Knee OsteoarthristisNCT07262931
Effect Of Sensory Motor Training Versus Resistance Training Among Individuals With Knee Osteoarthritis.
A study testing Sensory motor training and Resistance Training in people with Knee Osteoarthristis, run by Lahore University of Biological and Applied Sciences at 1 site in Pakistan.
Trial summary
This study aims to address this gap by comparing the effects of sensory-motor training versus resistance training on pain, balance and functional activities, specifically in patients with early-stage knee osteoarthritis. Read more about this study
- Who is it for?
- Ages 40 to 60 years
- Conditions the study is for
- Knee Osteoarthristis
- What is being tested?
- Sensory motor training and Resistance Training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 52 participants
- Where
- 1 sitePakistan
- Study dates
- 1 Dec 2025to 1 Jun 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Both males and females are included.
- Age group include 40-60 years.
- Not done any exercise for at least 3 months
- Tibiofemoral osteoarthritis
- Grade I and II osteoarthritis
Who cannot join
- • Cardiorespiratory diseases.
- Uncontrolled diabetes and Hypertension.
- Using ambulatory devices.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Effect Of Sensory Motor Training Versus Resistance Training On Improving Pain, Balance And Functional Activities Among Individuals With Knee Osteoarthritis
This study aims to address this gap by comparing the effects of sensory-motor training versus resistance training on pain, balance and functional activities, specifically in patients with early-stage knee osteoarthritis. In Pakistan, Knee Osteoarthritis is a common condition that significantly impacts many individuals' quality of life. While research exists on various exercise interventions for knee osteoarthritis, there is limited focus on patients with Grade 1 and 2 osteoarthritis. Understanding the most effective training method for this group will provide valuable insights for developing targeted rehabilitation programs, ultimately improving patient outcomes and quality of life.
Read the detailed description
Osteoarthritis of the knee is a degenerative condition that gradually affects the synovial joints. Following the stress, joint become damaged and unable to repair and is triggered by asymmetry in synovial tissues of joint such as articular cartilage, ligaments, subchondral bone, periarticular musculature, menisci, synovia or peripheral nerves. This structural harm leads to the breakdown of subchondral bone and cartilage, resulting in symptoms like stiffness, pain, and limited range of motion. It is just like a plane surface of road becoming uneven and pitted. Osteoarthritis of knee joint debilitates the individuals and they totally rely on others.
Interventions for treating knee osteoarthritis include pharmacological and therapeutic technique. Present clinical recommendations in grade 1 and 2 favor conservative management, like physical therapy, use of assistive devices and weight management due to their simplicity, minimal side effects, and more economical. Due to extensive evidence showing the positive impact of physical activity on individuals with osteoarthritis, exercise is frequently recommended as a key element in the rehabilitation journey.
In various physical workout plans, muscle strengthening holds significance due to the connection between pain, muscle weakness, and limited function. Yet, standard strengthening routines might not suffice for individuals having functional joint instability. A research study on this specific group of patients explored treatments targeting symptoms directly, aiming to enhance the efficiency of the rehabilitation regimen. Recently awareness has been given by focusing on sensory inputs such as balance and proprioception exercises. It may allow individual to adapt motor skills for dealing with disability on knee. Sensorimotor training is an effective treatment to restore motor programs in patients among different musculoskeletal disorders and chronic musculoskeletal pain. It adopts a phase-oriented treatment approach and consists of regulation of arousal, emotion and behavior.
The goal of sensorimotor therapy training in knee osteoarthritis is to gain functional activities, relieve pain. As osteoarthritis advances, sensory-motor abilities like neuromuscular control, static and dynamic balance, and proprioception decrease due to reduced daily physical activities and heightened pain perception. Therefore, incorporating agility, coordination, and balance exercises such as cross steps while walking backward, walking on unsymmetrical surfaces and verbal commands by therapist can be beneficial by challenging individuals with disruptive loads. This exposure helps the neuromuscular system adapt to situations that may trigger knee instability during daily activities. Resistance training refers to a workout method where muscles are engaged against a resistance or weight. This training approach aids in strength enhancement, muscle building, and endurance improvement. It encompasses utilizing weights, resistance bands, or engaging in bodyweight exercises. The benefits of resistance training include overall fitness enhancement, bone density improvement, metabolism boost, and better physical performance. Proper execution of resistance training is crucial to prevent injuries and optimize workout effectiveness
- Conditions
- Knee Osteoarthristis
- Being tested
- Sensory motor training, Resistance Training
- Keywords
- sensory motor training, resistance training, knee osteoarthritis, pain, balance, functional activities
- Medical subject headings
- Osteoarthritis, Knee, Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Sensory motor trainingOther
7.8. Interventions i FITT Principle: F: 2 times a week I: maximum to minimum T: Group 1 SMT, Group 2 RT T: 40-50 min Individuals were assigned 1:1 to either sensory motor training or resistance training.
