Chronic PainPNENCT07252596
Pain Neuroscience Education and Memory
A study testing Pain Neuroscience Education (PNE) in people with Chronic Pain, run by Evidence In Motion.
Trial summary
Brief Summary: The goal of this observational study (case series) is to determine whether Pain Neuroscience Education (PNE) can influence memory function and sensory awareness in adults (18 years and older) experiencing chronic pain lasting more than one year. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Chronic Pain
- What is being tested?
- Pain Neuroscience Education (PNE)
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- No sites listed yet
- Study dates
- Nov 2025to May 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age 18 and above
- Chronic pain > 1 year
- Provide written consent
- Proficient in reading and understanding English
Who cannot join
- Not willing to participate in the study
- Have received PNE as a treatment before
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Pain Neuroscience Education's Effect on Memory and Pain Drawings: An Exploratory Study
Brief Summary:
The goal of this observational study (case series) is to determine whether Pain Neuroscience Education (PNE) can influence memory function and sensory awareness in adults (18 years and older) experiencing chronic pain lasting more than one year.
Read more
The main questions it aims to answer are:
Does a single PNE session improve memory performance, as measured by the Montreal Cognitive Assessment (MoCA)?
Does PNE change sensory awareness, as represented by alterations in body pain drawings using a grid overlay method?
Participants will:
Complete pre-intervention assessments, including:
Numeric Pain Rating Scale (NPRS)
Body chart drawing to map pain area
Montreal Cognitive Assessment (MoCA)
Pain Catastrophization Scale (PCS)
Receive a 10-15 minute standardized PNE session delivered by a licensed clinician trained in pain science
Complete the same assessments immediately after the intervention to identify any changes in memory, sensory awareness, and pain perception
This study aims to explore whether PNE can positively impact cognitive and sensory functions affected by chronic pain, beyond its already-established effects on movement and pain intensity.
Read the detailed description
Detailed Description:
Chronic pain is a complex, multidimensional condition affecting approximately 25% of the global population. It is increasingly understood through the lens of brain-based changes, particularly the dynamic pain connectome, a network of brain regions involved in sensory, cognitive, and emotional processing. Functional reorganization in chronic pain patients may contribute to clinical symptoms beyond pain, such as memory loss, decreased sensory awareness, and altered motor control.
Pain Neuroscience Education (PNE) is an educational intervention that aims to reconceptualize a patient's understanding of pain to reduce fear-avoidance, pain catastrophization, and disability. Systematic reviews have demonstrated its effectiveness in reducing pain and improving movement. Early fMRI studies suggest that PNE may also deactivate pain-related brain areas and normalize brain function.
This case series seeks to explore the impact of a single PNE session on cognitive (memory) and sensory (body perception) outcomes in individuals with chronic pain. Participants (aged 18 and older) who meet inclusion criteria and consent to the study will undergo pre- and post-intervention assessments. These include:
Numeric Pain Rating Scale (NPRS)
Pain body chart (grid overlay method)
Montreal Cognitive Assessment (MoCA)
Pain Catastrophization Scale (PCS)
Following baseline assessments, participants will receive a 10-15 minute individualized PNE session delivered by licensed clinicians trained in advanced pain science. Immediately post-intervention, assessments will be repeated to evaluate changes.
The study aims to contribute to the understanding of how PNE may influence brain-related symptoms associated with chronic pain, specifically memory function and sensory mapping. Findings could provide early evidence to support broader applications of PNE beyond movement-related outcomes.
- Conditions
- Chronic Pain
- Being tested
- Pain Neuroscience Education (PNE)
- Keywords
- pain neuroscience education, Memory, Pain drawing, chronic pain
- Medical subject headings
- Chronic Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Pain Neuroscience Education (PNE)Behavioural
A 10-15 minute individualized educational session focusing on the neuroscience of pain. The session aims to reconceptualize the patient's understanding of their chronic pain by explaining the underlying biological, cognitive, and emotional mechanisms involved. Clinicians use a standardized checklist of metaphors and teaching tools tailored to the patient's clinical presentation.
| Study group | Role | What they receive |
|---|---|---|
| Pain Neuroscience Education (PNE) Intervention | Experimental | Participants will receive a standardized Pain Neuroscience Education session lasting 10 to 15 minutes, delivered by a clinician trained in advanced pain science. This educational intervention uses metaphors, examples, and images to teach patients about the biology of pain, aiming to reduce pain catastrophizing and improve cognitive and sensory outcomes. Receives: Behavioral: Pain Neuroscience Education (PNE) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Memory Function (Montreal Cognitive Assessment - MoCA)
Description: Change in MoCA score to assess improvement or decline in cognitive function, particularly memory, associated with chronic pain. The MoCA is scored out of 30; a change of 2 points or more is considered clinically meaningful.
