Diabetes Mellitus, Type 2NCT07258316
High Intensity Interval Training in Pre and Postmenopausal Women With Type II Diabetes.
A study testing High Intensity Interval Training (warm up, Mat exercises,cycling,HIIT exercises,cool down) in people with Diabetes Mellitus, Type 2 and Postmenopausal Symptoms, run by Riphah International University at 1 site in Pakistan.
Trial summary
Diabetes Mellitus (DM), a chronic metabolic disease-causing chronic hyperglycemia. Globally more than 90% cases are of type II diabetes mellitus (T2DM). Around 537 million adults worldwide had diabetes but according to data from Pakistan, female sufferers are marginally higher (26.4%) as compared to men (25.1%). Read more about this study
- Who is it for?
- Ages 40 to 60 years, women only
- Conditions the study is for
- Diabetes Mellitus, Type 2, Postmenopausal Symptoms
- What is being tested?
- High Intensity Interval Training (warm up, Mat exercises,cycling,HIIT exercises,cool down)
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 sitePakistan
- Study dates
- 25 Sep 2025to 25 Mar 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 60 years
- Women only
- No healthy volunteers
- Adult
Who may be able to join
- Female patients aged 40-65 years with physician-diagnosed T2DM.
- Premenopausal (regular menstruation) or postmenopausal (≥12 months amenorrhea) (self-reported).
- Participants who have not engaged in any structured exercise sessions or gym workouts in the past six months.
- Willing to follow supervised HIIT protocol and provide informed consent.
Who cannot join
- Cardiovascular, orthopedic, or endocrine conditions contraindicating exercise.
- Current use of insulin or hormone replacement therapy.
- Participation in structured exercise programs in the past 6 months.
- Cognitive impairment or psychiatric illness
Trial locations and contacts
1 site in 1 country.
Pakistan1 site
Ginnastic Health Centre, Islamabad
Islamabad, Islamabad Capital Territory, Pakistan, 44000
About this study
Official title: Comparative Effects of High-Intensity Interval Training in Pre and Postmenopausal Women With Type II Diabetes Mellitus
Diabetes Mellitus (DM), a chronic metabolic disease-causing chronic hyperglycemia. Globally more than 90% cases are of type II diabetes mellitus (T2DM). Around 537 million adults worldwide had diabetes but according to data from Pakistan, female sufferers are marginally higher (26.4%) as compared to men (25.1%). The main causes of DM II are genetic predispositions, including consanguinity, dietary changes, urbanization and sedentary lifestyles. It is reported that postmenopausal status is linked to worsened glycemic control, increased visceral adiposity and and inflammation, and women before menopause generally have improved lipid metabolism and insulin sensitivity. HIIT provides powerful and time-efficient benefits by alternating high-intensity workouts (85-95% HR_Max) with recovery.
Read the detailed description
Diabetes Mellitus (DM), is linked to impaired protein, lipid and carbohydrate metabolism, as well as impaired insulin secretion or its reduced sensitivity and this number will increase to almost 643 million by 2030 and 783 million by 2045. As estimated by the International Diabetes Federation (2021), the burden of DM type II is especially severe in Pakistan, where 33 million adults are affected by it, ranking Pakistan at number three globally. A study published in January 2025 in BMC Public Health found that the DALY burden of type 2 diabetes in Asian women was approximately 7,122 per 100,000, with behavioral risk factors (air pollution, fasting plasma glucose, and dietary risks) playing a significant role. The Study of Women's Health across the Nation (SWAN) cohort showed that Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) levels rose steadily during menopause this means that insulin resistance gets a lot worse for women during menopause. While another study reported that postmenopausal women have comparatively increased Low Density Lipo-protein (LDL) cholesterol, triglycerides, decreased high-density lipoprotein (HDL) cholesterol, increased C-Reactive Protein (CRP) and Interleukin-6 (IL-6), the markers of cardio-metabolic risk, as compared to premenopausal women. As estradiol deficiency is linked to decreased adiponectin and increased leptin, these hormonal changes also upset the balance of adipokines, exacerbating insulin resistance and inflammatory signaling pathways. After age 45, the odds ratio (OR) of getting T2DM was about 0.13, and the risks stopped rising after age 50-55. The key to managing type 2 diabetes is physical activity. Insulin sensitivity, systemic inflammation, fasting glucose, and HbA1c are all improved by conventional aerobic exercise. High-intensity interval training (HIIT) and other interventions meant to improve insulin sensitivity and