ii Groups with sufficient details
1 Experimental: Group1: Participants in the sensory-motor training group received 8-week program of exercise 2 times a week. It starts with a warm-up on stationary bicycle for 10 minutes, stretching exercises. In this group the main focus was on agility exercises that includes a balance board, walking on different directions, crossing steps while walking backward and forward and walking on different surfaces. The duration for these exercises was 40-50 minutes per session.
Resistance TrainingOther
The individuals allocated to the resistance training received a same 8-weeks exercise program twice a week. Exercise began with the same warm-up on stationary bicycle for 10 minutes then traction was applied, Isometric hip flexion and leg extension, stretching exercises for lower limb, Quadriceps and hamstring strengthening using ankle weights were used with frequency twice a week. 3 sets of 10 repetitions at 30 to 40% of 1RM and low to moderate intensity loads were applied for 15 minutes bilaterally.
| Study group | Role | What they receive |
|---|---|---|
| Sensory Motor Group | Experimental | Participants in the sensory-motor training group received 8-week program of exercise 2 times a week. It starts with a warm-up on stationary bicycle for 10 minutes, stretching exercises. Receives: Other: Sensory motor training |
| Resistance training group | Active comparator | The individuals allocated to the resistance training received a same 8-weeks exercise program twice a week. Exercise began with the same warm-up on stationary bicycle for 10 minutes then traction was applied, Isometric hip flexion and leg extension, stretching exercises for lower limb, Quadriceps and hamstring strengthening using ankle weights were used with frequency twice a week. 3 sets of 10 repetitions at 30 to 40% of 1RM and low to moderate intensity loads were applied for 15 minutes bilaterally. Receives: Other: Resistance Training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Visual Analogue Scale (VAS - Pain Outcome)
The Visual Analogue Scale is a simple, reliable tool used to quantify pain intensity on a 10 cm line ranging from "no pain" to "worst possible pain." Participants marked their pain level experienced in both knees over the past 24 hours.
It allows sensitive detection of even small changes in perceived pain.
Measured: 8 weeks
WOMAC Scale (Functional Activities Outcome)
The WOMAC Index is a validated questionnaire designed to evaluate pain, stiffness, and physical function specifically in individuals with knee or hip osteoarthritis.
It assesses daily functional limitations such as walking, stair climbing, and standing.
Higher scores indicate greater impairment, making it useful for monitoring treatment-related improvements.
Measured: 8 weeks
Secondary outcomes (1)
Timed Up and Go (TUG) Test - Balance Outcome
The Timed Up and Go test measures functional mobility, dynamic balance, and fall risk by timing how long a person takes to stand up from a chair, walk 3 meters, turn, return, and sit down.
It is quick, practical, and widely used in clinical settings. Longer completion times indicate poorer balance and mobility.
Measured: 8 Weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Dec 2025
- Study start1 Dec 2025 (estimated)
- Primary completion1 Jun 2026 (estimated)
- Study completion1 Jun 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Knee OsteoarthristisStudies of the same condition, open and under way.
- More trials run by Lahore University of Biological and Applied SciencesThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 52 participants (estimated)
Sponsor and investigators
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07262931
- Sponsor's protocol ID
- 21657
- Status last verified
- Nov 2025
- First submitted
- 19 Nov 2025
- Last updated
- 4 Dec 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Andriacchi TP, Favre J, Erhart-Hledik JC, Chu CR. A systems view of risk factors for knee osteoarthritis reveals insights into the pathogenesis of the disease. Ann Biomed Eng. 2015 Feb;43(2):376-87. doi: 10.1007/s10439-014-1117-2. Epub 2014 Sep 16.