Measured: At baseline (prior to the pain neuroscience education session) and immediately after completion of the treatment session
Sensory Awareness (Body Chart Pain Area - Grid Overlay Count)
Change in the number of grid blocks marked on the body pain chart to quantify alteration in perceived pain area, reflecting somatosensory representation changes.
Measured: At baseline (prior to the pain neuroscience education session) and immediately after completion of the treatment session
Secondary outcomes (2)
Self-Reported Pain Intensity (Numeric Pain Rating Scale - NPRS)
Change in pain intensity reported by the patient on an 11-point scale (0-10). The minimal clinically important difference (MCID) is 1.7 points.
Measured: At baseline (prior to the pain neuroscience education session) and immediately after completion of the treatment session
Pain Catastrophization (Pain Catastrophization Scale - PCS)
Change in PCS scores assessing catastrophic thinking related to pain on a 13-item, 5-point Likert scale. Higher scores indicate greater catastrophizing.
Measured: At baseline (prior to the pain neuroscience education session) and immediately after completion of the treatment session
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Nov 2025
- Study startNov 2025 (estimated)
- Primary completionFeb 2026 (estimated)
- Study completionMay 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (33)Papers the sponsor has linked to this study.
- Other trials for Chronic PainStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- This is a single-group assignment observational study (case series) where all participants receive the same intervention (Pain Neuroscience Education). Pre- and post-intervention measurements are taken to evaluate the effects of PNE on memory and sensory awareness in individuals with chronic pain.
- Masking
- None (open label)
- Enrolment
- 50 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Evidence In Motion
- Sponsor type
- University, hospital or other
- Collaborators
- University of Nevada, Las Vegas, Southwest Baptist University
- Responsible party
- Sponsor
- Investigators
- Adriaan Louw, PT, PhD, Principal investigator, Evidence In Motion
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07252596
- Sponsor's protocol ID
- PNEMEMORY202510
- Acronym
- PNE
- Status last verified
- Nov 2025
- First submitted
- 18 Nov 2025
- Last updated
- 26 Nov 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Sharing IPD requires time, personnel, infrastructure, and data curation, which might not be feasible due to funding or staffing limitations. In addition, the informed consent documents do not include a provision for IPD sharing. Participants have not agreed to data sharing beyond the original study purpose.
Publications
Sullivan MJL, Bishop SR, Pivik J. The Pain Catastrophizing Scale: Development and validation. Psychological Assessment
Lansdall CJ, McDougall F, Butler LM, Delmar P, Pross N, Qin S, McLeod L, Zhou X, Kerchner GA, Doody RS. Establishing Clinically Meaningful Change on Outcome Assessments Frequently Used in Trials of Mild Cognitive Impairment Due to Alzheimer's Disease. J Prev Alzheimers Dis. 2023;10(1):9-18. doi: 10.14283/jpad.2022.102.
PubMed 36641605Nasreddine ZS, Phillips NA, Bedirian V, Charbonneau S, Whitehead V, Collin I, Cummings JL, Chertkow H. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005 Apr;53(4):695-9. doi: 10.1111/j.1532-5415.2005.53221.x.
PubMed 15817019Sanders NW, Mann NH 3rd, Spengler DM. Pain drawing scoring is not improved by inclusion of patient-reported pain sensation. Spine (Phila Pa 1976). 2006 Nov 1;31(23):2735-41; discussion 2742-3. doi: 10.1097/01.brs.0000244674.99258.f9.
PubMed 17077744Lacey RJ, Lewis M, Jordan K, Jinks C, Sim J. Interrater reliability of scoring of pain drawings in a self-report health survey. Spine (Phila Pa 1976). 2005 Aug 15;30(16):E455-8. doi: 10.1097/01.brs.0000174274.38485.ee.
PubMed 16103839Matthews M, Rathleff MS, Vicenzino B, Boudreau SA. Capturing patient-reported area of knee pain: a concurrent validity study using digital technology in patients with patellofemoral pain. PeerJ. 2018 Mar 8;6:e4406. doi: 10.7717/peerj.4406. eCollection 2018.
PubMed 29568700Wand BM, Keeves J, Bourgoin C, George PJ, Smith AJ, O'Connell NE, Moseley GL. Mislocalization of sensory information in people with chronic low back pain: a preliminary investigation. Clin J Pain. 2013 Aug;29(8):737-43. doi: 10.1097/AJP.0b013e318274b320.
