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Respiratory FailureNCT07256860

Influence of Chest X-ray vs. Chest CT Scan on the Management of ICU Patients With Respiratory Failure

An observational study of Respiratory Failure, run by Meir Medical Center at 2 sites in Israel.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

Patients admitted to the intensive care unit (ICU) often require CT imaging. Performing this test on a critically ill patient involves risks, such as those associated with transferring a ventilated and unstable patient (respiratory or hemodynamic instability during transfer, unplanned extubation, unplanned removal of… Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Respiratory Failure
What is being tested?
Chest computed tomography scan
How many people
50 participants
Where
2 sitesIsrael
Study dates
21 Nov 2025to 1 Oct 2026
Phase
Observational
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • Adult, Older adult

Study population: All patients who underwent CT scans as part of their hospitalization in the intensive care unit for acute respiratory failure/hypoxemia, from January 2020 to January 2023.

Who may be able to join

None listed.

Who cannot join

  • -

Trial locations and contacts

2 sites in 1 country.

Israel2 sites
  • Meir medical center Kfar Saba

    Kfar Saba

  • Meir Medical Center

    Kfar Saba

Other trials in Israel

About this study

Official title: Influence of Chest X-ray vs. Chest CT Scan on the Management of ICU Patients With Respiratory Failure: A Retrospective Study.

Patients admitted to the intensive care unit (ICU) often require CT imaging. Performing this test on a critically ill patient involves risks, such as those associated with transferring a ventilated and unstable patient (respiratory or hemodynamic instability during transfer, unplanned extubation, unplanned removal of central catheters, drains, etc.), and those associated with intravenous contrast injection (renal impairment, anaphylactic reaction). Additionally, multiple CT scans may create a burden on the radiology department and medical staff, cause CT scans to be postponed for other patients, and increase hospitalization costs (1).

In a study conducted in 2014, approximately 533 CT scans were performed for 359 patients admitted to the ICU at 2 different medical centers. In this study, they examined the extent to which CT scanning affected patient care management by comparing the medical diagnosis given to the patient before and after the scan.

Read more

The diagnostic yield of the scan was 40% complete agreement between the diagnosis before and after the CT scan, about 6% partial agreement, and about 54% inconsistency. The CT scan resulted in new findings in the patient's diagnosis in 23% of cases, and in 54% of patients, the CT scan resulted in a change in the patient's treatment plan.

Among the patients who underwent a CT scan, about 23% experienced side effects or adverse events as a result of the scan, of which 6% were defined as life-threatening. The more critically ill the patient was, the greater the risk of these events (1).

In another study, which looked at a subgroup of septic patients in intensive care, there was no agreement between CT findings and the patients' treatment outcomes, and there was no significant effect of the CT scan on the patient's treatment plan (2).

In our previous work on all patients who underwent CT scans in the unit, we found that, in general, the rate of impact of CT scans on the patient's treatment plan was low compared to other studies, although in the group of patients hospitalized due to sepsis, the rate was similar - about a third of the patients. Among the patients hospitalized with multisystem trauma, about 31% of the patients had new traumatic findings on CT scans, but in only half of these patients did the test lead to a change in the treatment plan. It appears from this work that the group in which it was possible to retrospectively find the largest number of CT scans that could have been omitted was the group of patients with respiratory failure. The purpose of performing CT scans in these patients was mainly to look for pulmonary infiltrates, pleural effusions, or pulmonary embolism. With the exception of pulmonary embolism, a condition that is relatively rare compared to other diagnoses in patients with acute respiratory failure, the other diagnoses could also be confirmed by physical examination, ultrasound examination, or chest x-ray (these patients usually undergo a chest x-ray as part of the investigation of acute respiratory failure anyway), and this may be the reason why the CT scan did not add relevant information to change the treatment plan in these patients. However, we did not specifically examine in this study whether the chest x-ray showed all the findings seen on the chest CT scan, and whether the CT scan added new findings, and especially whether these new findings would have changed the treatment plan (such as pulmonary embolism). In this study, we would like to focus on this group of patients.

Being tested
Chest computed tomography scan
Keywords
chest x ray
Medical subject headings
Respiratory Insufficiency

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Chest computed tomography scanDiagnostic test

    Performing chest computed tomography scan in addition to chest x-ray in critically ill patients with acute respiratory failure

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. New findings in chest CT scan vs. chest x-ray

    To examine, among intensive care patients who underwent a chest CT scan for the purpose of investigating respiratory failure/hypoxemia, whether the CT scan revealed new findings that were not seen on a chest x-ray performed immediately prior to the scan, and whether these findings changed the patient's treatment.

    Measured: 1 year

  2. New findings in chest CT scan vs. chest x-ray and implications on therapy

    To examine, among intensive care patients who underwent a chest CT scan for the purpose of investigating respiratory failure/hypoxemia, whether the CT scan revealed new findings that were not seen on a chest x-ray performed immediately prior to the scan, and whether these findings changed the patient's treatment.

    Measured: 1 year

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted1 Dec 2025
  2. Study start21 Nov 2025
  3. Primary completion1 Oct 2026
  4. Study completion1 Oct 2026

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Other
Time perspective
Retrospective
Enrolment
50 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07256860
Sponsor's protocol ID
MMC-0240-25
Status last verified
Oct 2026
First submitted
20 Nov 2025
Last updated
9 Oct 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No

Publications

  • Levintas S, Meyer A, Dana E, Dichtwald S. The Influence of Chest CT Versus. Chest x-ray on the Management of Critically ill Patients: A Retrospective Study. J Intensive Care Med. 2026 Sep 28:8850666261493453. doi: 10.1177/08850666261493453. Online ahead of print.

    PubMed 42804188

Questions about this trial

What is this clinical trial studying?

An observational study of Respiratory Failure, run by Meir Medical Center at 2 sites in Israel.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 0 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 9 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 2 sites in Israel. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

New findings in chest CT scan vs. chest x-ray (time frame: 1 year). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07256860, which also lists 1 linked publication.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Oct 2026.

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