PubMed 25224078Gomiero AB, Kayo A, Abraao M, Peccin MS, Grande AJ, Trevisani VF. Sensory-motor training versus resistance training among patients with knee osteoarthritis: randomized single-blind controlled trial. Sao Paulo Med J. 2018 Jan-Feb;136(1):44-50. doi: 10.1590/1516-3180.2017.0174100917. Epub 2017 Dec 7.
PubMed 29236934
Study at a glance
From the registry record, last updated by the sponsor on 4 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect Of Sensory Motor Training Versus Resistance Training On Improving Pain, Balance And Functional Activities Among Individuals With Knee Osteoarthritis
- ClinicalTrials.gov ID
- NCT07262931
- Acronym / sponsor ID
- 21657
- Conditions
- Knee Osteoarthristis
- Keywords
- sensory motor training, resistance training, knee osteoarthritis, pain, balance, functional activities
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 52 participants (estimated)
- Lead sponsor
- Lahore University of Biological and Applied SciencesUniversity, hospital or other
- Study start
- 1 Dec 2025 (estimated)
- Primary completion
- 1 Jun 2026 (estimated)
- Study completion
- 1 Jun 2026 (estimated)
- First posted
- 4 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to address this gap by comparing the effects of sensory-motor training versus resistance training on pain, balance and functional activities, specifically in patients with early-stage knee osteoarthritis. In Pakistan, Knee Osteoarthritis is a common condition that significantly impacts many individuals' quality of life. While research exists on various exercise interventions for knee osteoarthritis, there is limited focus on patients with Grade 1 and 2 osteoarthritis. Understanding the most effective training method for this group will provide valuable insights for developing targeted rehabilitation programs, ultimately improving patient outcomes and quality of life.
Detailed description
Osteoarthritis of the knee is a degenerative condition that gradually affects the synovial joints. Following the stress, joint become damaged and unable to repair and is triggered by asymmetry in synovial tissues of joint such as articular cartilage, ligaments, subchondral bone, periarticular musculature, menisci, synovia or peripheral nerves. This structural harm leads to the breakdown of subchondral bone and cartilage, resulting in symptoms like stiffness, pain, and limited range of motion. It is just like a plane surface of road becoming uneven and pitted. Osteoarthritis of knee joint debilitates the individuals and they totally rely on others.
Interventions for treating knee osteoarthritis include pharmacological and therapeutic technique. Present clinical recommendations in grade 1 and 2 favor conservative management, like physical therapy, use of assistive devices and weight management due to their simplicity, minimal side effects, and more economical. Due to extensive evidence showing the positive impact of physical activity on individuals with osteoarthritis, exercise is frequently recommended as a key element in the rehabilitation journey.
In various physical workout plans, muscle strengthening holds significance due to the connection between pain, muscle weakness, and limited function. Yet, standard strengthening routines might not suffice for individuals having functional joint instability. A research study on this specific group of patients explored treatments targeting symptoms directly, aiming to enhance the efficiency of the rehabilitation regimen. Recently awareness has been given by focusing on sensory inputs such as balance and proprioception exercises. It may allow individual to adapt motor skills for dealing with disability on knee. Sensorimotor training is an effective treatment to restore motor programs in patients among different musculoskeletal disorders and chronic musculoskeletal pain. It adopts a phase-oriented treatment approach and consists of regulation of arousal, emotion and behavior.
The goal of sensorimotor therapy training in knee osteoarthritis is to gain functional activities, relieve pain. As osteoarthritis advances, sensory-motor abilities like neuromuscular control, static and dynamic balance, and proprioception decrease due to reduced daily physical activities and heightened pain perception. Therefore, incorporating agility, coordination, and balance exercises such as cross steps while walking backward, walking on unsymmetrical surfaces and verbal commands by therapist can be beneficial by challenging individuals with disruptive loads. This exposure helps the neuromuscular system adapt to situations that may trigger knee instability during daily activities. Resistance training refers to a workout method where muscles are engaged against a resistance or weight. This training approach aids in strength enhancement, muscle building, and endurance improvement. It encompasses utilizing weights, resistance bands, or engaging in bodyweight exercises. The benefits of resistance training include overall fitness enhancement, bone density improvement, metabolism boost, and better physical performance. Proper execution of resistance training is crucial to prevent injuries and optimize workout effectiveness
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Sensory Motor Group | Experimental | Other: Sensory motor trainingParticipants in the sensory-motor training group received 8-week program of exercise 2 times a week. It starts with a warm-up on stationary bicycle for 10 minutes, stretching exercises. |
| Resistance training group | Active comparator | Other: Resistance TrainingThe individuals allocated to the resistance training received a same 8-weeks exercise program twice a week. Exercise began with the same warm-up on stationary bicycle for 10 minutes then traction was applied, Isometric hip flexion and leg extension, stretching exercises for lower limb, Quadriceps and hamstring strengthening using ankle weights were used with frequency twice a week. 3 sets of 10 repetitions at 30 to 40% of 1RM and low to moderate intensity loads were applied for 15 minutes bilaterally. |
Who may qualify
- Ages
- 40 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Both males and females are included.