PubMed 23835768Farrar JT, Young JP Jr, LaMoreaux L, Werth JL, Poole MR. Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale. Pain. 2001 Nov;94(2):149-158. doi: 10.1016/S0304-3959(01)00349-9.
PubMed 11690728Kregel J, Meeus M, Malfliet A, Dolphens M, Danneels L, Nijs J, Cagnie B. Structural and functional brain abnormalities in chronic low back pain: A systematic review. Semin Arthritis Rheum. 2015 Oct;45(2):229-37. doi: 10.1016/j.semarthrit.2015.05.002. Epub 2015 May 16.
PubMed 26092329Watson JA, Ryan CG, Cooper L, Ellington D, Whittle R, Lavender M, Dixon J, Atkinson G, Cooper K, Martin DJ. Pain Neuroscience Education for Adults With Chronic Musculoskeletal Pain: A Mixed-Methods Systematic Review and Meta-Analysis. J Pain. 2019 Oct;20(10):1140.e1-1140.e22. doi: 10.1016/j.jpain.2019.02.011. Epub 2019 Mar 1.
PubMed 30831273Suso-Marti L, Cuenca-Martinez F, Alba-Quesada P, Munoz-Alarcos V, Herranz-Gomez A, Varangot-Reille C, Dominguez-Navarro F, Casana J. Effectiveness of Pain Neuroscience Education in Patients with Fibromyalgia: A Systematic Review and Meta-Analysis. Pain Med. 2022 Oct 29;23(11):1837-1850. doi: 10.1093/pm/pnac077.
PubMed 35587171Krebs-Roubicek E, Osterwalder R. [Gerontopsychiatry--collaboration between inpatient and outpatient care]. Ther Umsch. 1986 Jan;43(1):69-74. No abstract available. German.
PubMed 3952688Rastegarnia S, St-Laurent M, DuPre E, Pinsard B, Bellec P. Brain decoding of the Human Connectome Project tasks in a dense individual fMRI dataset. Neuroimage. 2023 Dec 1;283:120395. doi: 10.1016/j.neuroimage.2023.120395. Epub 2023 Oct 12.
PubMed 37832707Smallwood RF, Laird AR, Ramage AE, Parkinson AL, Lewis J, Clauw DJ, Williams DA, Schmidt-Wilcke T, Farrell MJ, Eickhoff SB, Robin DA. Structural brain anomalies and chronic pain: a quantitative meta-analysis of gray matter volume. J Pain. 2013 Jul;14(7):663-75. doi: 10.1016/j.jpain.2013.03.001. Epub 2013 May 17.
PubMed 23685185Hashmi JA, Baliki MN, Huang L, Baria AT, Torbey S, Hermann KM, Schnitzer TJ, Apkarian AV. Shape shifting pain: chronification of back pain shifts brain representation from nociceptive to emotional circuits. Brain. 2013 Sep;136(Pt 9):2751-68. doi: 10.1093/brain/awt211.
PubMed 23983029
Study at a glance
From the registry record, last updated by the sponsor on 26 Nov 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Pain Neuroscience Education's Effect on Memory and Pain Drawings: An Exploratory Study
- ClinicalTrials.gov ID
- NCT07252596
- Acronym / sponsor ID
- PNE / PNEMEMORY202510
- Conditions
- Chronic Pain
- Keywords
- pain neuroscience education, Memory, Pain drawing, chronic pain
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 50 participants (estimated)
- Lead sponsor
- Evidence In MotionUniversity, hospital or other
- Collaborators
- University of Nevada, Las Vegas, Southwest Baptist University
- Study start
- Nov 2025 (estimated)
- Primary completion
- Feb 2026 (estimated)
- Study completion
- May 2026 (estimated)
- First posted
- 26 Nov 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Brief Summary:
The goal of this observational study (case series) is to determine whether Pain Neuroscience Education (PNE) can influence memory function and sensory awareness in adults (18 years and older) experiencing chronic pain lasting more than one year.
The main questions it aims to answer are:
Does a single PNE session improve memory performance, as measured by the Montreal Cognitive Assessment (MoCA)?
Does PNE change sensory awareness, as represented by alterations in body pain drawings using a grid overlay method?
Participants will:
Complete pre-intervention assessments, including:
Numeric Pain Rating Scale (NPRS)
Body chart drawing to map pain area
Montreal Cognitive Assessment (MoCA)
Pain Catastrophization Scale (PCS)
Receive a 10-15 minute standardized PNE session delivered by a licensed clinician trained in pain science
Complete the same assessments immediately after the intervention to identify any changes in memory, sensory awareness, and pain perception
This study aims to explore whether PNE can positively impact cognitive and sensory functions affected by chronic pain, beyond its already-established effects on movement and pain intensity.
