Post-prandial Glucose ResponseNCT07254624
Pilot Assessment of Continuous Glucose Monitor for Post-meal Glucose Responses to Herbs and Spices.
A study testing Mix of five herbs and spices and Potato entree in people with Post-prandial Glucose Response, run by University of Alabama at Birmingham at 1 site in United States.
Trial summary
The purpose of this study is to determine whether continuous glucose monitoring is sensitive to quantifying the glucose response related to consumption of a starchy vegetable (potato) in combination with or separate from consumption of herbs and spices at the same meal. Read more about this study
- Who is it for?
- Ages 18 to 50 yearsHealthy volunteers can take part
- Conditions the study is for
- Post-prandial Glucose Response
- What is being tested?
- Mix of five herbs and spices and Potato entree
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 10 participants
- Where
- 1 siteUnited States
- Study dates
- 16 Mar 2026to Nov 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- body mass index (BMI): 20-35
- no dietary restriction or food allergies to study items
- weight stable
- access to a smart phone
- willingness to wear a continuous glucose monitor for the duration of the study (at minimum 10 days)
Who cannot join
- pregnancy or anticipating pregnancy or lactation
- food allergy to study items
- diagnosed diabetes (type 1 or 2) or taking diabetes medications
- history of bariatric surgery
- consumed >1 serving of potatoes daily before enrollment
- 5% weight loss or gain within the past 6 months
- medical conditions or medication that would prevent the ability to comply with the treatment assignment and/or affect blood glucose or energy balance
- condition which would prevent the ability to wear a continuous glucose monitor on the upper arm for the study duration
Trial locations and contacts
1 site in 1 country.
United States1 site
University of Alabama at Birmingham
Birmingham, Alabama, 35294
About this study
Official title: Glucosidase Inhibitors and Glucose Metabolism
The purpose of this study is to determine whether continuous glucose monitoring is sensitive to quantifying the glucose response related to consumption of a starchy vegetable (potato) in combination with or separate from consumption of herbs and spices at the same meal.
Read the detailed description
This is a pilot study which will enroll a maximum of 10 participants. There will be 3 different food entree preparations that participants will consume (1 entree per day within the 10 day period). The order in which participants eat the different entrees will be randomized. The 3 different food entree preparations are as follows: 1) prepared potato entree with no herbs and spices, 2) prepared potato entree paired with herbs and spices, 3) prepared potato entree with herbs and spices consumed at a subsequent meal.
Following enrollment, participants will be randomized to the order of entree preparation types and provided all of the entrees with the instructions for food preparation and order of consumption noted when they arrive at the scheduled study visit. The entrees will be standardized for caloric content, composition, and preparation method. Post-consumption glucose responses will be recorded by continuous glucose monitors, which will be provided to participants at the first study visit.
- Conditions
- Post-prandial Glucose Response
- Being tested
- Mix of five herbs and spices, Potato entree
- Keywords
- post-meal glucose response
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Mix of five herbs and spicesOther
Herb and spice blend of dried oregano, basil, rosemary, garlic powder and onion powder
Potato entreeOther
A potato entree with a fixed macronutrient and calorie content, and standardized preparation method to evoke a post-prandial glucose response
| Study group | Role | What they receive |
|---|---|---|
| Potato entree with no herbs or spices | Sham comparator | consumption of a standardized potato entree, matched for macronutrient, calorie and preparation method across arms Receives: Other: Potato entree |
| Potato entree with herbs or spices | Experimental | consumption of a standardized potato entree including a mix of five herbs and spices at a fixed amount, matched for macronutrient, calorie and preparation method across arms Receives: Other: Mix of five herbs and spices; Other: Potato entree |
| Potato entree with no herbs or spices, with herbs and spices mix at a subsequent meal | Sham comparator | consumption of a standardized potato entree, matched for macronutrient, calorie and preparation method across arms - with a provision including a mix of five herbs and spices at a fixed amount to be consumed at a subsequent meal within the same day (>2 hours following the potato entree consumption) Receives: Other: Mix of five herbs and spices; Other: Potato entree |
What is being measured
The primary outcome is the main question the study is designed to answer.
Post-prandial glucose response
Glucose response will be measured using continuous glucose monitors. These devices will capture changes in glucose response from the start of the meal to about 2 hours postprandial.
Measured: 0, 1, and 2 hours post-meal, as well as 24 hour continuous
Secondary outcomes (1)
Acceptance assessment
Feedback surveys to assess meal items likeability/acceptability, adherence and feasibility ('1-5' point scale, with '3' being 'neutral' and '5' indicating the participants 'strongly agree' with regarding the likeability and acceptability of the food item) in preparation for a full trial.
Measured: 0-10 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Nov 2025
- Study start16 Mar 2026
- Primary completionNov 2026 (estimated)
- Study completionNov 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Post-prandial Glucose ResponseStudies of the same condition, open and under way.
- More trials run by University of Alabama at BirminghamThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- Participants will serve as their own controls in this study. They will be randomized to the order they receive the prepared entrees. Post-prandial glucose responses will be compared across the three entree types.
