Respiratory FailureNCT07256860
Influence of Chest X-ray vs. Chest CT Scan on the Management of ICU Patients With Respiratory Failure
An observational study of Respiratory Failure, run by Meir Medical Center at 2 sites in Israel.
Trial summary
Patients admitted to the intensive care unit (ICU) often require CT imaging. Performing this test on a critically ill patient involves risks, such as those associated with transferring a ventilated and unstable patient (respiratory or hemodynamic instability during transfer, unplanned extubation, unplanned removal of… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Respiratory Failure
- What is being tested?
- Chest computed tomography scan
- How many people
- 50 participants
- Where
- 2 sitesIsrael
- Study dates
- 21 Nov 2025to 1 Oct 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Adult, Older adult
Study population: All patients who underwent CT scans as part of their hospitalization in the intensive care unit for acute respiratory failure/hypoxemia, from January 2020 to January 2023.
Who may be able to join
None listed.
Who cannot join
- -
Trial locations and contacts
2 sites in 1 country.
Israel2 sites
Meir medical center Kfar Saba
Kfar Saba
Meir Medical Center
Kfar Saba
About this study
Official title: Influence of Chest X-ray vs. Chest CT Scan on the Management of ICU Patients With Respiratory Failure: A Retrospective Study.
Patients admitted to the intensive care unit (ICU) often require CT imaging. Performing this test on a critically ill patient involves risks, such as those associated with transferring a ventilated and unstable patient (respiratory or hemodynamic instability during transfer, unplanned extubation, unplanned removal of central catheters, drains, etc.), and those associated with intravenous contrast injection (renal impairment, anaphylactic reaction). Additionally, multiple CT scans may create a burden on the radiology department and medical staff, cause CT scans to be postponed for other patients, and increase hospitalization costs (1).
In a study conducted in 2014, approximately 533 CT scans were performed for 359 patients admitted to the ICU at 2 different medical centers. In this study, they examined the extent to which CT scanning affected patient care management by comparing the medical diagnosis given to the patient before and after the scan.
Read more
The diagnostic yield of the scan was 40% complete agreement between the diagnosis before and after the CT scan, about 6% partial agreement, and about 54% inconsistency. The CT scan resulted in new findings in the patient's diagnosis in 23% of cases, and in 54% of patients, the CT scan resulted in a change in the patient's treatment plan.
Among the patients who underwent a CT scan, about 23% experienced side effects or adverse events as a result of the scan, of which 6% were defined as life-threatening. The more critically ill the patient was, the greater the risk of these events (1).
In another study, which looked at a subgroup of septic patients in intensive care, there was no agreement between CT findings and the patients' treatment outcomes, and there was no significant effect of the CT scan on the patient's treatment plan (2).
In our previous work on all patients who underwent CT scans in the unit, we found that, in general, the rate of impact of CT scans on the patient's treatment plan was low compared to other studies, although in the group of patients hospitalized due to sepsis, the rate was similar - about a third of the patients. Among the patients hospitalized with multisystem trauma, about 31% of the patients had new traumatic findings on CT scans, but in only half of these patients did the test lead to a change in the treatment plan. It appears from this work that the group in which it was possible to retrospectively find the largest number of CT scans that could have been omitted was the group of patients with respiratory failure. The purpose of performing CT scans in these patients was mainly to look for pulmonary infiltrates, pleural effusions, or pulmonary embolism. With the exception of pulmonary embolism, a condition that is relatively rare compared to other diagnoses in patients with acute respiratory failure, the other diagnoses could also be confirmed by physical examination, ultrasound examination, or chest x-ray (these patients usually undergo a chest x-ray as part of the investigation of acute respiratory failure anyway), and this may be the reason why the CT scan did not add relevant information to change the treatment plan in these patients. However, we did not specifically examine in this study whether the chest x-ray showed all the findings seen on the chest CT scan, and whether the CT scan added new findings, and especially whether these new findings would have changed the treatment plan (such as pulmonary embolism). In this study, we would like to focus on this group of patients.
- Conditions
- Respiratory Failure
- Being tested
- Chest computed tomography scan
- Keywords
- chest x ray
- Medical subject headings
- Respiratory Insufficiency
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Chest computed tomography scanDiagnostic test
Performing chest computed tomography scan in addition to chest x-ray in critically ill patients with acute respiratory failure
What is being measured
The primary outcome is the main question the study is designed to answer.
New findings in chest CT scan vs. chest x-ray
To examine, among intensive care patients who underwent a chest CT scan for the purpose of investigating respiratory failure/hypoxemia, whether the CT scan revealed new findings that were not seen on a chest x-ray performed immediately prior to the scan, and whether these findings changed the patient's treatment.
Measured: 1 year
New findings in chest CT scan vs. chest x-ray and implications on therapy
To examine, among intensive care patients who underwent a chest CT scan for the purpose of investigating respiratory failure/hypoxemia, whether the CT scan revealed new findings that were not seen on a chest x-ray performed immediately prior to the scan, and whether these findings changed the patient's treatment.
Measured: 1 year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Dec 2025
- Study start21 Nov 2025
- Primary completion1 Oct 2026
- Study completion1 Oct 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Respiratory FailureStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Retrospective
- Enrolment
- 50 participants (actual)
Sponsor and investigators
- Lead sponsor
- Meir Medical Center
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, sara dichtwald, Meir Medical Center
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07256860
- Sponsor's protocol ID
- MMC-0240-25
- Status last verified
- Oct 2026
- First submitted
- 20 Nov 2025
- Last updated
- 9 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Levintas S, Meyer A, Dana E, Dichtwald S. The Influence of Chest CT Versus. Chest x-ray on the Management of Critically ill Patients: A Retrospective Study. J Intensive Care Med. 2026 Sep 28:8850666261493453. doi: 10.1177/08850666261493453. Online ahead of print.