Detailed description
Detailed Description:
Chronic pain is a complex, multidimensional condition affecting approximately 25% of the global population. It is increasingly understood through the lens of brain-based changes, particularly the dynamic pain connectome, a network of brain regions involved in sensory, cognitive, and emotional processing. Functional reorganization in chronic pain patients may contribute to clinical symptoms beyond pain, such as memory loss, decreased sensory awareness, and altered motor control.
Pain Neuroscience Education (PNE) is an educational intervention that aims to reconceptualize a patient's understanding of pain to reduce fear-avoidance, pain catastrophization, and disability. Systematic reviews have demonstrated its effectiveness in reducing pain and improving movement. Early fMRI studies suggest that PNE may also deactivate pain-related brain areas and normalize brain function.
This case series seeks to explore the impact of a single PNE session on cognitive (memory) and sensory (body perception) outcomes in individuals with chronic pain. Participants (aged 18 and older) who meet inclusion criteria and consent to the study will undergo pre- and post-intervention assessments. These include:
Numeric Pain Rating Scale (NPRS)
Pain body chart (grid overlay method)
Montreal Cognitive Assessment (MoCA)
Pain Catastrophization Scale (PCS)
Following baseline assessments, participants will receive a 10-15 minute individualized PNE session delivered by licensed clinicians trained in advanced pain science. Immediately post-intervention, assessments will be repeated to evaluate changes.
The study aims to contribute to the understanding of how PNE may influence brain-related symptoms associated with chronic pain, specifically memory function and sensory mapping. Findings could provide early evidence to support broader applications of PNE beyond movement-related outcomes.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- This is a single-group assignment observational study (case series) where all participants receive the same intervention (Pain Neuroscience Education). Pre- and post-intervention measurements are taken to evaluate the effects of PNE on memory and sensory awareness in individuals with chronic pain.
| Arm | Type | Receives |
|---|---|---|
| Pain Neuroscience Education (PNE) Intervention | Experimental | Behavioral: Pain Neuroscience Education (PNE)Participants will receive a standardized Pain Neuroscience Education session lasting 10 to 15 minutes, delivered by a clinician trained in advanced pain science. This educational intervention uses metaphors, examples, and images to teach patients about the biology of pain, aiming to reduce pain catastrophizing and improve cognitive and sensory outcomes. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Age 18 and above
- Chronic pain > 1 year
- Provide written consent
- Proficient in reading and understanding English
Key exclusion criteria (2 listed)
- Not willing to participate in the study
- Have received PNE as a treatment before
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Pain Neuroscience Education (PNE)A 10-15 minute individualized educational session focusing on the neuroscience of pain. The session aims to reconceptualize the patient's understanding of their chronic pain by explaining the underlying biological, cognitive, and emotional mechanisms involved. Clinicians use a standardized checklist of metaphors and teaching tools tailored to the patient's clinical presentation. | Behavioural | Pain Neuroscience Education (PNE) Intervention |
Primary outcome
Memory Function (Montreal Cognitive Assessment - MoCA)
Time frame: At baseline (prior to the pain neuroscience education session) and immediately after completion of the treatment session
Description: Change in MoCA score to assess improvement or decline in cognitive function, particularly memory, associated with chronic pain. The MoCA is scored out of 30; a change of 2 points or more is considered clinically meaningful.
Sensory Awareness (Body Chart Pain Area - Grid Overlay Count)
Time frame: At baseline (prior to the pain neuroscience education session) and immediately after completion of the treatment session
Change in the number of grid blocks marked on the body pain chart to quantify alteration in perceived pain area, reflecting somatosensory representation changes.
2 secondary outcomes
Self-Reported Pain Intensity (Numeric Pain Rating Scale - NPRS)
Time frame: At baseline (prior to the pain neuroscience education session) and immediately after completion of the treatment session
Pain Catastrophization (Pain Catastrophization Scale - PCS)
Time frame: At baseline (prior to the pain neuroscience education session) and immediately after completion of the treatment session
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Nov 2025.
- BackgroundSullivan MJL, Bishop SR, Pivik J. The Pain Catastrophizing Scale: Development and validation. Psychological Assessment
- Background: PubMed 36641605Lansdall CJ, McDougall F, Butler LM, Delmar P, Pross N, Qin S, McLeod L, Zhou X, Kerchner GA, Doody RS. Establishing Clinically Meaningful Change on Outcome Assessments Frequently Used in Trials of Mild Cognitive Impairment Due to Alzheimer's Disease. J Prev Alzheimers Dis. 2023;10(1):9-18. doi: 10.14283/jpad.2022.102.