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 10 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Alabama at Birmingham
- Sponsor type
- University, hospital or other
- Collaborators
- McCormick Science Institute
- Responsible party
- Principal investigator, Daniel L. Smith, Jr., University of Alabama at Birmingham
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07254624
- Sponsor's protocol ID
- IRB-300015105
- Other IDs
- McCormick Science Institute
- Status last verified
- Jun 2026
- First submitted
- 19 Nov 2025
- Last updated
- 9 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Individual de-identified participant data will be shared or made publicly available for any publication of findings.
Study at a glance
From the registry record, last updated by the sponsor on 9 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Glucosidase Inhibitors and Glucose Metabolism
- ClinicalTrials.gov ID
- NCT07254624
- Acronym / sponsor ID
- IRB-300015105
- Conditions
- Post-prandial Glucose Response
- Keywords
- post-meal glucose response
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 10 participants (estimated)
- Lead sponsor
- University of Alabama at BirminghamUniversity, hospital or other
- Collaborators
- McCormick Science Institute
- Study start
- 16 Mar 2026 (actual)
- Primary completion
- Nov 2026 (estimated)
- Study completion
- Nov 2027 (estimated)
- First posted
- 28 Nov 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to determine whether continuous glucose monitoring is sensitive to quantifying the glucose response related to consumption of a starchy vegetable (potato) in combination with or separate from consumption of herbs and spices at the same meal.
Detailed description
This is a pilot study which will enroll a maximum of 10 participants. There will be 3 different food entree preparations that participants will consume (1 entree per day within the 10 day period). The order in which participants eat the different entrees will be randomized. The 3 different food entree preparations are as follows: 1) prepared potato entree with no herbs and spices, 2) prepared potato entree paired with herbs and spices, 3) prepared potato entree with herbs and spices consumed at a subsequent meal.
Following enrollment, participants will be randomized to the order of entree preparation types and provided all of the entrees with the instructions for food preparation and order of consumption noted when they arrive at the scheduled study visit. The entrees will be standardized for caloric content, composition, and preparation method. Post-consumption glucose responses will be recorded by continuous glucose monitors, which will be provided to participants at the first study visit.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 3
- Model description
- Participants will serve as their own controls in this study. They will be randomized to the order they receive the prepared entrees. Post-prandial glucose responses will be compared across the three entree types.
| Arm | Type | Receives |
|---|---|---|
| Potato entree with no herbs or spices | Sham comparator | Other: Potato entreeconsumption of a standardized potato entree, matched for macronutrient, calorie and preparation method across arms |
| Potato entree with herbs or spices | Experimental | Other: Mix of five herbs and spices, Other: Potato entreeconsumption of a standardized potato entree including a mix of five herbs and spices at a fixed amount, matched for macronutrient, calorie and preparation method across arms |
| Potato entree with no herbs or spices, with herbs and spices mix at a subsequent meal | Sham comparator | Other: Mix of five herbs and spices, Other: Potato entreeconsumption of a standardized potato entree, matched for macronutrient, calorie and preparation method across arms - with a provision including a mix of five herbs and spices at a fixed amount to be consumed at a subsequent meal within the same day (>2 hours following the potato entree consumption) |
Who may qualify
- Ages
- 18 to 50 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- body mass index (BMI): 20-35
- no dietary restriction or food allergies to study items
- weight stable
- access to a smart phone
- willingness to wear a continuous glucose monitor for the duration of the study (at minimum 10 days)
Key exclusion criteria (8 listed)
- pregnancy or anticipating pregnancy or lactation
- food allergy to study items
- diagnosed diabetes (type 1 or 2) or taking diabetes medications
- history of bariatric surgery
- consumed >1 serving of potatoes daily before enrollment
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Mix of five herbs and spicesHerb and spice blend of dried oregano, basil, rosemary, garlic powder and onion powder | Other | Potato entree with herbs or spices, Potato entree with no herbs or spices, with herbs and spices mix at a subsequent meal |
| Potato entreeA potato entree with a fixed macronutrient and calorie content, and standardized preparation method to evoke a post-prandial glucose response | Other | Potato entree with herbs or spices, Potato entree with no herbs or spices, Potato entree with no herbs or spices, with herbs and spices mix at a subsequent meal |
Primary outcome
Post-prandial glucose response
Time frame: 0, 1, and 2 hours post-meal, as well as 24 hour continuous
Glucose response will be measured using continuous glucose monitors. These devices will capture changes in glucose response from the start of the meal to about 2 hours postprandial.
1 secondary outcome
Acceptance assessment
Time frame: 0-10 days
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Jun 2026.
- Individual participant dataSharing planned: Yes. Individual de-identified participant data will be shared or made publicly available for any publication of findings.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Mix of five herbs and spices and Potato entree in people with Post-prandial Glucose Response, run by University of Alabama at Birmingham at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 9 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Post-prandial glucose response (time frame: 0, 1, and 2 hours post-meal, as well as 24 hour continuous). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Jun 2026.