Medial Tibial Stress SyndromeNCT07256808
Medial Tibial Stress Syndrome Prevention
A study testing Resistance Training in people with Medial Tibial Stress Syndrome, run by Rowan University at 1 site in United States.
Trial summary
This randomized controlled trial investigated whether a 10-week heavy resistance training program reduced the incidence of medial tibial stress syndrome (MTSS) in collegiate indoor track and field athletes. Read more about this study
- Who is it for?
- Ages 18 to 65 yearsHealthy volunteers can take part
- Conditions the study is for
- Medial Tibial Stress Syndrome
- What is being tested?
- Resistance Training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 26 participants
- Where
- 1 siteUnited States
- Study dates
- 14 Sep 2023to 14 Feb 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Collegiate athletes on the Indoor Track and Field team.
- Athletes must participate in at least one of the following:
- 60m-800m events (including hurdles)
- jumping events (including pole vault)
Who cannot join
- Subjects who have a history of musculoskeletal or neurologic conditions
- Who take medications that affect muscle tone
- Who have a body mass index >30.0 kg/m2 were excluded to screen to prevent adipose tissue from skewing the measurements.
- Any subject with any fractures, sprains, or strains of the lower extremities were excluded.
- Any subject with active MTSS, stress fracture, or other lower leg pathology symptoms at the time the initial survey was administered were excluded.
- Any athlete who does not participate in the 60m-800m events (including hurdles), or who does not participate in jumping events (including pole vault) were excluded.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Efficacy of a Lower Leg Strengthening Program in the Prevention of MTSS in Collegiate XC Runners
This randomized controlled trial investigated whether a 10-week heavy resistance training program reduced the incidence of medial tibial stress syndrome (MTSS) in collegiate indoor track and field athletes. Twenty-six athletes from Rowan University were randomly assigned to a treatment group (resistance training plus regular training) or a control group (regular training only). Muscle mechanical properties-including tone, stiffness, elasticity, stress relaxation time, and creep-were measured by MyotonPro device (non-invasive) at baseline, post-intervention, and at the end of the season. A 10-week observational follow-up during the indoor season included weekly MTSS symptom surveys. Differences in MTSS incidence and muscle properties were analyzed between groups.
- Conditions
- Medial Tibial Stress Syndrome
- Being tested
- Resistance Training
- Medical subject headings
- Medial Tibial Stress Syndrome
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Resistance TrainingOther
Participants performed a 10-week resistance training program, completing exercises twice daily for Weeks 1-2 and three times daily for Weeks 3-10, with 5 sessions per week for Weeks 1-7 and 6 sessions per week for Weeks 8-10. The program included exercises such as standing broad jumps, resisted ankle abduction, single-leg eccentric plantar flexion, and ankle rockers. Participants' muscle properties were assessed at the start and end of the intervention, with adherence monitored via remote video confirmation.
| Study group | Role | What they receive |
|---|---|---|
| Resistance Training Intervention | Experimental | Participants who received the heavy resistance training intervention in addition to their regular training. Receives: Other: Resistance Training |
| Regular Training | No intervention | Participants who continued their regular training without the additional intervention. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Subjective Medial Tibial Stress Syndrome Symptoms
Medial Tibial Stress Syndrome (MTSS) Score Survey
Measured: Through the running season -- approximately 11 weeks
Secondary outcomes (5)
Myotonometry Oscillation frequency
Represents the intrinsic tension of the muscle in its passive state, essentially the muscle's "tone".
Measured: From enrollment through the end of data collection -- approximately 25 weeks
Myotonometry dynamic stiffness
Measures the resistance of the tissue to deformation when subjected to an external force.
Measured: From enrollment through the end of data collection -- approximately 25 weeks
Myotonometry logarithmic decrement
Indicates the elasticity of the muscle
Measured: From enrollment through the end of data collection -- approximately 25 weeks
Myotonometry mechanical stress relaxation time
Measures the time it takes for the muscle to return to its original shape after being deformed.
Measured: From enrollment through the end of data collection -- approximately 25 weeks
Myotonometry creep
Describes the gradual elongation of the muscle under constant tensile stress over time.