inflammatory status. HIIT improves mitochondrial function, decreases inflammation, changes the distribution of body fat, and increases muscle glucose uptake to help manage type 2 diabetes in premenopausal and postmenopausal women. HIIT therefore enhances insulin sensitivity and glycemic control. According to meta-analyses, adults with type 2 diabetes who receive 8-12 weeks of HIIT experience significant decreases in their HbA1c (0.3-0.8%), fasting insulin (~20-30%), and CRP (~15-25%). In another study HIIT protocol were applied on the PCOS women with hormonal imbalances and metabolic issues Running at 100-110% of maximum aerobic velocity (MAV) was part of the training regimen, which was divided into 4-6 sets of 4 laps. For eight weeks, participants trained three times a week. The goal of this intense training program was to improve aerobic capacity and performance. Diabetes is prevalent worldwide; postmenopausal women are more vulnerable because of metabolic and hormonal changes. Previous studies have not much inquired the effect of glycemic control in varying menopausal status, although effectiveness of HIIT is proven for improving in insulin sensitivity and CRP in women and is considered a promising modality, but there is need to determine its effectiveness across women of varied menopausal status with T2DM. The aim of the study is to evaluate the effects of HIIT on glycemic control, Inflammatory markers, and Insulin sensitivity in pre versus postmenopausal women with T2DM and to support culturally appropriate menopause-sensitive exercise recommendations for women with T2DM.High-Intensity Interval Training (HIIT) provides a quick, non-pharmacological method to enhance insulin sensitivity, blood sugar regulation, body composition, and heart health, , this study intends to investigate how HIIT can specifically help manage blood sugar problems associated with hormonal changes associated with menopause.
- Conditions
- Diabetes Mellitus, Type 2, Postmenopausal Symptoms
- Being tested
- High Intensity Interval Training (warm up, Mat exercises,cycling,HIIT exercises,cool down), Control (warm up, Mat exercises,cycling,Resistance exercises,cool down)
- Medical subject headings
- Diabetes Mellitus, Type 2
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
High Intensity Interval Training (warm up, Mat exercises,cycling,HIIT exercises,cool down)Other
This will include 8 weeks of plan with total 27 sessions 3 times a week and each session will include warm up exercises ( Treadmill (Incline and Reverse), Mat Exercises (Cobra, Cat/camel stretches, Superman, Aeroplane and Skydiving exercises)and Cycling (Seated and un-supported). this will be of 10-15 minutes. Then HIIT exercises which includes High knees, Push ups, Russian crunches, Battle ropes, Weighted squats, Planks, Seated rows and Jumping jacks. Then cool- down exercises will be of 10-15 minutes and this will includes Full body Stretches (Quadriceps, Hamstrings, Piriformis, Calfs, Biceps, Triceps, Rhomboids, IT band, Trapezius, and Chest Stretches), whole exercise plan will take 60-90 minutes.
Control (warm up, Mat exercises,cycling,Resistance exercises,cool down)Other
This group will includes also recieve 8 weeks of exercises plan for 3/week warmup exercises same as the experimental group such as Treadmill (Incline and Reverse), Mat Exercises (Cobra, Cat/camel stretches, Superman, Aeroplane and Skydiving exercises)and Cycling (Seated and un-supported) forv about 10-15 miutes Resistance Exercises like (LAT Pull down, Leg Curls, Leg Extension, Hips Adductor/ Abductors, Seated Rowing, Rear deltoid machine). the progression will be increased gradually. Cool down exercises includes full body streching and the whole session will be of 60-90 minutes
| Study group | Role | What they receive |
|---|---|---|
| High Intensity Interval Training group | Experimental | The group will receive 8 weeks of High Intensity Interval Training (27 sessions, 3/week, 60-90 minutes). Progresssion for 1-4 weeks will of Workout Interval : Rest Interval will be 30 sec : 30 sec of each exercise and from week 5-8 the progression will be 30 sec : 15 sec. Both Warm-up and Cool down exercises will be of 10-15 minutes. Receives: Other: High Intensity Interval Training (warm up, Mat exercises,cycling,HIIT exercises,cool down) |
| Control group | Active comparator | This group will receive Resistance Exercises with alternate days 3 times per week for 8 weeks and total sessions will be 27. Both warmup and cool down will be of 10-15 minutes and progression will be increased gradually. This group will include different Resistance Exercises and the time duration will be 60-90 minutes Receives: Other: Control (warm up, Mat exercises,cycling,Resistance exercises,cool down) |
What is being measured
The primary outcome is the main question the study is designed to answer.