- Background: PubMed 15817019Nasreddine ZS, Phillips NA, Bedirian V, Charbonneau S, Whitehead V, Collin I, Cummings JL, Chertkow H. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005 Apr;53(4):695-9. doi: 10.1111/j.1532-5415.2005.53221.x.
- Background: PubMed 17077744Sanders NW, Mann NH 3rd, Spengler DM. Pain drawing scoring is not improved by inclusion of patient-reported pain sensation. Spine (Phila Pa 1976). 2006 Nov 1;31(23):2735-41; discussion 2742-3. doi: 10.1097/01.brs.0000244674.99258.f9.
- Background: PubMed 16103839Lacey RJ, Lewis M, Jordan K, Jinks C, Sim J. Interrater reliability of scoring of pain drawings in a self-report health survey. Spine (Phila Pa 1976). 2005 Aug 15;30(16):E455-8. doi: 10.1097/01.brs.0000174274.38485.ee.
- Background: PubMed 29568700Matthews M, Rathleff MS, Vicenzino B, Boudreau SA. Capturing patient-reported area of knee pain: a concurrent validity study using digital technology in patients with patellofemoral pain. PeerJ. 2018 Mar 8;6:e4406. doi: 10.7717/peerj.4406. eCollection 2018.
- Background: PubMed 23835768Wand BM, Keeves J, Bourgoin C, George PJ, Smith AJ, O'Connell NE, Moseley GL. Mislocalization of sensory information in people with chronic low back pain: a preliminary investigation. Clin J Pain. 2013 Aug;29(8):737-43. doi: 10.1097/AJP.0b013e318274b320.
- Background: PubMed 11690728Farrar JT, Young JP Jr, LaMoreaux L, Werth JL, Poole MR. Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale. Pain. 2001 Nov;94(2):149-158. doi: 10.1016/S0304-3959(01)00349-9.
- Background: PubMed 26092329Kregel J, Meeus M, Malfliet A, Dolphens M, Danneels L, Nijs J, Cagnie B. Structural and functional brain abnormalities in chronic low back pain: A systematic review. Semin Arthritis Rheum. 2015 Oct;45(2):229-37. doi: 10.1016/j.semarthrit.2015.05.002. Epub 2015 May 16.
- Background: PubMed 30831273Watson JA, Ryan CG, Cooper L, Ellington D, Whittle R, Lavender M, Dixon J, Atkinson G, Cooper K, Martin DJ. Pain Neuroscience Education for Adults With Chronic Musculoskeletal Pain: A Mixed-Methods Systematic Review and Meta-Analysis. J Pain. 2019 Oct;20(10):1140.e1-1140.e22. doi: 10.1016/j.jpain.2019.02.011. Epub 2019 Mar 1.
- Background: PubMed 35587171Suso-Marti L, Cuenca-Martinez F, Alba-Quesada P, Munoz-Alarcos V, Herranz-Gomez A, Varangot-Reille C, Dominguez-Navarro F, Casana J. Effectiveness of Pain Neuroscience Education in Patients with Fibromyalgia: A Systematic Review and Meta-Analysis. Pain Med. 2022 Oct 29;23(11):1837-1850. doi: 10.1093/pm/pnac077.
- Background: PubMed 3952688Krebs-Roubicek E, Osterwalder R. [Gerontopsychiatry--collaboration between inpatient and outpatient care]. Ther Umsch. 1986 Jan;43(1):69-74. No abstract available. German.
- Individual participant dataSharing planned: No. Sharing IPD requires time, personnel, infrastructure, and data curation, which might not be feasible due to funding or staffing limitations. In addition, the informed consent documents do not include a provision for IPD sharing. Participants have not agreed to data sharing beyond the original study purpose.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Adriaan Louw, PT, PhD principal investigator
Evidence In Motion
Questions about this trial
What is this clinical trial studying?
A study testing Pain Neuroscience Education (PNE) in people with Chronic Pain, run by Evidence In Motion.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 26 Nov 2025. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Adriaan Louw, PT, PhD (888-709-7096, adriaan@eimpt.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Memory Function (Montreal Cognitive Assessment - MoCA) (time frame: At baseline (prior to the pain neuroscience education session) and immediately after completion of the treatment session). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07252596, which also lists 33 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Nov 2025.