Measured: From enrollment through the end of data collection -- approximately 25 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Dec 2025
- Study start14 Sep 2023
- Primary completion14 Feb 2024
- Study completion14 Feb 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Medial Tibial Stress SyndromeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 26 participants (actual)
Sponsor and investigators
- Lead sponsor
- Rowan University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Jennifer A Longo, PhD, Principal investigator, Rowan University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07256808
- Sponsor's protocol ID
- Pro-2023-75
- Status last verified
- May 2025
- First submitted
- 11 May 2025
- Last updated
- 1 Dec 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 1 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Efficacy of a Lower Leg Strengthening Program in the Prevention of MTSS in Collegiate XC Runners
- ClinicalTrials.gov ID
- NCT07256808
- Acronym / sponsor ID
- Pro-2023-75
- Conditions
- Medial Tibial Stress Syndrome
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 26 participants (actual)
- Lead sponsor
- Rowan UniversityUniversity, hospital or other
- Study start
- 14 Sep 2023 (actual)
- Primary completion
- 14 Feb 2024 (actual)
- Study completion
- 14 Feb 2024 (actual)
- First posted
- 1 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized controlled trial investigated whether a 10-week heavy resistance training program reduced the incidence of medial tibial stress syndrome (MTSS) in collegiate indoor track and field athletes. Twenty-six athletes from Rowan University were randomly assigned to a treatment group (resistance training plus regular training) or a control group (regular training only). Muscle mechanical properties-including tone, stiffness, elasticity, stress relaxation time, and creep-were measured by MyotonPro device (non-invasive) at baseline, post-intervention, and at the end of the season. A 10-week observational follow-up during the indoor season included weekly MTSS symptom surveys. Differences in MTSS incidence and muscle properties were analyzed between groups.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Resistance Training Intervention | Experimental | Other: Resistance TrainingParticipants who received the heavy resistance training intervention in addition to their regular training. |
| Regular Training | No intervention | –Participants who continued their regular training without the additional intervention. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Collegiate athletes on the Indoor Track and Field team.
- Athletes must participate in at least one of the following:
- 60m-800m events (including hurdles)
- jumping events (including pole vault)
Key exclusion criteria (6 listed)
- Subjects who have a history of musculoskeletal or neurologic conditions
- Who take medications that affect muscle tone
- Who have a body mass index >30.0 kg/m2 were excluded to screen to prevent adipose tissue from skewing the measurements.
- Any subject with any fractures, sprains, or strains of the lower extremities were excluded.
- Any subject with active MTSS, stress fracture, or other lower leg pathology symptoms at the time the initial survey was administered were excluded.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Resistance TrainingParticipants performed a 10-week resistance training program, completing exercises twice daily for Weeks 1-2 and three times daily for Weeks 3-10, with 5 sessions per week for Weeks 1-7 and 6 sessions per week for Weeks 8-10. The program included exercises such as standing broad jumps, resisted ankle abduction, single-leg eccentric plantar flexion, and ankle rockers. Participants' muscle properties were assessed at the start and end of the intervention, with adherence monitored via remote video confirmation. | Other | Resistance Training Intervention |
Primary outcome
Subjective Medial Tibial Stress Syndrome Symptoms
Time frame: Through the running season -- approximately 11 weeks
Medial Tibial Stress Syndrome (MTSS) Score Survey
5 secondary outcomes
Myotonometry Oscillation frequency
Time frame: From enrollment through the end of data collection -- approximately 25 weeks
Myotonometry dynamic stiffness
Time frame: From enrollment through the end of data collection -- approximately 25 weeks
Myotonometry logarithmic decrement
Time frame: From enrollment through the end of data collection -- approximately 25 weeks
Myotonometry mechanical stress relaxation time
Time frame: From enrollment through the end of data collection -- approximately 25 weeks
Myotonometry creep
Time frame: From enrollment through the end of data collection -- approximately 25 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 Dec 2025.
- Individual participant dataSharing planned: No
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Jennifer A Longo, PhD principal investigator
Rowan University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Resistance Training in people with Medial Tibial Stress Syndrome, run by Rowan University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 1 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Subjective Medial Tibial Stress Syndrome Symptoms (time frame: Through the running season -- approximately 11 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Dec 2025.