Health AdultsNCT07260318
Acute Effects of Cricket Fast Bowling on Bone Turnover and Signaling Markers
A study testing Exercise in people with Health Adults, run by Loughborough University at 1 site in United Kingdom.
Trial summary
The goal of this study is to investigate the acute effects of cricket fast bowling on the bone turnover and signaling markers in healthy young males. The main question aims to answer: Does a single bout acute fast bowling change serum C-terminal telopeptide of type I collagen (CTX-I) and other bone turnover and… Read more about this study
- Who is it for?
- Ages 18 to 30 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Health Adults
- What is being tested?
- Exercise
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 14 participants
- Where
- 1 siteUnited Kingdom
- Study dates
- 20 Feb 2023to 31 Dec 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Healthy male
- Aged 18 - 30
- Cricket fast bowlers (a ball speed of ~100kmh) playing for a university team or above, such as British Universities and Colleges Sport (BUCS) or University Centre of Cricketing Excellence (UCCE)
- Injury free for the last 3 months
Who cannot join
- Diagnosed with any disease or use of any medication that affects bone turnover
- Fracture experienced within the previous year/season
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United Kingdom1 site
Loughborough Univeristy
Loughborough, Leicestershire, LE11 3TU
About this study
The goal of this study is to investigate the acute effects of cricket fast bowling on the bone turnover and signaling markers in healthy young males.
The main question aims to answer:
- Does a single bout acute fast bowling change serum C-terminal telopeptide of type I collagen (CTX-I) and other bone turnover and signaling markers levels?
Participants complete both the bowling and control trials, with a minimum washout period of one week between trials. During each trial, blood samples are collected at three time points: pre-, immediately post, and 2-hour post bowling/rest.
- Conditions
- Health Adults
- Being tested
- Exercise
- Keywords
- Cricket, Fast bowling, Bone turnover, Stress injuries
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ExerciseBehavioural
During the bowling trial, participants perform 8 sets of 6 deliveries (bowl at match intensity throughout), followed by 2-hour rest. Each set is interspersed by a 3-minute randomized fielding simulation. During the control trial, participants rest throughout instead of bowling.
| Study group | Role | What they receive |
|---|---|---|
| Arm Bowling + Control | Experimental | Participants first perform the bowling trial, followed by the control trial, with a minimum interval of one week between the two trials. Receives: Behavioral: Exercise |
| Arm Control + Bowling | Experimental | Participants first perform the control trial, followed by the bowling trial, with a minimum interval of one week between the two trials. Receives: Behavioral: Exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
Serum C-terminal telopeptide of type I collagen (CTX-I) concentration
Serum CTX-I concentration is measured using electrochemiluminescence immunoassay (ECLIA) and reported in nanograms per milliliter (ng/mL).
Measured: Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.
Secondary outcomes (7)
Serum N-terminal propeptide of type I collagen (PINP) concentration
Serum PINP concentration is measured using electrochemiluminescence immunoassay (ECLIA) and reported in nanograms per milliliter (ng/mL).
Measured: Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.
Serum parathyroid hormone (PTH) concentration
Serum PTH concentration is measured using electrochemiluminescence immunoassay (ECLIA) and reported in picograms per milliliter (pg/mL).
Measured: Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.
Serum sclerostin concentration
Serum sclerostin concentration is measured using an enzyme-linked immunosorbent assay (ELISA) and reported in picograms per milliliter (pg/mL).
Measured: Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.
Serum dickkopf Wnt signaling pathway inhibitor 1 (DKK1) concentration
Serum DKK1 concentration is measured using an enzyme-linked immunosorbent assay (ELISA) and reported in picograms per milliliter (pg/mL).
Measured: Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.
Serum osteoprotegerin (OPG) concentration
Serum OPG concentration is measured using an enzyme-linked immunosorbent assay (ELISA) and reported in picograms per milliliter (pg/mL).
Measured: Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.
Serum irisin concentration
Serum irisin concentration is measured using an enzyme-linked immunosorbent assay (ELISA) and reported in picograms per milliliter (pg/mL).
Measured: Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.