HbA1c
For monitoring long-term glycemic control, the average blood glucose over the past 2-3 months.
its values range from Normal: < 5.7%, Prediabetes: 5.7% - 6.4%, Diabetes: ≥ 6.5%
Measured: Baseline and 8 weeks
Fasting Blood Glucose
For Assessing short-term blood sugar control, used for onitoring glucose levels in metabolic disorders and Screening for insulin resistance or hypoglycemia..
Normal: 70 - 99 mg/dL (3.9 - 5.5 mmol/L), Prediabetes: 100 - 125 mg/dL (5.6 - 6.9 mmol/L), Diabetes: ≥ 126 mg/dL (≥ 7.0 mmol/L)
Measured: Baseline and 8 weeks
Fasting Insulin
Evaluating insulin resistance and sensitivity also use to monitoring and managing diabetes).
Normal: 2 - 20 µU/mL
Measured: Baseline and 8 week
Basic Lipid Profile testing including total cholesterol, Low-Density Lipoprotein-Cholesterol,High-Density Lipoprotein-Cholesterol and Triglycerides.
these are validated blood tests for diagnosing dyslipidemia. A lipid profile's normal ranges, in mg/dL, are: Total Cholesterol: < 200, LDL (Bad) Cholesterol: < 100 (or < 70 for those with diabetes), HDL (Good) Cholesterol: > 60, and Triglycerides: < 150
Measured: Baseline and 8 week
CRP
for Detecting and monitoring inflammation in the body) Normal: < 10 mg/L Elevated: > 10 mg/L
Measured: Baseline and 8 week
QUICKI (Quantitative Insulin Sensitivity Check Index)
Normal value ≥ 0.33.
- Estimating insulin sensitivity (higher = better sensitivity)
- An alternative to HOMA-IR, especially in research settings.
Measured: Baseline and 8 week
HOMA-IR (Homeostatic Model Assessment of Insulin Resistance)
Normal value < 2
- Estimating insulin resistance (higher = more resistance)
- Early detection of metabolic syndrome, prediabetes, or type 2 diabetes.
Measured: Baseline and 8 week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Dec 2025
- Study start25 Sep 2025
- Primary completion25 Mar 2026
- Study completion25 Mar 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Diabetes Mellitus, Type 2Studies of the same condition, open and under way.
- More trials run by Riphah International UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- There will be comparison between the two groups, experimental and control
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Huma Riaz, PhD, Principal investigator, Riphah Itnernational University, Islamabad Pakistan
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07258316
- Sponsor's protocol ID
- Mushafaeen Rizwan
- Status last verified
- Apr 2026
- First submitted
- 24 Aug 2025
- Last updated
- 3 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Motahari-Tabari N, Ahmad Shirvani M, Shirzad-E-Ahoodashty M, Yousefi-Abdolmaleki E, Teimourzadeh M. The effect of 8 weeks aerobic exercise on insulin resistance in type 2 diabetes: a randomized clinical trial. Glob J Health Sci. 2014 Aug 14;7(1):115-21. doi: 10.5539/gjhs.v7n1p115.
PubMed 25560330Mandrup CM, Egelund J, Nyberg M, Enevoldsen LH, Kjaer A, Clemmensen AE, Christensen AN, Suetta C, Frikke-Schmidt R, Steenberg DE, Wojtaszewski JFP, Hellsten Y, Stallknecht BM. Effects of menopause and high-intensity training on insulin sensitivity and muscle metabolism. Menopause. 2018 Feb;25(2):165-175. doi: 10.1097/GME.0000000000000981.
