randomized trial. Front Sports Act Living. 2024 May 7;6:1383325. doi: 10.3389/fspor.2024.1383325. eCollection 2024.
PubMed 38774280de Lima NS, De Sousa RAL, Amorim FT, Gripp F, Diniz E Magalhaes CO, Henrique Pinto S, Peixoto MFD, Monteiro-Junior RS, Bourbeau K, Cassilhas RC. Moderate-intensity continuous training and high-intensity interval training improve cognition, and BDNF levels of middle-aged overweight men. Metab Brain Dis. 2022 Feb;37(2):463-471. doi: 10.1007/s11011-021-00859-5. Epub 2021 Nov 11.
PubMed 34762211Tsai CL, Pai MC, Ukropec J, Ukropcova B. The Role of Physical Fitness in the Neurocognitive Performance of Task Switching in Older Persons with Mild Cognitive Impairment. J Alzheimers Dis. 2016 Apr 23;53(1):143-59. doi: 10.3233/JAD-151093.
PubMed 27128369Martin-Smith R, Cox A, Buchan DS, Baker JS, Grace F, Sculthorpe N. High Intensity Interval Training (HIIT) Improves Cardiorespiratory Fitness (CRF) in Healthy, Overweight and Obese Adolescents: A Systematic Review and Meta-Analysis of Controlled Studies. Int J Environ Res Public Health. 2020 Apr 24;17(8):2955. doi: 10.3390/ijerph17082955.
PubMed 32344773Wu Q, Niu X, Zhang Y, Song J, Chi A. A Comparative Study of Inhibition Function between High-Intensity Interval Training and Moderate-Intensity Continuous Training in Healthy People: A Systematic Review with Meta-Analysis. Int J Environ Res Public Health. 2023 Feb 6;20(4):2859. doi: 10.3390/ijerph20042859.
PubMed 36833556
Study at a glance
From the registry record, last updated by the sponsor on 3 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of High-Intensity Interval Training and Moderate-Intensity Continuous Training on Executive Functions, Cardiorespiratory and Physical Fitness in Older Adults With Mild Cognitive Impairment
- ClinicalTrials.gov ID
- NCT07248709
- Acronym / sponsor ID
- REC/0268 Sadia Khalid
- Conditions
- Mild Cognitive Impairment
- Keywords
- High-Intensity Interval Training, Moderate-Intensity Continuous Training, Mild Cognitive Impairment, Executive Function, Physical Fitness, Cardiorespiratory Fitness
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 68 participants (actual)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 5 Nov 2025 (actual)
- Primary completion
- 12 Apr 2026 (actual)
- Study completion
- 30 Apr 2026 (actual)
- First posted
- 25 Nov 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to determine the effects of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) on cognitive and physical fitness in community-dwelling adults diagnosed with Mild Cognitive Impairment (MCI).
A double-blinded randomized clinical trial will be conducted for ten months at Ruhama Welfare Foundation Society Lahore and Kainat Patient Care and Old Age Home, Lahore. The sample size is calculated through G-power and 68 participants will be recruited through the non-probability convenience sampling technique. Those who meet the inclusion criteria will be randomized into two groups through the online randomizer tool. Both experimental groups will undergo an 8-week intervention, consisting of three sessions per week with alternate-day training of 38 minutes. The HIIT group will perform exercise with each session consisting of four 4-minute intervals at 85-95% of their maximum heart rate, with 3-minute active recovery periods, while the MICT group will engage in continuous exercise for 28 minutes at 70-75% of their maximum heart rate. Assessment will be done at baseline, after the 4th week, 8th week, and follow-up at 12th week.