Bowling speed
Bowling speed is measured using a radar gun during the 8 overs of bowling and reported in miles per hour (MPH).
Measured: Bowling speed is measured during the bowling trial.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Dec 2025
- Study start20 Feb 2023
- Primary completion31 Dec 2025 (estimated)
- Study completion31 Dec 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Health AdultsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 14 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Loughborough University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Katherine Brooke-Wavell, Loughborough University
- Investigators
- Katherine Brooke-Wavell, Principal investigator, Loughborough University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07260318
- Sponsor's protocol ID
- 11201
- Status last verified
- Nov 2025
- First submitted
- 14 Nov 2025
- Last updated
- 3 Dec 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 3 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Acute Effects of Cricket Fast Bowling on Bone Turnover and Signaling Markers
- ClinicalTrials.gov ID
- NCT07260318
- Acronym / sponsor ID
- 11201
- Conditions
- Health Adults
- Keywords
- Cricket, Fast bowling, Bone turnover, Stress injuries
- Study type
- Interventional
- Recruitment status
- Enrolling by invitation
- Enrolment
- 14 participants (estimated)
- Lead sponsor
- Loughborough UniversityUniversity, hospital or other
- Study start
- 20 Feb 2023 (actual)
- Primary completion
- 31 Dec 2025 (estimated)
- Study completion
- 31 Dec 2025 (estimated)
- First posted
- 3 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this study is to investigate the acute effects of cricket fast bowling on the bone turnover and signaling markers in healthy young males.
The main question aims to answer:
- Does a single bout acute fast bowling change serum C-terminal telopeptide of type I collagen (CTX-I) and other bone turnover and signaling markers levels?
Participants complete both the bowling and control trials, with a minimum washout period of one week between trials. During each trial, blood samples are collected at three time points: pre-, immediately post, and 2-hour post bowling/rest.
Study design
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Arm Bowling + Control | Experimental | Behavioral: ExerciseParticipants first perform the bowling trial, followed by the control trial, with a minimum interval of one week between the two trials. |
| Arm Control + Bowling | Experimental | Behavioral: ExerciseParticipants first perform the control trial, followed by the bowling trial, with a minimum interval of one week between the two trials. |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Healthy male
- Aged 18 - 30
- Cricket fast bowlers (a ball speed of ~100kmh) playing for a university team or above, such as British Universities and Colleges Sport (BUCS) or University Centre of Cricketing Excellence (UCCE)
- Injury free for the last 3 months
Key exclusion criteria (2 listed)
- Diagnosed with any disease or use of any medication that affects bone turnover
- Fracture experienced within the previous year/season
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| ExerciseDuring the bowling trial, participants perform 8 sets of 6 deliveries (bowl at match intensity throughout), followed by 2-hour rest. Each set is interspersed by a 3-minute randomized fielding simulation. During the control trial, participants rest throughout instead of bowling. | Behavioural | Arm Bowling + Control, Arm Control + Bowling |
Primary outcome
Serum C-terminal telopeptide of type I collagen (CTX-I) concentration
Time frame: Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.
Serum CTX-I concentration is measured using electrochemiluminescence immunoassay (ECLIA) and reported in nanograms per milliliter (ng/mL).
7 secondary outcomes
Serum N-terminal propeptide of type I collagen (PINP) concentration
Time frame: Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.
Serum parathyroid hormone (PTH) concentration
Time frame: Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.
Serum sclerostin concentration
Time frame: Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.
Serum dickkopf Wnt signaling pathway inhibitor 1 (DKK1) concentration
Time frame: Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.
Serum osteoprotegerin (OPG) concentration
Time frame: Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.
Serum irisin concentration
Time frame: Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.
Bowling speed
Time frame: Bowling speed is measured during the bowling trial.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Dec 2025.
- Individual participant dataSharing planned: No
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Healthy Adult Participants
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Katherine Brooke-Wavell principal investigator
Loughborough University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Exercise in people with Health Adults, run by Loughborough University at 1 site in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 3 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Serum C-terminal telopeptide of type I collagen (CTX-I) concentration (time frame: Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Dec 2025; AzTrials last refreshed its copy on 7 Nov 2026.