PubMed 28953212Cybulska AM, Schneider-Matyka D, Wieder-Huszla S, Panczyk M, Jurczak A, Grochans E. Diagnostic markers of insulin resistance to discriminate between prediabetes and diabetes in menopausal women. Eur Rev Med Pharmacol Sci. 2023 Mar;27(6):2453-2468. doi: 10.26355/eurrev_202303_31779.
PubMed 37013763
Study at a glance
From the registry record, last updated by the sponsor on 3 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Effects of High-Intensity Interval Training in Pre and Postmenopausal Women With Type II Diabetes Mellitus
- ClinicalTrials.gov ID
- NCT07258316
- Acronym / sponsor ID
- Mushafaeen Rizwan
- Conditions
- Diabetes Mellitus, Type 2, Postmenopausal Symptoms
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 60 participants (actual)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 25 Sep 2025 (actual)
- Primary completion
- 25 Mar 2026 (actual)
- Study completion
- 25 Mar 2026 (actual)
- First posted
- 2 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Diabetes Mellitus (DM), a chronic metabolic disease-causing chronic hyperglycemia. Globally more than 90% cases are of type II diabetes mellitus (T2DM). Around 537 million adults worldwide had diabetes but according to data from Pakistan, female sufferers are marginally higher (26.4%) as compared to men (25.1%). The main causes of DM II are genetic predispositions, including consanguinity, dietary changes, urbanization and sedentary lifestyles. It is reported that postmenopausal status is linked to worsened glycemic control, increased visceral adiposity and and inflammation, and women before menopause generally have improved lipid metabolism and insulin sensitivity. HIIT provides powerful and time-efficient benefits by alternating high-intensity workouts (85-95% HR_Max) with recovery.
Detailed description
Diabetes Mellitus (DM), is linked to impaired protein, lipid and carbohydrate metabolism, as well as impaired insulin secretion or its reduced sensitivity and this number will increase to almost 643 million by 2030 and 783 million by 2045. As estimated by the International Diabetes Federation (2021), the burden of DM type II is especially severe in Pakistan, where 33 million adults are affected by it, ranking Pakistan at number three globally. A study published in January 2025 in BMC Public Health found that the DALY burden of type 2 diabetes in Asian women was approximately 7,122 per 100,000, with behavioral risk factors (air pollution, fasting plasma glucose, and dietary risks) playing a significant role. The Study of Women's Health across the Nation (SWAN) cohort showed that Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) levels rose steadily during menopause this means that insulin resistance gets a lot worse for women during menopause. While another study reported that postmenopausal women have comparatively increased Low Density Lipo-protein (LDL) cholesterol, triglycerides, decreased high-density lipoprotein (HDL) cholesterol, increased C-Reactive Protein (CRP) and Interleukin-6 (IL-6), the markers of cardio-metabolic risk, as compared to premenopausal women. As estradiol deficiency is linked to decreased adiponectin and increased leptin, these hormonal changes also upset the balance of adipokines, exacerbating insulin resistance and inflammatory signaling pathways. After age 45, the odds ratio (OR) of getting T2DM was about 0.13, and the risks stopped rising after age 50-55. The key to managing type 2 diabetes is physical activity. Insulin sensitivity, systemic inflammation, fasting glucose, and HbA1c are all improved by conventional aerobic exercise. High-intensity interval training (HIIT) and other interventions meant to improve insulin sensitivity and inflammatory status. HIIT improves mitochondrial function, decreases inflammation, changes the distribution of body fat, and increases muscle glucose uptake to help manage type 2 diabetes in premenopausal and postmenopausal women. HIIT therefore enhances insulin sensitivity and glycemic control. According to meta-analyses, adults with type 2 diabetes who receive 8-12 weeks of HIIT experience significant decreases in their HbA1c (0.3-0.8%), fasting