- Age group include 40-60 years.
- Not done any exercise for at least 3 months
- Tibiofemoral osteoarthritis
- Grade I and II osteoarthritis
Key exclusion criteria (3 listed)
- • Cardiorespiratory diseases.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Sensory motor training7.8. Interventions i FITT Principle: F: 2 times a week I: maximum to minimum T: Group 1 SMT, Group 2 RT T: 40-50 min Individuals were assigned 1:1 to either sensory motor training or resistance training. ii Groups with sufficient details 1 Experimental: Group1: Participants in the sensory-motor training group received 8-week program of exercise 2 times a week. It starts with a warm-up on stationary bicycle for 10 minutes, stretching exercises. In this group the main focus was on agility exercises that includes a balance board, walking on different directions, crossing steps while walking backward and forward and walking on different surfaces. The duration for these exercises was 40-50 minutes per session. | Other | Sensory Motor Group |
| Resistance TrainingThe individuals allocated to the resistance training received a same 8-weeks exercise program twice a week. Exercise began with the same warm-up on stationary bicycle for 10 minutes then traction was applied, Isometric hip flexion and leg extension, stretching exercises for lower limb, Quadriceps and hamstring strengthening using ankle weights were used with frequency twice a week. 3 sets of 10 repetitions at 30 to 40% of 1RM and low to moderate intensity loads were applied for 15 minutes bilaterally. | Other | Resistance training group |
Primary outcome
Visual Analogue Scale (VAS - Pain Outcome)
Time frame: 8 weeks
The Visual Analogue Scale is a simple, reliable tool used to quantify pain intensity on a 10 cm line ranging from "no pain" to "worst possible pain." Participants marked their pain level experienced in both knees over the past 24 hours. It allows sensitive detection of even small changes in perceived pain.
WOMAC Scale (Functional Activities Outcome)
Time frame: 8 weeks
The WOMAC Index is a validated questionnaire designed to evaluate pain, stiffness, and physical function specifically in individuals with knee or hip osteoarthritis. It assesses daily functional limitations such as walking, stair climbing, and standing. Higher scores indicate greater impairment, making it useful for monitoring treatment-related improvements.
1 secondary outcome
Timed Up and Go (TUG) Test - Balance Outcome
Time frame: 8 Weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Dec 2025.
- Background: PubMed 25224078Andriacchi TP, Favre J, Erhart-Hledik JC, Chu CR. A systems view of risk factors for knee osteoarthritis reveals insights into the pathogenesis of the disease. Ann Biomed Eng. 2015 Feb;43(2):376-87. doi: 10.1007/s10439-014-1117-2. Epub 2014 Sep 16.
- Background: PubMed 29236934Gomiero AB, Kayo A, Abraao M, Peccin MS, Grande AJ, Trevisani VF. Sensory-motor training versus resistance training among patients with knee osteoarthritis: randomized single-blind controlled trial. Sao Paulo Med J. 2018 Jan-Feb;136(1):44-50. doi: 10.1590/1516-3180.2017.0174100917. Epub 2017 Dec 7.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Sensory motor training and Resistance Training in people with Knee Osteoarthristis, run by Lahore University of Biological and Applied Sciences at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 4 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Muhammad Waqas Waheed, MS (Neuromuscular) (+923057570243, waqaswaheed612@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Visual Analogue Scale (VAS - Pain Outcome) (time frame: 8 weeks). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07262931, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Dec 2025.