Detailed description
Mild cognitive impairment is a syndrome defined as cognitive decline greater than expected for an individual's age and education level but that does not interfere notably with activities of daily life. Prevalence in population-based epidemiological studies ranges from 3% to 19% in adults older than 65 years. Some people with mild cognitive impairment seem to remain stable or return to normal over time, but more than half progress to dementia within 5 years. Mild cognitive impairment can thus be regarded as a risk state for dementia. The amnestic subtype of mild cognitive impairment has a high risk of progression to Alzheimer's disease, and it could constitute a prodromal stage of this disorder. One of the main causes of disability and dependency in older adults globally, dementia ranks as the seventh most common cause of all disorders. Globally, there were 55 million dementia sufferers in 2021; by 2030, that figure is expected to rise to 78 million, and by 2050, it will reach 139 million. Thankfully, there is a chance that postponing dementia onset by five years could cut its prevalence in half globally. Compared to just 3% of the age-matched group, 46% of people with mild cognitive impairment (MCI), an intermediate stage between normal cognition and dementia, will develop dementia within three years. As a result, MCI is a crucial phase in stopping dementia from getting worse. The multi-cognitive function of subjects with MCI declines.
HIIT can enhance cognitive performance through increased blood flow to the brain, promoting neurogenesis and synaptic plasticity, which are crucial for cognitive tasks. MICT also supports cognitive function. HIIT often produces superior results in a shorter time frame. HIIT involves short bursts of high-intensity exercise followed by rest or low-intensity periods, leading to significant cardiovascular adaptations such as increased VO2 max and improved heart efficiency. MICT, while beneficial, requires longer durations to achieve comparable gains in cardiorespiratory fitness (CRF). Engaging in regular physical exercise has been shown to delay age-related physiological and cognitive decline, reduce the risk of common diseases, and improve the subjective quality of life. Meanwhile, a large proportion of older adults are insufficiently physically active, potentially increasing societal health-related challenges connected to a growing older population. It is, therefore, important to provide both effective and attractive exercise methods adapted for this group. One of the proposed key factors in maximizing exercise effects is to exercise beyond moderate intensities, as in high-intensity interval training (HIIT). Although aerobic moderate-intensity continuous training (MICT) is performed at intensities below the anaerobic threshold, HIIT is broadly defined as short, repeated work intervals at an external intensity close to (80%-100%), or above (>100%) the intensity that elicits maximum oxygen uptake (Vo2 max), with passive or low intensity recovery between intervals.
While exercise is a promising intervention for cognitive health, the comparative efficacy of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) in older adults with MCI remains underexplored. This research seeks to provide useful insights examining the effects of HIIT and MICT on executive functions, cardiorespiratory fitness, and overall physical fitness. HIIT's potential time efficiency and physiological benefits may offer significant advantages over traditional exercise methods. The findings could inform clinical practice, shape public health guidelines, and lead to more effective exercise interventions, ultimately enhancing the quality of life for older adults at risk of cognitive decline.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Group A | Experimental | Other: High-Intensity Interval Training (HIIT)The High-Intensity Interval Training Group (HIIT) |
| Group B | Experimental | Other: Moderate-Intensity Continuous TrainingModerate-Intensity Continuous Training (MICT) |
Who may qualify
- Ages
- 60 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- older adults who had been diagnosed with MCI according to Peterson's criteria [Montreal Cognitive Assessment (MoCA) score <26 for those with 12 years or more of education and <25 for those with less than 12 years of education; activity of daily living scale ≤23; no clinical diagnosis of dementia]
- older adults who are physically normal (the six-item Katz Activities of Daily Living Scale should all be evaluated as "independent")
Key exclusion criteria (5 listed)
- Participants who have medical problems or co-morbidities that interdict their participation in the study.
- Unable to walk without an assistive device
- Diagnosed with neurodegenerative diseases such as Alzheimer's disease
- Having regular exercise habits (defined as exercise for ≥150 min per week).