insulin (~20-30%), and CRP (~15-25%). In another study HIIT protocol were applied on the PCOS women with hormonal imbalances and metabolic issues Running at 100-110% of maximum aerobic velocity (MAV) was part of the training regimen, which was divided into 4-6 sets of 4 laps. For eight weeks, participants trained three times a week. The goal of this intense training program was to improve aerobic capacity and performance. Diabetes is prevalent worldwide; postmenopausal women are more vulnerable because of metabolic and hormonal changes. Previous studies have not much inquired the effect of glycemic control in varying menopausal status, although effectiveness of HIIT is proven for improving in insulin sensitivity and CRP in women and is considered a promising modality, but there is need to determine its effectiveness across women of varied menopausal status with T2DM. The aim of the study is to evaluate the effects of HIIT on glycemic control, Inflammatory markers, and Insulin sensitivity in pre versus postmenopausal women with T2DM and to support culturally appropriate menopause-sensitive exercise recommendations for women with T2DM.High-Intensity Interval Training (HIIT) provides a quick, non-pharmacological method to enhance insulin sensitivity, blood sugar regulation, body composition, and heart health, , this study intends to investigate how HIIT can specifically help manage blood sugar problems associated with hormonal changes associated with menopause.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- There will be comparison between the two groups, experimental and control
| Arm | Type | Receives |
|---|---|---|
| High Intensity Interval Training group | Experimental | Other: High Intensity Interval Training (warm up, Mat exercises,cycling,HIIT exercises,cool down)The group will receive 8 weeks of High Intensity Interval Training (27 sessions, 3/week, 60-90 minutes). Progresssion for 1-4 weeks will of Workout Interval : Rest Interval will be 30 sec : 30 sec of each exercise and from week 5-8 the progression will be 30 sec : 15 sec. Both Warm-up and Cool down exercises will be of 10-15 minutes. |
| Control group | Active comparator | Other: Control (warm up, Mat exercises,cycling,Resistance exercises,cool down)This group will receive Resistance Exercises with alternate days 3 times per week for 8 weeks and total sessions will be 27. Both warmup and cool down will be of 10-15 minutes and progression will be increased gradually. This group will include different Resistance Exercises and the time duration will be 60-90 minutes |
Who may qualify
- Ages
- 40 to 60 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Female patients aged 40-65 years with physician-diagnosed T2DM.
- Premenopausal (regular menstruation) or postmenopausal (≥12 months amenorrhea) (self-reported).
- Participants who have not engaged in any structured exercise sessions or gym workouts in the past six months.
- Willing to follow supervised HIIT protocol and provide informed consent.
Key exclusion criteria (4 listed)
- Cardiovascular, orthopedic, or endocrine conditions contraindicating exercise.
- Current use of insulin or hormone replacement therapy.
- Participation in structured exercise programs in the past 6 months.
- Cognitive impairment or psychiatric illness
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| High Intensity Interval Training (warm up, Mat exercises,cycling,HIIT exercises,cool down)This will include 8 weeks of plan with total 27 sessions 3 times a week and each session will include warm up exercises ( Treadmill (Incline and Reverse), Mat Exercises (Cobra, Cat/camel stretches, Superman, Aeroplane and Skydiving exercises)and Cycling (Seated and un-supported). this will be of 10-15 minutes. Then HIIT exercises which includes High knees, Push ups, Russian crunches, Battle ropes, Weighted squats, Planks, Seated rows and Jumping jacks. Then cool- down exercises will be of 10-15 minutes and this will includes Full body Stretches (Quadriceps, Hamstrings, Piriformis, Calfs, Biceps, Triceps, Rhomboids, IT band, Trapezius, and Chest Stretches), whole exercise plan will take 60-90 minutes. | Other | High Intensity Interval Training group |