PubMed 42804188
Study at a glance
From the registry record, last updated by the sponsor on 9 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Influence of Chest X-ray vs. Chest CT Scan on the Management of ICU Patients With Respiratory Failure: A Retrospective Study.
- ClinicalTrials.gov ID
- NCT07256860
- Acronym / sponsor ID
- MMC-0240-25
- Conditions
- Respiratory Failure
- Keywords
- chest x ray
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 50 participants (actual)
- Lead sponsor
- Meir Medical CenterUniversity, hospital or other
- Study start
- 21 Nov 2025 (actual)
- Primary completion
- 1 Oct 2026 (actual)
- Study completion
- 1 Oct 2026 (actual)
- First posted
- 1 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Patients admitted to the intensive care unit (ICU) often require CT imaging. Performing this test on a critically ill patient involves risks, such as those associated with transferring a ventilated and unstable patient (respiratory or hemodynamic instability during transfer, unplanned extubation, unplanned removal of central catheters, drains, etc.), and those associated with intravenous contrast injection (renal impairment, anaphylactic reaction). Additionally, multiple CT scans may create a burden on the radiology department and medical staff, cause CT scans to be postponed for other patients, and increase hospitalization costs (1).
In a study conducted in 2014, approximately 533 CT scans were performed for 359 patients admitted to the ICU at 2 different medical centers. In this study, they examined the extent to which CT scanning affected patient care management by comparing the medical diagnosis given to the patient before and after the scan.
The diagnostic yield of the scan was 40% complete agreement between the diagnosis before and after the CT scan, about 6% partial agreement, and about 54% inconsistency. The CT scan resulted in new findings in the patient's diagnosis in 23% of cases, and in 54% of patients, the CT scan resulted in a change in the patient's treatment plan.
Among the patients who underwent a CT scan, about 23% experienced side effects or adverse events as a result of the scan, of which 6% were defined as life-threatening. The more critically ill the patient was, the greater the risk of these events (1).
In another study, which looked at a subgroup of septic patients in intensive care, there was no agreement between CT findings and the patients' treatment outcomes, and there was no significant effect of the CT scan on the patient's treatment plan (2).
In our previous work on all patients who underwent CT scans in the unit, we found that, in general, the rate of impact of CT scans on the patient's treatment plan was low compared to other studies, although in the group of patients hospitalized due to sepsis, the rate was similar - about a third of the patients. Among the patients hospitalized with multisystem trauma, about 31% of the patients had new traumatic findings on CT scans, but in only half of these patients did the test lead to a change in the treatment plan. It appears from this work that the group in which it was possible to retrospectively find the largest number of CT scans that could have been omitted was the group of patients with respiratory failure. The purpose of performing CT scans in these patients was mainly to look for pulmonary infiltrates, pleural effusions, or pulmonary embolism. With the exception of pulmonary embolism, a condition that is relatively rare compared to other diagnoses in patients with acute respiratory failure, the other diagnoses could also be confirmed by physical examination, ultrasound examination, or chest x-ray (these patients usually undergo a chest x-ray as part of the investigation of acute respiratory failure anyway), and this may be the reason why the CT scan did not add relevant information to change the treatment plan in these patients. However, we did not specifically examine in this study whether the chest x-ray showed all the findings seen on the chest CT scan, and whether the CT scan added new findings, and especially whether these new findings would have changed the treatment plan (such as pulmonary embolism). In this study, we would like to focus on this group of patients.
Study design
- Observational model
- Other
- Time perspective
- Retrospective
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Age groups
- Adult, Older adult
- Study population
- All patients who underwent CT scans as part of their hospitalization in the intensive care unit for acute respiratory failure/hypoxemia, from January 2020 to January 2023.
Key inclusion criteria (0 listed)
Key exclusion criteria (1 listed)
- -
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Chest computed tomography scanPerforming chest computed tomography scan in addition to chest x-ray in critically ill patients with acute respiratory failure | Diagnostic test | – |
Primary outcome
New findings in chest CT scan vs. chest x-ray
Time frame: 1 year
To examine, among intensive care patients who underwent a chest CT scan for the purpose of investigating respiratory failure/hypoxemia, whether the CT scan revealed new findings that were not seen on a chest x-ray performed immediately prior to the scan, and whether these findings changed the patient's treatment.
New findings in chest CT scan vs. chest x-ray and implications on therapy
Time frame: 1 year
To examine, among intensive care patients who underwent a chest CT scan for the purpose of investigating respiratory failure/hypoxemia, whether the CT scan revealed new findings that were not seen on a chest x-ray performed immediately prior to the scan, and whether these findings changed the patient's treatment.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Oct 2026.
- Derived from this study: PubMed 42804188Levintas S, Meyer A, Dana E, Dichtwald S. The Influence of Chest CT Versus. Chest x-ray on the Management of Critically ill Patients: A Retrospective Study. J Intensive Care Med. 2026 Sep 28:8850666261493453. doi: 10.1177/08850666261493453. Online ahead of print.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Respiratory Failure, run by Meir Medical Center at 2 sites in Israel.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 0 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 9 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Israel. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
New findings in chest CT scan vs. chest x-ray (time frame: 1 year). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07256860, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Oct 2026.