- Participating in other ongoing intervention study
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| High-Intensity Interval Training (HIIT)The HIIT group will engage in 28 min of alternating high-intensity and low-intensity exercise, where the high-intensity phase will be at 85-90% of maximum heart rate for 4 min, followed by a 3-min recovery period at 50-60% of maximum heart rate, repeated four times on a treadmill or stationary bicycle. (RPE ~16 on Borg scale) Total duration will be 38 minutes including warm up and cool down period. | Other | Group A |
| Moderate-Intensity Continuous TrainingThe MICT group's training will consist of continuous aerobic exercise for 28 min at 60-70% of maximum heart rate on a treadmill or stationary bicycle. (RPE ~13 on Borg scale) Total duration will be 38 minutes including warm up and cool down period. | Other | Group B |
Primary outcome
Montreal Cognitive Assessment (MoCA)
Time frame: Assessment at baseline, after the 4th week, 8th week, and follow-up at 12th week.
The Montreal Cognitive Assessment (MoCA) is a one-page, 30-point cognitive screening measurement scale that takes about 10 minutes to administer. There are 12 subtasks in the MoCA test that include memory, visuospatial orientation, executive functioning, phonemic fluency, and two-item abstract thinking task, attention, concentration, and working memory, language, orientation to time and place. A score of 26 is a cutoff score to differentiate between normal and abnormal. It has been extensively validated for its reliability and effectiveness in detecting cognitive deficits.
3 secondary outcomes
Trail Making Test
Time frame: Assessment at baseline, after the 4th week, 8th week, and follow-up at 12th week.
The Short Physical Performance Battery (SPPB)
Time frame: Assessment at baseline, after the 4th week, 8th week, and follow-up at 12th week.
6-Minute Walk Test (6MWT)
Time frame: Assessment at baseline, after the 4th week, 8th week, and follow-up at 12th week.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Jun 2026.
- Background: PubMed 38774280Shao Z, Huang J, Feng H, Hu M. Optimizing the physical activity intervention for older adults with mild cognitive impairment: a factorial randomized trial. Front Sports Act Living. 2024 May 7;6:1383325. doi: 10.3389/fspor.2024.1383325. eCollection 2024.
- Background: PubMed 34762211de Lima NS, De Sousa RAL, Amorim FT, Gripp F, Diniz E Magalhaes CO, Henrique Pinto S, Peixoto MFD, Monteiro-Junior RS, Bourbeau K, Cassilhas RC. Moderate-intensity continuous training and high-intensity interval training improve cognition, and BDNF levels of middle-aged overweight men. Metab Brain Dis. 2022 Feb;37(2):463-471. doi: 10.1007/s11011-021-00859-5. Epub 2021 Nov 11.
- Background: PubMed 27128369Tsai CL, Pai MC, Ukropec J, Ukropcova B. The Role of Physical Fitness in the Neurocognitive Performance of Task Switching in Older Persons with Mild Cognitive Impairment. J Alzheimers Dis. 2016 Apr 23;53(1):143-59. doi: 10.3233/JAD-151093.
- Background: PubMed 32344773Martin-Smith R, Cox A, Buchan DS, Baker JS, Grace F, Sculthorpe N. High Intensity Interval Training (HIIT) Improves Cardiorespiratory Fitness (CRF) in Healthy, Overweight and Obese Adolescents: A Systematic Review and Meta-Analysis of Controlled Studies. Int J Environ Res Public Health. 2020 Apr 24;17(8):2955. doi: 10.3390/ijerph17082955.
- Background: PubMed 36833556Wu Q, Niu X, Zhang Y, Song J, Chi A. A Comparative Study of Inhibition Function between High-Intensity Interval Training and Moderate-Intensity Continuous Training in Healthy People: A Systematic Review with Meta-Analysis. Int J Environ Res Public Health. 2023 Feb 6;20(4):2859. doi: 10.3390/ijerph20042859.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Aruba Saeed, PhD principal investigator
Riphah International University
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training in people with Mild Cognitive Impairment, run by Riphah International University at 2 sites in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Montreal Cognitive Assessment (MoCA) (time frame: Assessment at baseline, after the 4th week, 8th week, and follow-up at 12th week.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07248709, which also lists 5 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Jun 2026; AzTrials last refreshed its copy on 1 Nov 2026.