| Control (warm up, Mat exercises,cycling,Resistance exercises,cool down)This group will includes also recieve 8 weeks of exercises plan for 3/week warmup exercises same as the experimental group such as Treadmill (Incline and Reverse), Mat Exercises (Cobra, Cat/camel stretches, Superman, Aeroplane and Skydiving exercises)and Cycling (Seated and un-supported) forv about 10-15 miutes Resistance Exercises like (LAT Pull down, Leg Curls, Leg Extension, Hips Adductor/ Abductors, Seated Rowing, Rear deltoid machine). the progression will be increased gradually. Cool down exercises includes full body streching and the whole session will be of 60-90 minutes | Other | Control group |
Primary outcome
HbA1c
Time frame: Baseline and 8 weeks
For monitoring long-term glycemic control, the average blood glucose over the past 2-3 months. its values range from Normal: < 5.7%, Prediabetes: 5.7% - 6.4%, Diabetes: ≥ 6.5%
Fasting Blood Glucose
Time frame: Baseline and 8 weeks
For Assessing short-term blood sugar control, used for onitoring glucose levels in metabolic disorders and Screening for insulin resistance or hypoglycemia.. Normal: 70 - 99 mg/dL (3.9 - 5.5 mmol/L), Prediabetes: 100 - 125 mg/dL (5.6 - 6.9 mmol/L), Diabetes: ≥ 126 mg/dL (≥ 7.0 mmol/L)
Fasting Insulin
Time frame: Baseline and 8 week
Evaluating insulin resistance and sensitivity also use to monitoring and managing diabetes). Normal: 2 - 20 µU/mL
Basic Lipid Profile testing including total cholesterol, Low-Density Lipoprotein-Cholesterol,High-Density Lipoprotein-Cholesterol and Triglycerides.
Time frame: Baseline and 8 week
these are validated blood tests for diagnosing dyslipidemia. A lipid profile's normal ranges, in mg/dL, are: Total Cholesterol: < 200, LDL (Bad) Cholesterol: < 100 (or < 70 for those with diabetes), HDL (Good) Cholesterol: > 60, and Triglycerides: < 150
CRP
Time frame: Baseline and 8 week
for Detecting and monitoring inflammation in the body) Normal: < 10 mg/L Elevated: > 10 mg/L
QUICKI (Quantitative Insulin Sensitivity Check Index)
Time frame: Baseline and 8 week
Normal value ≥ 0.33. * Estimating insulin sensitivity (higher = better sensitivity) * An alternative to HOMA-IR, especially in research settings.
HOMA-IR (Homeostatic Model Assessment of Insulin Resistance)
Time frame: Baseline and 8 week
Normal value < 2 * Estimating insulin resistance (higher = more resistance) * Early detection of metabolic syndrome, prediabetes, or type 2 diabetes.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Apr 2026.
- Background: PubMed 25560330Motahari-Tabari N, Ahmad Shirvani M, Shirzad-E-Ahoodashty M, Yousefi-Abdolmaleki E, Teimourzadeh M. The effect of 8 weeks aerobic exercise on insulin resistance in type 2 diabetes: a randomized clinical trial. Glob J Health Sci. 2014 Aug 14;7(1):115-21. doi: 10.5539/gjhs.v7n1p115.
- Background: PubMed 28953212Mandrup CM, Egelund J, Nyberg M, Enevoldsen LH, Kjaer A, Clemmensen AE, Christensen AN, Suetta C, Frikke-Schmidt R, Steenberg DE, Wojtaszewski JFP, Hellsten Y, Stallknecht BM. Effects of menopause and high-intensity training on insulin sensitivity and muscle metabolism. Menopause. 2018 Feb;25(2):165-175. doi: 10.1097/GME.0000000000000981.
- Background: PubMed 37013763Cybulska AM, Schneider-Matyka D, Wieder-Huszla S, Panczyk M, Jurczak A, Grochans E. Diagnostic markers of insulin resistance to discriminate between prediabetes and diabetes in menopausal women. Eur Rev Med Pharmacol Sci. 2023 Mar;27(6):2453-2468. doi: 10.26355/eurrev_202303_31779.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Huma Riaz, PhD principal investigator
Riphah Itnernational University, Islamabad Pakistan
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing High Intensity Interval Training (warm up, Mat exercises,cycling,HIIT exercises,cool down) in people with Diabetes Mellitus, Type 2 and Postmenopausal Symptoms, run by Riphah International University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
HbA1c (time frame: Baseline and 8 weeks). The study lists 7 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07258316, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Apr 2026.